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Onderzoeker
Frédéric Clement
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
39
Resultaten
2022
Characterization of the cell-mediated immune response to Takeda’s live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting
Vianney Tricou
Raphael Gottardo
Michael A. Egan
Frédéric Clement
Geert Leroux-Roels
Xavier Sáez-Llorens
Astrid Borkowski
Derek Wallace
Hansi J. Dean
A1
Artikel in een tijdschrift
in
VACCINE
2022
Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium
Gwenn Waerlop
Geert Leroux-Roels
Teresa Lambe
Duncan Bellamy
Donata Medaglini
Elena Pettini
Rebecca Jane Cox
Mai-Chi Trieu
Richard Davies
Geir Bredholt
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2022
Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium
Sarah Begue
Gwenn Waerlop
Bruno Salaun
Michel Janssens
Duncan Bellamy
Rebecca Jane Cox
Richard Davies
Elena Gianchecchi
Donata Medaglini
Emanuele Montomoli
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2022
The role of cell-mediated immunity against influenza and its implications for vaccine evaluation
Yorick Janssens
Jasper Joye
Gwenn Waerlop
Frédéric Clement
Geert Leroux-Roels
Isabel Leroux-Roels
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2022
2018
Adjuvant-associated peripheral blood mRNA profiles and kinetics induced by the adjuvanted recombinant protein candidate tuberculosis vaccine M72/AS01 in Bacillus Calmette–Guérin-vaccinated adults
Robert A. van den Berg
Laurane De Mot
Geert Leroux-Roels
Viviane Bechtold
Frédéric Clement
Margherita Coccia
Erik Jongert
Thomas G. Evans
Paul Gillard
Robbert G. van der Most
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2018
2017
Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans
Wivine Burny
Andrea Callegaro
Viviane Bechtold
Frédéric Clement
Sophie Delhaye
Laurence Fissette
Michel Janssens
Geert Leroux-Roels
Arnaud Marchant
Robert A. van den Berg
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2017
Long-term persistence of cell-mediated and humoral responses to A(H1N1)pdm09 influenza virus vaccines and the role of the AS03 adjuvant system in adults during two randomized controlled trials
Robbert G. van der Most
Frédéric Clement
Julie Willekens
Walthère Dewé
Karl Walravens
David W. Vaughn
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
CLINICAL AND VACCINE IMMUNOLOGY
2017
Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages
Jonas Van Belleghem
Frédéric Clement
Maia Merabishvili
Rob Lavigne
Mario Vaneechoutte
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2017
2016
A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum
Kristina Radin
Frédéric Clement
Erik Jongert
Yann G-J Sterckx
Christian Ockenhouse
Jason Regules
Franck Lemiale
Geert Leroux-Roels
C3
Conferentie
2016
A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum
Kristina Radin
Frédéric Clement
Erik Jongert
Yann GJ Sterckx
Christian Ockenhouse
Jason Regules
Franck Lemiale
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
MALARIA JOURNAL
2016
Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine : results from a phase II, randomized, multicenter trial
Geert Leroux-Roels
Arnaud Marchant
Jack Levy
Pierre Van Damme
Tino F Schwarz
Yves Horsmans
Wolfgang Jilg
Peter G Kremsner
Edwige Haelterman
Frédéric Clement
et al.
A1
Artikel in een tijdschrift
in
CLINICAL IMMUNOLOGY
2016
2014
A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration
Giovanni Della Cioppa
Uwe Nicolay
Kelly Lindert
Geert Leroux-Roels
Frédéric Clement
Flora Castellino
Grazia Galli
Nicola Groth
Yotam Levin
Giuseppe Del Giudice
A1
Artikel in een tijdschrift
in
HUMAN VACCINES & IMMUNOTHERAPEUTICS
2014
Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01(E) in young children
Ally Olotu
Frédéric Clement
Erik Jongert
Johan Vekemans
Patricia Njuguna
Francis M Ndungu
Kevin Marsh
Geert Leroux-Roels
Philip Bejon
A1
Artikel in een tijdschrift
in
PLOS ONE
2014
Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines : randomized, double-blind study in malaria-naïve adults
Geert Leroux-Roels
Isabel Leroux-Roels
Frédéric Clement
Opokua Ofori-Anyinam
Marc Lievens
Erik Jongert
Philippe Moris
W Ripley Ballou
Joe Cohen
A1
Artikel in een tijdschrift
in
HUMAN VACCINES & IMMUNOTHERAPEUTICS
2014
Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine
Geert Leroux-Roels
Patricia Bourguignon
Julie Willekens
Michel Janssens
Frédéric Clement
Arnaud M Didierlaurent
Laurence Fissette
François Roman
Dominique Boutriau
A1
Artikel in een tijdschrift
in
CLINICAL AND VACCINE IMMUNOLOGY
2014
Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients
Patricia Bourguignon
Frédéric Clement
Frédéric Renaud
Vivien Le Bras
Marguerite Koutsoukos
Wivine Burny
Philippe Moris
Clarisse Lorin
Alix Collard
Geert Leroux-Roels
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF IMMUNOLOGICAL METHODS
2014
2013
Immunogenicity and safety of different formulations of an adjuvanted glycoprotein D genital herpes vaccine in healthy adults: a double-blind randomized trial
Geert Leroux-Roels
Frédéric Clement
Pierre Vandepapeliere
Marc Fourneau
Thomas Heineman
Gary Dubin
A1
Artikel in een tijdschrift
in
HUMAN VACCINES & IMMUNOTHERAPEUTICS
2013
Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial
Isabel Leroux-Roels
Sheron Forgus
FIEN DE BOEVER
Frédéric Clement
Marie-Ange Demoitié
Pascal Mettens
Philippe Moris
Edouard Ledent
Geert Leroux-Roels
Opokua Ofori-Anyinam
A1
Artikel in een tijdschrift
in
VACCINE
2013
Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine
Eva Van Braeckel
Isabelle Desombere
Frédéric Clement
Linos Vandekerckhove
Chris Verhofstede
Dirk Vogelaers
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
VACCINE
2013
Randomized phase I : safety, immunogenicity and mucosal antiviral activity in young healthy women vaccinated with HIV-1 Gp41 P1 peptide on virosomes
Geert Leroux-Roels
Cathy Maes
Frédéric Clement
Frank Van Engelenburg
Marieke van den Dobbelsteen
Michael Adler
Mario Amacker
Lucia Lopalco
Morgane Bomsel
Anick Chalifour
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2013
2012
A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein E subunit vaccine candidate in young and older adults
Isabel Leroux-Roels
Geert Leroux-Roels
Frédéric Clement
Pierre Vandepapelière
Ventzislav Vassilev
Edouard Ledent
Thomas C Heineman
A1
Artikel in een tijdschrift
in
JOURNAL OF INFECTIOUS DISEASES
2012
Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59® adjuvant: results from a dose-finding clinical trial in older adults
Giovanni Della Cioppa
Uwe Nicolay
Kelly Lindert
Geert Leroux-Roels
Frédéric Clement
Flora Castellino
Grazia Galli
Nicola Groth
Giuseppe Del Giudice
A1
Artikel in een tijdschrift
in
HUMAN VACCINES & IMMUNOTHERAPEUTICS
2012
Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum.
Frédéric Clement
Vincent Dewar
Eva Van Braeckel
Isabelle Desombere
Marianne Dewerchin
Christine Swysen
Marie-Ange Demoitié
Erik Jongert
Joe Cohen
Geert Leroux-Roels
et al.
A1
Artikel in een tijdschrift
in
MALARIA JOURNAL
2012
2011
An adjuvanted polyprotein HIV-1 vaccine induces polyfunctional cross-reactive CD4+ T cell responses in seronegative volunteers
Eva Van Braeckel
Patricia Bourguignon
Marguerite Koutsoukos
Frédéric Clement
Michel Janssens
Isabelle Carletti
Alix Collard
Marie-Ange Demoitié
Gerald Voss
Geert Leroux-Roels
et al.
A1
Artikel in een tijdschrift
in
CLINICAL INFECTIOUS DISEASES
2011
Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus Vaccine administered to adults during two randomized controlled trials
François Roman
Frédéric Clement
Walthère Dewé
Karl Walravens
Cathy Maes
Julie Willekens
FIEN DE BOEVER
Emmanuel Hanon
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
CLINICAL AND VACCINE IMMUNOLOGY
2011
H5N1 influenza vaccine formulated with AS03A induces strong cross-reactive and polyfunctional CD4 T-cell responses
Philippe Moris
Robbert van der Most
Isabel Leroux-Roels
Frédéric Clement
Mamadou Dramé
Emmanuel Hanon
Geert Leroux-Roels
Marcelle Van Mechelen
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL IMMUNOLOGY
2011
Vaccine-induced HIV seropositivity: a problem on the rise
Eva Van Braeckel
Marguerite Koutsoukos
Patricia Bourguignon
Frédéric Clement
Lisa McNally
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL VIROLOGY
2011
2010
An adjuvanted protein HIV vaccine induces polyfunctional CD4 T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers
Eva Van Braeckel
Frédéric Clement
Linos Vandekerckhove
Dirk Vogelaers
Geert Leroux-Roels
C3
Conferentie
2010
An adjuvanted protein HIV vaccine induces polyfunctional CD4(+) T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers
Eva Van Braeckel
Frédéric Clement
Linos Vandekerckhove
Dirk Vogelaers
Geert Leroux-Roels
C3
Conferentie
2010
Detection of mumps virus-specific memory B cells by transfer of peripheral blood mononuclear cells into immune-deficient mice
Corinne Vandermeulen
Lieven Verhoye
Sunil Vaidya
Frédéric Clement
Kevin E Brown
Karel Hoppenbrouwers
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
IMMUNOLOGY
2010
Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02A candidate tuberculosis vaccine in purified protein derivative-negative adults
Isabel Leroux-Roels
Geert Leroux-Roels
Opokua Ofori-Anyinam
Philippe Moris
Els De Kock
Frédéric Clement
Marie-Claude Dubois
Marguerite Koutsoukos
Marie-Ange Demoitie
Joe Cohen
et al.
A1
Artikel in een tijdschrift
in
CLINICAL AND VACCINE IMMUNOLOGY
2010
Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems
Isabel Leroux-Roels
Marguerite Koutsoukos
Frédéric Clement
Sophia Steyaert
Michel Janssens
Patricia Bourguignon
Kristen Cohen
Marcus Altfeld
Pierre Vandepapelière
Louise Pedneault
et al.
A1
Artikel in een tijdschrift
in
VACCINE
2010
2009
Evaluation of cellular immunity to mumps in vaccinated individuals with or without circulating antibodies up to 16 years after their last vaccination
Corinne Vandermeulen
Frédéric Clement
Mathieu Roelants
Pierre Van Damme
Karel Hoppenbrouwers
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
JOURNAL OF INFECTIOUS DISEASES
2009
2008
Induction of a potent polyfunctional CD4+T cell response by an adjuvanted protein HIV vaccine candidate in seronegative volunteers
Eva Van Braeckel
P Bourguignon
M Koutsoukos
Frédéric Clement
M Janssens
I Carletti
M Demoitie
G Voss
Geert Leroux-Roels
L McNally
C3
Conferentie
2008
Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers
Pierre Vandepapeliere
Yves Horsmans
Philippe Moris
Marcelle Van Mechelen
Michel Janssens
Marguerite Koutsoukos
Pascale Van Belle
Frédéric Clement
Emmanuel Hanon
Martine Wettendorff
et al.
A1
Artikel in een tijdschrift
in
VACCINE
2008
Vitamin D binding protein and the need for vitamin D in hemodialysis patients
Marijn Speeckaert
Griet Glorieux
Raymond Vanholder
Wim Van Biesen
Youri Taes
Frédéric Clement
Charline Wehlou
Joris Delanghe
A1
Artikel in een tijdschrift
in
JOURNAL OF RENAL NUTRITION
2008
2007
Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial
Isabel Leroux-Roels
Astrid Borkowski
Thomas Vanwolleghem
Mamadou Drame
Frédéric Clement
Eliane Hons
Jeanne-Marie Devaster
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
LANCET
2007
2005
The duration of in vitro stimulation with recall antigens determines the subset distribution of interferon-gamma-producing lymphoid cells: A kinetic analysis using the Interferon-gamma Secretion Assay (TM)
Isabelle Desombere
Frédéric Clement
Hanne Rigole
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
JOURNAL OF IMMUNOLOGICAL METHODS
2005
2002
Evaluation of a new rapid test for the combined detection of hepatitis B virus surface antigen and hepatitis B virus e antigen
Frédéric Clement
Pieter Dewint
Geert Leroux-Roels
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL MICROBIOLOGY
2002