Research Explorer

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Researcher

Gabriële Holtappels

Publications & Research Data

Awards & Distinctions

147 Results

2025

Distinct effects of biological treatments on eosinophils and neutrophils in chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelNan ZhangZhaofeng XuManon BlauwblommeElke VandewalleGabriële HoltappelsNatalie De RuyckFilip Van NieuwerburghStijn VanheePhilippe Gevaert et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Fractionated versus single-dose PSMA-targeted radioligand therapy as adjuvant therapy in a murine model for oral squamous cell carcinoma treated with immune checkpoint inhibitors

Michaël HenrotteDavid CreytensFilip De VosBenedicte DescampsLindsey DevisscherGabriële HoltappelsWouter HuvenneKen KersemansAmber MeskensSara Neyt et al.

Mechanisms and kinetics of wound healing in chronic rhinosinusitis patients after complete sinus surgery and its improvement by doxycycline therapy

Elke VandewalleEls De SchryverLien CalusManon BlauwblommePauline JanssenEllen KetelaereSharon Van NevelAnne-Sophie EeckelsNatalie De RuyckGabriële Holtappels et al.

A1 Journal Article in INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

Nasal mucosal brushings could be used to define the endotype in nasal inflammatory diseases

Elke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeManon BlauwblommeEllen KetelaereAnne-Sophie EeckelsThibaut Van ZeleStijn VanheePhilippe Gevaert

U Journal Article in Journal of Allergy and Clinical Immunology

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

Real-Life Effectiveness of Mepolizumab and Omalizumab in Sever Uncontrolled Chronic Rhinosinusitis with Nasal Polyps: A Prospective Study

Manon BlauwblommePhilippe GevaertGuy BrusselleGeert De VosAnne-Sophie EeckelsStijn VanheeElke VandewalleGabriële HoltappelsNatalie De RuyckEllen Ketelaere et al.

U Journal Article in Journal of Allergy and Clinical Immunology

2024

Case report : dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma : a proteome analysis

Manon BlauwblommePhilippe GevaertSharon Van NevelSebastian RiemannElke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeAnne-Sophie EeckelsStijn Vanhee et al.

A2 Journal Article in FRONTIERS IN ALLERGY

MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps

Yanran HuangZhaofeng XuGabriële HoltappelsYang ShenThibaut Van ZeleWeiping WenLuo ZhangNan ZhangClaus Bachert

A1 Journal Article in ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

2023

Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice

Olga KryskoDarya KorsakovaAndrea Renate TeufelbergerAmse De MeyerJill SteelsNatalie De RuyckJudith van OvostSharon Van NevelGabriële HoltappelsFrauke Coppieters et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Effects of biologics treatment in type 2-high chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelTim MeeseGabriële HoltappelsNatalie De RuyckStijn VanheeNan ZhangFilip Van NieuwerburghClaus Bachert

Olfaction in nasal polyp patients after Reboot surgery : an endotype-based prospective study

Sara Costa GomesTim DelemarreGabriële HoltappelsThibaut Van ZeleLara DeryckeEllen BonneAnne-Sophie EeckelsNan ZhangRichard Louis VoegelsClaus Bachert

A1 Journal Article in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps

Zhaofeng XuYanran HuangTim MeeseSharon Van NevelGabriële HoltappelsStijn VanheeBarbara M. BrökerZhengqi LiEllen De MeesterNatalie De Ruyck et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

2022

Granulocyte colony-stimulating factor : missing link for stratification of type 2-high and type 2-low chronic rhinosinusitis patients

Sharon Van NevelJozefien DeclercqGabriële HoltappelsBart LambrechtClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab and benralizumab reduce eosinophilic inflammation in nasal polyposis, do neutrophils take over?

Tim DelemarreElien GevaertGabriële HoltappelsNan ZhangHans NauwynckClaus Bachert

Reboot surgery for chronic rhinosinusitis with nasal polyposis : recurrence and smell kinetics

Sara Costa GomesCarlo CavaliereSimonetta MasieriThibaut Van ZelePhilippe GevaertGabriële HoltappelsNan ZhangPathmanaban RamasamyRichard Louis VoegelsClaus Bachert

A1 Journal Article in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

2021

A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps

Tim DelemarreGabriële HoltappelsNatalie De RuyckNan ZhangHans NauwynckClaus BachertElien Gevaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extent of inflammation in severe nasal polyposis and effect of sinus surgery on inflammation

Karin JonstamSaeed AlsharifStijn BogaertNicole SuchonosGabriële HoltappelsJonas Jae-Hyun ParkClaus Bachert

A1 Journal Article in ALLERGY

Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata

Sharon Van NevelJudith van OvostGabriële HoltappelsNatalie De RuyckNan ZhangHarald BraunTania MaesClaus BachertOlga Krysko

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Type 2 inflammatory shift in chronic rhinosinusitis during 2007-2018 in Belgium

K JonstamTim DelemarreGabriële HoltappelsLars-Olaf CardellM WestmanClaus Bachert

A1 Journal Article in LARYNGOSCOPE

2020

An underestimated predictive role for Type 2 inflammation in CRSsNP

Tim DelemarreGabriële HoltappelsNatalie De RuyckClaus BachertElien Gevaert

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine Aegerter et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic rhinosinusitis : assessment of changes in nociceptive neurons

Stijn BogaertKoen Van CrombruggenGabriële HoltappelsNatalie De RuyckNicole SuchonosJonas Jae-Hyun ParkClaus Bachert

A1 Journal Article in INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

Differential response of C57BL/6 and BALB/c mice in Alternaria alternata-induced allergic airway inflammation

Sharon Van NevelNatalie De RuyckGabriële HoltappelsClaus BachertOlga Krysko

Functional characterization of the first missense variant in CEP78, a founder allele associated with cone‐rod dystrophy, hearing loss and reduced male fertility

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsKirsten A. WunderlichMatias WagnerKonstantinos NikopoulosPernille MartensIrina Balikova et al.

A1 Journal Article in HUMAN MUTATION

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nasal IgE in subjects with allergic and non-allergic rhinitis

Jonas EckrichJulia HinkelAnna FischlEva HerrmannGabriële HoltappelsClaus BachertStefan Zielen

A1 Journal Article in WORLD ALLERGY ORGANIZATION JOURNAL

Type 2 inflammation in chronic rhinosinusitis without nasal polyps : another relevant endotype

Tim DelemarreGabriële HoltappelsNatalie De RuyckNan ZhangHans NauwynckClaus BachertElien Gevaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unravelling the expression of interleukin-9 in chronic rhinosinusitis : a possible role for Staphylococcus aureus

Tim DelemarreNatalie De RuyckGabriële HoltappelsClaus BachertElien Gevaert

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

2019

Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses

Mohamed H ShamjiIrene ThomsenJanice A LayhadiJasper KappenGabriële HoltappelsUmit SahinerAmy SwitzerStephen R DurhamOliver PabstClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Differentiating eosinophil and neutrophil inflammation in chronic rhinosinusitis with and without nasal polyps

Tim DelemarreGabriële HoltappelsNatalie De RuyckClaus BachertElien Gevaert

Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis

Karin JonstamBrian N SwansonLeda P MannentLars-Olaf CardellNian TianYing WangDonghui ZhangChunpeng FanGabriële HoltappelsJennifer D Hamilton et al.

A1 Journal Article in ALLERGY

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

Heleen ScheerensAshley SmithOlga LiLee HonigbergJeffrey M HarrisGabriële HoltappelsClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endoscopic sinus surgery for type‐2 CRS wNP : an endotype‐based retrospective study

Saeed AlsharifKarin JonstamThibaut Van ZelePhilippe GevaertGabriële HoltappelsClaus Bachert

A1 Journal Article in LARYNGOSCOPE

Expansion of the role and functional characterization of a missense variant in CEP78 associated with cone-rod dystrophy and hearing loss

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsIrina BalikovaLara DeryckeGabriële HoltappelsOlga KryskoThalia Van Laethem et al.

Immunologic mechanisms of a short-course of Lolium perenne peptide immunotherapy : a randomized, double-blind, placebo-controlled trial

Hanisah SharifIesha SinghLubna KouserRalph MösgesMarie-Alix BonnyAngeliki KaramaniRebecca V ParkinNicolas BovyUday KishoreAbigail Robb et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunomodulatory properties of lolium perenne peptides for the treatment of seasonal allergic rhinitis

JA LayhadiH SharifI SinghA RobbL KouserR ParkinU SahinerA EifanM Penagos PaniaguaG Vila-Nadal et al.

Sensitisation to staphylococcal enterotoxins and asthma severity : a longitudinal study in the EGEA cohort

Ina SintobinValerie SirouxGabriële HoltappelsChristophe PisonRachel NadifJean BousquetClaus Bachert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps

Y ZhangLara DeryckeGabriële HoltappelsXD WangL ZhangClaus BachertNan Zhang

A1 Journal Article in ALLERGY

The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps

Asif H. KhanGRIET VANDEPLASThi Minh Thao HuynhVijay N. JoishLeda MannentPeter TomassenThibaut Van ZeleLars-Olaf CardellJulia ArebroHeidi Olze et al.

A1 Journal Article in RHINOLOGY

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

LIEN CALUSNICHOLAS VAN BRUAENECedric BosteelsSarah DejonckheereThibaut Van ZeleGabriële HoltappelsClaus BachertPhilippe Gevaert

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

2018

Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota

Thanit ChalermwatanachaiRamiro Vilchez VargasGabriële HoltappelsTim LacoereRuy JaureguiFrederiek-Maarten KerckhofDietmar H PieperTom Van de WieleMario VaneechoutteThibaut Van Zele et al.

A1 Journal Article in SCIENTIFIC REPORTS

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

Margot BeringsPhilippe GevaertNatalie De RuyckLara DeryckeGabriële HoltappelsC PiletteClaus BachertBart LambrechtMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

In chronic spontaneous urticaria, IgE against staphylococcal enterotoxins is common and functional

S AltrichterT HawroM LiedtkeGabriële HoltappelsClaus BachertPS SkovM Maurer

A1 Journal Article in ALLERGY

Innate lymphoid cells in the upper airways : importance of CD117 and IL-1RI expression

Koen Van CrombruggenSylvie TaveirneGabriële HoltappelsGeorges LeclercqClaus Bachert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Local IgE in subjects with allergic and non‐allergic rhinitis (LISA)

J HinkelJ EckrichA FischlE HerrmannGabriële HoltappelsClaus BachertS Zielen

Staphylococcus aureus controls interleukin-5 release in upper airway inflammation

Claus BachertGabriële HoltappelsMaia MerabishviliT MeyerA MurrNan ZhangKoen Van CrombruggenElien GevaertU VölkerBM Bröker et al.

A1 Journal Article in JOURNAL OF PROTEOMICS

Staphylococcus aureus induces a mucosal type 2 immune response via epithelial cell-derived cytokines

Feng LanNan ZhangGabriële HoltappelsNatalie De RuyckOlga KryskoKoen Van CrombruggenHarald BraunSebastian L JohnstonNikos G PapadopoulosLuo Zhang et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerMaria NordengrünHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda Gonçalves et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2017

Characterization of human and Staphylococcus aureus proteins in respiratory mucosa by in vivo- and immunoproteomics

Frank SchmidtTanja MeyerNandakumar SundaramoorthyStephan MichalikKristin SurmannMaren DepkeVishnu DhopleManuela Gesell SalazarGabriële HoltappelsNan Zhang et al.

A1 Journal Article in JOURNAL OF PROTEOMICS

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

Elien GevaertNan ZhangOlga KryskoFeng LanGabriële HoltappelsNatalie De RuyckHans NauwynckShida YousefiHans-Uwe SimonClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-21 is increased in nasal polyposis and after stimulation with Staphylococcus aureus enterotoxin B

Lien CalusLara DeryckeMelissa DullaersThibaut Van ZeleNatalie De RuyckClaudina Perez NovoGabriële HoltappelsGeert De VosBart LambrechtClaus Bachert et al.

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Missense mutation in CEP78 in a family with cone-rod dystrophy, sensorineural hearing loss, obesity and subfertility

Giulia AscariStijn Van de SompeleLara DeryckeGabriële HoltappelsOlga KryskoJo Van DorpeDavid CreytensThalia Van LaethemIrina BalikovaJan Gerris et al.

Missense mutation in CEP78 in a family with cone-rod dystrophy, sensorineural hearing loss, obesity and subfertility.

Giulia AscariStijn Van de SompeleLara DeryckeGabriële HoltappelsOlga KryskoJo Van DorpeDavid CreytensThalia Van LaethemIrina BalikovaJan Gerris et al.

Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps

Karin JonstamMarit WestmanGabriële HoltappelsCecile TJ HolwegClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Suppression of allergen-induced basophil activation upon treatment with subcutaneous house dust mite immunotherapy: a prospective study

Margot BeringsNatalie De RuyckLara DeryckeGabriële HoltappelsClaus BachertBart LambrechtMelissa DullaersPhilippe Gevaert

The effect of systemic treatments on periostin expression reflects their interference with the eosinophilic inflammation in chronic rhinosinusitis with nasal polyps

Emile De SchryverLara DeryckeLIEN CALUSGabriële HoltappelsPeter HellingsThibaut Van ZeleClaus BachertPhilippe Gevaert

A1 Journal Article in RHINOLOGY

2016

Cytokine profile of nasal and middle ear polyps in a patient with Woakes' syndrome and eosinophilic otitis media

MARIE DE LOOFEls De LeenheerGabriële HoltappelsClaus Bachert

A2 Journal Article in BMJ CASE REPORTS

Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania

Xiangdong WangNan ZhangMingyu BoGabriële HoltappelsMing ZhengHongfei LouHong WangLuo ZhangClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Peter TomassenGRIET VANDEPLASThibaut Van ZeleLars-Olaf CardellJulia ArebroHeidi OlzeUlrike Förster-RuhrmannMarek L KowalskiAgnieszka Olszewska-ZiąberGabriële Holtappels et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism

Rogerio PezatoCindy ClaeysGabriële HoltappelsClaus BachertClaudina Perez Novo

A2 Journal Article in SINUSITIS

SplD- : a novel inhalant allergen from S. aureus causes Th2 bias in mice

Olga KryskoAndrea Renate TeufelbergerSebastian StentzelKatrien De GroveTania MaesGabriële HoltappelsBarbara BroekerClaus Bachert

Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without Aspirin Exacerbated Respiratory Disease

Rogerio PezatoMonika Świerczyńska-KrępaEwa Niżankowska-MogilnickaGabriële HoltappelsNatalie De RuyckMarek SanakLara DeryckeKoen Van CrombruggenClaus BachertClaudina Perez Novo

A1 Journal Article in CYTOKINE

Th2 biased upper airway inflammation is associated with an impaired response to viral infection with Herpes simplex virus 1

Feng LanXiang Dong WaneHans NauwynckGabriële HoltappelsLuo ZhangSebastian L JohnstonNikolaos G PapadopoulosClaus BachertNan Zhang

A1 Journal Article in RHINOLOGY

The protease SplD provides a link between asthma and mucosal S. aureus colonization

Andrea Renate TeufelbergerS StentzelHarald BraunTania MaesGabriële HoltappelsSharen ProvoostKatrien De GroveRudi BeyaertDmitri KryskoB Broeker et al.

2015

Association of mucosal organisms with patterns of inflammation in chronic rhinosinusitis

Thanit ChalermwatanachaiNan ZhangGabriële HoltappelsClaus Bachert

A1 Journal Article in PLOS ONE

Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue

Ilse BeckKoen Van CrombruggenGabriële HoltappelsFrançois DaubeufNelly FrossardClaus BachertKarolien De Bosscher

A1 Journal Article in PLOS ONE

Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue

Koen Van CrombruggenThomas VoglClaudina Perez NovoGabriële HoltappelsClaus Bachert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Is immunoglobulin E to Staphylococcus aureus enterotoxins associated with asthma at 20 years?

Ina SintobinThomas KeilSusanne LauLinus GrabenhenrichGabriële HoltappelsAndreas ReichUlrich WahnClaus Bachert

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

Pathophysiologie der chronischen Rhinosinusitis, konservative Therapieoptionen

Claus BachertGabriële Holtappels

A1 Journal Article in LARYNGO-RHINO-OTOLOGIE

Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options

Claus BachertGabriële Holtappels

A2 Journal Article in GMS CURRENT TOPICS IN OTORHINOLARYNGOLOGY. HEAD AND NECK SURGERY

Staphyloccoccus aureus induces a Th2 response via TSLP and IL-33 release in human airway mucosa

Feng LanNan ZhangGabriële HoltappelsNatalie De RuyckNikolaos G PapadopoulosSebastian L JohnstonClaus Bachert

Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in chronic rhinosinusitis with nasal polyps

Yu ZhangLara DeryckeLuo ZhangGabriële HoltappelsXiangdong WangNan ZhangClaus Bachert

Use of filter disks or sinus packs for single and repeated measurement of total and house dust mite specific IgE in nasal secretions

Margot BeringsNatalie De RuyckGabriële HoltappelsClaus BachertPhilippe Gevaert

2014

Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps

Thibaut Van ZeleGabriële HoltappelsPhilippe GevaertClaus Bachert

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Is immunoglobulin E to Staphylococcus aureus enterotoxins associated with asthma at 20 years of age?

Ina SintobinT KeilS LauL GrabenhenrichGabriële HoltappelsA ReichU WahnClaus Bachert

Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps

Lara DeryckeStefanie EyerichKoen Van CrombruggenClaudina Perez NovoGabriële HoltappelsNatalie De RuyckPhilippe GevaertClaus Bachert

A1 Journal Article in PLOS ONE

Staphyloccoccus aureus elicit epithelial cell-derived cytokine productions in human nasal tissue

F LanNan ZhangDX WangOlga KryskoGabriële HoltappelsNG PapadopoulosSL JohnstonClaus Bachert

Suppression of cytokine release by fluticasone furoate vs. mometasone furoate in human nasal tissue ex-vivo

Nan ZhangKoen Van CrombruggenGabriële HoltappelsFeng LanMichail KatotomichelakisLuo ZhangPetra HöggerClaus Bachert

A1 Journal Article in PLOS ONE

The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered

Rogerio PezatoClaudina Perez NovoGabriële HoltappelsNatalie De RuyckKoen Van CrombruggenGeert De VosClaus BachertLara Derycke

A1 Journal Article in IMMUNOBIOLOGY

2013

Inflammatory patterns in upper airway disease in the same geographical area may change over time

Michail KatotomichelakisPongsakorn TantilipikornGabriële HoltappelsNatalie De RuyckFeng LanThibaut Van ZeleSoranart MuangsomboonPerapun JareonchasriChaweewan BunnagVassilios Danielides et al.

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Short cigarette smoke exposure facilitates sensitisation and asthma development in mice

Ellen LanckackerKurt TournoyHamida HammadGabriële HoltappelsBart LambrechtGuy JoosTania Maes

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Sputum IgE and cytokines in asthma : relationship with sputum cellular profile

Maïté ManiseGabriële HoltappelsKoen Van CrombruggenFlorence SchleichClaus BachertRenaud Louis

A1 Journal Article in PLOS ONE

The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling

Olga KryskoTania MaesMaud PlantingaGabriële HoltappelsRosina ImiruPeter VandenabeeleGuy JoosDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling

Juan MengPeng ZhouYafeng LiuXuelian YiShixi LiuGabriële HoltappelsClaus BachertNan Zhang

A1 Journal Article in PLOS ONE

2012

A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows potent anti-inflammatory effects in an ex vivo human mucosal tissue model

Nan ZhangKoen Van CrombruggenGabriële HoltappelsClaus Bachert

A1 Journal Article in EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

Cytokine profiles in Japanese patients with chronic rhinosinusitis

Takayuki SejimaGabriële HoltappelsHisashi KikuchiShoichiro ImayoshiKeiichi IchimuraClaus Bachert

A1 Journal Article in ALLERGOLOGY INTERNATIONAL

Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue

XiangDong WangNan ZhangSarah GlorieuxGabriële HoltappelsMario VaneechoutteOlga KryskoLuo ZhangDeMin HanHans NauwynckClaus Bachert

A1 Journal Article in PLOS ONE

IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis

Lara DeryckeNan ZhangGabriële HoltappelsTINEKE DUTREClaus Bachert

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

IL-21 is increased in nasal polyposis and after stimulation with Staphylococus aureus enterotoxins

LIEN CALUSIne DeryckeNatalie De RuyckGabriële HoltappelsMelissa DullaersBart LambrechtClaus BachertPhilippe Gevaert

Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor

Inge TencyHans VerstraelenIVO KROESGabriële HoltappelsBruno VerhasseltMario VaneechoutteRita VerhelstMarleen Temmerman

A1 Journal Article in PLOS ONE

Inflammation and remodelling patterns in early stage chronic rhinosinusitis

NICHOLAS VAN BRUAENEClaudina Perez NovoKoen Van CrombruggenNatalie De RuyckGabriële HoltappelsPaul Van CauwenbergePhilippe GevaertClaus Bachert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps

T Groot KormelinkLIEN CALUSNatalie De RuyckGabriële HoltappelsClaus BachertFA RedegeldPhilippe Gevaert

A1 Journal Article in ALLERGY

RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP

Koen Van CrombruggenGabriële HoltappelsNatalie De RuyckLara DeryckePeter TomassenClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma

Claus BachertKristel Van SteenNan ZhangGabriële HoltappelsTom CattaertBärbel MausRoland BuhlChristian TaubeStephanie KornMarek Kowalski et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2011

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter Vandenabeele et al.

A1 Journal Article in ALLERGY

Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone

Koen Van CrombruggenLuc Van NassauwLara DeryckeJean-Piere TimmermansGabriële HoltappelsDavid HallClaus Bachert

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Increased nasal IL-5 levels act as a predisposing factor of asthma in southern China reply

Claus BachertNan ZhangGabriële HoltappelsPeter TomassenShixi LiuPing LinJean Bousquet

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

Nan ZhangGabriële HoltappelsPhilippe GevaertJoke PatouB DhaliwalHannah GouldClaus Bachert

A1 Journal Article in ALLERGY

2010

Chronic sinusitis and rhinitis: clinical terminology 'chronic rhinosinusitis' further supported

Koen Van CrombruggenNICHOLAS VAN BRUAENEGabriële HoltappelsClaus Bachert

A1 Journal Article in RHINOLOGY

CRTH2 mediates the activation of human Th2 cells in response to PGD2 released from IgE/anti-IgE treated nasal polyp tissue

Claudina Perez NovoGabriële HoltappelsShân L VinallLuzheng XueNan ZhangClaus BachertRoy Pettipher

A1 Journal Article in ALLERGY

Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis

Xiaoyuan LiJuan MengXiaoming QiaoYafeng LuiFeng LiuNan ZhangJie ZhangGabriële HoltappelsBa LuoPeng Zhuo et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of the nasal mucosa as a new target for leptin action

Jasmien TaildemanPieter DemetterIsabelle RottiersGabriële HoltappelsClaus BachertClaude CuvelierClaudina Perez Novo

A1 Journal Article in HISTOPATHOLOGY

Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis

F LiuJ ZhangY LiuNan ZhangGabriële HoltappelsP LinS LiuClaus Bachert

A1 Journal Article in ALLERGY

Oral steroids and doxycycline: Two different approaches to treat nasal polyps

Thibaut Van ZelePhilippe GevaertGabriële HoltappelsAchim BeulePeter John WormaldSusanne MayrGreet HensPeter HellingsFenna EbbensWytske Fokkens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasticity of the dendritic cells to activate T cells in chronic rhinosinusitis

Lara DeryckeClaus BachertGabriële Holtappels

A1 Journal Article in ALLERGY

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

Claus BachertNan ZhangGabriële HoltappelsLizzy De LobelPaul Van CauwenbergeShiXi LiuPing LinJean BousquetKristel Van Steen

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation

Claudina Perez NovoMonica Jedrzejczak-CzechowiczA Lewandowska-PolakCindy ClaeysGabriële HoltappelsPaul Van CauwenbergeML KowalskiClaus Bachert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

2009

Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization

Marie-Noelle CorriveauNan ZhangGabriële HoltappelsNadine Van RoyClaus Bachert

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients

Philippe GevaertC. HellmanL. LundbladJ. LundahlGabriële HoltappelsPaul Van CauwenbergeJan TavernierClaus Bachert

A1 Journal Article in ALLERGY

Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue

Joke PatouGabriële HoltappelsKaren AffleckPhilippe GevaertClaudina Perez NovoPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF INFLAMMATION-LONDON

Local Complement Activation in Nasal Polyposis

Thibaut Van ZeleFrauke CoppietersPhilippe GevaertGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in LARYNGOSCOPE

TGF-beta signaling and collagen deposition in chronic rhinosinusitis

NICHOLAS VAN BRUAENELara DeryckeClaudina Perez NovoPhilippe GevaertGabriële HoltappelsNatalie De RuyckClaude CuvelierPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2008

Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients

Thibaut Van ZeleMario VaneechoutteGabriële HoltappelsPhilippe GevaertPaul Van CauwenbergeClaus Bachert

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Nan ZhangThibaut Van ZeleClaudina Perez NovoNICHOLAS VAN BRUAENEGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps

Joke PatouPhilippe GevaertThibaut Van ZeleGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-cell regulation in chronic paranasal sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoTomasz M BasinskiThibaut Van ZeleGabriële HoltappelsNatalie De RuyckCarsten Schmidt-WeberCezmi AkdisPaul Van CauwenbergeClaus Bachert et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGF-beta isoforms and receptors in chronic sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoPhilippe GevaertGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus Bachert

Treatment of nasal polyposis with oral methylprednisolone: a double-blind, randomized, placebo-controlled trial with evaluation of clinical and biological activity

Thibaut Van ZelePhilippe GevaertGabriële HoltappelsB AchimP WormaldS MayrG HensP HellingsF EbbenssW Fokkens et al.

2007

Local immunoglobulin production in nasal polyposis is modulated by superantigens

Thibaut Van ZelePhilippe GevaertGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease

Philippe GevaertJoke PatouThibaut Van ZeleGabriële HoltappelsKarolien De BosscherWim Vanden BergheGuy HaegemanClaus Bachert

Remodelling in nasal polyposis is independent of TH-cell polarisation

Nan ZhangTV ZELEPhilippe GevaertGabriële HoltappelsP VAN CAUWENBERGEClaus Bachert

Staphylococcus aureus enterotoxin B stimulation in nasal polyps

Joke PatouThibaut Van ZeleGabriële HoltappelsPhilippe GevaertPaul Van CauwenbergeClaus Bachert

Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study

A SEMIC-JUSUFAGICClaus BachertPhilippe GevaertGabriële HoltappelsL LOWEA WOODCOCKA SIMPSONA CUSTOVIC

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell regulation in chronic sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoThibaut Van ZeleGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus BachertPhilippe Gevaert

Upper airway inflammation in chronic smoke exposed mice

Wouter HuvenneGabriële HoltappelsNatalie DERUYCKClaudia PEREZ NOVOPhilippe GevaertPaul Van CauwenbergeClaus Bachert

2006

Development of a rabbit model to study inflammation in nasal and paranasal cavities

Wouter HuvennePhilippe GevaertGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

Differentiation of chronic sinus diseases by measurement of inflammatory mediators

Thibaut Van ZeleSofie ClaeysPhilippe GevaertGEORGES VAN MAELEGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in ALLERGY

Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins

Claudina Perez NovoCindy ClaeysThibaut Van ZeleGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY

Local activation of the complement system in nasal polyps

Thibaut Van ZeleGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps

Philippe GevaertDoris Lang-LoidoltAndreas LacknerHeinz StammbergerHeribert StaudingerThibaut Van ZeleGabriële HoltappelsJan TavernierPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China

Nan ZhangGabriële HoltappelsCindy ClaeysGQ HUANGPaul Van CauwenbergeClaus Bachert

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY

2005

An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis

Nan ZhangPhilippe GevaertThibaut Van ZeleClaudina Perez NovoJoke PatouGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in RHINOLOGY

Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis

B LANGEKF LUKATK RETTIGGabriële HoltappelsClaus Bachert

A1 Journal Article in ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators

Sofie ClaeysHelen Van HoeckeGabriële HoltappelsPhilippe GevaertTine De BelderBruno VerhasseltPaul Van CauwenbergeClaus Bachert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue

Philippe GevaertGabriële HoltappelsSGO JOHANSSONClaude CuvelierP CAUWENBERGEClaus Bachert

A1 Journal Article in ALLERGY

2004

Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: Studies on the relationship

Claudina Perez NovoML KOWALSKIP KUNAA PTASINSKAGabriële HoltappelsPaul Van CauwenbergePhilippe GevaertS JOHANNSONClaus Bachert

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Collection of nasal secretions for immunological analysis

Jean-Baptiste WateletPhilippe GevaertGabriële HoltappelsPaul Van CauwenbergeClaus Bachert

A1 Journal Article in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Effects of cetirizine and fluticasone propionate nasal spray on symptoms and inflammatory mediators of seasonal allergic rhinitis

K DAHLB LANGEGabriële HoltappelsKF LUKATClaus Bachert

A1 Journal Article in ALLERGOLOGIE

Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD

G ROHDEPhilippe GevaertGabriële HoltappelsI BORGA WIETHEGEU ARINIRG SCHULTZE-WERNINGHAUSClaus Bachert

A1 Journal Article in RESPIRATORY MEDICINE

Macrophage mannose receptor in chronic sinus disease

Sofie ClaeysT DE BELDERGabriële HoltappelsPhilippe GevaertBruno VerhasseltPaul Van CauwenbergeClaus Bachert

A1 Journal Article in ALLERGY

Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease

G ROHDEPhilippe GevaertGabriële HoltappelsL FRANSENI BORGA WIETHEGEU ARINIAJan TavernierG SCHULTZE-WERNINGHAUSClaus Bachert

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

2003

Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis

Philippe GevaertClaus BachertGabriële HoltappelsClaudina Perez NovoJosé Van Der HeydenL FRANSENS DEPRAETEREH WALTERPaul Van CauwenbergeJan Tavernier

A1 Journal Article in ALLERGY

Human beta-defensins and toll-like receptors in the upper airway

Sofie ClaeysT DE BELDERGabriële HoltappelsPhilippe GevaertBruno VerhasseltPaul Van CauwenbergeClaus Bachert

A1 Journal Article in ALLERGY

IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma

Claus BachertPhilippe GevaertP HOWARTHGabriële HoltappelsPaul Van CauwenbergeSGO JOHANSSON

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA

Claudina Perez NovoJo VandesompeleGabriële HoltappelsFranki SpelemanPhilippe GevaertPaul Van CauwenbergeClaus Bachert

A1 Journal Article in BMC BIOTECHNOLOGY

2001

Expression of TGF-beta 1,-beta 2, EGF and PDGF in nasal secretions after sinus surgery

Jean-Baptiste WateletPhilippe GevaertClaus BachertMarie-Chantal HerteleerGabriële HoltappelsPaul Van Cauwenberge