Research Explorer

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Researcher

Emily De Lombaerde

Publications & Research Data

Awards & Distinctions

10 Results

2025

Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye

Weiran LiHelena VanlucheneLaura RaesKaren PeynshaertLiene VeysSofía González HernándezEmily De LombaerdeBruno De GeestNiek SandersLieve Moons et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim Deswarte et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2024

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting YeZifu ZhongFederica CappellessoKim DeswarteYong ChenHeleen LauwersEmily De LombaerdeMark GontsarikStefan LienenklausDorien Van Lysebetten et al.

A1 Journal Article in BIOMATERIALS

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

2023

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Alexander LamootJoris LammensEmily De LombaerdeZifu ZhongMark GontsarikYong ChenThomas De BeerBruno De Geest

A1 Journal Article in BIOMATERIALS SCIENCE

Synthesis and evaluation of ionizable lipids for lipid nanoparticle mediated RNA delivery

Emily De LombaerdeBruno De Geest

2021

Delivery routes matter : safety and efficacy of intratumoral immunotherapy

Emily De LombaerdeOlivier De WeverBruno De Geest

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER