Research Explorer

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Researcher

Elien Van Wonterghem

Publications & Research Data

Awards & Distinctions

51 Results

2026

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

Daan VerhaegeClint De NolfLore Van AckerWouter ClaeysJonas CasteleinElien Van WonterghemGriet Van ImschootPieter DujardinWard De SpiegelaereEsther Hoste et al.

A1 Journal Article in NATURE NEUROSCIENCE

Systemic inflammation modulates clearance and drives extra-hepatic distribution of extracellular vesicles

Svetlana PavlovaDoste R. MamandAndre GorgensAntje M. ZicklerWenyi ZhengXiuming LiangOscar P. B. WiklanderManuchehr Abedi-ValugerdiElien Van WonterghemJunhua Xie et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2025

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Xiuming LiangDhanu GuptaJunhua XieElien Van WonterghemLien Van HoeckeJustin HeanZheyu NiuMarziyeh GhaeidaminiOscar P. B. WiklanderWenyi Zheng et al.

A1 Journal Article in NATURE COMMUNICATIONS

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Junhua XieMarlies BurgelmanPieter DujardinJonas CasteleinGriet Van ImschootElien Van WonterghemHannah LernoutSjoerd SchettersCharysse VandendriesscheLien Van Hoecke et al.

A1 Journal Article in FLUIDS AND BARRIERS OF THE CNS

The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles

Junhua XieLien Van HoeckeElien Van WonterghemGriet Van ImschootVanessa AndriesLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in GUT MICROBES

2024

An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology

Lien Van HoeckeJonas CasteleinJunhua XieLore Van AckerGriet Van ImschootElien Van WonterghemIne VlaeminckDaan VerhaegeWouter ClaeysKeimpe Wierda et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Challenging the conventional wisdom : re-evaluating smpd3's role in extracellular vesicle biogenesis

Marlies BurgelmanPieter DujardinAnthony WillemsTino HochepiedGriet Van ImschootElien Van WonterghemLien Van HoeckeCharysse VandendriesscheRoosmarijn Vandenbroucke

A2 Journal Article in JOURNAL OF EXTRACELLULAR BIOLOGY

High-precision K isotopic analysis of cerebrospinal fluid and blood serum microsamples via multicollector inductively coupled plasma-mass spectrometry equipped with 1013 Ω faraday cup amplifier resistors

Kasper HobinMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in ANALYTICA CHIMICA ACTA

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis

Femke Van GaeverFleur MingneauSam VanherleYasmine DriegeMira HaegmanElien Van WonterghemJunhua XieRoosmarijn VandenbrouckeJerome J. A. HendriksRudi Beyaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The spreading and effects of human recombinant α-synuclein preformed fibrils in the cerebrospinal fluid of mice

Charysse VandendriesscheArnout BruggemanJoyce ForoozandehLien Van HoeckePieter DujardinJunhua XieGriet Van ImschootElien Van WonterghemJonas CasteleinCristiano Lucci et al.

A1 Journal Article in ENEURO

2023

Alzheimer's disease and age-related changes in the Cu isotopic composition of blood plasma and brain tissues of the APP^(NL-G-F) murine model revealed by multi-collector ICP-mass spectrometry

Kasper HobinMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in BIOLOGY-BASEL

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

Wouter ClaeysLien Van HoeckeHannah LernoutClint De NolfGriet Van ImschootElien Van WonterghemDaan VerhaegeJonas CasteleinAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology

Junhua XieArnout BruggemanClint De NolfCharysse VandendriesscheGriet Van ImschootElien Van WonterghemLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in EMBO JOURNAL

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua XieLien CoolsGriet Van ImschootElien Van WonterghemMarie PauwelsIne VlaeminckChloë De WitteSamir EL AndaloussiKeimpe WierdaLies De Groef et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation

Wouter ClaeysDaan VerhaegeGriet Van ImschootElien Van WonterghemLore Van AckerLaura AmelinckFederico Francesco De PontiCharlotte ScottAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Lidia YshiiEmanuela PasciutoPascal BielefeldLoriana MascaliPierre LemaitreMarika MarinoJames DooleyLubna KouserStijn VerschorenVasiliki Lagou et al.

A1 Journal Article in NATURE IMMUNOLOGY

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

High-precision isotopic analysis of Cu and Fe via multi-collector inductively coupled plasma-mass spectrometry reveals lipopolysaccharide-induced inflammatory effects in blood plasma and brain tissues

Kasper HobinMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in FRONTIERS IN CHEMISTRY

Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus

Elien Van WonterghemLien Van HoeckeGriet Van ImschootDaan VerhaegeMarlies BurgelmanRoosmarijn Vandenbroucke

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

2021

Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease

Lien Van HoeckeCaroline Van CauwenbergheVerena BoergerArnout BruggemanJonas CasteleinGriet Van ImschootElien Van WonterghemRobin DittrichWouter ClaeysJunhua Xie et al.

A1 Journal Article in BIOMEDICINES

Effect of endotoxemia induced by intraperitoneal injection of lipopolysaccharide on the Mg isotopic composition of biofluids and tissues in mice

Rosa GrigoryanMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in FRONTIERS IN MEDICINE

Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model

Helena BerlamontArnout BruggemanEva BauwensCharysse VandendriesscheElien ClareboutJunhua XieSofie De BruyckereGriet Van ImschootElien Van WonterghemRichard Ducatelle et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

Charysse VandendriesscheSriram BalusuCaroline Van CauwenbergheMarjana BrkićMarie PauwelsNele PlehiersArnout BruggemanPieter DujardinGriet Van ImschootElien Van Wonterghem et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C

Lien Van HoeckeCaroline Van CauwenbergheKristina DominkoGriet Van ImschootElien Van WonterghemJonas CasteleinJunhua XieWouter ClaeysCharysse VandendriesscheAnna Kremer et al.

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

2020

A murine model of hepatic encephalopathy : validation and neurobehavioral testing

Wouter ClaeysAnja GeertsSander LefereHans Van VlierbergheGriet Van ImschootElien Van WonterghemRoosmarijn VandenbrouckeChristophe Van Steenkiste

Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury

Evy LefevereManuel Salinas-NavarroLien AndriesLut NoterdaemeIsabelle EtienneElien Van WonterghemStefan VinckierBenjamin M. DavisTine Van BergenInge Van Hove et al.

A1 Journal Article in GLIA

2019

A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice

Jolien VandewalleSophie SteelandSara Van RyckeghemMelanie EggermontElien Van WonterghemRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2018

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease

Sophie SteelandNina GorléCharysse VandendriesscheSriram BalusuMarjana BrkićCaroline Van CauwenbergheGriet Van ImschootElien Van WonterghemRiet De RyckeAnna Kremer et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis

Sophie SteelandSara Van RyckeghemJolien VandewalleMarlies BallegeerElien Van WonterghemMelanie EggermontJohan DecruyenaereLiesbet De BusClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CRITICAL CARE MEDICINE

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

Nina GorléCaroline BlaecherEva BauwensCharysse VandendriesscheSriram BalusuJolien VandewalleCaroline Van CauwenbergheElien Van WonterghemGriet Van ImschootCheng Liu et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2016

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stephan StremerschRoosmarijn VandenbrouckeElien Van WonterghemAn HendrixStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Sriram BalusuElien Van WonterghemRiet De RyckeKoen RaemdonckStephan StremerschKris GevaertMarjana BrkićDelphine DemeestereValerie VanhoorenAn Hendrix et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

Ranhua XiongRoosmarijn VandenbrouckeKatleen BroosToon BransElien Van WonterghemClaude LibertJo DemeesterStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation

Sonja M KesslerStephan LaggaiElien Van WonterghemKatja GemperleinRolf MüllerJohannes HaybaeckRoosmarijn VandenbrouckeManfred OgrisClaude LibertAlexandra K Kiemer

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

2015

Amyloid β oligomers disrupt blood-CSF barrier integrity by activating matrix metalloproteinases

Marjana BrkićSriram BalusuElien Van WonterghemNina GorléIryna BenilovaAnna KremerInge Van HoveLieve MoonsBart De StrooperSelma Kanazir et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain

Steven TimmermansFilip Van HauwermeirenLeen PuimègeLien DejagerElien Van WonterghemValerie VanhoorenPieter MestdaghClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

Tatyana SklyarovaJolanda van HengelElien Van WonterghemClaude LibertFrans Van RoyRoosmarijn Vandenbroucke

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo

J AertsRoosmarijn VandenbrouckeR DeraSriram BalusuElien Van WonterghemL MoonsClaude LibertW DehaenL Arckens

A1 Journal Article in MEDIATORS OF INFLAMMATION

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineSofie LodensElien Van WonterghemRiet De RyckeN De GeestB HassanClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

2014

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineLeen PuimègeElien Van WonterghemHong ZhangClaude Libert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis

Lien DejagerSofie VandevyverMarlies BallegeerElien Van WonterghemLing-Ling AnJeffrey RiggsRoland KolbeckClaude Libert

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

Roosmarijn VandenbrouckeIneke VanlaereFilip Van HauwermeirenElien Van WonterghemC WilsonClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2013

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Roosmarijn VandenbrouckeEline DejonckheereFilip Van HauwermeirenSofie LodensRiet De RyckeElien Van WonterghemAn StaesKris GevaertCarlos López-OtinClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2012

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE