Research Explorer

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Researcher

Frédéric Clement

Awards & Distinctions

41 Results

2024

PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

PDXGhent : patient derived tumor xenografting mouse core facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

2022

Characterization of the cell-mediated immune response to Takeda’s live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting

Vianney TricouRaphael GottardoMichael A. EganFrédéric ClementGeert Leroux-RoelsXavier Sáez-LlorensAstrid BorkowskiDerek WallaceHansi J. Dean

A1 Journal Article in VACCINE

Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

Gwenn WaerlopGeert Leroux-RoelsTeresa LambeDuncan BellamyDonata MedagliniElena PettiniRebecca Jane CoxMai-Chi TrieuRichard DaviesGeir Bredholt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium

Sarah BegueGwenn WaerlopBruno SalaunMichel JanssensDuncan BellamyRebecca Jane CoxRichard DaviesElena GianchecchiDonata MedagliniEmanuele Montomoli et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of cell-mediated immunity against influenza and its implications for vaccine evaluation

Yorick JanssensJasper JoyeGwenn WaerlopFrédéric ClementGeert Leroux-RoelsIsabel Leroux-Roels

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2018

Adjuvant-associated peripheral blood mRNA profiles and kinetics induced by the adjuvanted recombinant protein candidate tuberculosis vaccine M72/AS01 in Bacillus Calmette–Guérin-vaccinated adults

Robert A. van den BergLaurane De MotGeert Leroux-RoelsViviane BechtoldFrédéric ClementMargherita CocciaErik JongertThomas G. EvansPaul GillardRobbert G. van der Most

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2017

Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans

Wivine BurnyAndrea CallegaroViviane BechtoldFrédéric ClementSophie DelhayeLaurence FissetteMichel JanssensGeert Leroux-RoelsArnaud MarchantRobert A. van den Berg et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Long-term persistence of cell-mediated and humoral responses to A(H1N1)pdm09 influenza virus vaccines and the role of the AS03 adjuvant system in adults during two randomized controlled trials

Robbert G. van der MostFrédéric ClementJulie WillekensWalthère DewéKarl WalravensDavid W. VaughnGeert Leroux-Roels

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages

Jonas Van BelleghemFrédéric ClementMaia MerabishviliRob LavigneMario Vaneechoutte

A1 Journal Article in SCIENTIFIC REPORTS

2016

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

Kristina RadinFrédéric ClementErik JongertYann G-J SterckxChristian OckenhouseJason RegulesFranck LemialeGeert Leroux-Roels

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

Kristina RadinFrédéric ClementErik JongertYann GJ SterckxChristian OckenhouseJason RegulesFranck LemialeGeert Leroux-Roels

A1 Journal Article in MALARIA JOURNAL

Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine : results from a phase II, randomized, multicenter trial

Geert Leroux-RoelsArnaud MarchantJack LevyPierre Van DammeTino F SchwarzYves HorsmansWolfgang JilgPeter G KremsnerEdwige HaeltermanFrédéric Clement et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

2014

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

Giovanni Della CioppaUwe NicolayKelly LindertGeert Leroux-RoelsFrédéric ClementFlora CastellinoGrazia GalliNicola GrothYotam LevinGiuseppe Del Giudice

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01(E) in young children

Ally OlotuFrédéric ClementErik JongertJohan VekemansPatricia NjugunaFrancis M NdunguKevin MarshGeert Leroux-RoelsPhilip Bejon

A1 Journal Article in PLOS ONE

Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines : randomized, double-blind study in malaria-naïve adults

Geert Leroux-RoelsIsabel Leroux-RoelsFrédéric ClementOpokua Ofori-AnyinamMarc LievensErik JongertPhilippe MorisW Ripley BallouJoe Cohen

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine

Geert Leroux-RoelsPatricia BourguignonJulie WillekensMichel JanssensFrédéric ClementArnaud M DidierlaurentLaurence FissetteFrançois RomanDominique Boutriau

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

Patricia BourguignonFrédéric ClementFrédéric RenaudVivien Le BrasMarguerite KoutsoukosWivine BurnyPhilippe MorisClarisse LorinAlix CollardGeert Leroux-Roels et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

2013

Immunogenicity and safety of different formulations of an adjuvanted glycoprotein D genital herpes vaccine in healthy adults: a double-blind randomized trial

Geert Leroux-RoelsFrédéric ClementPierre VandepapeliereMarc FourneauThomas HeinemanGary Dubin

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial

Isabel Leroux-RoelsSheron ForgusFIEN DE BOEVERFrédéric ClementMarie-Ange DemoitiéPascal MettensPhilippe MorisEdouard LedentGeert Leroux-RoelsOpokua Ofori-Anyinam

A1 Journal Article in VACCINE

Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine

Eva Van BraeckelIsabelle DesombereFrédéric ClementLinos VandekerckhoveChris VerhofstedeDirk VogelaersGeert Leroux-Roels

A1 Journal Article in VACCINE

Randomized phase I : safety, immunogenicity and mucosal antiviral activity in young healthy women vaccinated with HIV-1 Gp41 P1 peptide on virosomes

Geert Leroux-RoelsCathy MaesFrédéric ClementFrank Van EngelenburgMarieke van den DobbelsteenMichael AdlerMario AmackerLucia LopalcoMorgane BomselAnick Chalifour et al.

A1 Journal Article in PLOS ONE

2012

A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein E subunit vaccine candidate in young and older adults

Isabel Leroux-RoelsGeert Leroux-RoelsFrédéric ClementPierre VandepapelièreVentzislav VassilevEdouard LedentThomas C Heineman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59® adjuvant: results from a dose-finding clinical trial in older adults

Giovanni Della CioppaUwe NicolayKelly LindertGeert Leroux-RoelsFrédéric ClementFlora CastellinoGrazia GalliNicola GrothGiuseppe Del Giudice

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum.

Frédéric ClementVincent DewarEva Van BraeckelIsabelle DesombereMarianne DewerchinChristine SwysenMarie-Ange DemoitiéErik JongertJoe CohenGeert Leroux-Roels et al.

A1 Journal Article in MALARIA JOURNAL

2011

An adjuvanted polyprotein HIV-1 vaccine induces polyfunctional cross-reactive CD4+ T cell responses in seronegative volunteers

Eva Van BraeckelPatricia BourguignonMarguerite KoutsoukosFrédéric ClementMichel JanssensIsabelle CarlettiAlix CollardMarie-Ange DemoitiéGerald VossGeert Leroux-Roels et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus Vaccine administered to adults during two randomized controlled trials

François RomanFrédéric ClementWalthère DewéKarl WalravensCathy MaesJulie WillekensFIEN DE BOEVEREmmanuel HanonGeert Leroux-Roels

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

H5N1 influenza vaccine formulated with AS03A induces strong cross-reactive and polyfunctional CD4 T-cell responses

Philippe MorisRobbert van der MostIsabel Leroux-RoelsFrédéric ClementMamadou DraméEmmanuel HanonGeert Leroux-RoelsMarcelle Van Mechelen

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Vaccine-induced HIV seropositivity: a problem on the rise

Eva Van BraeckelMarguerite KoutsoukosPatricia BourguignonFrédéric ClementLisa McNallyGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

2010

An adjuvanted protein HIV vaccine induces polyfunctional CD4 T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

An adjuvanted protein HIV vaccine induces polyfunctional CD4(+) T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

Detection of mumps virus-specific memory B cells by transfer of peripheral blood mononuclear cells into immune-deficient mice

Corinne VandermeulenLieven VerhoyeSunil VaidyaFrédéric ClementKevin E BrownKarel HoppenbrouwersGeert Leroux-Roels

A1 Journal Article in IMMUNOLOGY

Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02A candidate tuberculosis vaccine in purified protein derivative-negative adults

Isabel Leroux-RoelsGeert Leroux-RoelsOpokua Ofori-AnyinamPhilippe MorisEls De KockFrédéric ClementMarie-Claude DuboisMarguerite KoutsoukosMarie-Ange DemoitieJoe Cohen et al.

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems

Isabel Leroux-RoelsMarguerite KoutsoukosFrédéric ClementSophia SteyaertMichel JanssensPatricia BourguignonKristen CohenMarcus AltfeldPierre VandepapelièreLouise Pedneault et al.

A1 Journal Article in VACCINE

2009

Evaluation of cellular immunity to mumps in vaccinated individuals with or without circulating antibodies up to 16 years after their last vaccination

Corinne VandermeulenFrédéric ClementMathieu RoelantsPierre Van DammeKarel HoppenbrouwersGeert Leroux-Roels

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2008

Induction of a potent polyfunctional CD4+T cell response by an adjuvanted protein HIV vaccine candidate in seronegative volunteers

Eva Van BraeckelP BourguignonM KoutsoukosFrédéric ClementM JanssensI CarlettiM DemoitieG VossGeert Leroux-RoelsL McNally

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

Pierre VandepapeliereYves HorsmansPhilippe MorisMarcelle Van MechelenMichel JanssensMarguerite KoutsoukosPascale Van BelleFrédéric ClementEmmanuel HanonMartine Wettendorff et al.

A1 Journal Article in VACCINE

Vitamin D binding protein and the need for vitamin D in hemodialysis patients

Marijn SpeeckaertGriet GlorieuxRaymond VanholderWim Van BiesenYouri TaesFrédéric ClementCharline WehlouJoris Delanghe

A1 Journal Article in JOURNAL OF RENAL NUTRITION

2007

Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial

Isabel Leroux-RoelsAstrid BorkowskiTHOMAS VANWOLLEGHEMMamadou DrameFrédéric ClementEliane HonsJeanne-Marie DevasterGeert Leroux-Roels

A1 Journal Article in LANCET

2005

The duration of in vitro stimulation with recall antigens determines the subset distribution of interferon-gamma-producing lymphoid cells: A kinetic analysis using the Interferon-gamma Secretion Assay (TM)

Isabelle DesombereFrédéric ClementHanne RigoleGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

2002

Evaluation of a new rapid test for the combined detection of hepatitis B virus surface antigen and hepatitis B virus e antigen

Frédéric ClementPieter DewintGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY