Research Explorer

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Researcher

Karolien De Bosscher

151 Results

2021

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

Jolien VandewalleClaude LibertKarolien De Bosscher

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie EggermontSylviane DewaeleLeen CatrysseGeert van LooRudi BeyaertRoman VangoitsenhovenToshinori NakayamaJan TavernierKarolien De BosscherClaude Libert

A1 Journal Article in ISCIENCE

2020

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De BosscherClaude Libert

A1 Journal Article in EMBO REPORTS

Improved glucocorticoid receptor ligands : fantastic beasts, but how to find them?

Laura Van MoortelKris GevaertKarolien De Bosscher

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

Dorien ClarisseFritz OffnerKarolien De Bosscher

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Nuclear receptor crosstalk : defining the mechanisms for therapeutic innovation

Karolien De BosscherSofie DesmetDorien ClarisseEva Estébanez-PerpiñaLuc Brunsveld

A1 Journal Article in NATURE REVIEWS ENDOCRINOLOGY

The glucocorticoid receptor in acute inflammation : new molecular insights and development of a new GR dimerization mutant

Kelly Van LooverenClaude LibertKarolien De Bosscher

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge VerbanckFilip BoyenMelanie EggermontLindsey De CommerRiet De RyckeMichiel De BruyneRaul TitoMarlies BallegeerSofie VandevyverTiago VelhoLuis Ferreira MoitaTino HochepiedKarolien De BosscherJeroen RaesFilip Van ImmerseelRudi BeyaertClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

Leen VandermostenIlse VanhorebeekKarolien De BosscherGhislain OpdenakkerPhilippe E. Van den Steen

A1 Journal Article in TRENDS IN PARASITOLOGY

Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice

Oonagh PaerewijckBrecht MaertensAurélie GagnaireKarolien De BosscherPeter Geldhof

A1 Journal Article in SCIENTIFIC REPORTS

Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses

Nadia BougarneViacheslav MylkaDariusz RatmanIlse BeckJonathan ThommisLode De CauwerJan TavernierBart StaelsClaude LibertKarolien De Bosscher

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Study of anti-inflammatory approaches as an alternative for glucocorticoids

Viacheslav MylkaKarolien De BosscherJan Tavernier

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies BallegeerJolien SouffriauLise Van WyngeneKelly Van LooverenTineke VanderhaeghenRudi BeyaertKarolien De BosscherJorma J PalvimoMarc Van MontaguClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Jolien SouffriauMelanie EggermontSara Van RyckeghemKelly Van LooverenLise Van WyngeneEvelien Van HammeMarnik VuylstekeRudi BeyaertKarolien De BosscherClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Adrenal hormones mediate disease tolerance in malaria

Leen VandermostenThao-Thy PhamSofie KnoopsCharlotte De GeestNatacha LaysKristof Van der MolenChristopher J KenyonManu VermaKaren E ChapmanFrans SchuitKarolien De BosscherGhislain OpdenakkerPhilippe E Van den Steen

A1 Journal Article in NATURE COMMUNICATIONS

Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development

Dorien BaetensTülay GüranBerenice B MendoncaNathalia L GomesLode De CauwerFrank PeelmanHannah VerdinMarnik VuylstekeMalaïka Van Der LindenHans StoopLeendert H LooijengaKarolien De BosscherMartine CoolsElfride De Baerethe ESR2 study groupKatleen De Preter

A1 Journal Article in GENETICS IN MEDICINE

Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march

Julie DeckersNadia BougarneViacheslav MylkaSofie DesmetAstrid LuypaertMichael DevosGiel TangheJustine Van MoorleghemManon VanheerswynghelsLode De CauwerJonathan ThommisMarnik VuylstekeJan TavernierBart LambrechtHamida HammadKarolien De Bosscher

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Dorien ClarisseKarlien Van WesemaelJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in PLOS ONE

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van WyngeneRiet De RyckeNozomi TakahashiPeter VandenabeeleJan TuckermannHolger M ReichardtFrancis ImpensRudi BeyaertKarolien De BosscherClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid resistance in multiple myeloma : mechanistic insights and therapeutic considerations

Dorien ClarisseKarolien De BosscherIlse Beck

Molecular actions of PPARα in lipid metabolism and inflammation

Nadia BougarneBasiel WeyersSofie DesmetJulie DeckersDavid W RayBart StaelsKarolien De Bosscher

A1 Journal Article in ENDOCRINE REVIEWS

Strategies and compounds to circumvent glucocorticoid-induced side effects

Astrid LuypaertWim Vanden BergheJan TavernierClaude LibertKarolien De Bosscher

Bookchapter in Immunopharmacology and inflammation

Study of the transcriptional crosstalk between metabolic nuclear receptors

Sofie DesmetKarolien De BosscherJan Tavernier

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

Viacheslav MylkaJulie DeckersDariusz RatmanLode De CauwerJonathan ThommisRiet De RyckeFrancis ImpensClaude LibertJan TavernierWim Vanden BergheKris GevaertKarolien De Bosscher

A1 Journal Article in AUTOPHAGY

Therapeutic mechanisms of glucocorticoids

Jolien VandewalleAstrid LuypaertKarolien De BosscherClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

2017

11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner

L. VandermostenC. De GeestS. KnoopsG. ThijsK. E. ChapmanKarolien De BosscherG. OpdenakkerP. E. Van den Steen

A1 Journal Article in SCIENTIFIC REPORTS

Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor

Zuzanna DrebertMark MacAskillDahlia Doughty-ShentonKarolien De BosscherMarc BrackePatrick WF HadokeIlse Beck

A1 Journal Article in VASCULAR PHARMACOLOGY

Compound A influences gene regulation of the dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment

Sofie DesmetNadia BougarneLaura Van MoortelLode De CauwerJonathan ThommisM VuylstekeDariusz RatmanR HoutmanJan TavernierKarolien De Bosscher

A1 Journal Article in SCIENTIFIC REPORTS

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

Dorien ClarisseJonathan ThommisKarlien Van WesemaelRene HoutmanDariusz RatmanJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in ONCOTARGET

Daucane esters from laserwort (Laserpitium latifolium L.) inhibit cytokine and chemokine production in human lung epithelial cells

Visnja PopovicJan GoemanJonathan ThommisArne HeyerickJurgen CaroenJohan Van der EyckenKarolien De Bosscher

A1 Journal Article in PHYTOMEDICINE

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De BosscherBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glucocorticoid receptor modulation of the colon cancer microenvironment

Zuzanna DrebertMarc BrackeIlse BeckKarolien De Bosscher

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in SCIENTIFIC REPORTS

Glucocorticoid receptors : finding the middle ground

Sofie DesmetKarolien De Bosscher

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts

Zuzanna DrebertElly De VlieghereJolien BridelanceOlivier De WeverKarolien De BosscherMarc BrackeIlse Beck

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia

Oonagh PaerewijckBrecht MaertensLeentje DreesenFrederik Van MeulderIris PeelaersDariusz RatmanRobert W LiErik LubbertsKarolien De BosscherPeter Geldhof

A1 Journal Article in SCIENTIFIC REPORTS

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Julie DeckersKarolien De BosscherBart LambrechtHamida Hammad

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Involvement of the glucocorticoid receptor in pro-inflammatory transcription factor inhibition by daucane esters from Laserpitium zernyi

Visnja PopovicJan GoemanNadia BougarneSven EyckermanArne HeyerickKarolien De BosscherJohan Van der Eycken

A1 Journal Article in JOURNAL OF NATURAL PRODUCTS

Plasmodium berghei NK65 in combination with IFN-γ induces endothelial glucocorticoid resistance via sustained activation of p38 and JNK

Karolina A. ZielińskaLode De CauwerSofie KnoopsKristof Van der MolenAlexander SneyersJonathan ThommisJ. Brian De SouzaGhislain OpdenakkerKarolien De BosscherPhilippe E. Van den Steen

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads

Chandra S ChirumamillaAjay PalaganiBalu KamarajKen DeclerckMarinus WC VerbeekOksana RyabtsovaKarolien De BosscherNadia BougarneBart RuttensKris GevaertRené HoutmanWinnok De VosJurgen JoossensPieter Van Der VekenKoen AugustynsXaveer Van OstadeAnnemie BogaertsHans De WinterWim Vanden Berghe

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution

Laura García-PupoJeney Ramírez SánchezDariusz RatmanClaudina Perez NovoKen DeclerckKarolien De BosscherMarios Nektarios MarkakisGerrit BeemsterArmando ZaldoYanier Nuñez FigueredoRené Delgado-HernándezWim Vanden Berghe

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity

Raffaele MoriJoris WaumanLaura IcardiJosé Van Der HeydenLode De CauwerFrank PeelmanKarolien De BosscherJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

The nature of the GRE influences the screening for GR-activity enhancing modulators

Karen DendonckerSteven TimmermansKelly Van LooverenLode De CauwerKarolien De BosscherClaude Libert

A1 Journal Article in PLOS ONE

The skin as a central player in house dust mite allergy

Julie DeckersKarolien De BosscherHamida Hammad

2016

Activation of the glucocorticoid receptor in acute inflammation : the SEDIGRAM concept

Karolien De BosscherIlse BeckDariusz RatmanWim Vanden BergheClaude Libert

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Dariusz RatmanViacheslav MylkaNadia BougarneMichal PawlakSandrine CaronNathalie HennuyerRéjane PaumelleLode De CauwerJonathan ThommisMark H RiderClaude LibertSam LievensJan TavernierBart StaelsKarolien De Bosscher

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Endothelial response to glucocorticoids in inflammatory diseases

Karolina A ZielińskaLaura Van MoortelGhislain OpdenakkerKarolien De BosscherPhilippe E Van den Steen

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A

Andres E Barcala TabarrozziLuz AndreoneJulie DeckersCarla N CastroMaría L GimenoLaura AriolfoPaula M BerguerMaría Antunica-NoguerolAna C LibermanSabine VettorazziJan P TuckermannKarolien De BosscherMarcelo J Perone

A1 Journal Article in SCIENTIFIC REPORTS

Modulation of protein-protein interactions for the development of novel therapeutics

Ioanna PettaSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in MOLECULAR THERAPY

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De ClercqDieter DefeverNele VanderroostAnn-Sophie De SmetSven EyckermanSerge Van CalenberghLennart MartensKarolien De BosscherClaude LibertDavod E HillMarc VidalJan Tavernier

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases

Ioanna PettaLien DejagerMarlies BallegeerSam LievensJan TavernierKarolien De BosscherClaude Libert

A2 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The mineralocorticoid receptor is involved in glucocorticoid resistance

Dorien ClarisseFritz OffnerKarolien De BosscherIlse Beck

Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach

Oonagh PaerewijckLeentje DreesenFrederik Van MeulderDariusz RatmanKarolien De BosscherRW LiPeter Geldhof

2015

Analysis of the protective immune response following intramuscular vaccination of calves against the intestinal parasite Cooperia oncophora

Frederik Van MeulderDariusz RatmanStefanie Van CoppernolleJimmy BorlooRW LiKoen ChiersWim Van Den BroeckKarolien De BosscherEdwin ClaereboutPeter Geldhof

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

Combination of dexamethasone with the selective glucocorticoid receptor modulator, Compound A, does not enhance glucocorticoid responsiveness in lymphoid malignancies

Dorien ClarisseFritz OffnerMarc BrackeKarolien De BosscherIlse Beck

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue

Ilse BeckKoen Van CrombruggenGabriële HoltappelsFrançois DaubeufNelly FrossardClaus BachertKarolien De Bosscher

A1 Journal Article in PLOS ONE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie VandevyverHamida HammadBart LambrechtKarolien De BosscherJohan GrootenClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Novel anti-inflammatory daucane esters from Laserpitium zernyi Hayek (Apiaceae)

Visnja PopovicJan GoemanNadia BougarneArne HeyerickKarolien De BosscherJohan Van der Eycken

Selective glucocorticoid receptor modulation : new directions with non-steroidal scaffolds

Nora SundahlJolien BridelanceClaude LibertKarolien De BosscherIlse Beck

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De VreeseNicholas Van SteenTom VerhaegheTom DesmetNadia BougarneKarolien De BosscherVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

The transcriptional co-regulation of hepatic lipid metabolism by GR and PPARα

Dariusz RatmanKarolien De BosscherJan Tavernier

Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach

Oonagh PaerewijckLeentje DreesenFrederik Van MeulderDariusz RatmanKarolien De BosscherRW LiPeter Geldhof

2014

Cofactor profiling of the glucocorticoid receptor from a cellular environment

Sofie DesmetLien DejagerDorien ClarisseJonathan ThommisDiana MelchersNiek BastiaensenRob RuijtenbeekIlse BeckClaude LibertRenée HoutmanOnno C MeijerKarolien De Bosscher

Bookchapter in Steroid receptors : methods and protocols

Determining the cofactor profile of the glucocorticoid receptor in lymphoid malignancies using MARCoNI

Dorien ClarisseSofie DesmetJonathan ThommisIlse BeckKarolien De Bosscher

Determining the coregulator profile of the endogenous glucocorticoid receptor in lymphoid malignancies using MARCoNI

Dorien ClarisseDariusz RatmanSofie DesmetJonathan ThommisRené HoutmanKarolien De BosscherIlse Beck

Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha

Leentje DreesenKarolien De BosscherGrietje GritBart StaelsErik LubbertsEric BaugePeter Geldhof

A1 Journal Article in INFECTION AND IMMUNITY

How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

Ellen DanneelsSarah GerloKaren HeyninckKathleen Van CraenenbroeckKarolien De BosscherGuy HaegemanDirk de Graaf

A1 Journal Article in PLOS ONE

Hypoxia-inducible lipid droplet-associated (HILPDA) Is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion

Frits MattijssenAnastasia GeorgiadiTresty AndasarieEwa SzalowskaAnnika ZotaAnja Krones-HerzigChristoph HeierDariusz RatmanKarolien De BosscherLing QiRudolf ZechnerStephan HerzigSander Kersten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro inhibition of the transcription factor NF-κB and cyclooxygenase by bamboo extracts

Laura Van HoyweghenKarolien De BosscherGuy HaegemanDieter DeforceArne Heyerick

A1 Journal Article in PHYTOTHERAPY RESEARCH

PPARα and IL-17A responses associated with the intestinal immune response against the protozoan parasite Giardia muris

Leentje DreesenKarolien De BosscherBart StaelsErik LubbertsEdwin ClaereboutPeter Geldhof

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells

Katarzyna Szarc vel SzicKen Op De BeeckDariusz RatmanAn WoutersIlse BeckKen DeclerckKaren HeyninckErik FransenMarc BrackeKarolien De BosscherFilip LardonGuy Van CampWim Vanden Berghe

A1 Journal Article in PLOS ONE

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden BergheClaude LibertMarc DiederichGuy Haegeman

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Sesquiterpenes from selected Laserpitium L. species as antimicrobial agents

Visnja PopovicDejan StojkovicMilos NikolicNadia BougarneJan GoemanArne HeyerickKarolien De BosscherMarina SokovicJohan Van der Eycken

The increasing complexity of glucocorticoid receptor signaling and regulation

Sofie DesmetIlse BeckNadia BougarneDorien ClarisseJulie DeckersDariusz RatmanJan TavernierKarolien De Bosscher

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

Michal PawlakEric BaugéWilliam BourguetKarolien De BosscherFanny LalloyerAnne TailleuxCorinna LebherzPhilippe LefebvreBart Staels

A1 Journal Article in HEPATOLOGY

2013

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie GossyeGeertrui DeneckerSam LievensMarc BrackeJan TavernierWim DeclercqKris GevaertWim Vanden BergheGuy HaegemanKarolien De Bosscher

A1 Journal Article in PLOS ONE

Giardia muris infection in mice is associated with the intestinal activation of the Peroxisome Proliferator-Activated Receptor Alpha followed by a protective IL-17A response

Leentje DreesenKarolien De BosscherBart StaelsErik LubbertsEric BaugePeter Geldhof

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering

Dariusz RatmanWim Vanden BergheLien DejagerClaude LibertJan TavernierIlse BeckKarolien De Bosscher

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitogen- and stress-activated protein kinase 1 (MSK1) regulates glucocorticoid response element (GRE) promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

PPARα and IL-17A responses associated with the intestinal immune response against the protozoan parasite Giardia muris

Leentje DreesenKarolien De BosscherBart StaelsErik LubbertsEdwin ClaereboutPeter Geldhof

The Sin3a repressor complex regulates the balance between the activities of different STAT proteins

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanKarolien De BosscherM BoutrosJan Tavernier

The novel selective glucocorticoid receptor modulator compound A maintains osteoblast function and the RANKL/OPG ratio in mice

Elena TsourdiSylvia ThieleKathrin SinningenKarolien De BosscherJan P TuckermannLorenz C HofbauerMartina Rauner

2012

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart LambrechtNelly FrossardKarolien De Bosscher

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells

Ana C LibermanMaria Antunica-NoguerolViviane Ferraz-de-PaulaJoao Palermo-NetoCarla N CastroJimena DrukerFlorian HolsboerMarcelo J PeroneSarah GerloKarolien De BosscherGuy HaegemanEduardo Arzt

A1 Journal Article in PLOS ONE

Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiSam LievensRaffaele MoriJulie PiessevauxLode De CauwerKarolien De BosscherJan Tavernier

A1 Journal Article in FASEB JOURNAL

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

S ThieleE TsourdiKarolien De BosscherJ TuckermannLC HofbauerM Rauner

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

Sylvia ThieleNicole ZieglerElena TsourdiKarolien De BosscherJan P TuckermannLorenz C HofbauerMartina Rauner

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

The HAT/HDAC interplay: multilevel control of STAT signaling

Laura IcardiKarolien De BosscherJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-RoelsKarolien De BosscherMichael BoutrosJan Tavernier

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2011

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

Alexander RauchValerie GossyeDebby BrackeElien GevaertPeggy JacquesKatrien Van BenedenBERNARD VANDOORENMartina RaunerLorenz C HofbauerGuy HaegemanDirk ElewautJan P TuckermannKarolien De Bosscher

A1 Journal Article in FASEB JOURNAL

Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells

Martina RaunerClaudia GoettschNicola SteinSylvia ThieleMartin BornhaeuserKarolien De BosscherGuy HaegemanJan TuckermannLorenz C Hofbauer

A1 Journal Article in ENDOCRINOLOGY

Glucocorticoid receptor mutants: man-made tools for functional research

Ilse BeckKarolien De BosscherGuy Haegeman

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling

Sam LievensFrank PeelmanKarolien De BosscherIrma LemmensJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Opposite regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiKarolien De BosscherRaffaele MoriLode De CauwerSam LievensJan Tavernier

STAT3 transcriptional activity is controlled by regulated acetylation

Jan TavernierLaura IcardiViola GesellchenRaffaele MoriSam LievensSven EyckermanJennyfer BultinckM BoutrosKarolien De Bosscher

2010

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance

Valerie GossyeDirk ElewautKatrien Van BenedenPieter DewintGuy HaegemanKarolien De Bosscher

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A

Steven RobertsonFatima Allie-ReidWim Vanden BergheKoch VisserAnke BinderDonita AfricanderMichael VismerKarolien De BosscherJanet HapgoodGuy HaegemanAnn Louw

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

Geert van LooMozes SzeNadia BougarneJelle PraetConor Mc GuireAndrea UllrichGuy HaegemanMarco PrinzRudi BeyaertKarolien De Bosscher

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?

Karolien De BosscherIlse BeckGuy Haegeman

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Crosstalk between TNF and glucocorticoid receptor signaling pathways

Tom Van BogaertKarolien De BosscherClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Molecular cross-talk between nuclear receptors and nuclear factor-kB

Ilse BeckGuy HaegemanKarolien De Bosscher

Bookchapter in From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems

Selective glucocorticoid receptor modulators

Karolien De Bosscher

A1 Journal Article in JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting inflammation using selective glucocorticoid receptor modulators

Karolien De BosscherGuy HaegemanDirk Elewaut

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

2009

A selective glucocorticoid receptor modulator improves muscle function in a mouse model for Duchenne muscular dystrophy

Tony HuynhAndrea TrebbinDavid CowleyFrancis BowlingGary M LeongAndrew M CotterillMark HarrisKarolien De BosscherGuy HaegemanAndrew J Hoey

Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPAR alpha

Nadia BougarneRejane PaumelleGuy HaegemanBart StaelsKarolien De Bosscher

Editorial material

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

Ilse BeckWim Vanden BergheLinda VermeulenKeith R YamamotoGuy HaegemanKarolien De Bosscher

A1 Journal Article in ENDOCRINE REVIEWS

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Valerie GossyeDirk ElewautNadia BougarneDebby BrackeSerge Van CalenberghGuy HaegemanKarolien De Bosscher

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: Possible partners in the combat against inflammation

Ilse BeckWim Vanden BergheSarah GerloNadia BougarneLinda VermeulenKarolien De BosscherGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

Marjan Van CleemputKo CattoorKarolien De BosscherGuy HaegemanDenis De KeukeleireArne Heyerick

A1 Journal Article in Journal of Natural Products

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Marjan Van CleemputArne HeyerickClaude LibertKatrien SwertsJan PhilippéDenis De KeukeleireGuy HaegemanKarolien De Bosscher

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

Karolien De BosscherGuy Haegeman

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

PPAR alpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappa B

Nadia BougarneRejane PaumelleSandrine CaronNathalie HennuyerRoxane MansouriPhilippe GervoisBart StaelsGuy HaegemanKarolien De Bosscher

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studying the therapeutic benefit of a glucocorticoid receptor phytomodulator in synoviocytes derived from rheumatoid arthritis patients

Valerie GossyeKarolien De Bosscher

The versatile role of MSKs in transcriptional regulation

Linda VermeulenWim Vanden BergheIlse BeckKarolien De BosscherGuy Haegeman

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

Pieter DewintValerie GossyeKarolien De BosscherWim Vanden BergheKatrien Van BenedenDieter DeforceSerge Van CalenberghU MULLER-LADNERBert Vander CruyssenAugust VerbruggenGuy HaegemanDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappa B inhibition

Ilse BeckWim Vanden BergheLinda VermeulenNadia BougarneBERT VANDER CRUYSSENGuy HaegemanKarolien De Bosscher

A1 Journal Article in EMBO JOURNAL

In-vitro and in-vivo evidence for the anti-inflammatory activity of hop bitter acids in mouse

Marjan Van CleemputArne HeyerickClaude LibertDenis De KeukeleireGuy HaegemanKarolien De Bosscher

Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems

Karolien De BosscherKathleen Van CraenenbroeckOnno C. MeijerGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk

Valerie GossyeGuy HaegemanKarolien De Bosscher

A1 Journal Article in FRONTIERS IN BIOSCIENCE

2007

Chemopreventive principles from Pueararia lobata flowers: In Vitro Evaluation of the Inhibition of the NF kappa B activating signaling pathway

L BEBREVSKAKarolien De BosscherGuy HaegemanI MERFORTS APERSL PIETERSA VLIETINCK

Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease

Philippe GevaertJoke PatouThibaut Van ZeleGabriële HoltappelsKarolien De BosscherWim Vanden BergheGuy HaegemanClaus Bachert

Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa

Frauke CoppietersBart LeroyDIANE BEYSENJAN HELLEMANSKarolien De BosscherGuy HaegemanKirsten RobberechtWim WuytsPaul CouckeElfride De Baere

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

2006

Cross-talk between nuclear receptors and nuclear factor kappa B

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ONCOGENE

2005

A fully dissociated compound of plant origin for inflammatory gene repression

Karolien De BosscherWim Vanden BergheIlse BeckWim Van MolleN HENNUYERJ HAPGOODClaude LibertB STAELSA LOUWGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent anti-inflammatory, fully dissociative compound for glucocorticoid receptor-mediated gene regulation

Pieter DewintKarolien De BosscherValerie GossyeWim Vanden BergheBert Vander CruyssenEric VeysGuy HaegemanDirk Elewaut

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

Kathleen Van CraenenbroeckKarolien De BosscherWim Vanden BerghePeter VanhoenackerGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2004

Analysis of Smad nucleocytoplasmic shuttling in living cells

Francisco J NicolásKarolien De BosscherBernhard SchmiererCaroline S Hill

A1 Journal Article in JOURNAL OF CELL SCIENCE

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

Karolien De BosscherCaroline S HillFrancisco J Nicolás

A1 Journal Article in BIOCHEMICAL JOURNAL

2003

A paradigm for gene regulation: Inflammation, NF-kappa B and PPAR

Wim Vanden BergheLinda VermeulenP DELERIVEKarolien De BosscherB STAELSGuy Haegeman

A1 Journal Article in PEROXISOMAL DISORDERS AND REGULATION OF GENES

Inhibition of cytokine production by the herbicide atrazine - Search for nuclear receptor targets

S DEVOSKarolien De BosscherB STAELSE BAUERFrank RoelsWim Vanden BergheGuy HaegemanR HOOGHEEL HOOGHE-PETERS

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of NF-kB by glucocorticoids

Karolien De BosscherWim Vanden BergheGuy Haegeman

Bookchapter in Nuclear Factor kB: Regulation and role in disease

The interplay between the glucocorticoid receptor and nuclear factor-kappa B or activator protein-1: Molecular mechanisms for gene repression

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ENDOCRINE REVIEWS

2002

DNA binding-independent induction of I kappa B alpha gene transcription by PPAR alpha

P DeleriveKarolien De BosscherWim Vanden BergheJC FruchartGuy HaegemanB Staels

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Induction and repression of NF-kappaB-driven inflammatory genes.

Wim Vanden BergheKarolien De BosscherLinda VermeulenGert De WildeGuy Haegeman

Bookchapter in Recent Advances in Glucocorticoid Receptor Action

2001

Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

2000

Glucocorticoids repress NF-kappa B-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.

Karolien De BosscherW VANDEN BERGHELinda VermeulenS PLAISANCEElke BooneGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors.

Karolien De BosscherW VANDEN BERGHEGuy Haegeman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

Wim Vanden BergheLinda VermeulenGert De WildeKarolien De BosscherElke BooneGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

1999

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappa B-dependent mechanism.

Wim Vanden BergheE FRANCESCONIKarolien De BosscherM RESCHE-RIGONGuy Haegeman

A1 Journal Article in MOLECULAR PHARMACOLOGY

In search of the molecular mechanism of gene repression by glucocorticoids

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

P1 Journal Article in MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING

In search of the molecular mechanism of gene repression by glucocorticoids.

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1.

P DELERIVEKarolien De BosscherS BESNARDWim Vanden BergheJM PETERSFJ GONZALEZJC FRUCHARTA TEDGUIGuy HaegemanB STAELS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear factor-kappa B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

Wim Vanden BergheKarolien De BosscherElke BooneS PLAISANCEGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1998

Cross-talk between steroids and NF-kappa B: what language?

A DUMONTSP HEHNERML SCHMITZJA GUSTAFSSONJ LIDENS OKRETPT VAN DER SAAGS WISSINKB VAN DER BURGP HERRLICHGuy HaegemanKarolien De BosscherWalter Fiers

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.

Wim Vanden BergheS PLAISANCEElke BooneKarolien De BosscherML SCHMITZWalter FiersGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1997

Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation

Karolien De BosscherM Lienhard SchmitzWim Vanden BergheStéphane PlaisanceWalter FiersGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA