Research Explorer

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Researcher

Karen Peynshaert

Publications & Research Data

Awards & Distinctions

35 Results

2026

Advancing nanoparticle delivery studies : flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue

Luca PaolettiKaat De ClerckEmma De CosterPietro MatricardiKatrien RemautKaren Peynshaert

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

Overcoming size barriers in retinal gene therapy via lipid nanoparticle-mediated delivery of full-length eys DNA

Sarah GoddaerEmma De CosterElise CallensEmma Van CaenegemOlivier Van den HeuleRob W. J. CollinKaren PeynshaertFilip Van NieuwerburghKevin BraeckmansKatrien Remaut

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

2025

Breaking barriers : photodisruption of the inner limiting membrane to unlock retinal gene therapy after intravitreal injection

Kaat De ClerckKaren PeynshaertKatrien RemautStefaan De Smedt

Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis

An-Katrien MinnaertVan-Phuc NguyenAranit HarizajIlia GoemaereBart Van PuyveldeMaarten DhaenensFélix SauvageDieter DeforceStefano SalmasoPaolo Caliceti et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye

Weiran LiHelena VanlucheneLaura RaesKaren PeynshaertLiene VeysSofía González HernándezEmily De LombaerdeBruno De GeestNiek SandersLieve Moons et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption

Kaat De ClerckEmma De CosterLuca PaolettiStefaan De SmedtKatrien RemautKaren Peynshaert

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

Toward successful retinal drug delivery after intravitreal injection : current strategies to overcome the inner limiting membrane

Kaat De ClerckStefaan De SmedtKatrien RemautKaren Peynshaert

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2024

Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Helena VanlucheneOriane GillonKaren PeynshaertStefaan De SmedtNiek SandersKoen RaemdonckKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2023

Every nano-step counts : a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy

Karen PeynshaertJoke DevoldereStefaan De SmedtKatrien Remaut

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

2022

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery

Karen PeynshaertHelena VanlucheneKaat De ClerckAn-Katrien MinnaertMorgane VerhoevenNoémie GouspillouNezahat BostanToshio HisatomiGeraldine AccouFélix Sauvage et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Laser-induced nanobubbles safely ablate vitreous opacities in vivo

Félix SauvageVan Phuc NguyenYanxiu LiAranit HarizajJ. SebagDimitri RoelsViktor Van HavereKaren PeynshaertRanhua XiongJuan Fraire et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Photodisruption of the inner limiting membrane : exploring ICG loaded nanoparticles as photosensitizers

Kaat De ClerckGeraldine AccouFélix SauvageKevin BraeckmansStefaan De SmedtKatrien RemautKaren Peynshaert

A1 Journal Article in PHARMACEUTICS

2021

Vaccinia virus protein B18R : influence on mRNA immunogenicity and translation upon non-viral delivery in different ocular cell types

An-Katrien MinnaertJoke DevoldereKaren PeynshaertLaure VercruysseStefaan De SmedtKatrien Remaut

A1 Journal Article in PHARMACEUTICS

2020

Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery : evaluation of the surface properties and effect on their distribution

P. S. ApaolazaM. BuschE. Asin-PrietoKaren PeynshaertR. RathodKatrien RemautN. DünkerA. Göpferich

A1 Journal Article in EXPERIMENTAL EYE RESEARCH

Influence of pathogenic stimuli on Müller cell transfection by lipoplexes

Karen PeynshaertJoke DevoldereFrederik PhilipsFauve VergauweStefaan De SmedtKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Ocular barriers to retinal delivery of intravitreal liposomes : impact of vitreoretinal interface

Shirin TavakoliKaren PeynshaertTatu LajunenJoke DevoldereEva M. del AmoMarika RuponenStefaan De SmedtKatrien RemautArto Urtti

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research

Karen PeynshaertJoke DevoldereAn-Katrien MinnaertStefaan De SmedtKatrien Remaut

A1 Journal Article in CURRENT EYE RESEARCH

Müller cells as a target for retinal therapy

Joke DevoldereKaren PeynshaertStefaan De SmedtKatrien Remaut

A1 Journal Article in DRUG DISCOVERY TODAY

Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration

Joke DevoldereKaren PeynshaertHeleen DewitteChristian VanhoveLies De GroefLieve MoonsSinem Yilmaz ÖzcanDeniz DalkaraStefaan De SmedtKatrien Remaut

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Photoablation of human vitreous opacities by light-induced vapor nanobubbles

Félix SauvageJuan FraireKatrien RemautJ SebagKaren PeynshaertMichael HarringtonFrans J Van de VeldeRanhua XiongMarie-Jose TassignonToon Brans et al.

A1 Journal Article in ACS NANO

The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane

Joke DevoldereMike WelsKaren PeynshaertHeleen DewitteStefaan De SmedtKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2018

In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye

Karen PeynshaertJoke DevoldereStefaan De SmedtKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Ovarian tissue cryopreservation in female-to-male transgender persons : insights in ovarian histology and physiology after prolonged androgen treatment

Chloë De RooSylvie LiermanKelly TillemanKaren PeynshaertKevin BraeckmansMirte CaanenCornelis LambalkSteven WeyersPetra De Sutter

What you see is what you get : the physicochemistry of nanoparticles dictates how they cross ocular delivery barriers and alter autophagy

Karen PeynshaertKatrien RemautStefaan De Smedt

2017

Coating of quantum dots strongly defines their effect on lysosomal health and autophagy

Karen PeynshaertStefaan J SoenenBella B ManshianShareen H DoakKevin BraeckmansStefaan De SmedtKatrien Remaut

A1 Journal Article in ACTA BIOMATERIALIA

Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy

Thomas MartensKaren PeynshaertThaís Leite NascimentoElias FattalMarcus KarlstetterThomas LangmannSerge PicaudJo DemeesterStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Fertility preservation for trans men : frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing exhibit normal meiotic spindles

Sylvie LiermanKelly TillemanKevin BraeckmansKaren PeynshaertSteven WeyersGuy T'SjoenPetra De Sutter

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Ovarian tissue cryopreservation in female-to-male transgender people : insights into ovarian histology and physiology after prolonged androgen treatment

Chloë De RooSylvie LiermanKelly TillemanKaren PeynshaertKevin BraeckmansMirte CaanenCornelis LambalkSteven WeyersGuy T'SjoenMaria Cornelissen et al.

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Toward smart design of retinal drug carriers : a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface

Karen PeynshaertJoke DevoldereValérie ForsterSerge PicaudChristian VanhoveStefaan De SmedtKatrien Remaut

A1 Journal Article in DRUG DELIVERY

2015

Frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing, for the purpose of fertility preservation for transsexual persons, show normal spindle formations

Sylvie LiermanKelly TillemanChloë De RooKevin BraeckmansKaren PeynshaertSteven WeyersGuy T'SjoenPetra De Sutter

Laser-induced vapor nanobubbles for efficient delivery of macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

2014

Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

A1 Journal Article in ACS NANO

Exploiting intrinsic nanoparticle toxicity: the pros and cons of nanoparticle-induced autophagy in biomedical research

Karen PeynshaertBella Barjouhi ManshianFreya JorisKevin BraeckmansStefaan De SmedtJo DemeesterStefaan Soenen

A1 Journal Article in CHEMICAL REVIEWS

2013

Assessing nanoparticle toxicity in cell-based assays : influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap

Freya JorisBella B ManshianKaren PeynshaertStefaan De SmedtKevin BraeckmansStefaan Soenen

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

2012

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat

M. Al SorajL. HeKaren PeynshaertJ. CousaertDries VercauterenKevin BraeckmansStefaan De SmedtArwin T. Jones

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE