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Onderzoeker
Kathleen Claes
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
281
Resultaten
2025
Family-level impact of germline genetic testing in childhood cancer : a multi family member interview analysis
Sophie Van Hoyweghen
Kathleen Claes
Robin de Putter
Claire E. Wakefield
Marie Van Poucke
Marieke Van Schoors
Sabine Hellemans
Lesley Verhofstadt
A1
Artikel in een tijdschrift
in
CANCERS
2025
Investigating chromosomal radiosensitivity in inborn errors of immunity : insights from DNA repair disorders and beyond
Elien Beyls
Evi Duthoo
Lynn Backers
Karlien Claes
[missing] RAPID Clinicians
Tessa Kerre
B. Lambrecht
Levi Hoste
B. Meertens
T. Van Genechten
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL IMMUNOLOGY
2025
Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish
Michiel Vanhooydonck
Elyne De Neef
Hanna De Saffel
Annekatrien Boel
Andy Willaert
Bert Callewaert
Kathleen Claes
Preprint
2025
Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients
Evi Duthoo
Elien Beyls
Lynn Backers
Thorkell Gudjónsson
Peiquan Huang
Leander Jonckheere
Sebastian Riemann
Bram Parton
Likun Du
Veronique Debacker
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF EXPERIMENTAL MEDICINE
2025
2024
Advances in CRISPR-mediated knock-in of disease- and cancer-related variants in zebrafish
Elyne De Neef
Michiel Vanhooydonck
Hanna De Saffel
Béatrice Lintermans
Andy Willaert
Bert Callewaert
Anne Vral
Kathleen Claes
C3
Conferentie
2024
Advances in CRISPR-mediated knock-in of disease-related variants in zebrafish
Elyne De Neef
Michiel Vanhooydonck
Hanna De Saffel
Béatrice Lintermans
Andy Willaert
Bert Callewaert
Anne Vral
Kathleen Claes
C3
Conferentie
2024
Asymmetric kidney cysts in a patient with negative family history
Othmane Mohib
Suzanne Vanhauwaert
Lisanne De Boeck
Kathleen Claes
Peter Janssens
Redactioneel materiaal
2024
EMQN best practice guidelines for genetic testing in hereditary breast and ovarian cancer
Trudi McDevitt
Miranda Durkie
Norbert Arnold
George J. Burghel
Samantha Butler
Kathleen Claes
Peter Logan
Rachel Robinson
Katie Sheils
Nicola Wolstenholme
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2024
Fishing for personalized ovarian cancer therapy
Charlotte Fieuws
Kathleen Claes
Koen Van de Vijver
Hannelore Denys
Proefschrift
2024
Gebruik van farmacogenetische tests in België
Kathleen Claes
Verslag
2024
Identification of potentially actionable genetic variants in epithelial ovarian cancer : a retrospective cohort study
Charlotte Fieuws
Joni Van der Meulen
Kristiaan Proesmans
Emiel De Jaeghere
Siebe Loontiens
Jo Van Dorpe
Philippe Tummers
Hannelore Denys
Koen Van de Vijver
Kathleen Claes
A1
Artikel in een tijdschrift
in
NPJ PRECISION ONCOLOGY
2024
In memory of Ludwine Messiaen, Ph.D. (1956-2024)
Elfride De Baere
Eric Legius
Reiner A. Veitia
Kathleen Claes
Biografie
2024
Knock-in of disease-related variants in the zebrafish model organism
Michiel Vanhooydonck
Elyne De Neef
Hanna De Saffel
Annekatrien Boel
Kathleen Claes
Andy Willaert
Bert Callewaert
U
Conferentie
2024
Myhre syndrome in adulthood : clinical variability and emerging genotype-phenotype correlations
Eva Vanbelleghem
Tim Van Damme
Aude Beyens
Sofie Symoens
Kathleen Claes
Julie De Backer
Ilse Meerschaut
Floris Vanommeslaeghe
Sigurd Delanghe
Jenneke van den Ende
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2024
Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish
Elyne De Neef
Michiel Vanhooydonck
Kathleen Claes
Bert Callewaert
Hanna De Saffel
Béatrice Lintermans
Andy Willaert
Anne Vral
C3
Conferentie
2024
Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish
Elyne De Neef
Michiel Vanhooydonck
Hanna De Saffel
Anne Vral
Andy Willaert
Bert Callewaert
Kathleen Claes
C3
Conferentie
2024
The clinical use of exome sequencing to diagnose PCD patients
Lore Pottie
Sofie Symoens
Elfride De Baere
Kathleen Claes
C3
Conferentie
2024
The psychological impact of genetic testing in childhood cancer : a systematic review
Sophie Van Hoyweghen
Kathleen Claes
Robin de Putter
Claire Wakefield
Marieke Van Schoors
Sabine Hellemans
Lesley Verhofstadt
A1
Artikel in een tijdschrift
in
PSYCHO-ONCOLOGY
2024
Towards improved Parsortix® efficiency for circulating tumor cell enrichment in pancreatic cancer
Nele Vandenbussche
Béatrice Lintermans
Tijs Merckaert
Charlotte Fieuws
Kris Gevaert
Kathleen Claes
C3
Conferentie
2024
Zebrafish avatars : toward functional precision medicine in low-grade serous ovarian cancer
Charlotte Fieuws
Jan Willem Bek
Bram Parton
Elyne De Neef
Olivier De Wever
Milena Hoorne
Marta F. Estrada
Jo Van Dorpe
Hannelore Denys
Koen Van de Vijver
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2024
2023
A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment
Elly De Vlieghere
Koen Van de Vijver
Eva Blondeel
Nathan Carpentier
Rouba Ghobeira
Jarne Pauwels
Sebastian Riemann
Manon Minsart
Charlotte Fieuws
Johanna Mestach
et al.
A1
Artikel in een tijdschrift
in
BIOMATERIALS RESEARCH
2023
Assessing recovery rates of mesenchymal and epithelial pancreatic tumor cells using the Parsortix system
Nele Vandenbussche
Bram Parton
Tijs Merckaert
Charlotte Fieuws
Kris Gevaert
Kathleen Claes
U
Conferentie
2023
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility
Jeroen Vierstraete
Charlotte Fieuws
David Creytens
Jo Van Dorpe
Andy Willaert
Anne Vral
Kathleen Claes
Redactioneel materiaal
2023
Clinical presentation of sporadic and hereditary pheochromocytoma/paraganglioma
Sofia Maria Lider Burciulescu
Caren Randon
Fréderic Duprez
Wouter Huvenne
David Creytens
Kathleen Claes
Robin de Putter
Guy T'Sjoen
Corin Badiu
Bruno Lapauw
A2
Artikel in een tijdschrift
in
ENDOCRINE ONCOLOGY
2023
ENIGMA CHEK2gether Project : a comprehensive study identifies functionally impaired CHEK2 germline missense variants associated with increased breast cancer risk
Lenka Stolarova
Petra Kleiblova
Petra Zemankova
Barbora Stastna
Marketa Janatova
Jana Soukupova
Maria Isabel Achatz
Christine Ambrosone
Paraskevi Apostolou
Banu K. Arun
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2023
HRAS-related epidermal nevus syndromes : expansion of the spectrum with first branchial arch defects
Aude Beyens
Charlotte Lietaer
Kathleen Claes
Elfride De Baere
Marleen Goeteyn
Bob Lerut
Hannes Syryn
Olivier Vanakker
Joni Van der Meulen
Lieve Vanwalleghem
et al.
A1
Artikel in een tijdschrift
in
CLINICAL GENETICS
2023
Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe
M. de With
A. Sadlon
E. Cecchin
V. Haufroid
F. Thomas
M. Joerger
R.H.N. van Schaik
R.H.J. Mathijssen
C.R. Largiadèr
Kathleen Claes
et al.
A1
Artikel in een tijdschrift
in
ESMO OPEN
2023
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
Denise G. O’Mahony
Susan J. Ramus
Melissa C. Southey
Nicola S. Meagher
Andreas Hadjisavvas
Esther M. John
Ute Hamann
Evgeny N. Imyanitov
Irene L. Andrulis
Priyanka Sharma
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2023
2022
Application of an ultrasensitive NGS-based blood test for the diagnosis of early-stage lung cancer : sensitivity, a hurdle still difficult to overcome
Malaïka Van der Linden
Bram Van Gaever
Lennart Raman
Karim Vermaelen
Ingel Demedts
Veerle Surmont
Ulrike Himpe
Yolande Lievens
Liesbeth Ferdinande
Franceska Dedeurwaerdere
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2022
Belgian guidelines for the frequency of participation of the Medical Centers of Human Genetics to external quality assessment schemes for analyses focused on rare diseases
Josephine Lantoine
Anne Brysse
Vinciane Dideberg
Kathleen Claes
Sofie Symoens
Wim Coucke
Valerie Benoit
Sonia Rombout
Martine De Rycke
Sara Seneca
et al.
C3
Conferentie
2022
Breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers using polygenic risk scores
Daniel R Barnes
Valentina Silvestri
Goska Leslie
Lesley McGuffog
Joe Dennis
Xin Yang
Julian Adlard
Bjarni A Agnarsson
Munaza Ahmed
Kristiina Aittomäki
et al.
A1
Artikel in een tijdschrift
in
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2022
Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants : application of a points-based ACMG/AMP approach
M Thomassen
RLS Mesman
TVO Hansen
M Menendez
M Rossing
A Esteban-Sánchez
E Tudini
T Törngren
MT Parsons
IS Pedersen
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2022
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers
Christopher Hakkaart
John F. Pearson
Louise Marquart
Joe Dennis
George A. R. Wiggins
Daniel R. Barnes
Bridget A. Robinson
Peter D. Mace
Kristiina Aittomäki
Irene L. Andrulis
et al.
A1
Artikel in een tijdschrift
in
COMMUNICATIONS BIOLOGY
2022
Genotype-phenotype associations in a large PTEN Hamartoma Tumor Syndrome (PHTS) patient cohort
Linda A. J. Hendricks
Nicoline Hoogerbrugge
Hanka Venselaar
Stefan Aretz
Isabel Spier
Eric Legius
Hilde Brems
Robin de Putter
Kathleen Claes
Gareth Evans
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICAL GENETICS
2022
Joint Belgian recommendation on screening for DPD-deficiency in patients treated with 5-FU, capecitabine (and tegafur)
Veerle Casneuf
Ivan Borbath
Marc Van den Eynde
Yolanda Verheezen
Wim Demey
Alain Verstraete
Kathleen Claes
Vincent Haufroid
Karen Geboes
A1
Artikel in een tijdschrift
in
ACTA CLINICA BELGICA
2022
Liquid biopsies for integrated cancer (differential) diagnosis : from whole-genome to targeted and from genomics to epigenomics
Malaïka Van der Linden
Jo Van Dorpe
Björn Menten
Kathleen Claes
Proefschrift
2022
Liquid biopsies to predict surgical resectability after FOLFIRINOX chemotherapy in patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma
Nele Vandenbussche
Luis Abreu De Carvalho
Kris Gevaert
Frederik Berrevoet
Kathleen Claes
C3
Conferentie
2022
Noncoding aberrations in mismatch repair genes underlie a substantial part of the missing heritability in Lynch syndrome
Iris B.A.W. Te Paske
Arjen R. Mensenkamp
Kornelia Neveling
Nicoline Hoogerbrugge
Marjolijn J.L. Ligtenberg
Richarda M. De Voer
Stéphanie Baert-Desurmont
Kathleen Claes
Kim De Leeneer
Lisa Elze
et al.
A1
Artikel in een tijdschrift
in
GASTROENTEROLOGY
2022
PRECISION : the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment
J. Thouvenin
C. Van Marcke
L. Decoster
G. Raicevic
K. Punie
M. Vandenbulcke
R. Salgado
E. Van Valckenborgh
B. Maes
S. Joris
et al.
A1
Artikel in een tijdschrift
in
ESMO OPEN
2022
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Elisa V. Bandera
Kathleen Claes
Robin de Putter
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2022
Practical guidance for molecular testing in metastatic prostate cancer : a Belgian perspective
Sofie Verbeke
S Verschuere
M-D Martin-Martinez
Bart Lelie
Louis Libbrecht
M Baldewijns
S Rorive
G Beniuga
J Eben
M-A Van Caillie
et al.
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF MEDICAL ONCOLOGY
2022
Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis : a standardized approach with underappreciated potential
Lennart Raman
Malaïka Van der Linden
Ciel De Vriendt
Bliede Van den Broeck
Kristoff Muylle
Dries Deeren
Franceska Dedeurwaerdere
Sofie Verbeke
Amélie Dendooven
Katrien De Grove
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2022
Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential
Lennart Raman
Malaïka Van Der Linden
Ciel De Vriendt
Bliede Van den Broeck
Kristoff Muylle
Dries Deeren
Franceska Dedeurwaerdere
Sofie Verbeke
Amélie Dendooven
Katrien De Grove
et al.
U
Artikel in een tijdschrift
in
Haematologica
2022
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
Levi Hoste
Lisa Roels
Leslie Naesens
Victor Bosteels
Stijn Vanhee
Sam Dupont
Cedric Bosteels
Robin Browaeys
Niels Vandamme
Kevin Verstaen
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF EXPERIMENTAL MEDICINE
2022
2021
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Juliette Coignard
Michael Lush
Jonathan Beesley
Tracy A. O'Mara
Joe Dennis
Jonathan P. Tyrer
Daniel R. Barnes
Lesley McGuffog
Goska Leslie
Manjeet K. Bolla
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2021
Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer
Franceska Dedeurwaerdere
Kathleen Claes
Jo Van Dorpe
Isabelle Rottiers
Joni Van der Meulen
Joke Breyne
Koen Swaerts
Geert Martens
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2021
Dealing with pseudogenes in in the next generation sequencing era
Kathleen Claes
Toon Rosseel
Kim De Leeneer
Hoofdstuk in een boek
in
Pseudogenes
2021
Enhanced MCP-1 release in early autosomal dominant polycystic kidney disease
Peter Janssens
Jean-Paul Decuypere
Stephanie De Rechter
Luc Breysem
Dorien Van Giel
Jaak Billen
An Hindryckx
Luc De Catte
Marcella Baldewijns
Kathleen Claes
et al.
A1
Artikel in een tijdschrift
in
KIDNEY INTERNATIONAL REPORTS
2021
Frequency of participation in external quality assessment programs focused on rare diseases : Belgian guidelines for human genetics centers
Josephine Lantoine
Anne Brysse
Vinciane Dideberg
Kathleen Claes
Sofie Symoens
Wim Coucke
Valerie Benoit
Sonia Rombout
Martine De Rycke
Sara Seneca
et al.
A1
Artikel in een tijdschrift
in
JMIR MEDICAL INFORMATICS
2021
Genetic testing in prostate cancer in clinical practice
Robin de Putter
Bram De Laere
Piet Ost
Kathleen Claes
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF MEDICAL ONCOLOGY
2021
Hereditary syndromes and pancreatic cancer
Kathleen Claes
Laura Pölsler
Johannes Zschocke
Hoofdstuk in een boek
in
Textbook of pancreatic cancer : principles and practice of surgical oncology
2021
Integration of genomics and transcriptomics allows the identification of rare DNA damage defects in PID patients with a cancer predisposition
Lynn Backers
Bram Parton
Mattias Van Heetvelde
Marieke De Bruyne
Kim De Leeneer
Simon Tavernier
Anne Vral
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2021
Integration of genomics and transcriptomics to identify DNA damage defects in PID patients prone to cancer
Lynn Backers
Bram Parton
Mattias Van Heetvelde
Marieke De Bruyne
Kim De Leeneer
Anne Vral
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2021
Integration of genomics and transcriptomics to identify DNAdamage defects in PID patients with a cancer predisposition
Lynn Backers
Bram Parton
Mattias Van Heetvelde
Marieke De Bruyne
Kim De Leeneer
Anne Vral
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2021
Missing heritability in Bloom syndrome : First report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene
Lynn Backers
Bram Parton
Marieke De Bruyne
Simon Tavernier
Kris Van Den Bogaert
Bart Lambrecht
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2021
Missing heritability in Bloom syndrome : first report of a deep intronic variant leading to pseudo‐exon activation in the BLM gene
Lynn Backers
Bram Parton
Marieke De Bruyne
Simon Tavernier
Kris Van Den Bogaert
Bart Lambrecht
Filomeen Haerynck
Kathleen Claes
A1
Artikel in een tijdschrift
in
CLINICAL GENETICS
2021
Myxoid hepatocellular adenoma, a rare variant of hepatocellular adenoma with distinct imaging features : a case report with immunohistochemical and molecular analysis and literature review
Nicolas De Vos
Joni Van der Meulen
Malaïka Van der Linden
Kathleen Claes
Ann-Sophie Candaele
Aude Vanlander
Roberto Troisi
Hans Van Vlierberghe
Peter Smeets
Jo Van Dorpe
et al.
A1
Artikel in een tijdschrift
in
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
2021
Pathogenic neurofibromatosis type 1 (NF1) RNA splicing resolved by targeted RNAseq
R. Koster
R. D. Brandao
D. Tserpelis
C. E. P. van Roozendaal
C. N. van Oosterhoud
Kathleen Claes
A. D. C. Paulussen
M. Sinnema
M. Vreeburg
V van der Schoot
et al.
A1
Artikel in een tijdschrift
in
NPJ GENOMIC MEDICINE
2021
Prevalence of germline pathogenic variants in cancer predisposing genes in Czech and Belgian pancreatic cancer patients
Greet Wieme
Jan Kral
Toon Rosseel
Petra Zemankova
Bram Parton
Michal Vocka
Mattias Van Heetvelde
Petra Kleiblova
Bettina Blaumeiser
Jana Soukupova
et al.
C3
Conferentie
2021
Prevalence of germline pathogenic variants in cancer predisposing genes in Czech and Belgian pancreatic cancer patients
Greet Wieme
Jan Kral
Toon Rosseel
Petra Zemankova
Bram Parton
Michal Vocka
Mattias Van Heetvelde
Petra Kleiblova
Bettina Blaumeiser
Jana Soukupova
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2021
Somatic mosaics in hereditary tumor predisposition syndromes
Verena Steinke-Lange
Robin de Putter
Elke Holinski-Feder
Kathleen Claes
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICAL GENETICS
2021
The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant
Inge M. M. Lakeman
Alexandra J. van den Broek
Julien A. M. Vos
Daniel R. Barnes
Julian Adlard
Irene L. Andrulis
Adalgeir Arason
Norbert Arnold
Banu K. Arun
Judith Balmana
et al.
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2021
Timing of blood sampling for butyrylcholinesterase phenotyping in patients with prolonged neuromuscular block after mivacurium or suxamethonium
Nesse Mintjens
Roy Brummans
Filiep Soetens
Kathleen Claes
Luc E. Vanlinthout
A1
Artikel in een tijdschrift
in
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2021
Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy
Jeroen Vierstraete
Charlotte Fieuws
Andy Willaert
Anne Vral
Kathleen Claes
A1
Artikel in een tijdschrift
in
DNA REPAIR
2021
2020
Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness
Vivek L. Patel
Evan L. Busch
Tara M. Friebel
Angel Cronin
Goska Leslie
Lesley McGuffog
Julian Adlard
Simona Agata
Bjarni A. Agnarsson
Munaza Ahmed
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2020
Atm deficient zebrafish model reveals conservation of the tumour suppressor function
Jeroen Vierstraete
Charlotte Fieuws
David Creytens
Jo Van Dorpe
Andy Willaert
Anne Vral
Kathleen Claes
C3
Conferentie
2020
Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families
Xin Yang
Goska Leslie
Alicja Doroszuk
Sandra Schneider
Jamie Allen
Brennan Decker
Alison M. Dunning
James Redman
James Scarth
Inga Plaskocinska
et al.
A1
Artikel in een tijdschrift
in
Journal of Clinical Oncology
2020
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Marc Tischkowitz
Chrystelle Colas
Sjaak Pouwels
Nicoline Hoogerbrugge
on behalf of European Reference Network GENTURI
on behalf of PHTS Guideline Dev Grp
Kathleen Claes
Bruce Poppe
Robin de Putter
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2020
Characterization of the cancer spectrum in men with germline BRCA1 and BRCA2 pathogenic variants : results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
Valentina Silvestri
Goska Leslie
Daniel R. Barnes
Bjarni A. Agnarsson
Kristiina Aittomäki
Elisa Alducci
Irene L. Andrulis
Rosa B. Barkardottir
Alicia Barroso
Daniel Barrowdale
et al.
A1
Artikel in een tijdschrift
in
JAMA ONCOLOGY
2020
Clinical spectrum of individuals with pathogenic NF1 missense variants affecting p.Met1149, p.Arg1276, and p.Lys1423 : genotype-phenotype study in neurofibromatosis type 1
Magdalena Koczkowska
Tom Callens
Yunjia Chen
Alicia Gomes
Alesha D. Hicks
Angela Sharp
Eric Johns
Kim Armfield Uhas
Linlea Armstrong
Katherine Armstrong Bosanko
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2020
Decreased DNA double‑strand break repair and enhanced chromosomal radiosensitivity in irradiated non‑tumorigenic human breast epithelial cells with a partial BRCA1 or BRCA2 knockdown
Annelot Baert
Maria Palermo
Mattias Van Heetvelde
Bram Verstraete
Julie Depuydt
Jeroen Vierstraete
Jan Philippé
Anna Sablina
Gianpaolo Perletti
Kathleen Claes
et al.
A2
Artikel in een tijdschrift
in
WORLD ACADEMY OF SCIENCES JOURNAL
2020
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
Karen Geboes
et al.
C3
Conferentie
2020
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
Vivien Béziat
Simon Tavernier
Yin-Huai Chen
Cindy S. Ma
Marie Materna
Arian Laurence
Jens Staal
Dominik Aschenbrenner
Lisa Roels
Lisa Worley
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF EXPERIMENTAL MEDICINE
2020
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Laura Fachal
Hugues Aschard
Jonathan Beesley
Daniel R. Barnes
Jamie Allen
Siddhartha Kar
Karen A. Pooley
Joe Dennis
Kyriaki Michailidou
Constance Turman
et al.
A1
Artikel in een tijdschrift
in
NATURE GENETICS
2020
First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation
Lynn Backers
Bram Parton
Stephanie Vermeulen
Marieke De Bruyne
Simon Tavernier
Kris Van Den Bogaert
Anne Vral
Ans Baeyens
Filomeen Haerynck
Bart Lambrecht
et al.
C3
Conferentie
2020
First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation
Lynn Backers
Bram Parton
Stephanie Vermeulen
Marieke De Bruyne
Kris Van Den Bogaert
Anne Vral
Ans Baeyens
Simon Tavernier
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2020
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Haoyu Zhang
Thomas U. Ahearn
Julie Lecarpentier
Daniel Barnes
Jonathan Beesley
Guanghao Qi
Xia Jiang
Tracy A. O’Mara
Ni Zhao
Manjeet K. Bolla
et al.
A1
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in
NATURE GENETICS
2020
Germline genetic findings which may impact therapeutic decisions in families with a presumed predisposition for hereditary breast and ovarian cancer
Carolina Velázquez
Kim De Leeneer
Eva M. Esteban-Cardeñosa
Francisco Avila Cobos
Enrique Lastra
Luis E. Abella
Virginia de la Cruz
Carmen D. Lobatón
Kathleen Claes
Mercedes Durán
et al.
A1
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in
CANCERS
2020
Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes
Thierry Frebourg
Svetlana Bajalica Lagercrantz
Carla Oliveira
Rita Magenheim
D. Gareth Evans
on behalf of European Reference Network GENTURI
Kathleen Claes
Bruce Poppe
Robin de Putter
A1
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in
EUROPEAN JOURNAL OF HUMAN GENETICS
2020
Isolation and engraftment of circulating tumor cells into zebrafish embryos to predict tumor response of ovarian cancer patients
Charlotte Fieuws
Jeroen Vierstraete
Koen Van de Vijver
Hannelore Denys
Kathleen Claes
C3
Conferentie
2020
Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene
Lynn Backers
Bram Parton
Marieke De Bruyne
Simon Tavernier
Kris Van Den Bogaert
Bart Lambrecht
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2020
Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene
Lynn Backers
Bram Parton
Marieke De Bruyne
Simon Tavernier
Kris Van Den Bogaert
Bart Lambrecht
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2020
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
Daniel R. Barnes
Matti A. Rookus
Lesley McGuffog
Goska Leslie
Thea M. Mooij
Joe Dennis
Nasim Mavaddat
Julian Adlard
Munaza Ahmed
Kristiina Aittomäki
et al.
A1
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in
GENETICS IN MEDICINE
2020
Shallow whole-genome sequencing of cell-free DNA for B-cell lymphoma diagnosis and disease monitoring : a standardized approach with underappreciated potential
Malaïka Van der Linden
Lennart Raman
Ciel De Vriendt
Bliede Van den Broeck
Kristoff Muylle
Dries Deeren
Kathleen Claes
Björn Menten
Fritz Offner
Jo Van Dorpe
C3
Conferentie
2020
Shallow whole-genome sequencing of cell-free DNA for B-cell lymphoma diagnosis and disease monitoring: a standardized approach with underappreciated potential
Malaïka Van der Linden
Lennart Raman
Ciel De Vriendt
Bliede Van den Broeck
Kristoff Muylle
Dries Deeren
Kathleen Claes
Björn Menten
Fritz Offner
Jo Van Dorpe
C3
Conferentie
2020
Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma
Lennart Raman
Malaïka Van der Linden
Kim Van der Eecken
Karim Vermaelen
Ingel Demedts
Veerle Surmont
Ulrike Himpe
Franceska Dedeurwaerdere
Liesbeth Ferdinande
Yolande Lievens
et al.
A1
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in
GENOME MEDICINE
2020
Surveillance recommendations for patients with Lynch syndrome and FAP : a monocentric study
Lieselot Baert
Kathleen Claes
Marc De Man
David Tate
Karen Geboes
A1
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in
ACTA GASTRO-ENTEROLOGICA BELGICA
2020
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
Helian Feng
Alexander Gusev
Bogdan Pasaniuc
Lang Wu
Jirong Long
Zomoroda Abu-full
Kristiina Aittomaki
Irene L. Andrulis
Hoda Anton-Culver
Antonis C. Antoniou
et al.
A1
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in
GENETIC EPIDEMIOLOGY
2020
Zebrafish as a model to study DNA repair and developmental defects following loss of Brca2 or Atm
Jeroen Vierstraete
Kathleen Claes
Anne Vral
Proefschrift
2020
cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance
Lynn Backers
Marieke De Bruyne
Simon Tavernier
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2020
2019
Analysis of patients with a personal and/or family history of pancreatic cancer with a custom designed broad cancer predisposition gene panel
Greet Wieme
Toon Rosseel
Bram Parton
Bettina Blaumeiser
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2019
Analysis of patients with a personal and/or family history of pancreatic cancer with a custom designed broad cancer predisposition gene panel
Greet Wieme
Toon Rosseel
Bram Parton
Bettina Blaumeiser
Jenneke van den Ende
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2019
Application of a custom designed broad cancer predisposition gene panel for the analysis of patients with a personal and/or family history of pancreatic cancer
Greet Wieme
Toon Rosseel
Bram Parton
Bettina Blaumeiser
Jenneke van den Ende
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2019
Assessment of radiation sensitivity in patients with a primary immunodeficiency disease
Anne Vral
Ans Baeyens
Kathleen Claes
Carolien Bonroy
Victoria Bonroy
Elien Beyls
Evi Duthoo
Lynn Backers
Stephanie Vermeulen
Filomeen Haerynck
C3
Conferentie
2019
Boosting care and knowledge about hereditary cancer : European Reference Network on Genetic Tumour Risk Syndromes
Janet R Vos
Lisette Giepmans
Claas Röhl
Nicoline Geverink
Nicoline Hoogerbrugge
on behalf of ERN Genturis
Bruce Poppe
Kathleen Claes
A1
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in
FAMILIAL CANCER
2019
Chromosomal radiosensitivity of triple negative breast cancer patients
Flavia Zita Francies
Olivia Herd
Alan Cairns
Sarah Nietz
Marshall Murdoch
Jacobus Slabbert
Kathleen Claes
Anne Vral
Ans Baeyens
A1
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in
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
2019
Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation
Magdalena Koczkowska
Tom Callens
Alicia Gomes
Angela Sharp
Yunjia Chen
Alesha D. Hicks
Arthur S. Aylsworth
Amedeo A. Azizi
Donald G. Basel
Gary Bellus
et al.
Correctie
2019
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
et al.
C3
Conferentie
2019
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
et al.
C3
Conferentie
2019
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
et al.
C3
Conferentie
2019
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
et al.
C3
Conferentie
2019
Detection of genome-wide copy number alterations in tumor tissue and cell-free DNA of pancreatic cancer patients
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Bram Parton
Jurgen van Limmen
ANN DE BRUYNE
Marc De Man
et al.
C3
Conferentie
2019
Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del) : an update of genotype-phenotype correlation
Magdalena Koczkowska
Tom Callens
Alicia Gomes
Angela Sharp
Yunjia Chen
Alesha D Hicks
Arthur S Aylsworth
Amedeo A Azizi
Donald G Basel
Gary Bellus
et al.
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2019
Faithfully recapitulating PARP inhibitor efficacy in zebrafish
Jeroen Vierstraete
Charlotte Fieuws
Andy Willaert
Anne Vral
Kathleen Claes
C3
Conferentie
2019
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Manuel A Ferreira
Eric R Gamazon
Fares Al-Ejeh
Kristiina Aittomaki
Irene L Andrulis
Hoda Anton-Culver
Adalgeir Arason
Volker Arndt
Kristan J Aronson
Banu K Arun
et al.
A1
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in
NATURE COMMUNICATIONS
2019
Height and body mass index as modifiers of breast cancer risk in BRCA1/2 mutation carriers : a Mendelian randomization study
Frank Qian
Shengfeng Wang
Jonathan Mitchell
Lesley McGuffog
Daniel Barrowdale
Goska Leslie
Jan C Oosterwijk
Wendy K Chung
D Gareth Evans
Christoph Engel
et al.
A1
Artikel in een tijdschrift
in
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2019
Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report
Eduard Callebout
Suzane Moura Ribeiro
Stéphanie Laurent
Marc De Man
Liesbeth Ferdinande
Kathleen Claes
Joni Van der Meulen
Karen Geboes
A1
Artikel in een tijdschrift
in
BMC CANCER
2019
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers
Frank Qian
Matti A Rookus
Goska Leslie
Harvey A Risch
Mark H Greene
Cora M Aalfs
Muriel A Adank
Julian Adlard
Bjarni A Agnarsson
Munaza Ahmed
et al.
A1
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in
BRITISH JOURNAL OF CANCER
2019
PCR based target enrichment for variant confirmation, gene panels and multiplex PCR sample tracking in a whole exome sequencing workflow
Frauke Coppieters
Thalia Van Laethem
Matthias De Smet
Paul Coucke
Elfride De Baere
Kathleen Claes
Björn Menten
Jo Vandesompele
Steve Lefever
C3
Conferentie
2019
Radiosensitivity analysis in patients with a primary immunodeficiency disease
Anne Vral
Ans Baeyens
Kathleen Claes
Carolien Bonroy
Victoria Bordon
Elien Beyls
Evi Duthoo
Lynn Backers
Stephanie Vermeulen
Filomeen Haerynck
C3
Conferentie
2019
Second hits in BRCA1- and BRCA2-associated breast and ovarian cancer : connecting coding to non-coding mechanisms of inactivation
Mattias Van Heetvelde
Kathleen Claes
Anne Vral
Kim De Leeneer
Proefschrift
2019
Shared heritability and functional enrichment across six solid cancers
Xia Jiang
Hilary K Finucane
Fredrick R Schumacher
Stephanie L Schmit
Jonathan P Tyrer
Younghun Han
Kyriaki Michailidou
Corina Lesseur
Karoline B Kuchenbaecker
Joe Dennis
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2019
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
Gisella Figlioli
Massimo Bogliolo
Irene Catucci
Laura Caleca
Sandra Viz Lasheras
Roser Pujol
Johanna I Kiiski
Taru A Muranen
Daniel R Barnes
Joe Dennis
et al.
A1
Artikel in een tijdschrift
in
NPJ BREAST CANCER
2019
The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases
Maria Luisa Cayuela
Kathleen Claes
Miguel Godinho Ferreira
Catarina Martins Henriques
Fredericus van Eeden
Máté Varga
Jeroen Vierstraete
Maria Caterina Mione
A1
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in
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2019
Twenty years of BRCA1 and BRCA2 molecular analysis at MMCI : current developments for the classification of variants
E Machackova
Kathleen Claes
M Mikova
J Hazova
E Stahlova Hrabincova
P Vasickova
M Trbusek
M Navratilova
M Svoboda
L Foretova
A2
Artikel in een tijdschrift
in
KLINICKÁ ONKOLOGIE
2019
cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance
Lynn Backers
Marieke De Bruyne
Simon Tavernier
Filomeen Haerynck
Kathleen Claes
C3
Conferentie
2019
miRNA expression profiles in BRCA1-associated breast cancers reveal upregulation of specific miRNAs in tumors lacking a clear second hit in a large proportion of the tumour
Mattias Van Heetvelde
Mieke R Van Bockstal
Jo Van Dorpe
Kim De Leeneer
Anne Vral
Kathleen Claes
C3
Conferentie
2019
2018
A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk
Yingchang Lu
Alicia Beeghly-Fadiel
Lang Wu
Xingyi Guo
Bingshan Li
Joellen M Schildkraut
Hae Kyung Im
Yian A Chen
Jennifer B Permuth
Brett M Reid
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2018
Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits
Mattias Van Heetvelde
Mieke Van Bockstal
Bruce Poppe
Kathleen Lambein
Toon Rosseel
Lilit Atanesyan
Dieter Deforce
Ivo Van Den Berghe
Kim De Leeneer
Jo Van Dorpe
et al.
A1
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in
CANCER LETTERS
2018
BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding
Leslie J Burke
Jan Sevcik
Gaetana Gambino
Emma Tudini
Eliseos J Mucaki
Ben C Shirley
Phillip Whiley
Michael T Parsons
Kim De Leeneer
Sara Gutiérrez-Enríquez
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2018
Chromosomal radiosensitivity and instability in triple negative and/or young breast cancer and Fanconi Anaemia patients in South Africa
Flavia Zita Francies
Ans Baeyens
Kathleen Claes
Anne Vral
Proefschrift
2018
Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei
Flavia Zita Francies
Rosalind Wainwright
Janet Poole
Kim De Leeneer
Ilse Coene
Greet Wieme
Hélène A Poirel
Bénédicte Brichard
Stephanie Vermeulen
Anne Vral
et al.
A1
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in
DNA REPAIR
2018
Extreme clustering of type-1 NF1 deletion breakpoints co-locating with G-quadruplex forming sequences
Anna Summerer
Victor-Felix Mautner
Meena Upadhyaya
Kathleen Claes
Josef Högel
David N Cooper
Ludwine Messiaen
Hildegard Kehrer-Sawatzki
A1
Artikel in een tijdschrift
in
HUMAN GENETICS
2018
Genotype-phenotype correlation in NF1 : evidence for a more severe phenotype associated with missense mutations affecting NF1 codons 844–848
Magdalena Koczkowska
Yunjia Chen
Tom Callens
Alicia Gomes
Angela Sharp
Sherrell Johnson
Meng-Chang Hsiao
Zhenbin Chen
Meena Balasubramanian
Christopher P Barnett
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF HUMAN GENETICS
2018
Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer
Greet Wieme
Toon Rosseel
Bettina Blaumeiser
Jenneke van den Ende
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2018
Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer
Greet Wieme
Bruce Poppe
Toon Rosseel
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2018
Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer
Greet Wieme
Toon Rosseel
Bettina Blaumeiser
Jenneke van den Ende
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2018
Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer
Greet Wieme
Toon Rosseel
Bettina Blaumeiser
Jenneke van den Ende
Sabine Tejpar
Bruce Poppe
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2018
Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations
Timothy R Rebbeck
Tara M Friebel
Eitan Friedman
Ute Hamann
Dezheng Huo
Ava Kwong
Edith Olah
Olufunmilayo I. Olopade
Angela R Solano
Soo-Hwang Teo
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2018
The BRCA1 c. 5096G > A p.Arg1699Gln (R1699Q) intermediate risk variant : breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium
Setareh Moghadasi
Huong D Meeks
Maaike PG Vreeswijk
Linda AM Janssen
Ake Borg
Hans Ehrencrona
Ylva Paulsson-Karlsson
Barbara Wappenschmidt
Christoph Engel
Andrea Gehrig
et al.
A1
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in
JOURNAL OF MEDICAL GENETICS
2018
Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11
Annelot Baert
Eva Machackova
Ilse Coene
Carol Cremin
Kristin Turner
Cheryl Portigal-Todd
Marie Jill Asrat
Jennifer Nuk
Allison Mindlin
Sean Young
et al.
A1
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in
HUMAN MUTATION
2018
Uncovering the role of atm in zebrafish
Jeroen Vierstraete
Anne Vral
Paul Coucke
Andy Willaert
Kathleen Claes
C3
Conferentie
2018
Uncovering the role of zebrafish in atm
Jeroen Vierstraete
Andy Willaert
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2018
Uncovering the role of zebrafish in atm
Jeroen Vierstraete
Andy Willaert
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2018
miRNA expression profiles in BRCA1-associated breast cancers reveal upregulation of specific miRNAs in tumours lacking a clear second hit in a large proportion of the tumour cells
Mattias Van Heetvelde
Mieke R Van Bockstal
Jo Van Dorpe
Kim De Leeneer
Anne Vral
Kathleen Claes
C3
Conferentie
2018
2017
Accurate Quantification of Homologous Recombination in Zebrafish: brca2 deficiency as a paradigm
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Anne Vral
Kathleen Claes
C3
Conferentie
2017
Accurate quantification of homologous recombination : a zebrafish BRCA2-/- model
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2017
Accurate quantification of homologous recombination : a zebrafish brca2-/- model
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2017
Accurate quantification of homologous recombination in zebrafish : brca2 deficiency as a paradigm
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Paul Coucke
Anne Vral
Kathleen Claes
A1
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in
SCIENTIFIC REPORTS
2017
Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay
Annelot Baert
Julie Depuydt
Tom Van Maerken
Bruce Poppe
Fransiska Malfait
Tim Van Damme
Sylvia De Nobele
Gianpaolo Perletti
Kim De Leeneer
Kathleen Claes
et al.
A1
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in
ONCOLOGY REPORTS
2017
Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression : identification of a modifier of breast cancer risk at locus 11q22.3
Yosr Hamdi
Penny Soucy
Karoline B. Kuchenbaeker
Tomi Pastinen
Arnaud Droit
Audrey Lemacon
Julian Adlard
Kristiina Aittomaki
Irene L. Andrulis
Adalgeir Arason
et al.
A1
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in
BREAST CANCER RESEARCH AND TREATMENT
2017
BRCA2 hypomorphic missense variants confer moderate risks of breast cancer
Hermela Shimelis
Romy LS Mesman
Catharina Von Nicolai
Asa Ehlen
Lucia Guidugli
Charlotte Martin
Fabienne MGR Calléja
Huong Meeks
Emily Hallberg
Jamie Hinton
et al.
A1
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in
CANCER RESEARCH
2017
Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers
Karoline B Kuchenbaecker
Lesley McGuffog
Daniel Barrowdale
Andrew Lee
Penny Soucy
Sue Healey
Joe Dennis
Michael Lush
Mark Robson
Amanda B Spurdle
et al.
A1
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in
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2017
Evaluation of relative quantification of alternatively spliced transcripts using droplet digital PCR
Mattias Van Heetvelde
Wouter Van Loocke
Wim Trypsteen
Annelot Baert
Katrien Vanderheyden
Brecht Crombez
Jo Vandesompele
Kim De Leeneer
Kathleen Claes
A2
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in
BIOMOLECULAR DETECTION AND QUANTIFICATION
2017
From human genetics to radiobiology : in vitro radiosensitivity in individuals with a germline defect in DNA damage response genes
Annelot Baert
Anne Vral
Kathleen Claes
Proefschrift
2017
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Catherine M Phelan
Karoline B Kuchenbaecker
Jonathan P Tyrer
Siddhartha P Kar
Kate Lawrenson
Stacey J Winham
Joe Dennis
Ailith Pirie
Marjorie J Riggan
Ganna Chornokur
et al.
A1
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in
NATURE GENETICS
2017
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Roger L Milne
Karoline B Kuchenbaecker
Kyriaki Michailidou
Jonathan Beesley
Siddhartha Kar
Sara Lindström
Shirley Hui
Audrey Lemaçon
Penny Soucy
Joe Dennis
et al.
A1
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in
NATURE GENETICS
2017
In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations
Joni Van der Meulen
Barbara Denys
Elien De Latter
Steve Lefever
Toon Rosseel
Wouter Steyaert
GRETA VAN DER CRUYSSEN
Isabelle Rottiers
David Creytens
Jo Van Dorpe
et al.
C3
Conferentie
2017
In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations
Joni Van der Meulen
Barbara Denys
Elien De Latter
Steve Lefever
Toon Rosseel
Wouter Steyaert
GRETA VAN DER CRUYSSEN
Isabelle Rottiers
David Creytens
Jo Van Dorpe
et al.
C3
Conferentie
2017
Incorporating PARP-inhibitors into clinical routine : a tailored treatment strategy to tackle ovarian cancer
Emiel De Jaeghere
Katrien Vandecasteele
Kathleen Claes
Amin Makar
Philippe Tummers
Veronique Cocquyt
Hannelore Denys
A1
Artikel in een tijdschrift
in
ACTA CLINICA BELGICA
2017
Pancreatic cancer : hope to improve prognosis through thorough analysis of DNA and RNA biomarkers for detection and therapy monitoring in liquid biopsies
Greet Wieme
Frederik Berrevoet
Aude Vanlander
Marc De Man
Karen Geboes
Jo Van Dorpe
Anne Hoorens
Malaïka Van der Linden
Jurgen van Limmen
ANN DE BRUYNE
et al.
C3
Conferentie
2017
Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores
Julie Lecarpentier
Valentina Silvestri
Karoline B Kuchenbaecker
Daniel Barrowdale
Joe Dennis
Lesley McGuffog
Penny Soucy
Goska Leslie
Piera Rizzolo
Anna Sara Navazio
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL ONCOLOGY
2017
Second hit landscape in BRCA-associated breast cancer
Mattias Van Heetvelde
Mieke Van Bockstal
Trees Lepez
Steve Lefever
Leen Pieters
Kathleen Lambein
Marleen Praet
Ivo Van Den Berghe
Frauke Coppieters
Nadine Van Roy
et al.
C3
Conferentie
2017
Second hit landscape in BRCA1/2-associated breast cancer
Mattias Van Heetvelde
Mieke Van Bockstal
Trees Lepez
Kathleen Lambein
Dieter Deforce
Anne Vral
Bruce Poppe
Kim De Leeneer
Jo Van Dorpe
Kathleen Claes
C3
Conferentie
2017
Study of homologous recombination repair in BRCA2 knockout zebrafish embryos
Jeroen Vierstraete
Andy Willaert
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2017
Study of homologous recombination repair in BRCA2 knockout zebrafish embryos
Jeroen Vierstraete
Andy Willaert
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2017
2016
An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers
Dana Madorsky-Feldman
Miri Sklair-Levy
Tamar Perri
Yael Laitman
Shani Paluch-Shimon
Rita Schmutzler
Kerstin Rhiem
Jenny Lester
Beth Y Karlan
Christian F Singer
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH AND TREATMENT
2016
BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers
Huong D Meeks
Honglin Song
Kyriaki Michailidou
Manjeet K Bolla
Joe Dennis
Qin Wang
Daniel Barrowdale
Debra Frost
Lesley McGuffog
Steve Ellis
et al.
A1
Artikel in een tijdschrift
in
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2016
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Alison M Dunning
Kyriaki Michailidou
Karoline B Kuchenbaecker
Deborah Thompson
Juliet D French
Jonathan Beesley
Catherine S Healey
Siddhartha Kar
Karen A Pooley
Elena Lopez-Knowles
et al.
A1
Artikel in een tijdschrift
in
NATURE GENETICS
2016
DNA diagnostics of hereditary hearing loss : a targeted resequencing approach combined with a mutation classification system
Manou Sommen
Isabelle Schrauwen
Geert Vandeweyer
Nele Boeckx
Jason J Corneveaux
Jenneke van den Ende
An Boudewyns
Els De Leenheer
Sandra Janssens
Kathleen Claes
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2016
Development of a blood test for selection of lung cancer patients who could benefit from immunotherapy.
Malaïka Van der Linden
Karim Vermaelen
Ingel Demedts
Veerle Surmont
Kathleen Claes
Björn Menten
Jo Van Dorpe
C3
Conferentie
2016
Evaluation of the role of germline RECQL variants in Belgian patients referred for genetic testing in the context of familial breast/ovarian cancer
Greet Wieme
Ilse Coene
Liselotte Vergote
Bruce Poppe
Fransiska Malfait
Tom Van Maerken
Kim De Leeneer
Kathleen Claes
C3
Conferentie
2016
Fine-scale mapping at 9p22.2 identifies candidate causal variants that modify ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
E Vigorito
KB Kuchenbaecker
J Beesley
J Adlard
BA Agnarsson
IL Andrulis
BK Arun
L Barjhoux
M Belotti
J Benitez
et al.
A1
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in
PLOS ONE
2016
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
K Lawrenson
S Kar
K McCue
K Kuchenbaeker
K Michailidou
J Tyrer
J Beesley
SJ Ramus
QY Li
MK Delgado
et al.
A1
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in
NATURE COMMUNICATIONS
2016
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
FJ Couch
KB Kuchenbaecker
K Michailidou
GA Mendoza-Fandino
S Nord
J Lilyquist
C Olswold
E Hallberg
S Agata
H Ahsan
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2016
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
C Zeng
XY Guo
JR Long
KB Kuchenbaecker
A Droit
K Michailidou
M Ghoussaini
S Kar
A Freeman
JL Hopper
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2016
Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
Annelot Baert
Julie Depuydt
Tom Van Maerken
Bruce Poppe
Fransiska Malfait
Katrien Storm
Jenneke van den Ende
Tim Van Damme
Sylvia De Nobele
Gianpaolo Perletti
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2016
Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women
Timothy R Rebbeck
Tara M Friebel
Nandita Mitra
Fei Wan
Stephanie Chen
Irene L Andrulis
Paraskevi Apostolou
Norbert Arnold
Banu K Arun
Daniel Barrowdale
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2016
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
Valentina Silvestri
Daniel Barrowdale
Anna Marie Mulligan
Susan L Neuhausen
Stephen Fox
Beth Y Karlan
Gillian Mitchell
Paul James
Darcy L Thull
Kristin K Zorn
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2016
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
Antoinette Hollestelle
Frederieke H van der Baan
Andrew Berchuck
Sharon E Johnatty
Katja K Aben
Bjarni A Agnarsson
Kristiina Aittomäki
Elisa Alducci
Irene L Andrulis
Hoda Anton-Culver
et al.
A1
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in
GYNECOLOGIC ONCOLOGY
2016
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
Melissa Southey
David E Goldgar
Robert Winqvist
Katri Pylkäs
Fergus Couch
Marc Tischkowitz
William D Foulkes
Joe Dennis
Kyriaki Michailidou
Elizabeth J van Rensburg
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF MEDICAL GENETICS
2016
Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants
Jeroen Vierstraete
Andy Willaert
Kris Vleminckx
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2016
Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2016
Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2016
Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients
Jeroen Vierstraete
Andy Willaert
Petra Vermassen
Leen Pieters
Paul Coucke
Anne Vral
Kathleen Claes
C3
Conferentie
2016
The genetic basis of undiagnosed muscular dystrophies and myopathies: results from 504 patients
Marco Savarese
Giuseppina Di Fruscio
Annalaura Torella
Chiara Fiorillo
Francesca Magri
Marina Fanin
Lucia Ruggiero
Giulia Ricci
Guja Astrea
Luigia Passamano
et al.
A1
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in
NEUROLOGY
2016
Thorough second hit analysis in BRCA1/2 associated breast cancer
Mattias Van Heetvelde
Trees Lepez
Leen Pieters
Steve Lefever
Jo Van Dorpe
Kathleen Lambein
Marleen Praet
ivo Van Den Berghe
Frauke Coppieters
Jo Vandesompele
et al.
C3
Conferentie
2016
Thorough second-hit analysis in BRCA1/2-associated breast cancer
Mattias Van Heetvelde
Trees Lepez
Leen Pieters
Steve Lefever
Jo Van Dorpe
Kathleen Lambein
Marleen Praet
Ivo Van Den Berghe
Frauke Coppieters
Jo Vandesompele
et al.
C3
Conferentie
2016
2015
Accurate quantification of transcripts : a RT-qPCR versus ddPCR comparison
Mattias Van Heetvelde
Wouter Van Loocke
Kim De Leeneer
Brecht Crombez
Annelot Baert
Katrien Vanderheyden
Kathleen Claes
C3
Conferentie
2015
An abnormally glycosylated isoform of erythropoietin in hemangioblastoma is associated with polycythemia
Sigurd E Delanghe
Jan Dierick
Thomas Maenhout
Lennart Zabeau
Jan Tavernier
Kathleen Claes
Joris Bleyen
Joris Delanghe
A1
Artikel in een tijdschrift
in
CLINICA CHIMICA ACTA
2015
An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Sophie Blein
Claire Bardel
Vincent Danjean
Lesley McGuffog
Sue Healey
Daniel Barrowdale
Andrew Lee
Joe Dennis
Karoline B Kuchenbaecker
Penny Soucy
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2015
Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers
Ignacio Blanco
Karoline Kuchenbaecker
Daniel Cuadras
Xianshu Wang
Daniel Barrowdale
Gorka Ruiz de Garibay
Pablo Librado
Alejandro Sánchez-Gracia
Julio Rozas
Núria Bonifaci
et al.
A1
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in
PLOS ONE
2015
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer
Timothy R Rebbeck
Nandita Mitra
Fei Wan
Olga M Sinilnikova
Sue Healey
Lesley McGuffog
Sylvie Mazoyer
Georgia Chenevix-Trench
Douglas F Easton
Antonis C Antoniou
et al.
A1
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in
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
2015
BRCA1, BRCA2 and PALB2 mutations and CHEK2 c. 1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer
FZ Francies
T Wainstein
Kim De Leeneer
A Cairns
M Murdoch
S Nietz
H Cubasch
Bruce Poppe
Tom Van Maerken
Brecht Crombez
et al.
A1
Artikel in een tijdschrift
in
BMC CANCER
2015
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
P Peterlongo
J Chang-Claude
KB Moysich
A Rudolph
RK Schmutzler
J Simard
P Soucy
RA Eeles
DF Easton
U Hamann
et al.
A1
Artikel in een tijdschrift
in
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2015
Decoding NF1 intragenic copy-number variations
Meng-Chang Hsiao
Arkadiusz Piotrowski
Tom Callens
Chuanhua Fu
Katharina Wimmer
Kathleen Claes
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF HUMAN GENETICS
2015
Flexible, scalable, and efficient targeted resequencing on a benchtop sequencer for variant detection in clinical practice
Kim De Leeneer
Jan Hellemans
Wouter Steyaert
Steve Lefever
Inge Vereecke
Eveline Debals
Brecht Crombez
Machteld Baetens
Mattias Van Heetvelde
Frauke Coppieters
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2015
Focus on 16p13.3 Locus in colon cancer
Evi Mampaey
Annelies Fieuw
Thalia Van Laethem
Liesbeth Ferdinande
Kathleen Claes
Wim Ceelen
Yves Van Nieuwenhove
Piet Pattyn
Marc De Man
Kim De Ruyck
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2015
High incidence of Noonan syndrome features including short stature and pulmonic stenosis in patients carrying NF1 missense mutations affecting p.Arg1809: genotype-phenotype correlation
Kitiwan Rojnueangnit
Jing Xie
Alicia Gomes
Angela Sharp
Tom Callens
Yunjia Chen
Ying Liu
Meagan Cochran
Mary-Alice Abbott
Joan Atkin
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2015
Huge variability in a huge gene: TTN variants identified in a large NGS-resequencing project
M Savarese
A Evila
G Di Fruscio
A Vihola
A Torella
G Tasca
F Magri
Sandra Janssens
L Ruggiero
Kathleen Claes
et al.
C3
Conferentie
2015
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
KB Kuchenbaecker
SJ Ramus
J Tyrer
A Lee
HC Shen
J Beesley
K Lawrenson
L McGuffog
S Healey
JM Lee
et al.
A1
Artikel in een tijdschrift
in
NATURE GENETICS
2015
Mucoviscidose en congenitale bilaterale afwezigheid van vas deferens: één ziekte met twee gezichten?
Hanne Debunne
Sandra Janssens
Kathleen Claes
Jan Gerris
A2
Artikel in een tijdschrift
in
TIJDSCHRIFT VOOR GENEESKUNDE
2015
Next generation sequencing on patients with LGMD and nonspecific myopathies: findings associated with ANO5 mutations
Marco Savarese
Giuseppina Di Fruscio
Giorgio Tasca
Lucia Ruggiero
Sandra Janssens
Jan De Bleecker
Marc Delpech
Olimpia Musumeci
Antonio Toscano
Corrado Angelini
et al.
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2015
Next generation sequencing to determine the cystic fibrosis mutation spectrum in Palestinian population
Osama Essawi
Mohammad A Farraj
Kim De Leeneer
Wouter Steyaert
Katia De Pauw
Anne De Paepe
Kathleen Claes
Tamer Essawi
Paul Coucke
A1
Artikel in een tijdschrift
in
DISEASE MARKERS
2015
Non coding RNA molecules as potential biomarkers in breast cancer
Kim De Leeneer
Kathleen Claes
A1
Artikel in een tijdschrift
in
Advances in Experimental Medicine and Biology
2015
Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome
Jo Robays
Sabine Stordeur
Frank Hulstaert
Tom Van Maerken
Kathleen Claes
Nicolas Janin
Gert Matthijs
Daphné 't Kint de Roodenbeke
Martine Berlière
Hans Wildiers
et al.
Verslag
2015
Oncogenetic testing for persons with hereditary endocrine cancer syndromes
Joan Vlayen
Marie Bex
Bert Bravenboer
Kathleen Claes
Bruno Lapauw
Alexandre Persu
Kris Poppe
Urielle Ullman
Tom Van Maerken
Laurent Vroonen
et al.
Verslag
2015
Oncogenetic testing, diagnosis and follow-up in Birt-Hogg-Dubé syndrome, familial atypical multiple mole melanoma syndrome and neurofibromatosis 1 and 2
Jo Robays
Sabine Stordeur
Frank Hulstaert
Jean-François Baurain
Lieve Brochez
Teofila Caplanusi
Kathleen Claes
Eric Legius
Sylvie Rottey
Dirk Schrijvers
et al.
Verslag
2015
The G2 micronucleus-assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 mutation
Annelot Baert
Julie Depuydt
Bruce Poppe
Tom Van Maerken
Fransiska Malfait
Tim Van Damme
Sylvia De Nobele
Kim De Leeneer
Kathleen Claes
Anne Vral
C3
Conferentie
2015
2014
A vestibular schwannoma in a patient with Birt-Hogg-Dube syndrome
Linde De Keyzer
Els De Leenheer
Kathleen Claes
Sandra Janssens
A1
Artikel in een tijdschrift
in
GENETIC COUNSELING
2014
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Karoline B Kuchenbaecker
Susan L Neuhausen
Mark Robson
Daniel Barrowdale
Lesley McGuffog
Anna Marie Mulligan
Irene L Andrulis
Amanda B Spurdle
Marjanka K Schmidt
Rita K Schmutzler
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH
2014
Breast-cancer risk in families with mutations in PALB2
AC Antoniou
S Casadei
T Heikkinen
D Barrowdale
K Pylkäs
J Roberts
A Lee
D Subramanian
Kim De Leeneer
F Fostira
et al.
A1
Artikel in een tijdschrift
in
NEW ENGLAND JOURNAL OF MEDICINE
2014
Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing
Phillip J Whiley
Miguel de la Hoya
Mads Thomassen
Alexandra Becker
Rita Brandão
Inge Sokilde Pedersen
Marco Montagna
Mireia Menéndez
Francisco Quiles
Sara Gutiérrez-Enríquez
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CHEMISTRY
2014
DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers
Ana Osorio
Roger L Milne
Karoline Kuchenbaecker
Tereza Vaclová
Guillermo Pita
Rosario Alonso
Paolo Peterlongo
Ignacio Blanco
Miguel de la Hoya
Mercedes Duran
et al.
A1
Artikel in een tijdschrift
in
PLOS GENETICS
2014
Dealing with pseudogenes in molecular diagnostics in the next-generation sequencing era
Kathleen Claes
Kim De Leeneer
Hoofdstuk in een boek
in
Pseudogenes : functions and protocols
2014
Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder
Douglas R Stewart
Hilde Brems
Alicia G Gomes
Sarah L Ruppert
Tom Callens
Jennifer Williams
Kathleen Claes
Michael B Bober
Rachel Hachen
Leonard B Kaban
et al.
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2014
Mate pair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations
Sarah Vergult
Ellen Van Binsbergen
Tom Sante
Silke Nowak
Olivier Vanakker
Kathleen Claes
Bruce Poppe
Nathalie Van der Aa
Markus J van Roosmalen
Karen Duran
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2014
Palindrome-mediated and replication-dependent pathogenic structural rearrangements within the NF1 gene
Meng-Chang Hsiao
Arkadiusz Piotrowski
John Alexander
Tom Callens
Chuanhua Fu
Fady M Mikhail
Kathleen Claes
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2014
SVA retrotransposon insertion-associated deletion represents a novel mutational mechanism underlying large genomic copy number changes with non-recurrent breakpoints
Julia Vogt
Kathrin Bengesser
Kathleen Claes
Katharina Wimmer
Victor-Felix Mautner
Rick van Minkelen
Eric Legius
Hilde Brems
Meena Upadhyaya
Josef Högel
et al.
A1
Artikel in een tijdschrift
in
GENOME BIOLOGY
2014
The G2 micronucleus assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 or BRCA2 mutation
Annelot Baert
Julie Depuydt
Bruce Poppe
Tom Van Maerken
Fransiska Malfait
Tim Van Damme
Sylvia De Nobele
Kim De Leeneer
Kathleen Claes
Anne Vral
C3
Conferentie
2014
The G2-micronucleus assay for the detection of in vitro chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers
Annelot Baert
Julie Depuydt
Bruce Poppe
Tom Van Maerken
Fransiska Malfait
Tim Van Damme
Kim De Leeneer
Kathleen Claes
Anne Vral
C3
Conferentie
2014
2013
A sensitive and specific diagnostic test for hearing loss using a microdroplet PCR-based approach and next generation sequencing
Isabelle Schrauwen
Manou Sommen
Jason J Corneveaux
Rebecca A Reiman
Nicole J Hackett
Charlotte Claes
Kathleen Claes
Maria Bitner-Glindzicz
Paul Coucke
Guy Van Camp
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
2013
Analysis of the novel Fanconi anemia gene SLX4/FANCP in familial breast cancer cases
Janine L Bakker
Saskia van Mil
Gerry Crossan
Nelly Sabbaghian
Kim De Leeneer
Bruce Poppe
Muriel Adank
Hans Gille
Henk Vergeul
Hanne Meijers-Heijboer
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2013
Development of an S-G2 micronucleus assay for the detection of in vitro chromosomal radiosensitivity in high-risk women subjected to early mammography screening for breast cancer
Anne Vral
Julie Depuydt
Annelot Baert
Bruce Poppe
Tom Van Maerken
Fransiska Malfait
Kim De Leeneer
Marc D'Hooghe
Kathleen Claes
C3
Conferentie
2013
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
Fergus J Couch
Xianshu Wang
Lesley McGuffog
Andrew Lee
Curtis Olswold
Karoline B Kuchenbaecker
Penny Soucy
Zachary Fredericksen
Daniel Barrowdale
Joe Dennis
et al.
A1
Artikel in een tijdschrift
in
PLOS GENETICS
2013
Lhermitte-Duclos disease with obstructive hydrocephalus : an illustrative case treated with endoscopic ventriculo-cisternostomy
C-A Sibille
M Triffaux
Kathleen Claes
Y Sznajer
M Gille
A1
Artikel in een tijdschrift
in
REVUE NEUROLOGIQUE
2013
Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations
Sarah Vergult
Ellen Van Binsbergen
Tom Sante
Silke Nowak
Olivier Vanakker
Kathleen Claes
Bruce Poppe
Nathalie Van der Aa
MJ Van Roosmalen
K Duran
et al.
C3
Conferentie
2013
Questioning the pathogenic role of the GLA p.Ala143Thr 'mutation' in Fabry disease: implications for screening studies and ERT
Wim Terryn
Raymond Vanholder
Dimitri Hemelsoet
Bart Leroy
Wim Van Biesen
G De Schoenmakere
Brigitte Wuyts
Kathleen Claes
Julie De Backer
Anne De Paepe
et al.
Hoofdstuk in een boek
in
JIMD reports : case and research reports 2012/5
2013
Radiation-induced myosin IIA expression stimulates collagen type I matrix reorganization
Stéphanie Blockhuys
Bart Van Rompaye
Riet De Rycke
Kathleen Lambein
Kathleen Claes
Marc Bracke
Carlos De Wagter
Olivier De Wever
A1
Artikel in een tijdschrift
in
RADIOTHERAPY AND ONCOLOGY
2013
Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives
Kathleen Claes
Julie Depuydt
A Malcolm R Taylor
James I Last
Annelot Baert
Peter Schietecatte
Veerle Vandersickel
Bruce Poppe
Kim De Leeneer
Marc D'Hooghe
et al.
A1
Artikel in een tijdschrift
in
NEUROMOLECULAR MEDICINE
2013
2012
Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
A Jakubowska
D Rozkrut
A Antoniou
U Hamann
RJ Scott
L McGuffog
S Healy
OM Sinilnikova
G Rennert
F Lejbkowicz
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2012
Characterization of the nonallelic homologous recombination hotspot PRS3 associated with type-3 NF1 deletions
Antje M Zickler
Stephanie Hampp
Ludwine Messiaen
Kathrin Bengesser
Tanja Mussotter
Angelika C Roehl
Katharina Wimmer
Victor-Felix Mautner
Lan Kluwe
Meena Upadhyaya
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2012
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing
Kim De Leeneer
Mieke Van Bockstal
Sara De Brouwer
NATALIA SWIETEK
Peter Schietecatte
N Sabbaghian
J Van den Ende
S Willocx
K Storm
B Blaumeiser
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH AND TREATMENT
2012
Identification of recurrent type-2 NF1 microdeletions reveals a mitotic nonallelic homologous recombination hotspot underlying a human genomic disorder
Julia Vogt
Tanja Mussotter
Kathrin Bengesser
Kathleen Claes
Josef Högel
Nadia Chuzhanova
Chuanhua Fu
Jenneke van den Ende
Victor-Felix Mautner
David N Cooper
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2012
Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations
Sarah Vergult
Ellen Van Binsbergen
Tom Sante
Silke Nowak
Olivier Vanakker
Kathleen Claes
Bruce Poppe
Nathalie Van der Aa
MJ Van Roosmalen
K Duran
et al.
C3
Conferentie
2012
Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type I-associated glomus tumors
Douglas R Stewart
Alexander Pemov
Eline Baert
Hilde Brems
Raf Sciot
Kathleen Claes
Evgenia Pak
Amalia Dutra
Chyi-Chia Richard Lee
Eric Legius
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2012
Multiple orbital neurofibromas, painful peripheral nerve tumors, distinctive face and marfanoid habitus: a new syndrome
D Babovic-Vuksanovic
Ludwine Messiaen
Christoph Nagel
Hilde Brems
Bernd Scheithauer
Ellen Denayer
Rong Mao
Ralf Sciot
Karen M Janowski
Martin U Schuhmann
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2012
Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families
DJ Osher
Kim De Leeneer
G Michils
N Hamel
E Tomiak
Bruce Poppe
K Leunen
E Legius
A Shuen
E Smith
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2012
Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients
Filomeen Haerynck
Kristel Van Steen
T Cattaert
Bart Loeys
Sabine Van daele
Petra Schelstraete
Kathleen Claes
M Van Thielen
I De Canck
JM Mahachie John
et al.
A1
Artikel in een tijdschrift
in
HUMAN IMMUNOLOGY
2012
Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing
Kim De Leeneer
Ilse Coene
Brecht Crombez
Justine Simkens
Rudy Van den Broecke
Alain Bols
Barbara Stragier
Ilse Vanhoutte
Anne De Paepe
Bruce Poppe
et al.
A1
Artikel in een tijdschrift
in
BREAST CANCER RESEARCH AND TREATMENT
2012
2011
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
Lara Bossini-Castillo
Jasper CA Broen
Carmen P Simeon
Lorenzo Beretta
Madelon C Vonk
Norberto Ortego-Centeno
Gerard Espinosa
Patricia Carreira
María Teresa Camps
Nuria Navarette
et al.
A1
Artikel in een tijdschrift
in
ANNALS OF THE RHEUMATIC DISEASES
2011
Combined effect of polymorphisms in Rad51 and XRCC3 on breast cancer risk and chromosomal radiosensitivity
Anne Vral
Petra Willems
Kathleen Claes
Bruce Poppe
Ans Baeyens
Gianpaolo Perletti
Hubert Thierens
A1
Artikel in een tijdschrift
in
MOLECULAR MEDICINE REPORTS
2011
Evaluation of RAD51C as a new breast cancer suceptibility gene in Belgian/Dutch population
Kim De Leeneer
M Van Bockstael
NATALIA SWIETEK
J Van den Ende
K Storm
B Blaumeiser
K Leunens
CJ van Asperen
JT Wijnen
E Legius
et al.
C3
Conferentie
2011
Massive parallel amplicon sequencing of the breast cancer genes BRCA1 and BRCA2: opportunities, challenges, and limitations
Kim De Leeneer
Jan Hellemans
Joachim De Schrijver
Machteld Baetens
Bruce Poppe
Wim Van Criekinge
Anne De Paepe
Paul Coucke
Kathleen Claes
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2011
Objective assessment of nasality in Flemish adults with neurofibromatosis type 1
Marjan Cosyns
Geert Mortier
Sandra Janssens
Kathleen Claes
John Van Borsel
C3
Conferentie
2011
Objective assessment of nasality in Flemish adults with neurofibromatosis type 1
Marjan Cosyns
Geert Mortier
Sandra Janssens
Kathleen Claes
John Van Borsel
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
2011
Practical tools to implement massive parallel pyrosequencing of PCR products in next generation molecular diagnostics
Kim De Leeneer
Joachim De Schrijver
Lieven Clement
Machteld Baetens
Steve Lefever
Sarah De Keulenaer
Wim Van Criekinge
Dieter Deforce
Filip Van Nieuwerburgh
Sofie Bekaert
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2011
Prostate cancer in Cowden syndrome: somatic loss and germline mutation of the PTEN gene
Mafalda Barbosa
Martinha Henrique
Jorge Pinto-Basto
Kathleen Claes
Gabriela Soares
A1
Artikel in een tijdschrift
in
CANCER GENETICS
2011
The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP)
Kathleen Claes
Karin Dahan
S Tejpar
Anne De Paepe
Maryse Bonduelle
Marc Abramowicz
Christine Verellen
Denis Franchimont
Eric Van Cutsem
Alex Kartheuser
A1
Artikel in een tijdschrift
in
ACTA GASTRO-ENTEROLOGICA BELGICA
2011
2010
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction
Antonio C Antoniou
Jonathan Beesley
Lesley McGuffog
Olga M Sinilnikova
Sue Healey
Susan L Neuhausen
Yuan Chung Ding
Timothy R Rebbeck
Jeffrey N Weitzel
Henry T Lynch
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2010
Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
XianShu Wang
V Shane Pankratz
Zachary Fredericksen
Robert Tarrell
Mary Karaus
Lesley McGuffog
Paul D Pharaoh
Bruce A Ponder
Alison M Dunning
Susan Peock
et al.
A1
Artikel in een tijdschrift
in
HUMAN MOLECULAR GENETICS
2010
IRF6 screening of syndromic and a priori non-syndromic cleft lip and palate patients : identification of a new type of minor VWS sign
L Desmyter
M Ghassibe
N Revencu
O Boute
M Lees
G François
C Verellen-Dumoulin
Y Sznajer
A Moncla
H Benateau
et al.
A2
Artikel in een tijdschrift
in
MOLECULAR SYNDROMOLOGY
2010
Kanker en erfelijkheid : van moleculaire diagnostiek tot psychologische begeleiding
Philippe De Wilde
Kathleen Claes
Kim De Leeneer
Bruce Poppe
Anne De Paepe
A2
Artikel in een tijdschrift
in
TIJDSCHRIFT VOOR GENEESKUNDE
2010
Leiden open variation database of the MUTYH gene
Astrid A Out
Cari MJ Tops
Maartje Nielsen
Marjan M Weiss
Ivonne JHM van Minderhout
Ivo FAC Fokkema
Marie-Pierre Buisine
Kathleen Claes
Chrystelle Colas
Riccardo Fodde
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2010
2009
Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes
Joke Werbrouck
Kim De Ruyck
Fréderic Duprez
Liv Veldeman
Kathleen Claes
Marc Van Eijkeren
Tom Boterberg
Petra Willems
Anne Vral
Wilfried De Neve
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
2009
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
AC Antoniou
OM Sinilnikova
L McGuffog
S Healey
H Nevanlinna
T Heikkinen
J Simard
AB Spurdle
J Beesley
XQ Chen
et al.
A1
Artikel in een tijdschrift
in
HUMAN MOLECULAR GENETICS
2009
Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
A Osorio
RL Milne
G Pita
P Peterlongo
T Heikkinen
J Simard
G Chenevix-Trench
AB Spurdle
J Beesley
X Chen
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2009
Functional redundancy of Exon 12 of BRCA2 revealed by a comprehensive analysis of the c.6853A > G (p.I2285V) variant
Li LL Li
Kajal Biswas
Laura Anne Habib
Sergey G Kuznetsov
Nancy Hamel
Tomas Kirchhoff
Nora Wong
Susan Armel
George Chong
SA Narod
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2009
Genotyping of Frequent BRCA1/2 SNPs with Unlabeled Probes A Supplement to HRMCA Mutation Scanning, Allowing the Strong Reduction of Sequencing Burden
Kim De Leeneer
Ilse Coene
Bruce Poppe
Anne De Paepe
Kathleen Claes
A1
Artikel in een tijdschrift
in
JOURNAL OF MOLECULAR DIAGNOSTICS
2009
Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association
Hilde Brems
Caroline Park
Ophélia Maertens
Alexander Pemov
Ludwine Messia
Meena Upadhyaya
Kathleen Claes
Eline Beert
Kristel Peeters
Victor Mautner
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2009
Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association (vol 69, pg 7393, 2009)
Hilde Brems
Caroline Park
Ophélia Maertens
Alexander Pemov
Ludwine Messiaen
Meena Upadhyaya
Kathleen Claes
Eline Beert
Kristel Peeters
Victor Mautner
et al.
Correctie
2009
2008
Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population
V DESCHOOLMEESTER
Nancy Van Damme
M BAAY
Kathleen Claes
E VAN MARCK
F BAERT
W WUYTS
M CABOOTER
J WEYLER
P VERMEULEN
et al.
A1
Artikel in een tijdschrift
in
European Journal of Cancer
2008
Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity
Petra Willems
Kathleen Claes
Ans Baeyens
Veerle Vandersickel
Joke Werbrouck
Kim De Ruyck
Bruce Poppe
Rudy Van den Broecke
Amin Makar
Emanuela Marras
et al.
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2008
Rapid and sensitive detection of BRCA1/2 mutations in a diagnostic setting: Comparison of two high-resolution melting platforms
Kim De Leeneer
Ilse Coene
Bruce Poppe
Anne De Paepe
Kathleen Claes
A1
Artikel in een tijdschrift
in
CLINICAL CHEMISTRY
2008
Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian
E MACHACKOVA
L FORETOVA
M LUKESOVA
P VASICKOVA
M NAVRATILOVA
Ilse Coene
H PAVLU
V KOSINOVA
J KUKLOVA
Kathleen Claes
A1
Artikel in een tijdschrift
in
BMC CANCER
2008
Two-tier approach for the detection of alpha-galactosidase A deficiency in a predominantly female haemodialysis population
W TERRYN
Bruce Poppe
B WUYTS
Kathleen Claes
B MAES
D VERBEELEN
Raymond Vanholder
K DE BOECK
Norbert Lameire
Anne De Paepe
et al.
A1
Artikel in een tijdschrift
in
NEPHROLOGY DIALYSIS TRANSPLANTATION
2008
Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients
Gert De Schoenmakere
Bruce Poppe
Birgitte Wuyts
Kathleen Claes
David Cassiman
Bart Maes
Dierik Verbeelen
Raymond Vanholder
Dirk R. Kuypers
Norbert Lameire
et al.
A1
Artikel in een tijdschrift
in
NEPHROLOGY DIALYSIS TRANSPLANTATION
2008
2007
Benign retroperitoneal schwannoma presenting as colitis: A case report
Gary Fass
Didier Hossey
Michel Nyst
Dirk Smets
Esmail Najar Saligheh
Ruth Duttmann
Kathleen Claes
Pierre Mendes da Costa
A1
Artikel in een tijdschrift
in
WORLD JOURNAL OF GASTROENTEROLOGY
2007
Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
Kim De Ruyck
Marcin Szaumkessel
Isabelle De Rudder
ANNELORE DEHOORNE
Anne Vral
Kathleen Claes
Anja Velghe
Jan Van Meerbeeck
Hubert Thierens
A1
Artikel in een tijdschrift
in
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
2007
2006
Spectrum of single- and multiexon NFI copy number changes in a cohort of 1,100 unselected NFI patients
K WIMMER
S YAO
Kathleen Claes
H KEHRER-SAWATZKI
S TINSCHERT
T DE RAEDT
E LEGIUS
T CALLENS
H BEIGLBOCK
Ophélia Maertens
et al.
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2006
TGF beta 1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors
Kim De Ruyck
Marc Van Eijkeren
Kathleen Claes
Klaus Bacher
Anne Vral
Wilfried De Neve
Hubert Thierens
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
2006
2005
Chromosomal radio sensitivity of breast cancer with a CHEK2 mutation
Ans Baeyens
Kathleen Claes
Petra Willems
Kim De Ruyck
Hubert Thierens
Anne Vral
A1
Artikel in een tijdschrift
in
CANCER GENETICS AND CYTOGENETICS
2005
Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: Association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes
Kim De Ruyck
Marc Van Eijkeren
Kathleen Claes
R MORTHIER
Anne De Paepe
Anne Vral
Leo De Ridder
Hubert Thierens
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
2005
Rapid detection of VHL exon deletions using real-time quantitative PCR
Jasmien Hoebeeck
R VAN DER LUIJT
Bruce Poppe
Els De Smet
Nurten Yigit
Kathleen Claes
R ZEWALD
GJ DE JONG
Anne De Paepe
Franki Speleman
et al.
A1
Artikel in een tijdschrift
in
LABORATORY INVESTIGATION
2005
Recente moleculaire inzichten in erfelijke borst- en ovariumkanker in België
Kathleen Claes
Bruce Poppe
Ilse Coene
L MESSIAEN
Anne De Paepe
A2
Artikel in een tijdschrift
in
TIJDSCHRIFT VOOR GENEESKUNDE
2005
2004
A homozygous MSH6 mutation in a child with café-au-lait spots, oligodendroglioma and rectal cancer
Fred H Menko
Gertjan L Kaspers
Gerrit A Meijer
Kathleen Claes
Johanna M van Hagen
Johan JP Gille
A2
Artikel in een tijdschrift
in
FAMILIAL CANCER
2004
BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families
Kathleen Claes
Bruce Poppe
Ilse Coene
Anne De Paepe
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2004
Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers
Ans Baeyens
Hubert Thierens
Kathleen Claes
Bruce Poppe
Leo De Ridder
Anne Vral
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
2004
Routine microsatellite instability testing in sporadic colorectal tumours
Nancy Van Damme
Pieter Demetter
Kathleen Claes
Bruce Poppe
F BAERT
J ROELENS
Anne De Paepe
Claude Cuvelier
Marc Peeters
C3
Conferentie
2004
2003
BRCA1/2 mutation spectrum and frequencies in Belgian breast/ovarian cancer families
Kathleen Claes
Bruce Poppe
Ilse Coene
Anne De Paepe
Ludwine Messiaen
C3
Conferentie
2003
Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2
Kathleen Claes
Bruce Poppe
E MACHACKOVA
Ilse Coene
L FORETOVA
Anne De Paepe
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2003
2002
Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition
Ans Baeyens
Hubert Thierens
Kathleen Claes
Bruce Poppe
Ludwine Messiaen
Leo De Ridder
Anne Vral
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2002
Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5 ' end of the BRCA1 gene.
Kathleen Claes
Jo Vandesompele
Bruce Poppe
K DAHAN
I COENE
Anne De Paepe
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
ONCOGENE
2002
2001
Genetisch advies bij het familiaal voorkomen van borstkanker
Bruce Poppe
I MEIRE
I DELVAUX
Kathleen Claes
L MESSIAEN
Anne De Paepe
A4
Artikel in een tijdschrift
in
Guneikeïa
2001
2000
Identification and characterisation of a founder mutation in the Belgian breast/ovarian cancer population
Kathleen Claes
Bruce Poppe
PETRA SCHEIR
M De Vos
I Delveaux
Ilse Coene
Anne De Paepe
Ludwine Messiaen
C3
Conferentie
2000
Nieuwe inzichten in de moleculaire oorzaken van familiale borst- en ovariumkanker
Kathleen Claes
Anne De Paepe
Ludwine Messiaen
A2
Artikel in een tijdschrift
in
TIJDSCHRIFT VOOR GENEESKUNDE
2000
1999
Genetic counselling and testing for hereditary breast and ovarian cancer: the gent(le) approach
M De Vos
Bruce Poppe
Isabelle Delvaux
Geert Mortier
Kathleen Claes
Ludwine Messiaen
Anne De Paepe
A1
Artikel in een tijdschrift
in
DISEASE MARKERS
1999
Mutation analysis of the BRCA1 and BRCA2 genes in the Belgian patient population and identification of a Belgian founder mutation BRCA1 IVS5+3A > G
Kathleen Claes
E Machackova
Martine De Vos
Bruce Poppe
Anne De Paepe
Ludwine Messiaen
A1
Artikel in een tijdschrift
in
DISEASE MARKERS
1999
Mutation analysis of the BRCA1 and BRCA2 genes results in the identification of novel and recurrent mutations in 6/16 Flemish patients with breast and/or ovarian cancer but not in 12 sporadic patients with early-onset disease
Kathleen Claes
Eva Machackova
Michel De Vos
Geert Mortier
Anne De Paepe
Ludwine Messiaen
A2
Artikel in een tijdschrift
in
HUMAN MUTATION
1999
1998
Improved conditions for PTT-analysis of the BRCA1, BRCA2, NF1 and APC genes
Kathleen Claes
Eva Machackova
TOM CALLENS
GRETA VAN DER CRUYSSEN
Ludwine Messiaen
A2
Artikel in een tijdschrift
in
TECHNICAL TIPS ONLINE
1998
1996
Immunolocalization of microtubules in root tips of Arabidopsis thaliana.
Kathleen Claes
Winy Messens
Patric Van Oostveldt
C1
Conferentie
1996