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Researcher
Karen Peynshaert
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
32
Results
2025
Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue
Luca Paoletti
Kaat De Clerck
Emma De Coster
Pietro Matricardi
Katrien Remaut
Karen Peynshaert
U
Journal Article
in
Drug Delivery and Translational Research
2025
Breaking barriers : photodisruption of the inner limiting membrane to unlock retinal gene therapy after intravitreal injection
Kaat De Clerck
Karen Peynshaert
Katrien Remaut
Stefaan De Smedt
Dissertation
2025
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis
An-Katrien Minnaert
Van-Phuc Nguyen
Aranit Harizaj
Ilia Goemaere
Bart Van Puyvelde
Maarten Dhaenens
Félix Sauvage
Dieter Deforce
Stefano Salmaso
Paolo Caliceti
et al.
U
Journal Article
in
Journal of Controlled Release
2025
Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption
Kaat De Clerck
Emma De Coster
Luca Paoletti
Stefaan De Smedt
Katrien Remaut
Karen Peynshaert
A1
Journal Article
in
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
2025
2024
Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells
Helena Vanluchene
Oriane Gillon
Karen Peynshaert
Stefaan De Smedt
Niek Sanders
Koen Raemdonck
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2024
2023
Every nano-step counts : a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy
Karen Peynshaert
Joke Devoldere
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EXPERT OPINION ON DRUG DELIVERY
2023
2022
ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery
Karen Peynshaert
Helena Vanluchene
Kaat De Clerck
An-Katrien Minnaert
Morgane Verhoeven
Noémie Gouspillou
Nezahat Bostan
Toshio Hisatomi
Geraldine Accou
Félix Sauvage
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2022
Laser-induced nanobubbles safely ablate vitreous opacities in vivo
Félix Sauvage
Van Phuc Nguyen
Yanxiu Li
Aranit Harizaj
J. Sebag
Dimitri Roels
Viktor Van Havere
Karen Peynshaert
Ranhua Xiong
Juan Fraire
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2022
Photodisruption of the inner limiting membrane : exploring ICG loaded nanoparticles as photosensitizers
Kaat De Clerck
Geraldine Accou
Félix Sauvage
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
Karen Peynshaert
A1
Journal Article
in
PHARMACEUTICS
2022
2021
Vaccinia virus protein B18R : influence on mRNA immunogenicity and translation upon non-viral delivery in different ocular cell types
An-Katrien Minnaert
Joke Devoldere
Karen Peynshaert
Laure Vercruysse
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
PHARMACEUTICS
2021
2020
Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery : evaluation of the surface properties and effect on their distribution
P. S. Apaolaza
M. Busch
E. Asin-Prieto
Karen Peynshaert
R. Rathod
Katrien Remaut
N. Dünker
A. Göpferich
A1
Journal Article
in
EXPERIMENTAL EYE RESEARCH
2020
Influence of pathogenic stimuli on Müller cell transfection by lipoplexes
Karen Peynshaert
Joke Devoldere
Frederik Philips
Fauve Vergauwe
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Ocular barriers to retinal delivery of intravitreal liposomes : impact of vitreoretinal interface
Shirin Tavakoli
Karen Peynshaert
Tatu Lajunen
Joke Devoldere
Eva M. del Amo
Marika Ruponen
Stefaan De Smedt
Katrien Remaut
Arto Urtti
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2020
2019
Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research
Karen Peynshaert
Joke Devoldere
An-Katrien Minnaert
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
CURRENT EYE RESEARCH
2019
Müller cells as a target for retinal therapy
Joke Devoldere
Karen Peynshaert
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DISCOVERY TODAY
2019
Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration
Joke Devoldere
Karen Peynshaert
Heleen Dewitte
Christian Vanhove
Lies De Groef
Lieve Moons
Sinem Yilmaz Özcan
Deniz Dalkara
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2019
Photoablation of human vitreous opacities by light-induced vapor nanobubbles
Félix Sauvage
Juan Fraire
Katrien Remaut
J Sebag
Karen Peynshaert
Michael Harrington
Frans J Van de Velde
Ranhua Xiong
Marie-Jose Tassignon
Toon Brans
et al.
A1
Journal Article
in
ACS NANO
2019
The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane
Joke Devoldere
Mike Wels
Karen Peynshaert
Heleen Dewitte
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
2018
In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye
Karen Peynshaert
Joke Devoldere
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2018
Ovarian tissue cryopreservation in female-to-male transgender persons : insights in ovarian histology and physiology after prolonged androgen treatment
Chloë De Roo
Sylvie Lierman
Kelly Tilleman
Karen Peynshaert
Kevin Braeckmans
Mirte Caanen
Cornelis Lambalk
Steven Weyers
Petra De Sutter
C3
Conference
2018
What you see is what you get : the physicochemistry of nanoparticles dictates how they cross ocular delivery barriers and alter autophagy
Karen Peynshaert
Katrien Remaut
Stefaan De Smedt
Dissertation
2018
2017
Coating of quantum dots strongly defines their effect on lysosomal health and autophagy
Karen Peynshaert
Stefaan J Soenen
Bella B Manshian
Shareen H Doak
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACTA BIOMATERIALIA
2017
Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy
Thomas Martens
Karen Peynshaert
Thaís Leite Nascimento
Elias Fattal
Marcus Karlstetter
Thomas Langmann
Serge Picaud
Jo Demeester
Stefaan De Smedt
Katrien Remaut
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2017
Fertility preservation for trans men : frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing exhibit normal meiotic spindles
Sylvie Lierman
Kelly Tilleman
Kevin Braeckmans
Karen Peynshaert
Steven Weyers
Guy T'Sjoen
Petra De Sutter
A1
Journal Article
in
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2017
Ovarian tissue cryopreservation in female-to-male transgender people : insights into ovarian histology and physiology after prolonged androgen treatment
Chloë De Roo
Sylvie Lierman
Kelly Tilleman
Karen Peynshaert
Kevin Braeckmans
Mirte Caanen
Cornelis Lambalk
Steven Weyers
Guy T'Sjoen
Maria Cornelissen
et al.
A1
Journal Article
in
REPRODUCTIVE BIOMEDICINE ONLINE
2017
Toward smart design of retinal drug carriers : a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface
Karen Peynshaert
Joke Devoldere
Valérie Forster
Serge Picaud
Christian Vanhove
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DELIVERY
2017
2015
Frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing, for the purpose of fertility preservation for transsexual persons, show normal spindle formations
Sylvie Lierman
Kelly Tilleman
Chloë De Roo
Kevin Braeckmans
Karen Peynshaert
Steven Weyers
Guy T'Sjoen
Petra De Sutter
C3
Conference
2015
Laser-induced vapor nanobubbles for efficient delivery of macromolecules in live cells
Ranhua Xiong
Koen Raemdonck
Karen Peynshaert
Ine Lentacker
Ine De Cock
Jo Demeester
Stefaan De Smedt
Andre Skirtach
Kevin Braeckmans
P1
Conference
2015
2014
Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells
Ranhua Xiong
Koen Raemdonck
Karen Peynshaert
Ine Lentacker
Ine De Cock
Jo Demeester
Stefaan De Smedt
Andre Skirtach
Kevin Braeckmans
A1
Journal Article
in
ACS NANO
2014
Exploiting intrinsic nanoparticle toxicity: the pros and cons of nanoparticle-induced autophagy in biomedical research
Karen Peynshaert
Bella Barjouhi Manshian
Freya Joris
Kevin Braeckmans
Stefaan De Smedt
Jo Demeester
Stefaan Soenen
A1
Journal Article
in
CHEMICAL REVIEWS
2014
2013
Assessing nanoparticle toxicity in cell-based assays : influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap
Freya Joris
Bella B Manshian
Karen Peynshaert
Stefaan De Smedt
Kevin Braeckmans
Stefaan Soenen
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2013
2012
siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat
M. Al Soraj
L. He
Karen Peynshaert
J. Cousaert
Dries Vercauteren
Kevin Braeckmans
Stefaan De Smedt
Arwin T. Jones
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012