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Researcher
Gabriële Holtappels
Profile
Projects
Publications
Activities
Awards & Distinctions
139
Results
2024
MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps
Yanran Huang
Zhaofeng Xu
Gabriële Holtappels
Yang Shen
Thibaut Van Zele
Weiping Wen
Luo Zhang
Nan Zhang
Claus Bachert
A1
Journal Article
in
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
2024
2023
Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice
Olga Krysko
Darya Korsakova
Andrea Renate Teufelberger
Amse De Meyer
Jill Steels
Natalie De Ruyck
Judith van Ovost
Sharon Van Nevel
Gabriële Holtappels
Frauke Coppieters
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
Effects of biologics treatment in type 2-high chronic rhinosinusitis with nasal polyp patients
Sharon Van Nevel
Tim Meese
Gabriële Holtappels
Natalie De Ruyck
Stijn Vanhee
Nan Zhang
Filip Van Nieuwerburgh
Claus Bachert
C3
Conference
2023
Olfaction in nasal polyp patients after Reboot surgery : an endotype-based prospective study
Sara Costa Gomes
Tim Delemarre
Gabriële Holtappels
Thibaut Van Zele
Lara Derycke
Ellen Bonne
Anne-Sophie Eeckels
Nan Zhang
Richard Louis Voegels
Claus Bachert
A1
Journal Article
in
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2023
The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps
Zhaofeng Xu
Yanran Huang
Tim Meese
Sharon Van Nevel
Gabriële Holtappels
Stijn Vanhee
Barbara M. Bröker
Zhengqi Li
Ellen De Meester
Natalie De Ruyck
et al.
A1
Journal Article
in
CLINICAL IMMUNOLOGY
2023
2022
Granulocyte colony-stimulating factor : missing link for stratification of type 2-high and type 2-low chronic rhinosinusitis patients
Sharon Van Nevel
Jozefien Declercq
Gabriële Holtappels
Bart Lambrecht
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2022
Mepolizumab and benralizumab reduce eosinophilic inflammation in nasal polyposis, do neutrophils take over?
Tim Delemarre
Elien Gevaert
Gabriële Holtappels
Nan Zhang
Hans Nauwynck
Claus Bachert
C3
Conference
2022
Reboot surgery for chronic rhinosinusitis with nasal polyposis : recurrence and smell kinetics
Sara Costa Gomes
Carlo Cavaliere
Simonetta Masieri
Thibaut Van Zele
Philippe Gevaert
Gabriële Holtappels
Nan Zhang
Pathmanaban Ramasamy
Richard Louis Voegels
Claus Bachert
A1
Journal Article
in
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2022
2021
A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps
Tim Delemarre
Gabriële Holtappels
Natalie De Ruyck
Nan Zhang
Hans Nauwynck
Claus Bachert
Elien Gevaert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2021
Extent of inflammation in severe nasal polyposis and effect of sinus surgery on inflammation
Karin Jonstam
Saeed Alsharif
Stijn Bogaert
Nicole Suchonos
Gabriële Holtappels
Jonas Jae-Hyun Park
Claus Bachert
A1
Journal Article
in
ALLERGY
2021
Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata
Sharon Van Nevel
Judith van Ovost
Gabriële Holtappels
Natalie De Ruyck
Nan Zhang
Harald Braun
Tania Maes
Claus Bachert
Olga Krysko
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
Type 2 inflammatory shift in chronic rhinosinusitis during 2007-2018 in Belgium
K Jonstam
Tim Delemarre
Gabriële Holtappels
Lars-Olaf Cardell
M Westman
Claus Bachert
A1
Journal Article
in
LARYNGOSCOPE
2021
2020
An underestimated predictive role for Type 2 inflammation in CRSsNP
Tim Delemarre
Gabriële Holtappels
Natalie De Ruyck
Claus Bachert
Elien Gevaert
C3
Conference
2020
Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis
Elien Gevaert
Tim Delemarre
Joyceline De Volder
Nan Zhang
Gabriële Holtappels
Natalie De Ruyck
Emma Persson
Ines Heyndrickx
Kenneth Verstraete
Helena Catharine Aegerter
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2020
Chronic rhinosinusitis : assessment of changes in nociceptive neurons
Stijn Bogaert
Koen Van Crombruggen
Gabriële Holtappels
Natalie De Ruyck
Nicole Suchonos
Jonas Jae-Hyun Park
Claus Bachert
A1
Journal Article
in
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
2020
Differential response of C57BL/6 and BALB/c mice in Alternaria alternata-induced allergic airway inflammation
Sharon Van Nevel
Natalie De Ruyck
Gabriële Holtappels
Claus Bachert
Olga Krysko
C3
Conference
2020
Functional characterization of the first missense variant in CEP78, a founder allele associated with cone‐rod dystrophy, hearing loss and reduced male fertility
Giulia Ascari
Frank Peelman
Pietro Farinelli
Toon Rosseel
Nina Lambrechts
Kirsten A. Wunderlich
Matias Wagner
Konstantinos Nikopoulos
Pernille Martens
Irina Balikova
et al.
A1
Journal Article
in
HUMAN MUTATION
2020
Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33
Andrea Renate Teufelberger
Sharon Van Nevel
Paco Hulpiau
Maria Nordengrün
Savvas Savvides
Sarah De Graeve
Srinivas Akula
Gabriële Holtappels
Natalie De Ruyck
Wim Declercq
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2020
Nasal IgE in subjects with allergic and non-allergic rhinitis
Jonas Eckrich
Julia Hinkel
Anna Fischl
Eva Herrmann
Gabriële Holtappels
Claus Bachert
Stefan Zielen
A1
Journal Article
in
WORLD ALLERGY ORGANIZATION JOURNAL
2020
Type 2 inflammation in chronic rhinosinusitis without nasal polyps : another relevant endotype
Tim Delemarre
Gabriële Holtappels
Natalie De Ruyck
Nan Zhang
Hans Nauwynck
Claus Bachert
Elien Gevaert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2020
Unravelling the expression of interleukin-9 in chronic rhinosinusitis : a possible role for Staphylococcus aureus
Tim Delemarre
Natalie De Ruyck
Gabriële Holtappels
Claus Bachert
Elien Gevaert
A1
Journal Article
in
CLINICAL AND TRANSLATIONAL ALLERGY
2020
2019
Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses
Mohamed H Shamji
Irene Thomsen
Janice A Layhadi
Jasper Kappen
Gabriële Holtappels
Umit Sahiner
Amy Switzer
Stephen R Durham
Oliver Pabst
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2019
Differentiating eosinophil and neutrophil inflammation in chronic rhinosinusitis with and without nasal polyps
Tim Delemarre
Gabriële Holtappels
Natalie De Ruyck
Claus Bachert
Elien Gevaert
C3
Conference
2019
Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis
Karin Jonstam
Brian N Swanson
Leda P Mannent
Lars-Olaf Cardell
Nian Tian
Ying Wang
Donghui Zhang
Chunpeng Fan
Gabriële Holtappels
Jennifer D Hamilton
et al.
A1
Journal Article
in
ALLERGY
2019
Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma
Heleen Scheerens
Ashley Smith
Olga Li
Lee Honigberg
Jeffrey M Harris
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2019
Endoscopic sinus surgery for type‐2 CRS wNP : an endotype‐based retrospective study
Saeed Alsharif
Karin Jonstam
Thibaut Van Zele
Philippe Gevaert
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
LARYNGOSCOPE
2019
Expansion of the role and functional characterization of a missense variant in CEP78 associated with cone-rod dystrophy and hearing loss
Giulia Ascari
Frank Peelman
Pietro Farinelli
Toon Rosseel
Nina Lambrechts
Irina Balikova
Lara Derycke
Gabriële Holtappels
Olga Krysko
Thalia Van Laethem
et al.
C3
Conference
2019
Immunologic mechanisms of a short-course of Lolium perenne peptide immunotherapy : a randomized, double-blind, placebo-controlled trial
Hanisah Sharif
Iesha Singh
Lubna Kouser
Ralph Mösges
Marie-Alix Bonny
Angeliki Karamani
Rebecca V Parkin
Nicolas Bovy
Uday Kishore
Abigail Robb
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2019
Immunomodulatory properties of lolium perenne peptides for the treatment of seasonal allergic rhinitis
JA Layhadi
H Sharif
I Singh
A Robb
L Kouser
R Parkin
U Sahiner
A Eifan
M Penagos Paniagua
G Vila-Nadal
et al.
C3
Conference
2019
Sensitisation to staphylococcal enterotoxins and asthma severity : a longitudinal study in the EGEA cohort
Ina Sintobin
Valerie Siroux
Gabriële Holtappels
Christophe Pison
Rachel Nadif
Jean Bousquet
Claus Bachert
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2019
Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps
Y Zhang
Lara Derycke
Gabriële Holtappels
XD Wang
L Zhang
Claus Bachert
Nan Zhang
A1
Journal Article
in
ALLERGY
2019
The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps
Asif Hameed Khan
Griet Vandeplas
Thi Minh Thao Huynh
Vijay N. Joish
Leda Mannent
Peter Tomassen
Thibaut Van Zele
Lars-Olaf Cardell
Julia Arebro
Heidi Olze
et al.
A1
Journal Article
in
RHINOLOGY
2019
Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis
Lien Calus
Nicholas Van Bruaene
Cédric Bosteels
Sarah Dejonckheere
Thibaut Van Zele
Gabriële Holtappels
Claus Bachert
Philippe Gevaert
A1
Journal Article
in
CLINICAL AND TRANSLATIONAL ALLERGY
2019
2018
Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota
Thanit Chalermwatanachai
Ramiro Vilchez Vargas
Gabriële Holtappels
Tim Lacoere
Ruy Jauregui
Frederiek-Maarten Kerckhof
Dietmar H Pieper
Tom Van de Wiele
Mario Vaneechoutte
Thibaut Van Zele
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2018
FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy
Margot Berings
Philippe Gevaert
Natalie De Ruyck
Lara Derycke
Gabriële Holtappels
C Pilette
Claus Bachert
Bart Lambrecht
Melissa Dullaers
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2018
In chronic spontaneous urticaria, IgE against staphylococcal enterotoxins is common and functional
S Altrichter
T Hawro
M Liedtke
Gabriële Holtappels
Claus Bachert
PS Skov
M Maurer
A1
Journal Article
in
ALLERGY
2018
Innate lymphoid cells in the upper airways : importance of CD117 and IL-1RI expression
Koen Van Crombruggen
Sylvie Taveirne
Gabriële Holtappels
Georges Leclercq
Claus Bachert
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2018
Local IgE in subjects with allergic and non‐allergic rhinitis (LISA)
J Hinkel
J Eckrich
A Fischl
E Herrmann
Gabriële Holtappels
Claus Bachert
S Zielen
C3
Conference
2018
Staphylococcus aureus controls interleukin-5 release in upper airway inflammation
Claus Bachert
Gabriële Holtappels
Maia Merabishvili
T Meyer
A Murr
Nan Zhang
Koen Van Crombruggen
Elien Gevaert
U Völker
BM Bröker
et al.
A1
Journal Article
in
JOURNAL OF PROTEOMICS
2018
Staphylococcus aureus induces a mucosal type 2 immune response via epithelial cell-derived cytokines
Feng Lan
Nan Zhang
Gabriële Holtappels
Natalie De Ruyck
Olga Krysko
Koen Van Crombruggen
Harald Braun
Sebastian L Johnston
Nikos G Papadopoulos
Luo Zhang
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2018
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D
Andrea Renate Teufelberger
Maria Nordengrün
Harald Braun
Tania Maes
Katrien De Grove
Gabriële Holtappels
Clara O'Brien
Sharen Provoost
Hamida Hammad
Amanda Gonçalves
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2018
2017
Characterization of human and Staphylococcus aureus proteins in respiratory mucosa by in vivo- and immunoproteomics
Frank Schmidt
Tanja Meyer
Nandakumar Sundaramoorthy
Stephan Michalik
Kristin Surmann
Maren Depke
Vishnu Dhople
Manuela Gesell Salazar
Gabriële Holtappels
Nan Zhang
et al.
A1
Journal Article
in
JOURNAL OF PROTEOMICS
2017
Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation
Elien Gevaert
Nan Zhang
Olga Krysko
Feng Lan
Gabriële Holtappels
Natalie De Ruyck
Hans Nauwynck
Shida Yousefi
Hans-Uwe Simon
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2017
IL-21 is increased in nasal polyposis and after stimulation with Staphylococcus aureus enterotoxin B
Lien Calus
Lara Derycke
Melissa Dullaers
Thibaut Van Zele
Natalie De Ruyck
Claudina Perez Novo
Gabriële Holtappels
Geert De Vos
Bart Lambrecht
Claus Bachert
et al.
A1
Journal Article
in
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
2017
Missense mutation in CEP78 in a family with cone-rod dystrophy, sensorineural hearing loss, obesity and subfertility
Giulia Ascari
Stijn Van de Sompele
Lara Derycke
Gabriële Holtappels
Olga Krysko
Jo Van Dorpe
David Creytens
Thalia Van Laethem
Irina Balikova
Jan Gerris
et al.
C3
Conference
2017
Missense mutation in CEP78 in a family with cone-rod dystrophy, sensorineural hearing loss, obesity and subfertility.
Giulia Ascari
Stijn Van de Sompele
Lara Derycke
Gabriële Holtappels
Olga Krysko
Jo Van Dorpe
David Creytens
Thalia Van Laethem
Irina Balikova
Jan Gerris
et al.
C3
Conference
2017
Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps
Karin Jonstam
Marit Westman
Gabriële Holtappels
Cecile TJ Holweg
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2017
Suppression of allergen-induced basophil activation upon treatment with subcutaneous house dust mite immunotherapy: a prospective study
Margot Berings
Natalie De Ruyck
Lara Derycke
Gabriële Holtappels
Claus Bachert
Bart Lambrecht
Melissa Dullaers
Philippe Gevaert
C3
Conference
2017
The effect of systemic treatments on periostin expression reflects their interference with the eosinophilic inflammation in chronic rhinosinusitis with nasal polyps
Emile De Schryver
Lara Derycke
Lien Calus
Gabriële Holtappels
Peter Hellings
Thibaut Van Zele
Claus Bachert
Philippe Gevaert
A1
Journal Article
in
RHINOLOGY
2017
2016
Cytokine profile of nasal and middle ear polyps in a patient with Woakes' syndrome and eosinophilic otitis media
MARIE DE LOOF
Els De Leenheer
Gabriële Holtappels
Claus Bachert
A2
Journal Article
in
BMJ CASE REPORTS
2016
Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania
Xiangdong Wang
Nan Zhang
Mingyu Bo
Gabriële Holtappels
Ming Zheng
Hongfei Lou
Hong Wang
Luo Zhang
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2016
Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers
Peter Tomassen
Griet Vandeplas
Thibaut Van Zele
Lars-Olaf Cardell
Julia Arebro
Heidi Olze
Ulrike Förster-Ruhrmann
Marek L Kowalski
Agnieszka Olszewska-Ziąber
Gabriële Holtappels
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2016
LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism
Rogerio Pezato
Cindy Claeys
Gabriële Holtappels
Claus Bachert
Claudina Perez Novo
A2
Journal Article
in
SINUSITIS
2016
SplD- : a novel inhalant allergen from S. aureus causes Th2 bias in mice
Olga Krysko
Andrea Renate Teufelberger
Sebastian Stentzel
Katrien De Grove
Tania Maes
Gabriële Holtappels
Barbara Broeker
Claus Bachert
C3
Conference
2016
Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without Aspirin Exacerbated Respiratory Disease
Rogerio Pezato
Monika Świerczyńska-Krępa
Ewa Niżankowska-Mogilnicka
Gabriële Holtappels
Natalie De Ruyck
Marek Sanak
Lara Derycke
Koen Van Crombruggen
Claus Bachert
Claudina Perez Novo
A1
Journal Article
in
CYTOKINE
2016
Th2 biased upper airway inflammation is associated with an impaired response to viral infection with Herpes simplex virus 1
Feng Lan
Xiang Dong Wane
Hans Nauwynck
Gabriële Holtappels
Luo Zhang
Sebastian L Johnston
Nikolaos G Papadopoulos
Claus Bachert
Nan Zhang
A1
Journal Article
in
RHINOLOGY
2016
The protease SplD provides a link between asthma and mucosal S. aureus colonization
Andrea Renate Teufelberger
S Stentzel
Harald Braun
Tania Maes
Gabriële Holtappels
Sharen Provoost
Katrien De Grove
Rudi Beyaert
Dmitri Krysko
B Broeker
et al.
C3
Conference
2016
2015
Association of mucosal organisms with patterns of inflammation in chronic rhinosinusitis
Thanit Chalermwatanachai
Nan Zhang
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
PLOS ONE
2015
Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue
Ilse Beck
Koen Van Crombruggen
Gabriële Holtappels
François Daubeuf
Nelly Frossard
Claus Bachert
Karolien De Bosscher
A1
Journal Article
in
PLOS ONE
2015
Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue
Koen Van Crombruggen
Thomas Vogl
Claudina Perez Novo
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2015
Is immunoglobulin E to Staphylococcus aureus enterotoxins associated with asthma at 20 years?
Ina Sintobin
Thomas Keil
Susanne Lau
Linus Grabenhenrich
Gabriële Holtappels
Andreas Reich
Ulrich Wahn
Claus Bachert
A1
Journal Article
in
PEDIATRIC ALLERGY AND IMMUNOLOGY
2015
Pathophysiologie der chronischen Rhinosinusitis, konservative Therapieoptionen
Claus Bachert
Gabriële Holtappels
A1
Journal Article
in
LARYNGO-RHINO-OTOLOGIE
2015
Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
Claus Bachert
Gabriële Holtappels
A2
Journal Article
in
GMS CURRENT TOPICS IN OTORHINOLARYNGOLOGY. HEAD AND NECK SURGERY
2015
Staphyloccoccus aureus induces a Th2 response via TSLP and IL-33 release in human airway mucosa
Feng Lan
Nan Zhang
Gabriële Holtappels
Natalie De Ruyck
Nikolaos G Papadopoulos
Sebastian L Johnston
Claus Bachert
C3
Conference
2015
Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in chronic rhinosinusitis with nasal polyps
Yu Zhang
Lara Derycke
Luo Zhang
Gabriële Holtappels
Xiangdong Wang
Nan Zhang
Claus Bachert
C3
Conference
2015
Use of filter disks or sinus packs for single and repeated measurement of total and house dust mite specific IgE in nasal secretions
Margot Berings
Natalie De Ruyck
Gabriële Holtappels
Claus Bachert
Philippe Gevaert
C3
Conference
2015
2014
Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps
Thibaut Van Zele
Gabriële Holtappels
Philippe Gevaert
Claus Bachert
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
2014
Is immunoglobulin E to Staphylococcus aureus enterotoxins associated with asthma at 20 years of age?
Ina Sintobin
T Keil
S Lau
L Grabenhenrich
Gabriële Holtappels
A Reich
U Wahn
Claus Bachert
C3
Conference
2014
Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps
Lara Derycke
Stefanie Eyerich
Koen Van Crombruggen
Claudina Perez Novo
Gabriële Holtappels
Natalie De Ruyck
Philippe Gevaert
Claus Bachert
A1
Journal Article
in
PLOS ONE
2014
Staphyloccoccus aureus elicit epithelial cell-derived cytokine productions in human nasal tissue
F Lan
Nan Zhang
DX Wang
Olga Krysko
Gabriële Holtappels
NG Papadopoulos
SL Johnston
Claus Bachert
C3
Conference
2014
Suppression of cytokine release by fluticasone furoate vs. mometasone furoate in human nasal tissue ex-vivo
Nan Zhang
Koen Van Crombruggen
Gabriële Holtappels
Feng Lan
Michail Katotomichelakis
Luo Zhang
Petra Högger
Claus Bachert
A1
Journal Article
in
PLOS ONE
2014
The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered
Rogerio Pezato
Claudina Perez Novo
Gabriële Holtappels
Natalie De Ruyck
Koen Van Crombruggen
Geert De Vos
Claus Bachert
Lara Derycke
A1
Journal Article
in
IMMUNOBIOLOGY
2014
2013
Inflammatory patterns in upper airway disease in the same geographical area may change over time
Michael Katotomichelakis
Pongsakorn Tantilipikorn
Gabriële Holtappels
Natalie De Ruyck
Feng Lan
Thibaut Van Zele
Soranart Muangsomboon
Perapun Jareonchasri
Chaweewan Bunnag
Vassilios Danielides
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
2013
Short cigarette smoke exposure facilitates sensitisation and asthma development in mice
Ellen Lanckacker
Kurt Tournoy
Hamida Hammad
Gabriële Holtappels
Bart Lambrecht
Guy Joos
Tania Maes
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2013
Sputum IgE and cytokines in asthma : relationship with sputum cellular profile
Maïté Manise
Gabriële Holtappels
Koen Van Crombruggen
Florence Schleich
Claus Bachert
Renaud Louis
A1
Journal Article
in
PLOS ONE
2013
The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling
Olga Krysko
Tania Maes
Maud Plantinga
Gabriële Holtappels
Rosina Imiru
Peter Vandenabeele
Guy Joos
Dmitri Krysko
Claus Bachert
A1
Journal Article
in
ALLERGY
2013
The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling
Juan Meng
Peng Zhou
Yafeng Liu
Xuelian Yi
Shixi Liu
Gabriële Holtappels
Claus Bachert
Nan Zhang
A1
Journal Article
in
PLOS ONE
2013
2012
A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows potent anti-inflammatory effects in an ex vivo human mucosal tissue model
Nan Zhang
Koen Van Crombruggen
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2012
Cytokine profiles in Japanese patients with chronic rhinosinusitis
Takayuki Sejima
Gabriële Holtappels
Hisashi Kikuchi
Shoichiro Imayoshi
Keiichi Ichimura
Claus Bachert
A1
Journal Article
in
ALLERGOLOGY INTERNATIONAL
2012
Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue
XiangDong Wang
Nan Zhang
Sarah Glorieux
Gabriële Holtappels
Mario Vaneechoutte
Olga Krysko
Luo Zhang
DeMin Han
Hans Nauwynck
Claus Bachert
A1
Journal Article
in
PLOS ONE
2012
IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis
Lara Derycke
Nan Zhang
Gabriële Holtappels
Tineke Dutré
Claus Bachert
A1
Journal Article
in
JOURNAL OF CYSTIC FIBROSIS
2012
IL-21 is increased in nasal polyposis and after stimulation with Staphylococus aureus enterotoxins
Lien Calus
Ine Derycke
Natalie De Ruyck
Gabriële Holtappels
Melissa Dullaers
Bart Lambrecht
Claus Bachert
Philippe Gevaert
C3
Conference
2012
Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor
Inge Tency
Hans Verstraelen
Ivo Kroes
Gabriële Holtappels
Bruno Verhasselt
Mario Vaneechoutte
Rita Verhelst
Marleen Temmerman
A1
Journal Article
in
PLOS ONE
2012
Inflammation and remodelling patterns in early stage chronic rhinosinusitis
Nicholas Van Bruaene
Claudina Perez Novo
Koen Van Crombruggen
Natalie De Ruyck
Gabriële Holtappels
Paul Van Cauwenberge
Philippe Gevaert
Claus Bachert
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2012
Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps
T Groot Kormelink
Lien Calus
Natalie De Ruyck
Gabriële Holtappels
Claus Bachert
FA Redegeld
Philippe Gevaert
A1
Journal Article
in
ALLERGY
2012
RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP
Koen Van Crombruggen
Gabriële Holtappels
Natalie De Ruyck
Lara Derycke
Peter Tomassen
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2012
Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma
Claus Bachert
Kristel Van Steen
Nan Zhang
Gabriële Holtappels
Tom Cattaert
Bärbel Maus
Roland Buhl
Christian Taube
Stephanie Korn
Marek Kowalski
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2012
2011
Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis
Olga Krysko
Gabriële Holtappels
Nan Zhang
Malgorzata Kubica
Kim Deswarte
Lara Derycke
Sofie Claeys
Hamida Hammad
Guy Brusselle
Peter Vandenabeele
et al.
A1
Journal Article
in
ALLERGY
2011
Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone
Koen Van Crombruggen
Luc Van Nassauw
Lara Derycke
Jean-Piere Timmermans
Gabriële Holtappels
David Hall
Claus Bachert
A1
Journal Article
in
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
2011
Increased nasal IL-5 levels act as a predisposing factor of asthma in southern China reply
Claus Bachert
Nan Zhang
Gabriële Holtappels
Peter Tomassen
Shixi Liu
Ping Lin
Jean Bousquet
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2011
Mucosal tissue polyclonal IgE is functional in response to allergen and SEB
Nan Zhang
Gabriële Holtappels
Philippe Gevaert
Joke Patou
B Dhaliwal
Hannah Gould
Claus Bachert
A1
Journal Article
in
ALLERGY
2011
2010
CRTH2 mediates the activation of human Th2 cells in response to PGD2 released from IgE/anti-IgE treated nasal polyp tissue
Claudina Perez Novo
Gabriële Holtappels
Shân L Vinall
Luzheng Xue
Nan Zhang
Claus Bachert
Roy Pettipher
A1
Journal Article
in
ALLERGY
2010
Chronic sinusitis and rhinitis: clinical terminology 'chronic rhinosinusitis' further supported
Koen Van Crombruggen
Nicholas Van Bruaene
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
RHINOLOGY
2010
Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis
Xiaoyuan Li
Juan Meng
Xiaoming Qiao
Yafeng Lui
Feng Liu
Nan Zhang
Jie Zhang
Gabriële Holtappels
Ba Luo
Peng Zhuo
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2010
Identification of the nasal mucosa as a new target for leptin action
Jasmien Taildeman
Pieter Demetter
Isabelle Rottiers
Gabriële Holtappels
Claus Bachert
Claude Cuvelier
Claudina Perez Novo
A1
Journal Article
in
HISTOPATHOLOGY
2010
Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis
F Liu
J Zhang
Y Liu
Nan Zhang
Gabriële Holtappels
P Lin
S Liu
Claus Bachert
A1
Journal Article
in
ALLERGY
2010
Oral steroids and doxycycline: Two different approaches to treat nasal polyps
Thibaut Van Zele
Philippe Gevaert
Gabriële Holtappels
Achim Beule
Peter John Wormald
Susanne Mayr
Greet Hens
Peter Hellings
Fenna Ebbens
Wytske Fokkens
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2010
Plasticity of the dendritic cells to activate T cells in chronic rhinosinusitis
Lara Derycke
Claus Bachert
Gabriële Holtappels
A1
Journal Article
in
ALLERGY
2010
Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
Claus Bachert
Nan Zhang
Gabriële Holtappels
Lizzy De Lobel
Paul Van Cauwenberge
ShiXi Liu
Ping Lin
Jean Bousquet
Kristel Van Steen
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2010
T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation
Claudina Perez Novo
Monica Jedrzejczak-Czechowicz
A Lewandowska-Polak
Cindy Claeys
Gabriële Holtappels
Paul Van Cauwenberge
ML Kowalski
Claus Bachert
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2010
2009
Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization
Marie-Noelle Corriveau
Nan Zhang
Gabriële Holtappels
Nadine Van Roy
Claus Bachert
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
2009
Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients
Philippe Gevaert
C. Hellman
L. Lundblad
J. Lundahl
Gabriële Holtappels
Paul Van Cauwenberge
Jan Tavernier
Claus Bachert
A1
Journal Article
in
ALLERGY
2009
Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
Joke Patou
Gabriële Holtappels
Karen Affleck
Philippe Gevaert
Claudina Perez Novo
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
JOURNAL OF INFLAMMATION-LONDON
2009
Local Complement Activation in Nasal Polyposis
Thibaut Van Zele
Frauke Coppieters
Philippe Gevaert
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
LARYNGOSCOPE
2009
TGF-beta signaling and collagen deposition in chronic rhinosinusitis
Nicholas Van Bruaene
Lara Derycke
Claudina Perez Novo
Philippe Gevaert
Gabriële Holtappels
Natalie De Ruyck
Claude Cuvelier
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2009
2008
Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
Thibaut Van Zele
Mario Vaneechoutte
Gabriële Holtappels
Philippe Gevaert
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY
2008
Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
Nan Zhang
Thibaut Van Zele
Claudina Perez Novo
Nicholas Van Bruaene
Gabriële Holtappels
Natalie De Ruyck
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2008
Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
Joke Patou
Philippe Gevaert
Thibaut Van Zele
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2008
T-cell regulation in chronic paranasal sinus disease
Nicholas Van Bruaene
Claudina Perez Novo
Tomasz M Basinski
Thibaut Van Zele
Gabriële Holtappels
Natalie De Ruyck
Carsten Schmidt-Weber
Cezmi Akdis
Paul Van Cauwenberge
Claus Bachert
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2008
TGF-beta isoforms and receptors in chronic sinus disease
Nicholas Van Bruaene
Claudina Perez Novo
Philippe Gevaert
Gabriële Holtappels
Natalie De Ruyck
Paul Van Cauwenberge
Claus Bachert
C3
Conference
2008
Treatment of nasal polyposis with oral methylprednisolone: a double-blind, randomized, placebo-controlled trial with evaluation of clinical and biological activity
Thibaut Van Zele
Philippe Gevaert
Gabriële Holtappels
B Achim
P Wormald
S Mayr
G Hens
P Hellings
F Ebbenss
W Fokkens
et al.
C3
Conference
2008
2007
Local immunoglobulin production in nasal polyposis is modulated by superantigens
Thibaut Van Zele
Philippe Gevaert
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2007
Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease
Philippe Gevaert
Joke Patou
Thibaut Van Zele
Gabriële Holtappels
Karolien De Bosscher
Wim Vanden Berghe
Guy Haegeman
Claus Bachert
C3
Conference
2007
Remodelling in nasal polyposis is independent of TH-cell polarisation
Nan Zhang
TV ZELE
Philippe Gevaert
Gabriële Holtappels
P VAN CAUWENBERGE
Claus Bachert
C3
Conference
2007
Staphylococcus aureus enterotoxin B stimulation in nasal polyps
Joke Patou
Thibaut Van Zele
Gabriële Holtappels
Philippe Gevaert
Paul Van Cauwenberge
Claus Bachert
C3
Conference
2007
Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study
A SEMIC-JUSUFAGIC
Claus Bachert
Philippe Gevaert
Gabriële Holtappels
L LOWE
A WOODCOCK
A SIMPSON
A CUSTOVIC
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2007
T cell regulation in chronic sinus disease
Nicholas Van Bruaene
Claudina Perez Novo
Thibaut Van Zele
Gabriële Holtappels
Natalie De Ruyck
Paul Van Cauwenberge
Claus Bachert
Philippe Gevaert
C3
Conference
2007
Upper airway inflammation in chronic smoke exposed mice
Wouter Huvenne
Gabriële Holtappels
Natalie DERUYCK
Claudia PEREZ NOVO
Philippe Gevaert
Paul Van Cauwenberge
Claus Bachert
C3
Conference
2007
2006
Development of a rabbit model to study inflammation in nasal and paranasal cavities
Wouter Huvenne
Philippe Gevaert
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
C1
Conference
2006
Differentiation of chronic sinus diseases by measurement of inflammatory mediators
Thibaut Van Zele
Sofie Claeys
Philippe Gevaert
Georges Van Maele
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
ALLERGY
2006
Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins
Claudina Perez Novo
Cindy Claeys
Thibaut Van Zele
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY
2006
Local activation of the complement system in nasal polyps
Thibaut Van Zele
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
C3
Conference
2006
Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
Philippe Gevaert
Doris Lang-Loidolt
Andreas Lackner
Heinz Stammberger
Heribert Staudinger
Thibaut Van Zele
Gabriële Holtappels
Jan Tavernier
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2006
Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China
Nan Zhang
Gabriële Holtappels
Cindy Claeys
GQ HUANG
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
AMERICAN JOURNAL OF RHINOLOGY
2006
2005
An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis
Nan Zhang
Philippe Gevaert
Thibaut Van Zele
Claudina Perez Novo
Joke Patou
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
RHINOLOGY
2005
Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis
B LANGE
KF LUKAT
K RETTIG
Gabriële Holtappels
Claus Bachert
A1
Journal Article
in
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
2005
Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators
Sofie Claeys
Helen Van Hoecke
Gabriële Holtappels
Philippe Gevaert
Tine De Belder
Bruno Verhasselt
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2005
Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue
Philippe Gevaert
Gabriële Holtappels
SGO JOHANSSON
Claude Cuvelier
P CAUWENBERGE
Claus Bachert
A1
Journal Article
in
ALLERGY
2005
2004
Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: Studies on the relationship
Claudina Perez Novo
ML KOWALSKI
P KUNA
A PTASINSKA
Gabriële Holtappels
Paul Van Cauwenberge
Philippe Gevaert
S JOHANNSON
Claus Bachert
A1
Journal Article
in
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
2004
Collection of nasal secretions for immunological analysis
Jean-Baptiste Watelet
Philippe Gevaert
Gabriële Holtappels
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2004
Effects of cetirizine and fluticasone propionate nasal spray on symptoms and inflammatory mediators of seasonal allergic rhinitis
K DAHL
B LANGE
Gabriële Holtappels
KF LUKAT
Claus Bachert
A1
Journal Article
in
ALLERGOLOGIE
2004
Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD
G ROHDE
Philippe Gevaert
Gabriële Holtappels
I BORG
A WIETHEGE
U ARINIR
G SCHULTZE-WERNINGHAUS
Claus Bachert
A1
Journal Article
in
RESPIRATORY MEDICINE
2004
Macrophage mannose receptor in chronic sinus disease
Sofie Claeys
T DE BELDER
Gabriële Holtappels
Philippe Gevaert
Bruno Verhasselt
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
ALLERGY
2004
Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease
G ROHDE
Philippe Gevaert
Gabriële Holtappels
L FRANSEN
I BORG
A WIETHEGE
U ARINIA
Jan Tavernier
G SCHULTZE-WERNINGHAUS
Claus Bachert
A1
Journal Article
in
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
2004
2003
Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis
Philippe Gevaert
Claus Bachert
Gabriële Holtappels
Claudina Perez Novo
José Van Der Heyden
L FRANSEN
S DEPRAETERE
H WALTER
Paul Van Cauwenberge
Jan Tavernier
A1
Journal Article
in
ALLERGY
2003
Human beta-defensins and toll-like receptors in the upper airway
Sofie Claeys
T DE BELDER
Gabriële Holtappels
Philippe Gevaert
Bruno Verhasselt
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
ALLERGY
2003
IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma
Claus Bachert
Philippe Gevaert
P HOWARTH
Gabriële Holtappels
Paul Van Cauwenberge
SGO JOHANSSON
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2003
Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA
Claudina Perez Novo
Jo Vandesompele
Gabriële Holtappels
Franki Speleman
Philippe Gevaert
Paul Van Cauwenberge
Claus Bachert
A1
Journal Article
in
BMC BIOTECHNOLOGY
2003
2001
Expression of TGF-beta 1,-beta 2, EGF and PDGF in nasal secretions after sinus surgery
Jean-Baptiste Watelet
Philippe Gevaert
Claus Bachert
Marie-Chantal Herteleer
Gabriële Holtappels
Paul Van Cauwenberge
C3
Conference
2001