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Researcher
Karolien De Bosscher
Profile
Projects
Publications
Activities
Awards & Distinctions
167
Results
2022
Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor
Dorien Clarisse
Lisa Deng
Karolien De Bosscher
Achim Lother
A1
Journal Article
in
BRITISH JOURNAL OF PHARMACOLOGY
2022
Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties
Kato Bredael
Silke Geurs
Dorien Clarisse
Karolien De Bosscher
Matthias D'hooghe
A1
Journal Article
in
JOURNAL OF CHEMISTRY
2022
Compound A attenuates proinflammatory cytokine-induced endoplasmic reticulum stress in beta cells and displays beneficial therapeutic effects in a mouse model of autoimmune diabetes
Luz Andreone
Florencia Fuertes
Carolina Sétula
Andres E. Barcala Tabarrozzi
Miranda S. Orellano
Ricardo A. Dewey
Rita Bottino
Karolien De Bosscher
Marcelo J. Perone
U
Journal Article
in
Cellular and Molecular Life Sciences
2022
Hepatic glucocorticoid‐induced transcriptional regulation is androgen‐dependent after chronic but not acute glucocorticoid exposure
Jacobus C. Buurstede
Susana N. Paul
Karolien De Bosscher
Onno C. Meijer
Jan Kroon
A1
Journal Article
in
FASEB JOURNAL
2022
Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation
Silke Geurs
Dorien Clarisse
Freya Baele
Jorick Franceus
Tom Desmet
Karolien De Bosscher
Matthias D'hooghe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2022
Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets
Laura Van Moortel
Jonathan Thommis
Brecht Maertens
An Staes
Dorien Clarisse
Delphine De Sutter
Claude Libert
Onno C. Meijer
Sven Eyckerman
Kris Gevaert
et al.
A1
Journal Article
in
BIOMEDICINE & PHARMACOTHERAPY
2022
Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding
Steven Timmermans
Nicolette J.D. Verhoog
Kelly Van Looveren
Sylviane Dewaele
Tino Hochepied
Melanie Eggermont
Barbara Gilbert
Anne Boerema-de Munck
Tineke Vanderhaeghen
Joke Vanden Berghe
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2022
Reprogramming of glucocorticoid receptor function by hypoxia
Tineke Vanderhaeghen
Steven Timmermans
Deepika Watts
Ville Paakinaho
Melanie Eggermont
Jolien Vandewalle
Charlotte Wallaeys
Lise Van Wyngene
Kelly Van Looveren
Louise Nuyttens
et al.
A1
Journal Article
in
EMBO REPORTS
2022
The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma
Silke Geurs
Eleni Staessens
Dorien Clarisse
Karolien De Bosscher
Matthias D'hooghe
C3
Conference
2022
The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma
Silke Geurs
Dorien Clarisse
Eleni Staessens
Karolien De Bosscher
Matthias D'hooghe
C3
Conference
2022
2021
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Jolien Vandewalle
Steven Timmermans
Ville Paakinaho
Lies Vancraeynest
Liza Dewyse
Tineke Vanderhaeghen
Charlotte Wallaeys
Lise Van Wyngene
Kelly Van Looveren
Louise Nuyttens
et al.
A1
Journal Article
in
CELL METABOLISM
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky
Amal Kamal Abdel-Aziz
Sara Abdelfatah
Mahmoud Abdellatif
Asghar Abdoli
Steffen Abel
Hagai Abeliovich
Marie H. Abildgaard
Yakubu Princely Abudu
Abraham Acevedo-Arozena
et al.
A1
Journal Article
in
AUTOPHAGY
2021
How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
Dorien Clarisse
Karolien De Bosscher
Editorial material
2021
Regulatory role of the intestinal microbiota in the immune response against Giardia
Brecht Maertens
Aurélie Gagnaire
Oonagh Paerewijck
Karolien De Bosscher
Peter Geldhof
A1
Journal Article
in
SCIENTIFIC REPORTS
2021
The role of glucocorticoid resistance and TNFR1 signaling in sepsis
Jolien Vandewalle
Claude Libert
Karolien De Bosscher
Dissertation
2021
ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation
Lise Van Wyngene
Tineke Vanderhaeghen
Ioanna Petta
Steven Timmermans
Katrien Corbeels
Bart Van der Schueren
Jolien Vandewalle
Kelly Van Looveren
Charlotte Wallaeys
Melanie Eggermont
et al.
A1
Journal Article
in
ISCIENCE
2021
2020
Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system
Kelly Van Looveren
Steven Timmermans
Tineke Vanderhaeghen
Charlotte Wallaeys
Marlies Ballegeer
Jolien Souffriau
Melanie Eggermont
Jolien Vandewalle
Lise Van Wyngene
Karolien De Bosscher
et al.
A1
Journal Article
in
EMBO REPORTS
2020
Improved glucocorticoid receptor ligands : fantastic beasts, but how to find them?
Laura Van Moortel
Kris Gevaert
Karolien De Bosscher
A1
Journal Article
in
FRONTIERS IN ENDOCRINOLOGY
2020
Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies
Dorien Clarisse
Fritz Offner
Karolien De Bosscher
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
2020
Nuclear receptor crosstalk : defining the mechanisms for therapeutic innovation
Karolien De Bosscher
Sofie Desmet
Dorien Clarisse
Eva Estébanez-Perpiña
Luc Brunsveld
A1
Journal Article
in
NATURE REVIEWS ENDOCRINOLOGY
2020
The glucocorticoid receptor in acute inflammation : new molecular insights and development of a new GR dimerization mutant
Kelly Van Looveren
Claude Libert
Karolien De Bosscher
Dissertation
2020
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
Jolien Souffriau
Steven Timmermans
Tineke Vanderhaeghen
Charlotte Wallaeys
Kelly Van Looveren
Lindsy Aelbrecht
Sylviane Dewaele
Jolien Vandewalle
Evy Goossens
Serge Verbanck
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2020
2019
Critical roles of endogenous glucocorticoids for disease tolerance in malaria
Leen Vandermosten
Ilse Vanhorebeek
Karolien De Bosscher
Ghislain Opdenakker
Philippe E. Van den Steen
A1
Journal Article
in
TRENDS IN PARASITOLOGY
2019
Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice
Oonagh Paerewijck
Brecht Maertens
Aurélie Gagnaire
Karolien De Bosscher
Peter Geldhof
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses
Nadia Bougarne
Viacheslav Mylka
Dariusz Ratman
Ilse Beck
Jonathan Thommis
Lode De Cauwer
Jan Tavernier
Bart Staels
Claude Libert
Karolien De Bosscher
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2019
Risks and benefits of corticosteroids in arthritic diseases in the clinic
Ioanna Petta
Isabelle Peene
Dirk Elewaut
Lars Vereecke
Karolien De Bosscher
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2019
Study of anti-inflammatory approaches as an alternative for glucocorticoids
Viacheslav Mylka
Karolien De Bosscher
Jan Tavernier
Dissertation
2019
Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors
Yves Depetter
Silke Geurs
Jorick Franceus
Damijan Knez
Tom Desmet
Karolien De Bosscher
Olivier De Wever
Stanislav Gobec
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYSELECT
2019
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Karen Dendoncker
Steven Timmermans
Jolien Vandewalle
Melanie Eggermont
Joanna Lempiäinen
Ville Paakinaho
Evelien Van Hamme
Sylviane Dewaele
Sofie Vandevyver
Marlies Ballegeer
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2019
Unraveling the role of IL-17A in the intestinal immune response against Giardia
Oonagh Paerewijck
Peter Geldhof
Karolien De Bosscher
Dissertation
2019
2018
A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation
Jolien Souffriau
Melanie Eggermont
Sara Van Ryckeghem
Kelly Van Looveren
Lise Van Wyngene
Evelien Van Hamme
Marnik Vuylsteke
Rudi Beyaert
Karolien De Bosscher
Claude Libert
A1
Journal Article
in
SCIENTIFIC REPORTS
2018
Adrenal hormones mediate disease tolerance in malaria
Leen Vandermosten
Thao-Thy Pham
Sofie Knoops
Charlotte De Geest
Natacha Lays
Kristof Van der Molen
Christopher J Kenyon
Manu Verma
Karen E Chapman
Frans Schuit
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development
Dorien Baetens
Tülay Güran
Berenice B Mendonca
Nathalia L Gomes
Lode De Cauwer
Frank Peelman
Hannah Verdin
Marnik Vuylsteke
Malaïka Van der Linden
Hans Stoop
et al.
A1
Journal Article
in
GENETICS IN MEDICINE
2018
Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march
Julie Deckers
Nadia Bougarne
Viacheslav Mylka
Sofie Desmet
Astrid Luypaert
Michael Devos
Giel Tanghe
Justine Van Moorleghem
Manon Vanheerswynghels
Lode De Cauwer
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2018
Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies
Dorien Clarisse
Karlien Van Wesemael
Jan Tavernier
Fritz Offner
Ilse Beck
Karolien De Bosscher
A1
Journal Article
in
PLOS ONE
2018
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
Marlies Ballegeer
Kelly Van Looveren
Steven Timmermans
Melanie Eggermont
Sofie Vandevyver
Fabien Henri Thery
Karen Dendoncker
Jolien Souffriau
Jolien Vandewalle
Lise Van Wyngene
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2018
Glucocorticoid resistance in multiple myeloma : mechanistic insights and therapeutic considerations
Dorien Clarisse
Karolien De Bosscher
Ilse Beck
Dissertation
2018
Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts
Zuzanna Drebert
Elly De Vlieghere
Jolien Bridelance
Olivier De Wever
Karolien De Bosscher
Marc Bracke
Ilse Beck
A1
Journal Article
in
EXPERIMENTAL CELL RESEARCH
2018
Molecular actions of PPARα in lipid metabolism and inflammation
Nadia Bougarne
Basiel Weyers
Sofie Desmet
Julie Deckers
David W Ray
Bart Staels
Karolien De Bosscher
A1
Journal Article
in
ENDOCRINE REVIEWS
2018
Strategies and compounds to circumvent glucocorticoid-induced side effects
Astrid Luypaert
Wim Vanden Berghe
Jan Tavernier
Claude Libert
Karolien De Bosscher
Bookchapter
in
Immunopharmacology and inflammation
2018
Study of the transcriptional crosstalk between metabolic nuclear receptors
Sofie Desmet
Karolien De Bosscher
Jan Tavernier
Dissertation
2018
The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Viacheslav Mylka
Julie Deckers
Dariusz Ratman
Lode De Cauwer
Jonathan Thommis
Riet De Rycke
Francis Impens
Claude Libert
Jan Tavernier
Wim Vanden Berghe
et al.
A1
Journal Article
in
AUTOPHAGY
2018
Therapeutic mechanisms of glucocorticoids
Jolien Vandewalle
Astrid Luypaert
Karolien De Bosscher
Claude Libert
A1
Journal Article
in
TRENDS IN ENDOCRINOLOGY AND METABOLISM
2018
2017
11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner
L. Vandermosten
C. De Geest
S. Knoops
G. Thijs
K. E. Chapman
Karolien De Bosscher
G. Opdenakker
P. E. Van den Steen
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor
Zuzanna Drebert
Mark MacAskill
Dahlia Doughty-Shenton
Karolien De Bosscher
Marc Bracke
Patrick WF Hadoke
Ilse Beck
A1
Journal Article
in
VASCULAR PHARMACOLOGY
2017
Compound A influences gene regulation of the dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment
Sofie Desmet
Nadia Bougarne
Laura Van Moortel
Lode De Cauwer
Jonathan Thommis
M Vuylsteke
Dariusz Ratman
R Houtman
Jan Tavernier
Karolien De Bosscher
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies
Dorien Clarisse
Jonathan Thommis
Karlien Van Wesemael
Rene Houtman
Dariusz Ratman
Jan Tavernier
Fritz Offner
Ilse Beck
Karolien De Bosscher
A1
Journal Article
in
ONCOTARGET
2017
Daucane esters from laserwort (Laserpitium latifolium L.) inhibit cytokine and chemokine production in human lung epithelial cells
Visnja Popovic
Jan Goeman
Jonathan Thommis
Arne Heyerick
Jurgen Caroen
Johan Van der Eycken
Karolien De Bosscher
A1
Journal Article
in
PHYTOMEDICINE
2017
Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
Julie Deckers
Dorine Sichien
Maud Plantinga
Justine Van Moorleghem
Manon Vanheerswynghels
Esther Hoste
Bernard Malissen
David Dombrowicz
Martin Guilliams
Karolien De Bosscher
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2017
Glucocorticoid receptor modulation of the colon cancer microenvironment
Zuzanna Drebert
Marc Bracke
Ilse Beck
Karolien De Bosscher
Dissertation
2017
Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
Ioanna Petta
Nadia Bougarne
Jolien Vandewalle
Lien Dejager
Sofie Vandevyver
Marlies Ballegeer
Sofie Desmet
Jonathan Thommis
Lode De Cauwer
Sam Lievens
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Glucocorticoid receptors : finding the middle ground
Sofie Desmet
Karolien De Bosscher
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2017
Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia
Oonagh Paerewijck
Brecht Maertens
Leentje Dreesen
Frederik Van Meulder
Iris Peelaers
Dariusz Ratman
Robert W Li
Erik Lubberts
Karolien De Bosscher
Peter Geldhof
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin
Julie Deckers
Karolien De Bosscher
Bart Lambrecht
Hamida Hammad
A1
Journal Article
in
IMMUNOLOGICAL REVIEWS
2017
Involvement of the glucocorticoid receptor in pro-inflammatory transcription factor inhibition by daucane esters from Laserpitium zernyi
Visnja Popovic
Jan Goeman
Nadia Bougarne
Sven Eyckerman
Arne Heyerick
Karolien De Bosscher
Johan Van der Eycken
A1
Journal Article
in
JOURNAL OF NATURAL PRODUCTS
2017
Plasmodium berghei NK65 in combination with IFN-γ induces endothelial glucocorticoid resistance via sustained activation of p38 and JNK
Karolina A. Zielińska
Lode De Cauwer
Sofie Knoops
Kristof Van der Molen
Alexander Sneyers
Jonathan Thommis
J. Brian De Souza
Ghislain Opdenakker
Karolien De Bosscher
Philippe E. Van den Steen
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2017
Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads
Chandra S Chirumamilla
Ajay Palagani
Balu Kamaraj
Ken Declerck
Marinus WC Verbeek
Oksana Ryabtsova
Karolien De Bosscher
Nadia Bougarne
Bart Ruttens
Kris Gevaert
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2017
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution
Laura García-Pupo
Jeney Ramírez Sánchez
Dariusz Ratman
Claudina Perez Novo
Ken Declerck
Karolien De Bosscher
Marios Nektarios Markakis
Gerrit Beemster
Armando Zaldo
Yanier Nuñez Figueredo
et al.
A1
Journal Article
in
BRAIN BEHAVIOR AND IMMUNITY
2017
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity
Raffaele Mori
Joris Wauman
Laura Icardi
José Van Der Heyden
Lode De Cauwer
Frank Peelman
Karolien De Bosscher
Jan Tavernier
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
The nature of the GRE influences the screening for GR-activity enhancing modulators
Karen Dendoncker
Steven Timmermans
Kelly Van Looveren
Lode De Cauwer
Karolien De Bosscher
Claude Libert
A1
Journal Article
in
PLOS ONE
2017
The skin as a central player in house dust mite allergy
Julie Deckers
Karolien De Bosscher
Hamida Hammad
Dissertation
2017
2016
Activation of the glucocorticoid receptor in acute inflammation : the SEDIGRAM concept
Karolien De Bosscher
Ilse Beck
Dariusz Ratman
Wim Vanden Berghe
Claude Libert
A1
Journal Article
in
TRENDS IN PHARMACOLOGICAL SCIENCES
2016
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
Dariusz Ratman
Viacheslav Mylka
Nadia Bougarne
Michal Pawlak
Sandrine Caron
Nathalie Hennuyer
Réjane Paumelle
Lode De Cauwer
Jonathan Thommis
Mark H Rider
et al.
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2016
Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation
Dorien Clarisse
Karolien De Bosscher
Ilse Beck
C3
Conference
2016
Endothelial response to glucocorticoids in inflammatory diseases
Karolina A Zielińska
Laura Van Moortel
Ghislain Opdenakker
Karolien De Bosscher
Philippe E Van den Steen
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2016
GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A
Andres E Barcala Tabarrozzi
Luz Andreone
Julie Deckers
Carla N Castro
María L Gimeno
Laura Ariolfo
Paula M Berguer
María Antunica-Noguerol
Ana C Liberman
Sabine Vettorazzi
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2016
Modulation of protein-protein interactions for the development of novel therapeutics
Ioanna Petta
Sam Lievens
Claude Libert
Jan Tavernier
Karolien De Bosscher
A1
Journal Article
in
MOLECULAR THERAPY
2016
Proteome-scale binary interactomics in human cells
Sam Lievens
José Van Der Heyden
Delphine Masschaele
Leentje De Ceuninck
Ioanna Petta
Surya Gupta
Veronic De Puysseleyr
Virginie Vauthier
Irma Lemmens
Dries De Clercq
et al.
A1
Journal Article
in
MOLECULAR & CELLULAR PROTEOMICS
2016
The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases
Ioanna Petta
Lien Dejager
Marlies Ballegeer
Sam Lievens
Jan Tavernier
Karolien De Bosscher
Claude Libert
A2
Journal Article
in
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
2016
The mineralocorticoid receptor is involved in glucocorticoid resistance
Dorien Clarisse
Fritz Offner
Karolien De Bosscher
Ilse Beck
C3
Conference
2016
Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach
Oonagh Paerewijck
Leentje Dreesen
Frederik Van Meulder
Dariusz Ratman
Karolien De Bosscher
RW Li
Peter Geldhof
C3
Conference
2016
2015
Analysis of the protective immune response following intramuscular vaccination of calves against the intestinal parasite Cooperia oncophora
Frederik Van Meulder
Dariusz Ratman
Stefanie Van Coppernolle
Jimmy Borloo
RW Li
Koen Chiers
Wim Van Den Broeck
Karolien De Bosscher
Edwin Claerebout
Peter Geldhof
A1
Journal Article
in
INTERNATIONAL JOURNAL FOR PARASITOLOGY
2015
Combination of dexamethasone with the selective glucocorticoid receptor modulator, Compound A, does not enhance glucocorticoid responsiveness in lymphoid malignancies
Dorien Clarisse
Fritz Offner
Marc Bracke
Karolien De Bosscher
Ilse Beck
C3
Conference
2015
Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation
Dorien Clarisse
Karolien De Bosscher
Ilse Beck
C3
Conference
2015
Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation
Dorien Clarisse
Karolien De Bosscher
Ilse Beck
C3
Conference
2015
Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue
Ilse Beck
Koen Van Crombruggen
Gabriële Holtappels
François Daubeuf
Nelly Frossard
Claus Bachert
Karolien De Bosscher
A1
Journal Article
in
PLOS ONE
2015
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
Lien Dejager
Karen Dendoncker
Melanie Eggermont
Jolien Souffriau
Filip Van Hauwermeiren
Monique Willart
Elien Van Wonterghem
Thomas Naessens
Marlies Ballegeer
Sofie Vandevyver
et al.
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2015
Novel anti-inflammatory daucane esters from Laserpitium zernyi Hayek (Apiaceae)
Visnja Popovic
Jan Goeman
Nadia Bougarne
Arne Heyerick
Karolien De Bosscher
Johan Van der Eycken
C3
Conference
2015
Selective glucocorticoid receptor modulation : new directions with non-steroidal scaffolds
Nora Sundahl
Jolien Bridelance
Claude Libert
Karolien De Bosscher
Ilse Beck
A1
Journal Article
in
PHARMACOLOGY & THERAPEUTICS
2015
Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors
Rob De Vreese
Nicholas Van Steen
Tom Verhaeghe
Tom Desmet
Nadia Bougarne
Karolien De Bosscher
Veronick Benoy
Wanda Haeck
Ludo Van Den Bosch
Matthias D'hooghe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2015
The transcriptional co-regulation of hepatic lipid metabolism by GR and PPARα
Dariusz Ratman
Karolien De Bosscher
Jan Tavernier
Dissertation
2015
Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach
Oonagh Paerewijck
Leentje Dreesen
Frederik Van Meulder
Dariusz Ratman
Karolien De Bosscher
RW Li
Peter Geldhof
C3
Conference
2015
2014
Cofactor profiling of the glucocorticoid receptor from a cellular environment
Sofie Desmet
Lien Dejager
Dorien Clarisse
Jonathan Thommis
Diana Melchers
Niek Bastiaensen
Rob Ruijtenbeek
Ilse Beck
Claude Libert
Renée Houtman
et al.
Bookchapter
in
Steroid receptors : methods and protocols
2014
Determining the cofactor profile of the glucocorticoid receptor in lymphoid malignancies using MARCoNI
Dorien Clarisse
Sofie Desmet
Jonathan Thommis
Ilse Beck
Karolien De Bosscher
C3
Conference
2014
Determining the coregulator profile of the endogenous glucocorticoid receptor in lymphoid malignancies using MARCoNI
Dorien Clarisse
Dariusz Ratman
Sofie Desmet
Jonathan Thommis
René Houtman
Karolien De Bosscher
Ilse Beck
C3
Conference
2014
Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha
Leentje Dreesen
Karolien De Bosscher
Grietje Grit
Bart Staels
Erik Lubberts
Eric Bauge
Peter Geldhof
A1
Journal Article
in
INFECTION AND IMMUNITY
2014
How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines
Ellen Danneels
Sarah Gerlo
Karen Heyninck
Kathleen Van Craenenbroeck
Karolien De Bosscher
Guy Haegeman
Dirk de Graaf
A1
Journal Article
in
PLOS ONE
2014
Hypoxia-inducible lipid droplet-associated (HILPDA) Is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion
Frits Mattijssen
Anastasia Georgiadi
Tresty Andasarie
Ewa Szalowska
Annika Zota
Anja Krones-Herzig
Christoph Heier
Dariusz Ratman
Karolien De Bosscher
Ling Qi
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2014
In vitro inhibition of the transcription factor NF-κB and cyclooxygenase by bamboo extracts
Laura Van Hoyweghen
Karolien De Bosscher
Guy Haegeman
Dieter Deforce
Arne Heyerick
A1
Journal Article
in
PHYTOTHERAPY RESEARCH
2014
PPARα and IL-17A responses associated with the intestinal immune response against the protozoan parasite Giardia muris
Leentje Dreesen
Karolien De Bosscher
Bart Staels
Erik Lubberts
Edwin Claerebout
Peter Geldhof
C3
Conference
2014
Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Katarzyna Szarc vel Szic
Ken Op De Beeck
Dariusz Ratman
An Wouters
Ilse Beck
Ken Declerck
Karen Heyninck
Erik Fransen
Marc Bracke
Karolien De Bosscher
et al.
A1
Journal Article
in
PLOS ONE
2014
Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1
Karolien De Bosscher
Ilse Beck
Lien Dejager
Nadia Bougarne
Anthoula Gaigneaux
Sebastien Chateauvieux
Dariusz Ratman
Marc Bracke
Jan Tavernier
Wim Vanden Berghe
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2014
Sesquiterpenes from selected Laserpitium L. species as antimicrobial agents
Visnja Popovic
Dejan Stojkovic
Milos Nikolic
Nadia Bougarne
Jan Goeman
Arne Heyerick
Karolien De Bosscher
Marina Sokovic
Johan Van der Eycken
C3
Conference
2014
The increasing complexity of glucocorticoid receptor signaling and regulation
Sofie Desmet
Ilse Beck
Nadia Bougarne
Dorien Clarisse
Julie Deckers
Dariusz Ratman
Jan Tavernier
Karolien De Bosscher
A2
Journal Article
in
PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE
2014
The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
Michal Pawlak
Eric Baugé
William Bourguet
Karolien De Bosscher
Fanny Lalloyer
Anne Tailleux
Corinna Lebherz
Philippe Lefebvre
Bart Staels
A1
Journal Article
in
HEPATOLOGY
2014
2013
Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation
Ilse Beck
Zuzanna Drebert
Ruben Hoya-Arias
Ali A Bahar
Michael Devos
Dorien Clarisse
Sofie Desmet
Nadia Bougarne
Bart Ruttens
Valerie Gossye
et al.
A1
Journal Article
in
PLOS ONE
2013
Giardia muris infection in mice is associated with the intestinal activation of the Peroxisome Proliferator-Activated Receptor Alpha followed by a protective IL-17A response
Leentje Dreesen
Karolien De Bosscher
Bart Staels
Erik Lubberts
Eric Bauge
Peter Geldhof
C3
Conference
2013
How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering
Dariusz Ratman
Wim Vanden Berghe
Lien Dejager
Claude Libert
Jan Tavernier
Ilse Beck
Karolien De Bosscher
A1
Journal Article
in
MOLECULAR AND CELLULAR ENDOCRINOLOGY
2013
Mitogen- and stress-activated protein kinase 1 (MSK1) regulates glucocorticoid response element (GRE) promoter activity in a glucocorticoid concentration-dependent manner
Ilse Beck
Dorien Clarisse
Nadia Bougarne
Sam Okret
Guy Haegeman
Karolien De Bosscher
C3
Conference
2013
Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner
Ilse Beck
Dorien Clarisse
Nadia Bougarne
Sam Okret
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACOLOGY
2013
PPARα and IL-17A responses associated with the intestinal immune response against the protozoan parasite Giardia muris
Leentje Dreesen
Karolien De Bosscher
Bart Staels
Erik Lubberts
Edwin Claerebout
Peter Geldhof
C3
Conference
2013
The Sin3a repressor complex regulates the balance between the activities of different STAT proteins
Laura Icardi
Raffaele Mori
Viola Gesellchen
Sven Eyckerman
Judith Verhelst
Koen Vercauteren
Xavier Saelens
Philip Meuleman
Karolien De Bosscher
M Boutros
et al.
C3
Conference
2013
The novel selective glucocorticoid receptor modulator compound A maintains osteoblast function and the RANKL/OPG ratio in mice
Elena Tsourdi
Sylvia Thiele
Kathrin Sinningen
Karolien De Bosscher
Jan P Tuckermann
Lorenz C Hofbauer
Martina Rauner
C3
Conference
2013
2012
A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma
Laurent L Reber
François Daubeuf
Maud Plantinga
Lode De Cauwer
Sarah Gerlo
Wim Waelput
Serge Van Calenbergh
Jan Tavernier
Guy Haegeman
Bart Lambrecht
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2012
Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells
Ana C Liberman
Maria Antunica-Noguerol
Viviane Ferraz-de-Paula
Joao Palermo-Neto
Carla N Castro
Jimena Druker
Florian Holsboer
Marcelo J Perone
Sarah Gerlo
Karolien De Bosscher
et al.
A1
Journal Article
in
PLOS ONE
2012
Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2
Laura Icardi
Sam Lievens
Raffaele Mori
Julie Piessevaux
Lode De Cauwer
Karolien De Bosscher
Jan Tavernier
A1
Journal Article
in
FASEB JOURNAL
2012
Selective glucocorticoid receptor modulation maintains bone mineral density in mice
Sylvia Thiele
Nicole Ziegler
Elena Tsourdi
Karolien De Bosscher
Jan P Tuckermann
Lorenz C Hofbauer
Martina Rauner
A1
Journal Article
in
JOURNAL OF BONE AND MINERAL RESEARCH
2012
Selective glucocorticoid receptor modulation maintains bone mineral density in mice
S Thiele
E Tsourdi
Karolien De Bosscher
J Tuckermann
LC Hofbauer
M Rauner
C3
Conference
2012
The HAT/HDAC interplay: multilevel control of STAT signaling
Laura Icardi
Karolien De Bosscher
Jan Tavernier
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2012
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
Laura Icardi
Raffaele Mori
Viola Gesellchen
Sven Eyckerman
Lode De Cauwer
Judith Verhelst
Koen Vercauteren
Xavier Saelens
Philip Meuleman
Geert Leroux-Roels
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2012
2011
An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation
Alexander Rauch
Valerie Gossye
Debby Bracke
Elien Gevaert
Peggy Jacques
Katrien Van Beneden
Bernard Vandooren
Martina Rauner
Lorenz C Hofbauer
Guy Haegeman
et al.
A1
Journal Article
in
FASEB JOURNAL
2011
Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells
Martina Rauner
Claudia Goettsch
Nicola Stein
Sylvia Thiele
Martin Bornhaeuser
Karolien De Bosscher
Guy Haegeman
Jan Tuckermann
Lorenz C Hofbauer
A1
Journal Article
in
ENDOCRINOLOGY
2011
Glucocorticoid receptor mutants: man-made tools for functional research
Ilse Beck
Karolien De Bosscher
Guy Haegeman
A1
Journal Article
in
TRENDS IN ENDOCRINOLOGY AND METABOLISM
2011
MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling
Sam Lievens
Frank Peelman
Karolien De Bosscher
Irma Lemmens
Jan Tavernier
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2011
Opposite regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2
Laura Icardi
Karolien De Bosscher
Raffaele Mori
Lode De Cauwer
Sam Lievens
Jan Tavernier
C3
Conference
2011
STAT3 transcriptional activity is controlled by regulated acetylation
Jan Tavernier
Laura Icardi
Viola Gesellchen
Raffaele Mori
Sam Lievens
Sven Eyckerman
Jennyfer Bultinck
M Boutros
Karolien De Bosscher
C3
Conference
2011
2010
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance
Valerie Gossye
Dirk Elewaut
Katrien Van Beneden
Pieter Dewint
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2010
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A
Steven Robertson
Fatima Allie-Reid
Wim Vanden Berghe
Koch Visser
Anke Binder
Donita Africander
Michael Vismer
Karolien De Bosscher
Janet Hapgood
Guy Haegeman
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2010
Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis
Geert van Loo
Mozes Sze
Nadia Bougarne
Jelle Praet
Conor Mc Guire
Andrea Ullrich
Guy Haegeman
Marco Prinz
Rudi Beyaert
Karolien De Bosscher
A1
Journal Article
in
MOLECULAR ENDOCRINOLOGY
2010
Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?
Karolien De Bosscher
Ilse Beck
Guy Haegeman
A1
Journal Article
in
BRAIN BEHAVIOR AND IMMUNITY
2010
Crosstalk between TNF and glucocorticoid receptor signaling pathways
Tom Van Bogaert
Karolien De Bosscher
Claude Libert
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2010
Molecular cross-talk between nuclear receptors and nuclear factor-kB
Ilse Beck
Guy Haegeman
Karolien De Bosscher
Bookchapter
in
From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems
2010
Selective glucocorticoid receptor modulators
Karolien De Bosscher
A1
Journal Article
in
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
2010
Targeting inflammation using selective glucocorticoid receptor modulators
Karolien De Bosscher
Guy Haegeman
Dirk Elewaut
A1
Journal Article
in
CURRENT OPINION IN PHARMACOLOGY
2010
2009
A selective glucocorticoid receptor modulator improves muscle function in a mouse model for Duchenne muscular dystrophy
Tony Huynh
Andrea Trebbin
David Cowley
Francis Bowling
Gary M Leong
Andrew M Cotterill
Mark Harris
Karolien De Bosscher
Guy Haegeman
Andrew J Hoey
C3
Conference
2009
Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPAR alpha
Nadia Bougarne
Rejane Paumelle
Guy Haegeman
Bart Staels
Karolien De Bosscher
Editorial material
2009
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Ilse Beck
Wim Vanden Berghe
Linda Vermeulen
Keith R Yamamoto
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
ENDOCRINE REVIEWS
2009
Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts
Valerie Gossye
Dirk Elewaut
Nadia Bougarne
Debby Bracke
Serge Van Calenbergh
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
ARTHRITIS AND RHEUMATISM
2009
Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: Possible partners in the combat against inflammation
Ilse Beck
Wim Vanden Berghe
Sarah Gerlo
Nadia Bougarne
Linda Vermeulen
Karolien De Bosscher
Guy Haegeman
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2009
Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds
Marjan Van Cleemput
Ko Cattoor
Karolien De Bosscher
Guy Haegeman
Denis De Keukeleire
Arne Heyerick
A1
Journal Article
in
Journal of Natural Products
2009
Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ
Marjan Van Cleemput
Arne Heyerick
Claude Libert
Katrien Swerts
Jan Philippé
Denis De Keukeleire
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
MOLECULAR NUTRITION & FOOD RESEARCH
2009
Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids
Karolien De Bosscher
Guy Haegeman
A1
Journal Article
in
MOLECULAR ENDOCRINOLOGY
2009
PPAR alpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappa B
Nadia Bougarne
Rejane Paumelle
Sandrine Caron
Nathalie Hennuyer
Roxane Mansouri
Philippe Gervois
Bart Staels
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2009
Studying the therapeutic benefit of a glucocorticoid receptor phytomodulator in synoviocytes derived from rheumatoid arthritis patients
Valerie Gossye
Karolien De Bosscher
Dissertation
2009
The versatile role of MSKs in transcriptional regulation
Linda Vermeulen
Wim Vanden Berghe
Ilse Beck
Karolien De Bosscher
Guy Haegeman
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
2009
2008
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis
Pieter Dewint
Valerie Gossye
Karolien De Bosscher
Wim Vanden Berghe
Katrien Van Beneden
Dieter Deforce
Serge Van Calenbergh
U MULLER-LADNER
Bert Vander Cruyssen
August Verbruggen
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2008
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappa B inhibition
Ilse Beck
Wim Vanden Berghe
Linda Vermeulen
Nadia Bougarne
BERT VANDER CRUYSSEN
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
EMBO JOURNAL
2008
In-vitro and in-vivo evidence for the anti-inflammatory activity of hop bitter acids in mouse
Marjan Van Cleemput
Arne Heyerick
Claude Libert
Denis De Keukeleire
Guy Haegeman
Karolien De Bosscher
C3
Conference
2008
Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems
Karolien De Bosscher
Kathleen Van Craenenbroeck
Onno C. Meijer
Guy Haegeman
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACOLOGY
2008
Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk
Valerie Gossye
Guy Haegeman
Karolien De Bosscher
A1
Journal Article
in
FRONTIERS IN BIOSCIENCE
2008
2007
Chemopreventive principles from Pueararia lobata flowers: In Vitro Evaluation of the Inhibition of the NF kappa B activating signaling pathway
L BEBREVSKA
Karolien De Bosscher
Guy Haegeman
I MERFORT
S APERS
L PIETERS
A VLIETINCK
C3
Conference
2007
Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease
Philippe Gevaert
Joke Patou
Thibaut Van Zele
Gabriële Holtappels
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
Claus Bachert
C3
Conference
2007
Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa
Frauke Coppieters
Bart Leroy
Diane Beysen
Jan Hellemans
Karolien De Bosscher
Guy Haegeman
KIRSTEN ROBBERECHT
Wim Wuyts
Paul Coucke
Elfride De Baere
A1
Journal Article
in
AMERICAN JOURNAL OF HUMAN GENETICS
2007
2006
Cross-talk between nuclear receptors and nuclear factor kappa B
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
A1
Journal Article
in
ONCOGENE
2006
2005
A fully dissociated compound of plant origin for inflammatory gene repression
Karolien De Bosscher
Wim Vanden Berghe
Ilse Beck
Wim Van Molle
N HENNUYER
J HAPGOOD
Claude Libert
B STAELS
A LOUW
Guy Haegeman
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2005
Potent anti-inflammatory, fully dissociative compound for glucocorticoid receptor-mediated gene regulation
Pieter Dewint
Karolien De Bosscher
Valerie Gossye
Wim Vanden Berghe
Bert Vander Cruyssen
Eric Veys
Guy Haegeman
Dirk Elewaut
C3
Conference
2005
Role of glucocorticoids in dopamine-related neuropsychiatric disorders
Kathleen Van Craenenbroeck
Karolien De Bosscher
Wim Vanden Berghe
Peter Vanhoenacker
Guy Haegeman
A1
Journal Article
in
MOLECULAR AND CELLULAR ENDOCRINOLOGY
2005
2004
Analysis of Smad nucleocytoplasmic shuttling in living cells
Francisco J Nicolás
Karolien De Bosscher
Bernhard Schmierer
Caroline S Hill
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2004
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells
Karolien De Bosscher
Caroline S Hill
Francisco J Nicolás
A1
Journal Article
in
BIOCHEMICAL JOURNAL
2004
2003
A paradigm for gene regulation: Inflammation, NF-kappa B and PPAR
Wim Vanden Berghe
Linda Vermeulen
P DELERIVE
Karolien De Bosscher
B STAELS
Guy Haegeman
A1
Journal Article
in
PEROXISOMAL DISORDERS AND REGULATION OF GENES
2003
Inhibition of cytokine production by the herbicide atrazine - Search for nuclear receptor targets
S DEVOS
Karolien De Bosscher
B STAELS
E BAUER
Frank Roels
Wim Vanden Berghe
Guy Haegeman
R HOOGHE
EL HOOGHE-PETERS
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2003
Regulation of NF-kB by glucocorticoids
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
Bookchapter
in
Nuclear Factor kB: Regulation and role in disease
2003
The interplay between the glucocorticoid receptor and nuclear factor-kappa B or activator protein-1: Molecular mechanisms for gene repression
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
A1
Journal Article
in
ENDOCRINE REVIEWS
2003
2002
DNA binding-independent induction of I kappa B alpha gene transcription by PPAR alpha
P Delerive
Karolien De Bosscher
Wim Vanden Berghe
JC Fruchart
Guy Haegeman
B Staels
A1
Journal Article
in
MOLECULAR ENDOCRINOLOGY
2002
Induction and repression of NF-kappaB-driven inflammatory genes.
Wim Vanden Berghe
Karolien De Bosscher
Linda Vermeulen
Gert De Wilde
Guy Haegeman
Bookchapter
in
Recent Advances in Glucocorticoid Receptor Action
2002
2001
Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
A1
Journal Article
in
MOLECULAR ENDOCRINOLOGY
2001
2000
Glucocorticoids repress NF-kappa B-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.
Karolien De Bosscher
W VANDEN BERGHE
Linda Vermeulen
S PLAISANCE
Elke Boone
Guy Haegeman
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2000
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors.
Karolien De Bosscher
W VANDEN BERGHE
Guy Haegeman
A1
Journal Article
in
JOURNAL OF NEUROIMMUNOLOGY
2000
Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
Wim Vanden Berghe
Linda Vermeulen
Gert De Wilde
Karolien De Bosscher
Elke Boone
Guy Haegeman
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2000
1999
Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappa B-dependent mechanism.
Wim Vanden Berghe
E FRANCESCONI
Karolien De Bosscher
M RESCHE-RIGON
Guy Haegeman
A1
Journal Article
in
MOLECULAR PHARMACOLOGY
1999
In search of the molecular mechanism of gene repression by glucocorticoids
Karolien De Bosscher
Wim Vanden Berghe
Elke Boone
Guy Haegeman
P1
Conference
1999
In search of the molecular mechanism of gene repression by glucocorticoids.
Karolien De Bosscher
Wim Vanden Berghe
Elke Boone
Guy Haegeman
[0-9]{2}
1999
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1.
P DELERIVE
Karolien De Bosscher
S BESNARD
Wim Vanden Berghe
JM PETERS
FJ GONZALEZ
JC FRUCHART
A TEDGUI
Guy Haegeman
B STAELS
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1999
The nuclear factor-kappa B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.
Wim Vanden Berghe
Karolien De Bosscher
Elke Boone
S PLAISANCE
Guy Haegeman
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1999
1998
Cross-talk between steroids and NF-kappa B: what language?
A DUMONT
SP HEHNER
ML SCHMITZ
JA GUSTAFSSON
J LIDEN
S OKRET
PT VAN DER SAAG
S WISSINK
B VAN DER BURG
P HERRLICH
et al.
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
1998
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.
Wim Vanden Berghe
S PLAISANCE
Elke Boone
Karolien De Bosscher
ML SCHMITZ
Walther Fiers
Guy Haegeman
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1998
1997
Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation
Karolien De Bosscher
M Lienhard Schmitz
Wim Vanden Berghe
Stéphane Plaisance
Walther Fiers
Guy Haegeman
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
1997