Research Explorer

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Researcher

Frans Belpaire

Publications & Research Data

Awards & Distinctions

95 Results

2018

Metformin treatment in patients with type 2 diabetes and chronic kidney disease stages 3A, 3B, or 4

Jean-Daniel LalauFarshad KajbafYoussef BennisAnne-Sophie Hurtel-LemaireFrans BelpaireMarc E De Broe

A1 Journal Article in DIABETES CARE

2008

Physiological aspects determining the pharmacokinetic properties of drugs in "The Practice of Medicinal Chemistry" (3rd Edition)

Koen BousseryFrans BelpaireJohan Van de Voorde

Bookchapter in The Practice of Medicinal Chemistry

2007

Abrupt awakening phenomenon associated with gamma-hydroxybutyrate use: A case series

Diederik Van SassenbroeckN DE NEVEPeter De PaepeFrans BelpaireAlain VerstraetePaul CalleWalter Buylaert

A1 Journal Article in CLINICAL TOXICOLOGY

2003

Characterization of the pharmacokinetic and pharmacodynamic interaction between gamma-hydroxybutyrate and ethanol in the rat

Diederik Van SassenbroeckPeter De PaepeFrans BelpaireWalter Buylaert

A1 Journal Article in TOXICOLOGICAL SCIENCES

Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure

G LESAFFERR DE SMETT D'HEUVAERTFrans BelpaireNorbert LameireRaymond Vanholder

A1 Journal Article in KIDNEY INTERNATIONAL

Medical problems related to recreational drug use at nocturnal dance parties

Diederik Van SassenbroeckPaul CalleF ROUSSEAUAlain VerstraeteFrans BelpaireKoenraad MonsieursR HAENTJENSJ ALONSIUSJ VAN BRANTEGEMW HAENEN et al.

A2 Journal Article in European Journal of emergency medicine

Pharmacokinetic-pharmacodynamic modeling of the hypnotic effect of gamma-hydroxybutyrate

Diederik Van SassenbroeckWalter BuylaertFrans Belpaire

The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat

Peter De PaepeFrans BelpaireG VAN HOEYPaul BoonWalter Buylaert

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Tolerance to the hypnotic and electroencephalographic effect of gamma-hydroxybutyrate in the rat: pharmacokinetic and pharmacodynamic aspects

Diederik Van SassenbroeckPeter De PaepeFrans BelpairePaul BoonWalter Buylaert

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACOLOGY

Urinary excretion of the uraemic toxin p-cresol in the rat : contribution of glucuronidation to its metabolization

Gerrit LesafferRITA DE SMETFrans BelpaireBruno Van VlemMarijn Van HulleRita CornelisNorbert LameireRaymond Vanholder

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

2002

Het cytochroom-P450-enzymsysteem: Genetisch polymorfisme en geneesmiddelen-interacties.

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Hypovolemia does not influence the pharmacokinetics and pharmacodynamics of gamma-hydroxybutyrate in the rat

Diederik Van SassenbroeckPeter De PaepeFrans BelpaireW BUYLAERT

Influence of hypovolemia on the pharmacokinetics and electroencephalographic effect of gamma-hydroxybutyrate in the rat

Diederik Van SassenbroeckPeter De PaepeFrans BelpairePaul BoonWalter Buylaert

A1 Journal Article in ANESTHESIOLOGY

Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock

Peter De PaepeFrans BelpaireWalter Buylaert

A1 Journal Article in CLINICAL PHARMACOKINETICS

Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit Part I - experimental approach after in vivo intravenous infusion.

Els De LetterKarine ClauwaertFrans BelpaireWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit Part II: post-mortem infusion in trachea or stomach.

Els De LetterFrans BelpaireKarine ClauwaertWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update.

Alex HemeryckFrans Belpaire

A1 Journal Article in CURRENT DRUG METABOLISM

Tolerance to gamma-hydroxybutyrate in the rat: pharmakinetic and pharmacodynamic aspects

Diederik Van SassenbroeckPeter De PaepeFrans BelpaireW BUYLAERT

2001

Development and validation of a high-performance liquid chromatographic method for the determination of gamma-hydroxybutyric acid in rat plasma.

CA DE VRIENDTDiederik Van SassenbroeckMarie RosseelEJ VAN DE VELDEAlain VerstraeteY VANDER HEYDENFrans Belpaire

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B

Influence of naloxone on the increased sensitivity to propofol during hypovolemia in the rat

Peter De PaepeDiederik Van SassenbroeckFrans BelpaireWalter Buylaert

A1 Journal Article in CRITICAL CARE MEDICINE

Metoprolol-paroxetine interaction in human liver microsomes: Stereoselective aspects and prediction of the in vivo interaction.

Alex HemeryckCA DE VRIENDTFrans Belpaire

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Relationship between gamma-hydroxybutyrate plasma concentrations and its electroencephalographic effects in the rat

Diederik Van SassenbroeckPeter De PaepeFrans BelpaireMarie RosseelPhilip MartensPaul BoonWalter Buylaert

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACOLOGY

2000

Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: In vitro studies using human liver microsomes.

Alex HemeryckC DE VRIENDTFrans Belpaire

A1 Journal Article in JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat

Peter De PaepeFrans BelpaireMarie RosseelG VAN HOEYPaul BoonWalter Buylaert

A1 Journal Article in ANESTHESIOLOGY

Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with rabbits

Els De LetterPeter De PaepeKarine ClauwaertFrans BelpaireWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers.

Alex HemeryckRomain LefebvreC DE VRIENDTFrans Belpaire

A1 Journal Article in CLINICAL PHARMACOLOGY & THERAPEUTICS

The effect of selective serotonin reuptake inhibitors on the cytochrome p450-mediated metabolism of warfarin, propafenone, and metoprolol

Alex HemeryckFrans Belpaire

The influence of hemodynamic failure on the pharmacokinetics and pharmacodynamics of major analgesics and anesthetics in the rat

Peter De PaepeWalter BuylaertFrans Belpaire

1999

Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.

Liping PanRobert Vander SticheleMarie RosseelJA BERLON DE SCHEPPERFrans Belpaire

A1 Journal Article in THERAPEUTIC DRUG MONITORING

In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol.

Liping PanFrans Belpaire

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat

Peter De PaepeFrans BelpaireG VAN HOEYPaul BoonWalter Buylaert

A1 Journal Article in JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: In vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

Alex HemeryckC DE VRIENDTFrans Belpaire

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Relationship between etomidate plasma concentration and EEG effect in the rat

Peter De PaepeGert Van HoeyFrans BelpaireMarie RosseelPaul BoonWalter Buylaert

A1 Journal Article in PHARMACEUTICAL RESEARCH

1998

Comparison of two high-performance liquid chromatographic methods for monitoring plasma concentrations of haloperidol and reduced haloperidol.

Liping PanMarie RosseelFrans Belpaire

A1 Journal Article in THERAPEUTIC DRUG MONITORING

Diagnostic performance of the EMIT-tox (R) benzodiazepine immunoassay, FPIA serum benzodiazepine immunoassay, and radioreceptor assay in suspected acute poisoning.

Alain VerstraeteFrans BelpaireGeert Leroux-Roels

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning.

K FONCKC HAENEBALCKEA HEMERYCKFrans BelpaireLuc JordaensPaul CalleWalter Buylaert

A1 Journal Article in Journal of toxicology. Clinical toxicology

In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

LP PANC DE VRIENDTFrans Belpaire

A1 Journal Article in PHARMACOGENETICS

The influence of hemorrhagic shock on the pharmacokinetics and the analgesic effect of morphine in the rat

Peter De PaepeFrans BelpaireMarie RosseelWalter Buylaert

A1 Journal Article in FUNDAMENTAL & CLINICAL PHARMACOLOGY

The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

Frans BelpaireP WIJNANTA TEMMERMANBB RASMUSSENK BROSEN

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Variability morphine disposition during long-term subcutaneous infusion in terminally ill cancer patients.

A VermeireJean Paul RemonMarie RosseelFrans BelpaireJacques DevulderMarcus Bogaert

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

1997

Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.

LP PANP WIJNANTC DE VRIENDTMarie RosseelFrans Belpaire

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics and effects of drugs during shock and resuscitation

Peter De PaepeFrans BelpaireWalter Buylaert

A2 Journal Article in PERIODICUM BIOLOGORUM

1996

Cytochrome P450: Genetic polymorphism and drug interactions.

Frans BelpaireMarcus Bogaert

A1 Journal Article in ACTA CLINICA BELGICA

Direct high-performance liquid chromatography determination of diastereomeric oxprenolol glucuronides.

Martine LaethemFrans BelpaireMarcus Bogaert

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS

Enantioselectieve farmacokinetiek van cardiovasculaire geneesmiddelen : speciesverschillen en invloed van inflammatie

Martine LaethemFrans BelpaireMarc Bogaert

Hepatotoxicity of N,N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61

Walter BuylaertPaul CallePeter De PaepeA VERSTRAETEN SAMYNDirk VogelaersM VANDENBULCKEFrans Belpaire

A2 Journal Article in HUMAN & EXPERIMENTAL TOXICOLOGY

Hepatotoxicity of N,N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61

Walter BuylaertPaul CalleP DEPAEPEAlain VerstraeteN SAMYNDirk VogelaersM VANDENBULCKEFrans Belpaire

A1 Journal Article in HUMAN & EXPERIMENTAL TOXICOLOGY

High performance liquid chromatography determination of dextromethorphan and its metabolites in urine using solid-phase extraction.

RA BARTOLETTIFrans BelpaireMarie Rosseel

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The fate of xenobiotics in living organisms

Frans BelpaireMarcus Bogaert

Bookchapter in The practice of medicinal chemistry

1995

Determination of dextromethorphan and its metabolites in urine by high-performance liquid chromatography using solid-phase extraction

Marie RosseelRA BartolettiFrans Belpaire

A2 Journal Article in J. Pharm. belg., 50, 387

Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit.

Martine LaethemFrans BelpaireP WijnantMarcus Bogaert

A1 Journal Article in PHARMACEUTICAL RESEARCH

Influence of endotoxin on the enantioselective disposition of drugs in different species

Martine LaethemP WijnantFrans BelpaireMG Bogaert

Pharmacokinetics and electroencephalographic effects of etomidate in the rat

Peter De PaepeG Van HoeyFrans BelpaireMarie RosseelPaul BoonW Buylaert

Protein binding of propranolol and verapamil enantiomers in maternal and foetal serum.

Frans BelpairePascal WijnantP VANTRAPPENMarc DhontAlain VerstraeteMarcus Bogaert

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Severe diltiazem poisoning with intestinal pseudo-obstruction: case report and toxicological data

JP FauvilleP HantsonP HonoréFrans BelpaireMarie RosseelP Mahieu

A2 Journal Article in Clin, toxicol., 33, 273-277

SEVERE DILTIAZEM POISONING WITH INTESTINAL PSEUDOOBSTRUCTION - CASE-REPORT AND TOXICOLOGICAL DATA.

JP FAUVILLEP HANTSONP HONOREFrans BelpaireMarie RosseelP MAHIEU

A1 Journal Article in Journal of toxicology. Clinical toxicology

Stereoselective pharmacokinetics of oxprenolol and its glucoronides

Martine LaethemRomain LefebvreFrans BelpaireP WijnantMarcus Bogaert

A2 Journal Article in JOURNAL OF CLINICAL PHARMACOLOGY

STEREOSELECTIVE PHARMACOKINETICS OF OXPRENOLOL AND ITS GLUCURONIDES IN HUMANS.

Martine LaethemRomain LefebvreFrans BelpaireHL VanhoeMarcus Bogaert

A1 Journal Article in CLINICAL PHARMACOLOGY & THERAPEUTICS

Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil : species differences and influence of endotoxin

Martine LaethemFrans BelpairePascal WijnantMarcus Bogaert

A1 Journal Article in CHIRALITY

1994

Enantioselective inhibitory effect of nicardipine on the hepatic-clearance of propranolol in man.

I VERCRUYSSEFrans BelpaireP WYNANTDL MASSARTAG DUPONT

A1 Journal Article in CHIRALITY

Influence of endotoxin on the stereoselective pharmacokinetics of oxpre-nolol, propranolol, and verapamil in the rat.

Martine LaethemFrans BelpairePascal WijnantMarie RosseelMarcus Bogaert

A1 Journal Article in CHIRALITY

Metabolism and hepatotoxicity of N,N-dimethyl-formamide, N-hydroxymethyl-N-methyl-formamide, and N-methylformamide in the rat.

M VANDENBULCKEMarie RosseelP WIJNANTSWalter BuylaertFrans Belpaire

A1 Journal Article in ARCHIVES OF TOXICOLOGY

The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes

I VercruysseAn VermeulenFrans BelpaireDL MassartAG Dupont

A1 Journal Article in FUNDAMENTAL & CLINICAL PHARMACOLOGY

1993

Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat

An VermeulenFrans BelpaireFrits De SmetIsabelle VercruysseMarcus Bogaert

A1 Journal Article in JOURNALS OF GERONTOLOGY

Chiral high-performance liquid Chromatographie determination of oxprenolol in plasma.

Martine LaethemMarie RosseelP WIJNANTFrans Belpaire

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS

Influence of human recombinant interleukin-1ß on the enantioselective disposition of propranolol in rats

An VermeulenFrans BelpaireFrits De SmetMarcus Bogaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Pharmacokinetics of antibiotics against Gram-negatives infections in CAPD

Norbert LameireFrans Belpaire

SIMULTANEOUS DETERMINATION OF N,N-DIMETHYLFORMAMIDE, N-MONOMETHYLFORMAMIDE AND N-HYDROXYMETHYL-N-METHYLFORMAMIDE IN RAT PLASMA BY CAPILLARY GAS-CHROMATOGRAPHY.

Marie RosseelFrans BelpaireN SAMIJNP WIJNANT

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS

Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure

Frans BelpaireMarie RosseelAn VermeulenFrits de SmetMarcus Bogaert

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

1992

Anticholinesterase poisoning : an overview of pharmacotherapy

Jan WillemsFrans Belpaire

Bookchapter in Clinical and experimental toxicology of organophosphates and carbamates

Effect of interleukin 1-beta on enantioselective protein binding and pharmacokinetics of propanolol in the rat

Frans BelpaireA VermeulenFrits de SmetMarcus Bogaert

A2 Journal Article in Abstr. Intern. Symp. Blood Binding and drug Transfer, Basel, Switzerland, september 18-19, 1992. Intern. J. Clin. Pharmacol. Ther. To xicol., 30, 296

Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat

An VermeulenFrans BelpaireFrits de SmetMarie RosseelMarcus Bogaert

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Inhibition of the metabolism of propranolol by nicardipine in rats: an in vitro study

I VercruysseAn VermeulenFrans BelpaireDL MassartAG Dupont

Liquid chromatographic determination of oxytetracycline in bovine plasma by double-phase extraction

Hans NelisJ VANDENBRANDENAart de KruifFrans BelpaireAndreas De Leenheer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Plasma concentrations of pralidoxine methylsulphate in organophosphorus poisoned patients.

Jan WillemsJP LANGENBERGAlain VerstraeteM DELOOSEB VANHAESEBROECKG GOETHALSFrans BelpaireWalter BuylaertDirk VogelaersFrancis Colardyn

A1 Journal Article in ARCHIVES OF TOXICOLOGY

The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat

An VermeulenFrans BelpaireEmmanuel MoermanFrits De SmetMarcus Bogaert

A1 Journal Article in CHIRALITY

1991

Comparison of the bioavailability of two slow release preparations of disopyramide

Marcus BogaertFrans BelpaireG De WildeRomain Lefebvre

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Drug distribution in relation to drug-drug interactions

Frans BelpaireMarcus Bogaert

Enantioselective pharmacokinetics of propranolol in the rat: marked differences between rat and man

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

High-performance liquid chromatographic method for the simultaneous determination of R-(−)- and S-(+)-hexobarbital in rat plasma

An VermeulenMarie RosseelFrans Belpaire

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS

Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate

Marie RosseelAn VermeulenFrans Belpaire

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS

Species differences in protein binding

The enantiomeric distribution of propranolol is not influenced by its ß-blocking activity

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACOLOGY

The influence of aging on the stereoselective pharmacokinetics and the metabolism of metoprolol in the rat

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

1990

Effect of aging on the pharmacokinetics of atenolol, metoprolol and propranolol in the rat

Frans BelpaireFrits De SmetLJ VynckierAn VermeulenMarie RosseelMarcus BogaertL Chauvelot-Moachon

A1 Journal Article in JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stereoselective pharmacokinetics of propranolol in the rat

An VermeulenFrans BelpaireE MoermanMT RosseelFrits De SmetMarcus Bogaert

Stereoselectivity of plasma protein binding and its pharmacokinetic consequences

Frans BelpaireAn VermeulenMarcus Bogaert

1988

Influence of food on steady state serum concentrations of theophylline from two controlled release preparations

Romain LefebvreFrans BelpaireMarcus Bogaert

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

1981

Non-interaction of cimetidine with digoxin absorption

Luc JordaensJacques HoegaertsFrans Belpaire

A1 Journal Article in ACTA CLINICA BELGICA

1980

Analysis of fluorouracil in human plasma by combined gas-liquid chromatography mass spectrometry

Marie-Claire Cosyns-DuyckAnnie AM CruylAndreas De LeenheerAndré De SchryverJohn HuysFrans Belpaire

A1 Journal Article in BIOMEDICAL MASS SPECTROMETRY

Bioavailability of bromhexine in the horse

P De BackerLMR Vandecasteele-ThienpontJAA JonckheereFrans BelpaireM DebackereAndreas De Leenheer

A1 Journal Article in ZENTRALBLATT FUR VETERINARMEDIZIN REIHE A

Identification and quantitation of 5-fluorouridine in rat urine after administration of 5-fluorouracil or 5-fluoro-2'-deoxyuridine

CF GelijkensPatrick SandraFrans BelpaireAndreas De Leenheer

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Pharmacokinetics of bromhexine in the dog

LMR Vandecasteele-ThienpontFrans BelpaireRA BraeckmanAndreas De Leenheer

A1 Journal Article in ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH

Selected ion monitoring assay for bromhexine in biological-fluids

JAA JonckheereLinda ThienpontAndreas De LeenheerPatrick De BackerMichel DebackereFrans Belpaire

A1 Journal Article in BIOMEDICAL MASS SPECTROMETRY

CGC simultaneous determination of N,N-dimethylformamide, N-monomethylformamide and N-hydroxymethyl-N-mcthylformamide in rat plasma. Proc. 15th Int. Symp. Capillary Chromatography, Riva del Garda, Italy, May 24-27, 1993, Vol. I, pp. 714-720.

Marie RosseelFrans BelpaireM VANDEN BULCKEP WUNANT