Research Explorer

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Researcher

Karin Weening

Publications & Research Data

Awards & Distinctions

33 Results

2025

Phase Ia study of MIDRIX4-LUNG, a tetravalent autologous dendritic cell immunotherapy, in patients with metastatic non-small cell lung cancer

D. StevensJoline IngelsElisabeth BrabantsSandra Van LintCeline EveraertKarin WeeningKelly HeynsS. DesmetPam DevrekerNele Lootens et al.

2024

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum

Joline IngelsLaurenz De CockDieter StevensRupert MayerFabien Henri TheryGuillem Sanchez SanchezDavid VermijlenKarin WeeningSaskia De SmetNele Lootens et al.

A1 Journal Article in CELL REPORTS MEDICINE

2023

MIDRIXNEO-LUNG : safety and immunogenicity of a neoantigen-presenting autologous dendritic cell therapy in resected NSCLC patients

Joline IngelsLaurenz De CockDieter StevensKarin WeeningVeerle SurmontJo Van DorpeFrancis ImpensBjörn MentenKarim VermaelenBart Vandekerckhove

Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Lore BillietLaurenz De CockGuillem Sanchez SanchezRupert MayerGlenn GoetgelukStijn De MunterMelissa PilleJoline IngelsHanne JansenKarin Weening et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The phosphatidylserine receptor TIM1 promotes infection of enveloped hepatitis E virus

Laura CorneillieIrma LemmensClaire MontpellierMartin FerriéKarin WeeningFreya Van HoutteXavier HanoulleLaurence CocquerelAli AmaraJan Tavernier et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Melissa PilleJohn AvilaGuillem Sanchez SanchezGlenn GoetgelukStijn De MunterHanne JansenLore BillietKarin WeeningHaipeng XueSarah Bonte et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Virus-host protein interaction network of the hepatitis E virus ORF2-4 by mammalian two-hybrid assays

Laura CorneillieIrma LemmensKarin WeeningAmse De MeyerFreya Van HoutteJan TavernierPhilip Meuleman

A1 Journal Article in VIRUSES-BASEL

2022

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

Joline IngelsLaurenz De CockRupert MayerPam DevrekerKarin WeeningKelly HeynsNele LootensSaskia De SmetMarieke BrusseelStijn De Munter et al.

A1 Journal Article in CYTOTHERAPY

2021

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Sarah BonteStijn De MunterLore BillietGlenn GoetgelukJoline IngelsHanne JansenMelissa PilleLaurenz De CockKarin WeeningTom Taghon et al.

A1 Journal Article in ONCOIMMUNOLOGY

2020

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage

Lore BillietGlenn GoetgelukSarah BonteStijn De MunterLaurenz De CockMelissa PilleJoline IngelsHanne JansenKarin WeeningFilip Van Nieuwerburgh et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Barbara DepreterKarin WeeningKarl VandepoeleMagnus EssandBarbara De MoerlooseMaria ThemeliJacqueline CloosDiana HanekampIne MoorsINGE D'HONT et al.

A1 Journal Article in HAEMATOLOGICA

The human fetal thymus generates invariant effector γδ T cells

Paola TieppoMaria PapadopoulouDeborah GattiNaomi McGovernJerry K. Y. ChanFrancoise GosselinGlenn GoetgelukKarin WeeningLing MaNicolas Dauby et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2019

TARP as immunotherapeutic target in AML expressed in the LSC compartment

Barbara DepreterKarin WeeningKarl VandepoeleM EssandBarbara De MoerlooseM ThemeliJ CloosD HanekampIne MoorsINGE D'HONT et al.

2018

Nanobody based dual specific CARs

Stijn De MunterJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleKarin WeeningTessa KerreHinrich AbkenBart Vandekerckhove

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2017

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Isabelle DesombereAhmed Atef Ahmed Abouzeid MesalamRichard A UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin WeeningThomas F Baumert et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Yasmine Van CaeneghemStijn De MunterPaola TieppoGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqTessa Kerre et al.

A1 Journal Article in ONCOIMMUNOLOGY

Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein

Philip MeulemanAhmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin Weening et al.

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukMargreet BrouwerNicolas ThiaultYasmine Van CaeneghemStijn De MunterKarin WeeningSarah Bonte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2016

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Ann BaeyensEvelien NaessensAnouk Van NuffelKarin WeeningAnne-Marie ReillyEva ClaeysWim TrypsteenLinos VandekerckhoveSven EyckermanKris Gevaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

2015

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeKarin WeeningMats Persson et al.

Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells

Yasmine Van CaeneghemGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqFritz OffnerHinrich AbkenTessa Kerre et al.

2014

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

Lander FoquetCornelus C HermsenGeert-Jan van GemertEva Van BraeckelKarin WeeningRobert SauerweinPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2012

Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation

Y KawabeKarin WeeningJ Marquay-MarkiewiczP Schaap

A1 Journal Article in DEVELOPMENT

2010

Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes

Jason KingMelanie KeimRegina TeoKarin WeeningMridu KapurKarina McQuillanJonathan RyvesBen RogersEmma DaltonRobin SB Williams et al.

A1 Journal Article in PLOS ONE

2007

Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG

Elisa Alvarez-CurtoKarin WeeningPauline Schaap

A1 Journal Article in BIOCHEMICAL JOURNAL

Vectors for expression of proteins with single or combinatorial fluorescent protein and tandem affinity purification tags in Dictyostelium

ME MeimaKarin WeeningP Schaap

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

2003

Characterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum

Marcel E MeimaKarin WeeningPauline Schaap

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting activities of the aggregative and late PDSA promoters in Dictyostelium development

Karin WeeningIrene Verkerke-Van WijkChristopher R ThompsonRichard H KessinGregory J PodgorskiPauline Schaap

A1 Journal Article in DEVELOPMENTAL BIOLOGY

2002

CAMP signaling in Dictyostelium : complexity of cAMP synthesis, degradation and detection

S SaranME MeimaE Alvarez-CurtoKarin WeeningDE RozenP Schaap

A1 Journal Article in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

2001

The protein kinase YakA regulates G-protein-linked signaling responses during growth and development of Dictyostelium

Saskia van EsKarin WeeningPeter N Devreotes

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

A novel protein kinase, YakA, regulates G-protein mediated signal transduction responses

S van EsKarin WeeningPN Devreotes