Research Explorer

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Researcher

Dorien De Vlieger

Awards & Distinctions

13 Results

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

2020

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Robbert BoudewijnsHendrik Jan ThibautSuzanne J. F. KapteinRong LiValentijn VergoteLaura SeldeslachtsJohan Van WeyenberghCarolien De KeyzerLindsey BervoetsSapna Sharma et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Poehlmann et al.

A1 Journal Article in CELL

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Pohlmann et al.

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection

Dorien De VliegerKatja HoffmannInge Van MolleWim NerinckxLien Van HoeckeMarlies BallegeerSarah CreytensHan RemautHartmut HengelBert Schepens et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Single domain-based antivirals to combat viral infections

Dorien De VliegerXavier SaelensBert Schepens

2018

Single-domain antibodies and their formatting to combat viral infections

Dorien De VliegerMarlies BallegeerIebe RosseyBert SchepensXavier Saelens

A2 Journal Article in ANTIBODIES

Vaccine options for influenza : thinking small

Bert SchepensDorien De VliegerXavier Saelens

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

2017

Chemical-controlled activation of antiviral myxovirus resistance protein 1

Judith VerhelstLien Van HoeckeJan SpitaelsDorien De VliegerAnnasaheb KolpeXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2015

Co-immunoprecipitation of the mouse Mx1 protein with the influenza A virus nucleoprotein

Judith VerhelstDorien De VliegerXavier Saelens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Comparison of the antiviral activity of Mus spretus Mx1 and Mus musculus A2G Mx1 against influenza A viruses

Judith VerhelstJan SpitaelsCindy NürnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalther FiersXavier Saelens

Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses

Judith VerhelstJan SpitaelsCindy NurnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY