Research Explorer

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Researcher

Elke Bogaert

Awards & Distinctions

36 Results

2025

Myopathic aggregation-prone variants in the TDP-43 prion-like domain: genetics paving the way.

Pedro Ervilha PereiraJan De BleeckerElke BogaertBart Dermaut

U Journal Article in Brain : a journal of neurology

2024

Haploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability

Maria del Rocio Pérez BacaEva JacobsLies VantommePontus LeBlancElke BogaertAnnelies DheedeneLaurenz De CockSadegheh HaghshenasAidin ForoutanMichael A Levy et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene causes a novel neurodevelopmental disorder

Maria del Rocio Pérez BacaMaria PalomaresMichiel VanhooydonckEva D'haeneEva Z. JacobsLies VantommeFernando Santos-SimarroRoser Lleuger-PujolSixto García-MiñaúrItsaso Losantos-García et al.

Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene causes a novel neurodevelopmental disorder

Maria del Rocio Pérez BacaMaria PalomaresMichiel VanhooydonckEva D'haeneEva JacobsLies VantommeFernando Santos-SimarroRoser Lleuger-PujolSixto García-MiñáurItsaso Losantos-García et al.

Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene underlies a neurodevelopmental disorder

Maria del Rocio Pérez BacaMaría Palomares BraloMichiel VanhooydonckLisa HamerlinckEva D'haeneSebastian LeimbacherEva JacobsLaurenz De CockErika D'haenensAnnelies Dheedene et al.

Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene underlies a neurodevelopmental disorder

Maria del Rocio Pérez BacaMaria Palomares BraloMichiel VanhooydonckLisa HamerlinckEva D'haeneSebastian LeimbacherEva JacobsLaurenz De CockErika D'haenensZoë Malfait et al.

2023

C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD

Pedro Ervilha PereiraNika SchuermansAntoon MeylemansPontus LeBlancLauren VersluysKE CopleyJD RubienC AltheimerMyra PeetermansElke Debackere et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

Exome sequencing and multigene panel testing in 1,411 patients with adult-onset neurologic disorders

Nika SchuermansHannah VerdinJody GhijselsMadeleine HellemansElke DebackereElke BogaertSofie SymoensLeslie NaesensElien LecomteDavid Crosiers et al.

A1 Journal Article in NEUROLOGY-GENETICS

Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling

Nika SchuermansSalima El ChehadehDimitri HemelsoetJérémie GautheronMarie-Christine VantyghemSonia NouiouaMeriem TazirCorinne VigourouxMartine AuclairElke Bogaert et al.

A1 Journal Article in NATURE GENETICS

SRSF1 haploinsufficiency is responsible for a syndromic developmental disorder associated with intellectual disability

Elke BogaertAurore GardeThierry GautierKathleen RooneyYannis DuffourdPontus LeBlancEmma Van ReemptsFrederic Tran Mau-ThemIngrid M. WentzensenKit Sing Au et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism : possible implication for Alzheimer's disease

M DenechaudSarah GeursT ComptdaerS BégardA Garcia-NúñezLA PechereauT BouilletY VermeirenPP De DeynR Perbet et al.

A1 Journal Article in PROGRESS IN NEUROBIOLOGY

2022

A novel neurodevelopmental syndrome caused by loss-of-function of the Zinc Finger Homeobox 3 (ZFHX3) gene

Maria del Rocio Pérez BacaEva JacobsLies VantommePontus LeBlancElke BogaertAnnelies DheedeneLaurenz De CockBart DermautAidin ForoutanJennifer Kerkhof et al.

A structural variant of the C-terminal prion-like domain of TDP-43 causes vacuolar muscle degeneration

Pedro Ervilha PereiraNika SchuermansAntoon MeylemansPontus LeBlancL VersluysElke DebackereOlivier VanakkerSara JanssensJonathan BaetsK Verhoeven et al.

Expanding the TDP-43 proteinopathy pathway from neurons to muscle : physiological and pathophysiological functions

Lauren VersluysPedro Ervilha PereiraNika SchuermansBoel De PaepeJan De BleeckerElke BogaertBart Dermaut

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Lipodystrophy due to genetic deficiency of picornavirus host factor and obesity regulator PLAAT3

Nika SchuermansSalima El ChehadehDimitri HemelsoetElke BogaertElke DebackerePascale HilbertNike Van DoninckMarie-Caroline TaquetToon RosseelGriet De Clercq et al.

Shortcutting the diagnostic odyssey : the multidisciplinary program for undiagnosed rare diseases in adults (UD-PrOZA)

Nika SchuermansDimitri HemelsoetWim TerrynSanne SteyaertRudy Van CosterPaul CouckeWouter SteyaertBert CallewaertElke BogaertPatrick Verloo et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

2018

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

B SwinnenA Bento-AbreuTF GendronS BoeynaemsElke BogaertR NuytsM TimmersW ScheveneelsN HersmusJ Wang et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins

J SteyaertW ScheveneelsJ VannesteP Van DammeW RobberechtP CallaertsElke BogaertL Van Den Bosch

A1 Journal Article in HUMAN MOLECULAR GENETICS

Molecular dissection of FUS points at synergistic effect of low-complexity domains in toxicity

Elke BogaertS BoeynaemsM KatoL GuoTR CaulfieldJ SteyaertW ScheveneelsN WilmansW HaeckN Hersmus et al.

A1 Journal Article in CELL REPORTS

2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

Steven BoeynaemsElke BogaertDenes KovacsAlbert KonijnenbergEvy TimmermanAlex VolkovMainak GuharoyMathias De DeckerTom JaspersVeronica H. Ryan et al.

U Journal Article in Molecular Cell

Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics

Steven BoeynaemsElke BogaertDenes KovacsAlbert KonijnenbergEvy TimmermanAlex VolkovMainak GuharoyMathias De DeckerTom JaspersVeronica H Ryan et al.

A1 Journal Article in MOLECULAR CELL

2016

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD

S BoeynaemsElke BogaertE MichielsI GijselinckAnne SiebenA JovičićG De BaetsW ScheveneelsJ SteyaertI Cuijt et al.

A1 Journal Article in SCIENTIFIC REPORTS

Inside out : the role of nucleocytoplasmic transport in ALS and FTLD

S BoeynaemsElke BogaertP Van DammeL Van Den Bosch

A1 Journal Article in ACTA NEUROPATHOLOGICA

2015

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

A JovičićJ MertensS BoeynaemsElke BogaertN ChaiSB YamadaJW PaulS SunJR HerdyG Bieri et al.

A1 Journal Article in NATURE NEUROSCIENCE

2012

HDAC6 at the intersection of neuroprotection and neurodegeneration

Constantin d'YdewalleElke BogaertLudo Van Den Bosch

A1 Journal Article in TRAFFIC

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice

KA StaatsElke BogaertN HersmusT JaspersT LuytenG BultynckJB ParysC HisatsuneK MikoshibaP Van Damme et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis

Elke BogaertA GorisP Van DammeV GeelenR LemmensMA van EsLH van den BergK SleegersN VerpoortenV Timmerman et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

2011

G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production

E CousseeP De SmetElke BogaertI ElensP Van DammeP WillemsW KoopmanL Van Den BoschG Callewaert

A1 Journal Article in CELL CALCIUM

2010

Amyotrophic lateral sclerosis and excitotoxicity : from pathological mechanism to therapeutic target

Elke BogaertC. d'YdewalleL. Van Den Bosch

A1 Journal Article in CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS

VEGF protects motor neurons against excitotoxicity by upregulation of GluR2

Elke BogaertPhilip Van DammeKoen PoesenJoke DhondtNicole HersmusDora KiralyWendy ScheveneelsWim RobberechtLudo Van Den Bosch

A1 Journal Article in NEUROBIOLOGY OF AGING

2009

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

M BanA GorisAR LorentzenA BakerT MihalovaG IngramDR BoothRN HeardGJ StewartElke Bogaert et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

2008

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration

Koen PoesenDiether LambrechtsPhilip Van DammeJoke DhondtFlorian BenderNicolas FrankElke BogaertBart ClaesLine HeylenAn Verheyen et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Philip Van DammeAnnelies Van HoeckeDiether LambrechtsPeter VanackerElke BogaertJohn van SwietenPeter CarmelietLudo Van Den BoschWim Robberecht

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2007

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

P Van DammeElke BogaertM DewilN HersmusD KiralyW ScheveneelsI BockxD BraekenN VerpoortenK Verhoeven et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2006

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis

L. Van Den BoschP. Van DammeElke BogaertW. Robberecht

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases

Elke BogaertP Van DammeL Van Den BoschW Robberecht

A1 Journal Article in MUSCLE & NERVE