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Researcher
Bruno De Geest
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
294
Results
2025
A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity
Zifu Zhong
Marie Deventer
Yong Chen
Stijn Vanhee
Inés Lammens
Kim Deswarte
Yi Huang
Tingting Ye
Haixiu Wang
Lutz Nuhn
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2025
A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells
Justine Aelvoet
Zifu Zhong
Claudia Mariela Brenis Gómez
Helena Catharine Aegerter
Benoit Louage
Bart Lambrecht
Bruno De Geest
Martijn Schuijs
A1
Journal Article
in
ADVANCED MATERIALS
2025
Cell-specific mRNA delivery via nanobody-functionalized lipid nanoparticles
Linglong Chen
Hans Van Der Weken
Olivier Zwaenepoel
Irina Okkelman
Justine Aelvoet
Emma Van Denberghe
Jan Gettemans
Ruslan Dmitriev
Bruno De Geest
Eric Cox
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2025
Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation
Bianka Golba
Irene De Franceschi
Zifu Zhong
Martijn Schuijs
Claudia Mariela Brenis Gómez
Heleen Lauwers
Benoit Louage
Iasona Sheshi
Nezha Badi
Bruno De Geest
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2025
Development of tailored indole-blocked triazolinediones for site-selective bioconjugation
Elias Denijs
Johan Winne
Bruno De Geest
Dissertation
2025
Dual lipid modulation overcomes ferroptosis resistance in high-risk neuroblastoma
Ine Koeken
Magali Walravens
Roberto Fernández-Acosta
Ruben Van Hoyweghen
Iuliana Vintea
Yingyi Kong
Bianka Golba
Jonas Dehairs
Ali Talebi
Johannes V. Swinnen
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2025
Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist
Hanne Verschuere
Sabah Kasmi
Lutz Nuhn
Sènan Mickaël D'Almeida
Qiwen Zhu
Zifu Zhong
Sandy Adjemian Catani
Benoit Louage
Jana De Vrieze
Haijun Yu
et al.
A1
Journal Article
in
RSC ADVANCES
2025
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Sofie Rennen
Victor Bosteels
Clint De Nolf
Greta Webb
Karo Van Lil
Sandra Maréchal
Jessica Vetters
Evelien Van De Velde
Farzaneh Fayazpour
Ria Roelandt
et al.
Preprint
2025
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Sofie Rennen
Victor Bosteels
Clint De Nolf
Sandra Maréchal
Jessica Vetters
Karo Van Lil
Greta Webb
Janne Swinnen
Evelien Van De Velde
Farzaneh Fayazpour
et al.
A1
Journal Article
in
CELL REPORTS
2025
Poly(2-Hydroxymethyl-2-Oxazoline) as Super-Hydrophilic Antifouling Polymer
Somdeb Jana
Milan Roels
Meike N. Leiske
Yann Bernhard
Bruno De Geest
Kristof Van Hecke
Richard Hoogenboom
U
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2025
Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo
Yong Chen
Emily De Lombaerde
Aimee-Rose Bugler-Lamb
Zifu Zhong
Martijn Schuijs
Claudia Mariela Brenis Gómez
Jamie De Baere
Mark Gontsarik
Heleen Lauwers
Kim Deswarte
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2025
2024
Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation
Emily De Lombaerde
Xiaole Cui
Yong Chen
Zifu Zhong
Julie Deckers
Giulia Mencarelli
Lisa Opsomer
Haixiu Wang
Jamie De Baere
Stefan Lienenklaus
et al.
A1
Journal Article
in
ACS NANO
2024
CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity
Tingting Ye
Zifu Zhong
Federica Cappellesso
Kim Deswarte
Yong Chen
Heleen Lauwers
Emily De Lombaerde
Mark Gontsarik
Stefan Lienenklaus
Dorien Van Lysebetten
et al.
A1
Journal Article
in
BIOMATERIALS
2024
Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery
Emily De Lombaerde
Yong Chen
Tingting Ye
Julie Deckers
Giulia Mencarelli
Kim Deswarte
Heleen Lauwers
Ruben De Coen
Sabah Kasmi
Sanne Bevers
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2024
Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo
Yong Chen
Zihan Xia
Ujjwal Suwal
Pekka Rappu
Jyrki Heino
Olivier De Wever
Bruno De Geest
A1
Journal Article
in
CHEMICAL SCIENCE
2024
HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells
Weiwei Mu
Yong Chen
Zifu Zhong
Benoit Louage
Heleen Lauwers
Nick Devoogdt
Jurgen Haustraete
Bruno De Geest
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2024
Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice
Sonia Jangra
Alexander Lamoot
Gagandeep Singh
Gabriel Laghlali
Yong Chen
Tingting Ye
Adolfo García-Sastre
Bruno De Geest
Michael Schotsaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2024
Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity
Alexander Lamoot
Sonia Jangra
Gabriel Laghlali
Prajakta Warang
Lauren A. Chang
Seok‐Chan Park
Gagandeep Singh
Kim Deswarte
Zifu Zhong
Benoit Louage
et al.
A1
Journal Article
in
SMALL
2024
Lipid nanoparticle formulation strategies for peptide-based cancer vaccines
Tingting Ye
Bruno De Geest
Dissertation
2024
Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds
Benoit Louage
Demi Defreyne
Heleen Lauwers
Jamie De Baere
Annemiek Uvyn
Haixia Peng
Yong Chen
Bruno De Geest
A1
Journal Article
in
BIOMACROMOLECULES
2024
Multivalent antibody-recruiting molecules : a novel anti-tumor therapy strategy harnessing the immune response
Haixia Peng
Bruno De Geest
Dissertation
2024
PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups
Alina G. Heck
Carolina Medina-Montano
Zifu Zhong
Kim Deswarte
Katharina Eigen
Judith Stickdorn
Johannes Kockelmann
Maximilian Scherger
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2024
Relevance of controlled cooling and freezing phases in T-cell cryopreservation
Gust Nuytten
Bruno De Geest
Thomas De Beer
A1
Journal Article
in
CRYOBIOLOGY
2024
Synthesis and evaluation of TLR7/8 and STING agonist conjugates of tumor-targeted cancer immunotherapy
Yi Huang
Bruno De Geest
Dissertation
2024
Thermally triggered triazolinedione-tyrosine bioconjugation with improved chemo- and site-selectivity
Elias Denijs
Kamil Ünal
Kevin Bevernaege
Sabah Kasmi
Bruno De Geest
Johan Winne
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2024
Thermosensitive polymer prodrug nanoparticles prepared by an all-aqueous nanoprecipitation process and application to combination therapy
Léa Guerassimoff
Marianne Ferrere
Simon Van Herck
Samy Dehissi
Valérie Nicolas
Bruno De Geest
Julien Nicolas
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2024
2023
(Macro)molecular strategies for lipid nanoparticles and T cell engineering
Bianka Golba
Bruno De Geest
Dissertation
2023
A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment
Elly De Vlieghere
Koen Van de Vijver
Eva Blondeel
Nathan Carpentier
Rouba Ghobeira
Jarne Pauwels
Sebastian Riemann
Manon Minsart
Charlotte Fieuws
Johanna Mestach
et al.
A1
Journal Article
in
BIOMATERIALS RESEARCH
2023
Amidation of methyl ester-functionalised poly(2-oxazoline)s as a powerful tool to create dual pH- and temperature-responsive polymers as potential drug delivery systems
Meike Leiske
Ronak Singha
Somdeb Jana
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
POLYMER CHEMISTRY
2023
Amphiphilic zwitterionic bioderived block copolymers from glutamic acid and c holesterol : ability to form nanoparticles and serve as vectors for the delivery of 6-mercaptopurine
Meike Leiske
Christopher Kuenneth
Jonas De Breuck
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
MACROMOLECULAR CHEMISTRY AND PHYSICS
2023
Challenges in neoantigen-directed therapeutics
Lien Lybaert
Steve Lefever
Bruno Fant
Evelien Smits
Bruno De Geest
Karine Breckpot
Luc Dirix
Steven A. Feldman
Wim Van Criekinge
Kris Thielemans
et al.
A1
Journal Article
in
CANCER CELL
2023
Design of fluorescent polymeric thermometers based on anthrapyrazolone functionalized oligo(ethylene glycol) methacrylates
S. Saravanan
Anashwara Babu
Ronald Merckx
Zifu Zhong
Mageshwari Anandan
Venkatramaiah Nutalapati
Bruno De Geest
Richard Hoogenboom
Valentin-Victor Jerca
Samarendra Maji
A1
Journal Article
in
MATERIALS CHEMISTRY FRONTIERS
2023
Hapten/myristoyl functionalized poly(propyleneimine) dendrimers as potent cell surface recruiters of antibodies for mediating innate immune killing
Annemiek Uvyn
Marle Elisabeth Jacqueline Vleugels
Bas de Waal
Ahmed Emad Ibrahim Hamouda
Shikha Dhiman
Benoit Louage
Lorenzo Albertazzi
Damya Laoui
E. W. Meijer
Bruno De Geest
A1
Journal Article
in
ADVANCED MATERIALS
2023
Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells
Meike Leiske
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
BIOACTIVE MATERIALS
2023
Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia
Lauren A. Chang
Angela Choi
Raveen Rathnasinghe
Prajakta Warang
Moataz Noureddine
Sonia Jangra
Yong Chen
Bruno De Geest
Michael Schotsaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue
Zifu Zhong
Yong Chen
Kim Deswarte
Heleen Lauwers
Emily De Lombaerde
Xiaole Cui
Simon Van Herck
Tingting Ye
Mark Gontsarik
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2023
LXR signaling controls homeostatic dendritic cell maturation
Victor Bosteels
Sandra Maréchal
Clint De Nolf
Sofie Rennen
Jonathan Maelfait
Simon Tavernier
Jessica Vetters
Evelien Van De Velde
Farzaneh Fayazpour
Kim Deswarte
et al.
A1
Journal Article
in
SCIENCE IMMUNOLOGY
2023
Sequence-defined antibody-recruiting macromolecules
Resat Aksakal
Corentin Tonneaux
Annemiek Uvyn
Mathieu Fossépré
Hatice Turgut
Nezha Badi
Mathieu Surin
Bruno De Geest
Filip Du Prez
A1
Journal Article
in
CHEMICAL SCIENCE
2023
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Helena Braet
Peter-Paul Fransen
Yong Chen
Simon Van Herck
Remco Mariën
Valérie Vanhoorne
Wim Ceelen
Annemieke Madder
Steven Ballet
Richard Hoogenboom
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
Alexander Lamoot
Joris Lammens
Emily De Lombaerde
Zifu Zhong
Mark Gontsarik
Yong Chen
Thomas De Beer
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS SCIENCE
2023
Synthesis and evaluation of ionizable lipids for lipid nanoparticle mediated RNA delivery
Emily De Lombaerde
Bruno De Geest
Dissertation
2023
Towards a rational design of antibody‐recruiting molecules through a computational microscopy view of their interactions with the target antibody
Annemiek Uvyn
Corentin Tonneaux
Mathieu Fossépré
Aude Ouvrier‐Buffet
Bruno De Geest
Mathieu Surin
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2023
Visible light conjugation with triazolinediones as a route to degradable poly(ethylene glycol)-lipids for mRNA lipid nanoparticle formulation
Bianka Golba
Matthieu Soete
Zifu Zhong
Niek Sanders
Filip Du Prez
Hannes Houck
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2023
2022
An intelligent nanovehicle armed with multifunctional navigation for precise delivery of toll‐like receptor 7/8 agonist and immunogenic cell death amplifiers to eliminate solid tumors and trigger durable antitumor immunity
Yanyun Hao
Hui Li
Huajun Zhao
Yutong Liu
Xiaoyan Ge
Xia Li
Hongfei Chen
Ailu Yang
Jing Zou
Xue Li
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2022
Characterization of SARS-CoV-2 spike mutations important for infection of mice and escape from human immune sera
Raveen Rathnasinghe
Sonia Jangra
Chengjin Ye
Anastasija Cupic
Gagandeep Singh
Carles Martínez-Romero
Lubbertus C. F. Mulder
Thomas Kehrer
Soner Yildiz
Angela Choi
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2022
In situ tumor vaccination with calcium‐linked degradable coacervate nanocomplex co‐delivering photosensitizer and TLR7/8 agonist to trigger effective anti‐tumor immune responses
Yutong Liu
Hui Li
Huajun Zhao
Yanyun Hao
Simon Van Herck
Zejun Xu
Guan Wang
Xiao Wang
Xinke Zhang
Xiaoyan Ge
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2022
Lipid nanoparticle formulation of the TLR3 agonist polyI:C as a vaccine adjuvant
Alexander Lamoot
Bruno De Geest
Dissertation
2022
pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages
Leonard Kaps
Anne Huppertsberg
Niklas Choteschovsky
Adrian Klefenz
Feyza Durak
Babara Schrörs
Mustafa Diken
Emma Eichler
Sebastian Rosigkeit
Sascha Schmitt
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2022
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine
Sonia Jangra
Gabriel Laghlali
Angela Choi
Raveen Rathnasinghe
Yong Chen
Soner Yildiz
Lynda Coughlan
Adolfo García-Sastre
Bruno De Geest
Michael Schotsaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
Tumor‐selective activation of Toll‐like receptor 7/8 agonist nano‐immunomodulator generates safe anti‐tumor Immune responses upon systemic administration
Yanyun Hao
Hui Li
Xiaoyan Ge
Yang Liu
Xia Li
Yutong Liu
Hongfei Chen
Shiying Zhang
Jing Zou
Lingling Huang
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2022
2021
Biomaterials applications of cyclic polymers
Bianka Golba
Edmondo M. Benetti
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS
2021
Covalent cell surface conjugation of nanoparticles by a combination of metabolic labeling and click chemistry
Alexander Lamoot
Annemiek Uvyn
Sabah Kasmi
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021
Delivery routes matter : safety and efficacy of intratumoral immunotherapy
Emily De Lombaerde
Olivier De Wever
Bruno De Geest
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
2021
From design to clinic: engineered nanobiomaterials for immune normalization therapy of cancer
Madiha Saeed
Fangming Chen
Jiayi Ye
Yang Shi
Twan Lammers
Bruno De Geest
Zhi Ping Xu
Haijun Yu
A1
Journal Article
in
ADVANCED MATERIALS
2021
Lipid nature and alkyl length influence lymph node accumulation of lipid-polyethylene glycol amphiphiles
Jana De Vrieze
Antonio Pires da Silva Baptista
Lutz Nuhn
Simon Van Herck
Kim Deswarte
Haijun Yu
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
ADVANCED THERAPEUTICS
2021
Lipid-polyglutamate nanoparticle vaccine platform
Dorien Van Lysebetten
Alessio Malfanti
Kim Deswarte
Kaloian Koynov
Bianka Golba
Tingting Ye
Zifu Zhong
Sabah Kasmi
Alexander Lamoot
Yong Chen
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2021
Lipid-polymer conjugates for innate immune activation
Jana De Vrieze
Bruno De Geest
Dissertation
2021
Multivalent antibody recruiting molecules as a novel type of cancer immunotherapy
Annemiek Uvyn
Bruno De Geest
Dissertation
2021
Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables
Edward Geeurickx
Lien Lippens
Pekka Rappu
Bruno De Geest
Olivier De Wever
An Hendrix
A1
Journal Article
in
NATURE PROTOCOLS
2021
Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators
Anne Huppertsberg
Leonard Kaps
Zifu Zhong
Sascha Schmitt
Judith Stickdorn
Kim Deswarte
Francis Combes
Christian Czysch
Jana De Vrieze
Sabah Kasmi
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2021
Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021
2020
Control over imidazoquinoline immune stimulation by pH-degradable poly(norbornene) nanogels
Johannes Kockelmann
Judith Stickdorn
Sabah Kasmi
Jana De Vrieze
Michaela Pieszka
David Yuen W. Ng
Sunil A. David
Bruno De Geest
Lutz Nuhn
A1
Journal Article
in
BIOMACROMOLECULES
2020
Current status of COVID-19 (pre)clinical vaccine development
Tingting Ye
Zifu Zhong
Adolfo Garcia-Sastre
Michael Schotsaert
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020
Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent
Jana De Vrieze
Simon Van Herck
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2020
Design of polymeric carriers for cancer chemo- and immunotherapy
Alexandra Van Driessche
Bruno De Geest
Dissertation
2020
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids
Srinath Govindarajan
Eveline Verheugen
Koen Venken
Djoere Gaublomme
Margaux Maelegheer
Eva Cloots
Fien Gysens
Bruno De Geest
Tan‐Yun Cheng
D Branch Moody
et al.
A1
Journal Article
in
EMBO REPORTS
2020
Feasibility of mechanical extrusion to coat nanoparticles with extracellular vesicle membranes
Jan Van Deun
Quentin Roux
Sarah Deville
Thibaut Van Acker
Pekka Rappu
Ilkka Miinalainen
Jyrki Heino
Frank Vanhaecke
Bruno De Geest
Olivier De Wever
et al.
A1
Journal Article
in
CELLS
2020
Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy
Hui Li
Simon Van Herck
Yongjun Liu
Yanyun Hao
Xiaochu Ding
Lutz Nuhn
Zifu Zhong
Francis Combes
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
ACS BIOMATERIALS SCIENCE & ENGINEERING
2020
Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction
Joeri Tulkens
Glenn Vergauwen
Jan Van Deun
Edward Geeurickx
Bert Dhondt
Lien Lippens
Marie-Angélique De Scheerder
Ilkka Miinalainen
Pekka Rappu
Bruno De Geest
et al.
A1
Journal Article
in
GUT
2020
Multivalent antibody-recruiting macromolecules : linking increased binding affinity with enhanced innate immune killing
Annemiek Uvyn
Bruno De Geest
A1
Journal Article
in
CHEMBIOCHEM
2020
Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics
Simon Van Herck
Bruno De Geest
A1
Journal Article
in
ACTA PHARMACOLOGICA SINICA
2020
Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages
Yann Bernhard
Ondrej Sedlacek
Joachim Van Guyse
Johan Bender
Zifu Zhong
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
BIOMACROMOLECULES
2020
Poly(2-methyl-2-oxazoline) conjugates with doxorubicin : from synthesis of high drug loading water-soluble constructs to in vitro anti-cancer properties
Ondrej Sedlacek
Alexandra Van Driessche
Annemiek Uvyn
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2020
Polymer- and lipid-based nanomaterials and conjugates for cancer therapy
Sabah Kasmi
Bruno De Geest
Dissertation
2020
Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles
Bi Wang
Simon Van Herck
Yong Chen
Xiangyang Bai
Zifu Zhong
Kim Deswarte
Bart Lambrecht
Niek Sanders
Stefan Lienenklaus
Hans W. Scheeren
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2020
Prilling of API/fatty acid suspensions : screening of additives for drug release modification
Elien De Coninck
Valérie Vanhoorne
Matthieu Boone
G Van Assche
Bruno De Geest
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Recombinant DnaK orally administered protects axenic European sea bass against vibriosis
Eamy Nursaliza Yaacob
Parisa Norouzitallab
Bruno De Geest
Aline Bajek
Kristof Dierckens
Peter Bossier
Daisy Vanrompay
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2020
Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
Preprint
2020
Synthetic rhamnose glycopolymer cell-surface receptor for endogenous antibody recruitment
Ruben De Coen
Lutz Nuhn
Chamani Perera
Maria Arista-Romero
Martijn Risseeuw
Alec Freyn
Raffael Nachbagauer
Lorenzo Albertazzi
Serge Van Calenbergh
David A. Spiegel
et al.
A1
Journal Article
in
BIOMACROMOLECULES
2020
Tumor engineered model for low-grade serous ovarian carcinoma (LGSOC) : mimicking the tumor environment on a cellular and biophysical level
Elly De Vlieghere
Eva Blondeel
Wim Ceelen
Bruno De Geest
Geert Berx
Sandra Van Vlierberghe
Olivier De Wever
C3
Conference
2020
Zebrafish embryos allow prediction of nanoparticle circulation times in mice and facilitate quantification of nanoparticle-cell interactions
Nils-Jorgen Knudsen Dal
Agnese Kocere
Jens Wohlmann
Simon Van Herck
Tobias A. Bauer
Julien Resseguier
Shahla Bagherifam
Hilde Hyldmo
Matthias Barz
Bruno De Geest
et al.
A1
Journal Article
in
SMALL
2020
2019
A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window
Zhiyue Zhang
Hui Li
Sabah Kasmi
Simon Van Herck
Kim Deswarte
Bart Lambrecht
Richard Hoogenboom
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells
Annemiek Uvyn
Ruben De Coen
Olivier De Wever
Kim Deswarte
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2019
Design and synthesis of cyclic peptide-bile acid conjugates for improving the therapeutic potential of peptide drugs
Dorien Van Lysebetten
Annemieke Madder
Bruno De Geest
Dissertation
2019
Efficient innate immune killing of cancer cells triggered by cell-surface anchoring of multivalent antibody-recruiting polymers
Annemiek Uvyn
Ruben De Coen
Mandy Gruijs
Cees W. Tuk
Jana De Vrieze
Marjolein van Egmond
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
Interactive polymers for innate immune activation
Simon Van Herck
Bruno De Geest
Dissertation
2019
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
Jana De Vrieze
Benoit Louage
Kim Deswarte
Zifu Zhong
Ruben De Coen
Simon Van Herck
Lutz Nuhn
Camilla Kaas Frich
Alexander N Zelikin
Stefan Lienenklaus
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
Prilling of API/fatty acid suspensions : processability and characterisation
Elien De Coninck
Valérie Vanhoorne
Ahmed Elmahdy
Matthieu Boone
G Van Assche
D Markl
Bruno De Geest
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Synthetic carbohydrate biomaterials for innate immune-engineering
Ruben De Coen
Bruno De Geest
Dissertation
2019
The future of layer-by-layer assembly : a tribute to ACS Nano associate editor Helmuth Möhwald
Shuang Zhao
Frank Caruso
Lars Dähne
Gero Decher
Bruno De Geest
Jinchen Fan
Neus Feliu
Yury Gogotsi
Paula T Hammond
Mark C Hersam
et al.
A1
Journal Article
in
ACS NANO
2019
Tumor engineered model for peritoneal metastasis with controllable stiffness
Elly De Vlieghere
Wim Ceelen
Bruno De Geest
Heidi Declercq
Sandra Van Vlierberghe
Olivier De Wever
C3
Conference
2019
Tumor engineered scaffolds recapitulate a human peritoneal tumor environment at the cellular and biophysical level
Elly De Vlieghere
Wim Ceelen
Bruno De Geest
Heidi Declercq
Sandra Van Vlierberghe
Olivier De Wever
C3
Conference
2019
Tumor engineering a clinical relevant model that recapitulates the tumor environment of peritoneal metastases in vitro and in vivo
Elly De Vlieghere
Emiel De Jaeghere
Glenn Wagemans
Thibaut Van Acker
Christian Vanhove
Sarah Neyts
Geert Berx
Frank Vanhaecke
Wim Ceelen
Bruno De Geest
et al.
C3
Conference
2019
Unexpected reactivity switch in the statistical copolymerization of 2-oxazolines and 2-oxazines enabling the one-step synthesis of amphiphilic gradient copolymers
Ondrej Sedlacek
Kathleen Lava
Bart Verbraeken
Sabah Kasmi
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2019
Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach
Simon Van Herck
Behrouz Hassannia
Benoit Louage
Raquel Pita Compostizo
Ruben De Coen
Wim Vanden Berghe
Tom Vanden Berghe
Bruno De Geest
A1
Journal Article
in
EUROPEAN POLYMER JOURNAL
2019
2018
A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry : from chemical characterization to in vivo biodistribution
Francielle Pelegrin Garcia
Marlène Rippe
Mychelle VP Companhoni
Talitha Fernandes Stefanello
Benoit Louage
Simon Van Herck
Lucie Sancey
Jean-Luc Coll
Bruno De Geest
Celso Vataru Nakamura
et al.
A2
Journal Article
in
BIOMATERIALS SCIENCE
2018
Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models
Federico Fenaroli
Urska Repnik
Yitian Xu
Kerstin Johann
Simon Van Herck
Pradip Dey
Frode Miltzov Skjeldal
Dominik M Frei
Shahla Bagherifam
Agnese Kocere
et al.
A1
Journal Article
in
ACS NANO
2018
FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles
Lutz Nuhn
Simon Van Herck
Andreas Best
Kim Deswarte
Maria Kokkinopoulou
Ingo Lieberwirth
Kaloian Koynov
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2018
Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
Emiel De Jaeghere
Elly De Vlieghere
Jasper Van Hoorick
Sandra Van Vlierberghe
Glenn Wagemans
Leen Pieters
Elodie Melsens
Marleen Praet
Jo Van Dorpe
Matthieu Boone
et al.
A1
Journal Article
in
BIOMATERIALS
2018
High-aspect-ratio nano-materials for biomedical applications
Hui Li
Bruno De Geest
Dissertation
2018
Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue
Euna Yoo
Alex CD Salyer
Michael JH Brush
Yupeng Li
Kathryn L Trautman
Nikunj M Shukla
Ans De Beuckelaer
Stefan Lienenklaus
Kim Deswarte
Bart Lambrecht
et al.
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2018
Immunoengineering through cancer vaccines - A personalized and multi-step vaccine approach towards precise cancer immunity
Lien Lybaert
Karim Vermaelen
Bruno De Geest
Lutz Nuhn
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates
Simon Van Herck
Kim Deswarte
Lutz Nuhn
Zifu Zhong
João Portela Catani
Yupeng Li
Niek Sanders
Stefan Lienenklaus
Stefaan De Koker
Bart Lambrecht
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2018
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia
Bartosz Wiernicki
Irina Ingold
Feng Qu
Simon Van Herck
Yulia Y. Tyurina
Hülya Bayır
Behnaz A. Abhari
Jose Pedro Friedmann Angeli
Sze Men Choi
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2018
Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses
Lutz Nuhn
Stefaan De Koker
Sandra Van Lint
Zifu Zhong
João Portela Catani
Francis Combes
Kim Deswarte
Yupeng Li
Bart Lambrecht
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED MATERIALS
2018
pH-Sensitive hydrazone-linked doxorubicin nanogels via polymeric-activated ester scaffolds : synthesis, assembly, and in vitro and in vivo evaluation in tumor-bearing zebrafish
Alexandra Van Driessche
Agnese Kocere
Hannelien Everaert
Lutz Nuhn
Simon Van Herck
Gareth Griffiths
Federico Fenaroli
Bruno De Geest
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2018
Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties
Bo Lou
Ans De Beuckelaer
George Dakwar
Katrien Remaut
Johan Grooten
Kevin Braeckmans
Bruno De Geest
Enrico Mastrobattista
Stefaan De Koker
Wim E. Hennink
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist
Lutz Nuhn
Lien Van Hoecke
Kim Deswarte
Bert Schepens
Yupeng Li
Bart Lambrecht
Stefaan De Koker
Sunil A David
Xavier Saelens
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS
2018
Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against a Vibrio anguillarum infection
Eamy Nursaliza Yaacob
Bruno De Geest
Jens Goethals
Aline Bajek
Kristof Dierckens
Peter Bossier
Daisy Vanrompay
A1
Journal Article
in
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
2018
Targeting protumoral tumor-associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation
Lutz Nuhn
Evangelia Bolli
Sam Massa
Isabel Vandenberghe
Kiavash Movahedi
Bart Devreese
Jo A Van Ginderachter
Bruno De Geest
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2018
The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses
Joris Lammens
Séverine Mortier
Laurens De Meyer
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Simon Van Herck
Jos Corver
Ingmar Nopens
Valérie Vanhoorne
Bruno De Geest
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
The small GTPase Rab27B stimulates secretion of a subpopulation of ARRDC1-positive small extracellular vesicles (SEV)
Lien Lippens
Robin Boiy
Bert Dhondt
Bruno De Geest
Katrien Vandecasteele
Hannelore Denys
Olivier De Wever
An Hendrix
C3
Conference
2018
Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant
Simon Van Herck
Lien Van Hoecke
Benoit Louage
Lien Lybaert
Ruben De Coen
Sabah Kasmi
Aaron P Esser-Kahn
Sunil A David
Lutz Nuhn
Bert Schepens
et al.
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2018
2017
Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization
Sabah Kasmi
Benoit Louage
Lutz Nuhn
Glenn Verstraete
Simon Van Herck
Mies J van Steenbergen
Chris Vervaet
Wim E Hennink
Bruno De Geest
A1
Journal Article
in
POLYMER CHEMISTRY
2017
Amphiphilic ferrocene-containing PEG block copolymers as micellar nanocarriers and smart surfactants
Arda Alkan
Sarah Wald
Benoit Louage
Bruno De Geest
Katharina Landfester
Frederik R. Wurm
A1
Journal Article
in
LANGMUIR
2017
Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide
Vimal Kumar Udhayakumar
Ans De Beuckelaer
Joanne McCaffrey
Cian M McCrudden
Jonathan L Kirschman
Daryll Vanover
Lien Van Hoecke
Kenny Roose
Kim Deswarte
Bruno De Geest
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2017
Cancer cell lysate entrapment in CaCO3 engineered with polymeric TLR-agonists : immune-modulating microparticles in view of personalized antitumor vaccination
Lien Lybaert
Keun Ah Ryu
Lutz Nuhn
Riet De Rycke
Olivier De Wever
Alfred C Chon
Aaron P Esser-Kahn
Bruno De Geest
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2017
Design of immune-modulating polymeric microparticles in view of cell-derived cancer vaccination
Lien Lybaert
Bruno De Geest
Dissertation
2017
Design, synthesis and evaluation of advanced polymeric taxane formulations
Benoit Louage
Bruno De Geest
Dissertation
2017
Developments and future clinical outlook of taxane nanomedicines
Benoit Louage
Olivier De Wever
Wim E Hennink
Bruno De Geest
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2017
Heterocellular 3D scaffolds as biomimetic of peritoneal metastases
Elly De Vlieghere
Emiel De Jaeghere
Jasper Van Hoorick
Glenn Wagemans
Leen Pieters
Elodie Melsens
Sara Neyt
Bruno De Geest
Peter Dubruel
Wim Ceelen
et al.
C3
Conference
2017
Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo
Emiel De Jaeghere
Elly De Vlieghere
Jasper Van Hoorick
Glenn Wagemans
Leen Pieters
Elodie Melsens
Sara Neyt
Rouba Ghobeira
Rino Morent
Jo Van Dorpe
et al.
C3
Conference
2017
Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo
Elly De Vlieghere
Emiel De Jaeghere
Jasper Van Hoorick
Glenn Wagemans
Leen Pieters
Elodie Melsens
Sara Neyt
Bruno De Geest
Peter Dubruel
Wim Ceelen
et al.
C3
Conference
2017
Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo
Elly De Vlieghere
Emiel De Jaeghere
Jasper Van Hoorick
Glenn Wagemans
Leen Pieters
Elodie Melsens
Sara Neyt
Bruno De Geest
Peter Dubruel
Wim Ceelen
et al.
C3
Conference
2017
Immobilization of 2-deoxy-D-ribose-5-phosphate aldolase in polymeric thin films via the Langmuir-Schaefer technique
Stefan Reinicke
Huw C Rees
Pieter Espeel
Nane Vanparijs
Carolin Bisterfeld
Markus Dick
Ruben R Rosencrantz
Gerald Brezesinski
Bruno De Geest
Filip Du Prez
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2017
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12
Stefaan De Koker
Lien Van Hoecke
Ans De Beuckelaer
Kenny Roose
Kim Deswarte
Monique Willart
Pieter Bogaert
Thomas Naessens
Bruno De Geest
Xavier Saelens
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Micellar paclitaxel-initiated RAFT polymer conjugates with acid-sensitive behavior
Benoit Louage
Mies J. van Steenbergen
Lutz Nuhn
Martijn Risseeuw
Izet Karalic
Johan Winne
Serge Van Calenbergh
Wim E Hennink
Bruno De Geest
A1
Journal Article
in
ACS MACRO LETTERS
2017
Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs
Benoit Louage
Liesa Tack
Yadong Wang
Bruno De Geest
A1
Journal Article
in
POLYMER CHEMISTRY
2017
Polyelectrolyte-enrobed cancer cells in view of personalized immune-therapy
Lien Lybaert
Keun Ah Ryu
Riet De Rycke
Alfred C Chon
Olivier De Wever
Karim Vermaelen
Aaron Esser-Kahn
Bruno De Geest
A1
Journal Article
in
ADVANCED SCIENCE
2017
Preparation and characterization of alginate microparticles containing a model protein for oral administration in gnotobiotic European sea bass (Dicentrarchus labrax) larvae
Eamy Nursaliza Yaacob
Jens Goethals
Aline Bajek
Kristof Dierckens
Peter Bossier
Bruno De Geest
Daisy Vanrompay
A1
Journal Article
in
MARINE BIOTECHNOLOGY
2017
Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis
Glenn Verstraete
L. Vandenbussche
Sabah Kasmi
Lutz Nuhn
D. Brouckaert
Jeroen Van Renterghem
W. Grymonpre
Valérie Vanhoorne
Tom Coenye
Bruno De Geest
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Transiently thermoresponsive polymers and their applications in biomedicine
Nane Vanparijs
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2017
Tyrosine-triazolinedione bioconjugation as site-selective protein modification starting from RAFT-derived polymers
Stef Vandewalle
Ruben De Coen
Bruno De Geest
Filip Du Prez
A1
Journal Article
in
ACS MACRO LETTERS
2017
Uptake of long protein-polyelectrolyte nanotubes by dendritic cells
Diana G Ramírez-Wong
Saghi Saghazadeh
Simon Van Herck
Bruno De Geest
Alain M Jonas
Sophie Demoustier-Champagne
A1
Journal Article
in
BIOMACROMOLECULES
2017
2016
A generic polymer-protein ligation strategy for vaccine delivery
Lien Lybaert
Nane Vanparijs
Kaat Fierens
Martijn Schuijs
Lutz Nuhn
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
BIOMACROMOLECULES
2016
Administration of bacterial heat shock protein 70 to induce a protective innate immune response in European sea bass larvae (Dicentrarchus labrax) against Vibrio anguillarum
Eamy Nursaliza Yaacob
Bruno De Geest
Jens Goethals
Aline Bajeck
Kristof Dierckens
Peter Bossier
Daisy Vanrompay
C3
Conference
2016
Core/shell protein-reactive nanogels via a combination of RAFT polymerization and vinyl sulfone postmodification
Nane Vanparijs
Lutz Nuhn
Samantha J Paluck
Maria Kokkinopoulou
Ingo Lieberwirth
Heather D Maynard
Bruno De Geest
A1
Journal Article
in
NANOMEDICINE
2016
Design of protein-reactive polymers and core-crosslinked nanoparticles in view of vaccine delivery
Nane Vanparijs
Bruno De Geest
Dissertation
2016
Duality of β-glucan microparticles: antigen carrier and immunostimulants
Kim Baert
Bruno De Geest
Henri De Greve
Eric Cox
Bert Devriendt
A1
Journal Article
in
INTERNATIONAL JOURNAL OF NANOMEDICINE
2016
Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery
Stefaan De Koker
Jivei Cui
Nane Vanparijs
Lorenzo Albertazzi
Johan Grooten
Frank Caruso
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
Glenn Verstraete
Jeroen Van Renterghem
Pieter-Jan Van Bockstal
Sabah Kasmi
Bruno De Geest
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination
Zhiyue Zhang
Bert Schepens
Lutz Nuhn
Xavier Saelens
Michael Schotsaert
Nico Callewaert
Riet De Rycke
Qilu Zhang
Sébastien Moins
Samira Benali
et al.
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2016
Interactive RAFT polymer-decorated gold nanoparticles for biomedical use
Zhiyue Zhang
Bruno De Geest
Dissertation
2016
NewTumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
Elly De Vlieghere
Marc Bracke
Pieter Demetter
Wim Ceelen
Christian Vanhove
Bruno De Geest
Olivier De Wever
C3
Conference
2016
pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation
Lutz Nuhn
Nane Vanparijs
Ans De Beuckelaer
Lien Lybaert
Glenn Verstraete
Kim Deswarte
Stefan Lienenklaus
Nikunj M Shukla
Alex CD Salyer
Bart Lambrecht
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2016
pH-Degradable mannosylated nanogels for dendritic cell targeting
Ruben De Coen
Nane Vanparijs
Martijn Risseeuw
Lien Lybaert
Benoit Louage
Stefaan De Koker
Vimal Kumar Udhayakumar
Johan Grooten
Leeanne Taylor
Neil Ayres
et al.
A1
Journal Article
in
BIOMACROMOLECULES
2016
pH-independent immediate release polymethacrylate formulations : an observational study
Bart Claeys
Reinout Vandeputte
Bruno De Geest
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
2016
Poly(N-isopropylacrylamide) coated gold nanoparticles as colourimetric temperature and salt sensors
Samarendra Maji
Belgin Cesur
Zhiyue Zhang
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
POLYMER CHEMISTRY
2016
Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against Vibrio anguillarum
Eamy Nursaliza Yaacob
Bruno De Geest
Jens Goethals
Aline Bajek
Kristof Dierckens
Peter Bossier
Daisy Vanrompay
C3
Conference
2016
Recombinant ferritin-H induces immunosupression in European sea bass larvae (Dicentrarchus labrax) rather than immunostmulation and protection against Vibrio anguillarum
Eamy Nursaliza Yaacob
Bruno De Geest
Jens Goethals
Aline Bajeck
Kristof Dierckens
Peter Bossier
Daisy Vanrompay
C3
Conference
2016
Salt-driven deposition of thermoresponsive polymer-coated metal nanoparticles on solid substrates
Zhiyue Zhang
Samarendra Maji
André Antunes
Riet De Rycke
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery
Hui Li
Kaat Fierens
Zhiyue Zhang
Nane Vanparijs
Martijn Schuijs
Katleen Van Steendam
Natalia Feiner Gracia
Riet De Rycke
Thomas De Beer
Ans De Beuckelaer
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2016
Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers
Zhiyue Zhang
Nane Vanparijs
Stef Vandewalle
Filip Du Prez
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
POLYMER CHEMISTRY
2016
Super resolution imaging of nanoparticles cellular uptake and trafficking
Daan van der Zwaag
Nane Vanparijs
Sjors Wijnands
Riet De Rycke
Bruno De Geest
Lorenzo Albertazzi
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2016
Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains
Sabah Kasmi
Benoit Louage
Lutz Nuhn
Alexandra Van Driessche
Jan Van Deun
Izet Karalic
Martijn Risseeuw
Serge Van Calenbergh
Richard Hoogenboom
Riet De Rycke
et al.
A1
Journal Article
in
BIOMACROMOLECULES
2016
Well-defined polymer-paclitaxel prodrugs by a grafting-from-drug approach
Benoit Louage
Lutz Nuhn
Martijn Risseeuw
Nane Vanparijs
Ruben De Coen
Izet Karalic
Serge Van Calenbergh
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
2015
Acid-labile thermoresponsive copolymers that combine fast pH-triggered hydrolysis and high stability under neutral conditions
Qilu Zhang
Zhanyao Hou
Benoit Louage
Dingying Zhou
Nane Vanparijs
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2015
Capsules changing in brittleness due to leaching of plasticizing agents
Kim Van Tittelboom
Elke Gruyaert
J Sucaet
Bruno De Geest
Jean Paul Remon
Nele De Belie
C1
Conference
2015
Colorimetric logic gates based on poly(2-alkyl-2-oxazoline)coated gold nanoparticles
Victor Retamero De La Rosa
Zhiyue Zhang
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2015
Degradable ketal-based block copolymer nanoparticles for anticancer drug delivery : a systematic evaluation
Benoit Louage
Qilu Zhang
Nane Vanparijs
Lenny Voorhaar
Sofie Vande Casteele
Yang Shi
Wim E Hennink
Jan Van Bocxlaer
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
BIOMACROMOLECULES
2015
Linear polyethylenimine as (multi) functional initiator for organocatalytic L-lactide polymerization
Olivier Coulembier
Sébastien Moins
Samarendra Maji
Zhiyue Zhang
Bruno De Geest
Philippe Dubois
Richard Hoogenboom
A1
Journal Article
in
JOURNAL OF MATERIALS CHEMISTRY B
2015
Microparticles as antigen delivery systems for oral vaccination
Rebecca De Smet
Claude Cuvelier
Bruno De Geest
Dissertation
2015
One-pot preparation of inert well-defined polymers by RAFT polymerization and in situ end group transformation
Qilu Zhang
Lenny Voorhaar
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2015
Polymer-protein conjugation via a 'grafting to' approach: a comparative study of the performance of protein-reactive RAFT chain transfer agents
Nane Vanparijs
Samarendra Maji
Benoit Louage
Lenny Voorhaar
Duchan Laplace
Qilu Zhang
Y Shi
Wim E Hennink
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
POLYMER CHEMISTRY
2015
Rational design of a hexapeptide hydrogelator for controlled-release drug delivery
Mathieu Bibian
Jeroen Mangelschots
James Gardiner
Lynne Waddington
Maria M Diaz Acevedo
Bruno De Geest
Bruno Van Mele
Annemieke Madder
Richard Hoogenboom
Sam Ballet
A1
Journal Article
in
JOURNAL OF MATERIALS CHEMISTRY B
2015
Sequence-selective DNA recognition and enhanced cellular up-take by peptide–steroid conjugates
Yara Ruiz Garcia
Abhishek Iyer
Dorien Van Lysebetten
Y Vladimir Pabon
Benoit Louage
Malgorzata Honcharenko
Bruno De Geest
CI Edvard Smith
Roger Strömberg
Annemieke Madder
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2015
Solvent-free mechanochemical synthesis of a bicyclononyne tosylate: a fast route towards bioorthogonal clickable poly(2-oxazoline)s
Mathias Glassner
Samarendra Maji
Victor Retamero De La Rosa
Nane Vanparijs
Kanykei Ryskulova
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
POLYMER CHEMISTRY
2015
Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake
Abhishek Iyer
Dorien Van Lysebetten
Yara Ruiz Garcia
Benoit Louage
Bruno De Geest
Annemieke Madder
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2015
Tailoring cellular uptake of gold nanoparticles via the hydrophilic-to-hydrophobic ratio of their (co)polymer coating
Zhiyue Zhang
Katleen Van Steendam
Samarendra Maji
Lieve Balcaen
Yulia Anoshkina
Qilu Zhang
Glenn Vanluchene
Riet De Rycke
Frank Vanhaecke
Dieter Deforce
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2015
The road to an immune-priming strategy: a case of gnotobiotic European sea bass (Dicentrarchus labrax) larvae
Eamy Nursaliza Yaacob
Bruno De Geest
Stanislas Laureau
Jens Goethals
Katelijn Schautteet
Stefanie Lagae
Daisy Vanrompay
Kristof Dierckens
Peter Bossier
C3
Conference
2015
Thermoresponsive polymer coated gold nanoparticles: from MADIX/RAFT copolymerization of N-vinylpyrrolidone and N-vinylcaprolactam to salt and temperature induced nanoparticle aggregation
Samarendra Maji
Zhiyue Zhang
Lenny Voorhaar
Sophie Pieters
Birgit Stubbe
Sandra Van Vlierberghe
Peter Dubruel
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
RSC ADVANCES
2015
Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators
Nane Vanparijs
Ruben De Coen
Duchan Laplace
Benoit Louage
Samarendra Maji
Lien Lybaert
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2015
Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
Elly De Vlieghere
Félix Gremonprez
Laurine Verset
Lore Mariën
Christopher Jones
Bram De Craene
Geert Berx
Benedicte Descamps
Christian Vanhove
Jean Paul Remon
et al.
A1
Journal Article
in
BIOMATERIALS
2015
β-glucan microparticles targeted to APN as mucosal antigen delivery system in oral vaccination of piglets against ETEC infections
Kim Baert
Bruno De Geest
Bert Devriendt
Eric Cox
C3
Conference
2015
β-glucan microparticles targeted to epithelial APN as oral antigen delivery system
Kim Baert
Bruno De Geest
Riet De Rycke
André Antunes
Henri De Greve
Eric Cox
Bert Devriendt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
2014
Bio-hybrid tumor cell-templated capsules: a generic formulation strategy for tumor associated antigens in view of immune therapy
Lien Lybaert
Elly De Vlieghere
Riet De Rycke
Nane Vanparijs
Olivier De Wever
Stefaan De Koker
Bruno De Geest
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2014
Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer-protein conjugates with transient solubility
Qilu Zhang
Nane Vanparijs
Benoit Louage
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
POLYMER CHEMISTRY
2014
Fast and accurate partial hydrolysis of poly(2-ethyl-2-oxazoline) into tailored linear polyethylenimine copolymers
Victor Retamero De La Rosa
Eva Bauwens
Bryn Monnery
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
POLYMER CHEMISTRY
2014
Hydrogen bonded multilayer films based on poly(2-oxazoline)s and tannic acid
Anandhakumar Sundaramurthy
Maarten Vergaelen
Samarendra Maji
Rachel Auzély-Velty
Zhiyue Zhang
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2014
Just spray it: LbL assembly enters a new age
Marijke Dierendonck
Stefaan De Koker
Riet De Rycke
Bruno De Geest
A1
Journal Article
in
SOFT MATTER
2014
Micro-particle encapsulated carcinoma-associated fibroblast (CAF) deceive and redirect disseminated cancer cells
Elly De Vlieghere
Laurine Verset
Christian Vanhove
Lore Mariën
Jean Paul Remon
Pieter Demetter
Marc Bracke
Bruno De Geest
Olivier De Wever
C3
Conference
2014
Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers
Marijke Dierendonck
Kaat Fierens
Riet De Rycke
Lien Lybaert
Samarendra Maji
Zhiyue Zhang
Qilu Zhang
Richard Hoogenboom
Bart Lambrecht
Johan Grooten
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2014
Nanoporous microparticles : towards a generic vaccine formulation platform
Marijke Dierendonck
Bruno De Geest
Stefaan De Koker
Dissertation
2014
Nanoporous polyelectrolyte vaccine microcarriers: a formulation platform for enhancing humoral and cellular immune responses
Stefaan De Koker
Kaat Fierens
Marijke Dierendonck
Riet De Rycke
Bart Lambrecht
Johan Grooten
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Spray-dried polyelectrolyte microparticles in oral antigen delivery : stability, biocompatibility and cellular uptake
Rebecca De Smet
Stephanie VERSCHUERE
Liesbeth Allais
Georges Leclercq
Marijke Dierendonck
Bruno De Geest
Isabel Van Driessche
Tine Demoor
Claude Cuvelier
A1
Journal Article
in
BIOMACROMOLECULES
2014
Straightforward RAFT procedure for the synthesis of heterotelechelic poly(acrylamide)s
Sofie Wallyn
Zhiyue Zhang
Frank Driessen
Joanna Pietrasik
Bruno De Geest
Richard Hoogenboom
Filip Du Prez
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2014
2013
Beta-glucan particles as novel antigen delivery systems : towards oral vaccination
Rebecca De Smet
Stephanie Verschuere
Tine Demoor
Liesbeth Allais
Charles Pilette
Marijke Dierendonck
Bruno De Geest
Claude Cuvelier
C3
Conference
2013
Beta-glucan particles as novel antigen delivery systems: towards oral vaccination
Rebecca De Smet
Stephanie VERSCHUERE
Liesbeth Allais
Tine Demoor
Bruno De Geest
Claude Cuvelier
C3
Conference
2013
CAF-encapsulated mico-particels capture free cancer cells from the peritoneal fluid
Elly De Vlieghere
Laurine Verset
Christian Vanhove
Lore Mariën
Jean Paul Remon
Pieter Demetter
Marc Bracke
Bruno De Geest
Olivier De Wever
C3
Conference
2013
Complexity from simplicity : unique polymer capsules, rods, monoliths, and liquid marbles prepared via HIPE in microfluidics
Muhammed Gökmen
Busra Dereli
Bruno De Geest
Filip Du Prez
A1
Journal Article
in
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
2013
Dual temperature- and pH-responsive polymers for protein conjugation and vaccine design
Bruno De Geest
Qilu Zhang
Nane Vanparijs
Benoit Louage
Zhiyue Zhang
Richard Hoogenboom
C3
Conference
2013
Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel
Wesley De Jaeghere
Bruno De Geest
Jan Van Bocxlaer
Jean Paul Remon
Chris Vervaet
André Antunes
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs
André Antunes
Bruno De Geest
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
2013
Hydrogen bonded polymeric multilayer films assembled below and above the cloud point temperature
André Antunes
Marijke Dierendonck
Gertjan Vancoillie
Jean Paul Remon
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2013
Improved anti-inflammatory effects in rabbit eye model using biodegradable poly beta-amino ester nanoparticles of triamcinolone acetonide
Araz Sabzevari
Khosro Adibkia
Hassan Hashemi
Bruno De Geest
Navid Mohsenzadeh
Fatemeh Atyabi
Mohammad Hossein Ghahremani
Mohammad-Reza Khoshayand
Rassoul Dinarvand
A1
Journal Article
in
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2013
Magnetically engineered microcapsules as intracellular anchors for remote control over cellular mobility
Anton M Pavlov
Bruno De Geest
Benoit Louage
Lien Lybaert
Stefaan De Koker
Zdenek Koudelka
Andrei V Sapelkin
Gleb B Sukhorukov
A1
Journal Article
in
ADVANCED MATERIALS
2013
Mechanical strength and intracellular uptake of CaCO₃- templated LbL capsules composed of biodegradable polyelectrolytes: the influence of the number of layers
Raghavendra Palankar
Bat-El Pinchasik
Stephan Schmidt
Bruno De Geest
Andreas Fery
Helmuth Möhwald
Andre Skirtach
Mihaela Delcea
A1
Journal Article
in
JOURNAL OF MATERIALS CHEMISTRY B
2013
Microparticles delivery system in gnotobiotic European sea bass larvae (Dicentrarchus labrax, L. 1758)
Eamy Nursaliza Yaacob
Bruno De Geest
Daisy Vanrompay
Kristof Dierckens
Peter Bossier
A4
Journal Article
in
COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES
2013
One-step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells
Bert Devriendt
Kim Baert
Marijke Dierendonck
Herman Favoreel
Stefaan De Koker
Jean Paul Remon
Bruno De Geest
Eric Cox
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Polyelectrolyte microparticles as biomimetic mucosal delivery vehicles facilitate antigen presentation by dendritic cells
Bert Devriendt
Kim Baert
Marijke Dierendonck
Herman Favoreel
Jean Paul Remon
Bruno De Geest
Eric Cox
C3
Conference
2013
Polysaccharide-based responsive nanogels for controlled drug delivery
Rachel Auzely-Velty
Jing Jing
Emilie Hachet
David Alaimo
Elly De Vlieghere
Anna Szarpak
Christine Jerome
Bruno De Geest
C3
Conference
2013
Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms
Anouk Vervaeck
Lien Saerens
Bruno De Geest
Thomas De Beer
R Carleer
P Adriaensens
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Salt plays a pivotal role in the temperature-responsive aggregation and layer-by-layer assembly of polymer-decorated gold nanoparticles
Zhiyue Zhang
Samarendra Maji
André Antunes
Riet De Rycke
Qilu Zhang
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2013
Solvent-free drug crystal engineering for drug nano- and micro suspensions
André Antunes
Bruno De Geest
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2013
Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions
Bart Claeys
Ruben De Coen
Bruno De Geest
Victor Retamero De La Rosa
Richard Hoogenboom
Robert Carleer
Peter Adriaensens
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Systematic processing of beta-tricalcium phosphate for efficient protein loading and in vitro analysis of antigen uptake
Vinayaraj Ozhukil Kollath
Bruno De Geest
Steven Mullens
Stefaan De Koker
Jan Luyten
Rosita Persoons
Karl Traina
Jean Paul Remon
Rudi Cloots
A1
Journal Article
in
ADVANCED ENGINEERING MATERIALS
2013
Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid-polymer conjugates
Jing Jing
David Alaimo
Elly De Vlieghere
Christine Jérôme
Olivier De Wever
Bruno De Geest
Rachel Auzély-Velty
A1
Journal Article
in
JOURNAL OF MATERIALS CHEMISTRY B
2013
Yeast particles targeted to APN as antigen delivery system to porcine immune cells
Kim Baert
Bert Devriendt
Bruno De Geest
Eric Cox
C3
Conference
2013
β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination
Rebecca De Smet
Tine Demoor
Stephanie Verschuere
Melissa Dullaers
Gary R Ostroff
Georges Leclercq
Liesbeth Allais
Charles Pilette
Marijke Dierendonck
Bruno De Geest
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2013
2012
Biomimetic polyelectrolyte microparticles facilitate antigen presentation by porcine dendritic cells
Bert Devriendt
Kim Baert
Marijke Dierendonck
Herman Favoreel
Jean Paul Remon
Bruno De Geest
Eric Cox
C3
Conference
2012
Crossing the barrier: targeting epithelial receptors for enhanced oral vaccine delivery
Bert Devriendt
Bruno De Geest
Bruno Goddeeris
Eric Cox
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012
Development and evaluation of solvent-free processing techniques for poorly water soluble drugs
André Antunes
Jean Paul Remon
Bruno De Geest
Dissertation
2012
Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1
Liesbeth De Cock
Olivier De Wever
Sandra Van Vlierberghe
Els Vanderleyden
Peter Dubruel
Filip De Vos
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
SOFT MATTER
2012
Engineered 3D microporous gelatin scaffolds to study cell migration
Liesbeth De Cock
Olivier De Wever
Hamida Hammad
Bart Lambrecht
Els Vanderleyden
Peter Dubruel
Filip De Vos
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2012
Interaction between polymeric multilayer capsules and immune cells
Marijke Dierendonck
Stefaan De Koker
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012
Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?
Huub Van Kuringen
Joke Lenoir
Els Adriaens
Johan Bender
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
MACROMOLECULAR BIOSCIENCE
2012
Patchiness of embedded particles and film stiffness control through concentration of gold nanoparticles
Dorothee Kohler
Narayanan Madaboosi
Mihaela Delcea
Stephan Schmidt
Bruno De Geest
Dmitry Volodkin
Helmuth Möhwald
Andre Skirtach
A1
Journal Article
in
ADVANCED MATERIALS
2012
Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding
Bart Claeys
Anouk Vervaeck
Chris Vervaet
Jean Paul Remon
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2012
Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
Bruno De Geest
Monique Willart
Hamida Hammad
Bart Lambrecht
Charlotte Pollard
Pieter Bogaert
Marina De Filette
Xavier Saelens
Chris Vervaet
Jean Paul Remon
et al.
A1
Journal Article
in
ACS NANO
2012
Polymeric multilayer capsules for drug delivery
Stefaan De Koker
Richard Hoogenboom
Bruno De Geest
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2012
Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering
Tuğba Dışpınar
Wim Van Camp
Liesbeth De Cock
Bruno De Geest
Filip Du Prez
A1
Journal Article
in
MACROMOLECULAR BIOSCIENCE
2012
Redox-responsive degradation of poly(ethylene glycol) (PEG) based cryogels
Filip Du Prez
Tuğba Dışpınar
Liesbeth De Cock
Bruno De Geest
C3
Conference
2012
Single step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells
Bert Devriendt
Kim Baert
Marijke Dierendonck
Herman Favoreel
Jean Paul Remon
Bruno De Geest
Eric Cox
C3
Conference
2012
Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
Bruno De Geest
Monique Willart
Bart Lambrecht
Charlotte Pollard
Chris Vervaet
Jean Paul Remon
Johan Grooten
Stefaan De Koker
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2012
Targeting aminopeptidase N, a newly identified receptor for F4ac fimbriae, enhances the intestinal mucosal immune response
Vesna Melkebeek
K Rasschaert
Philippe Bellot
K Tilleman
Herman Favoreel
Dieter Deforce
Bruno De Geest
Bruno Goddeeris
Eric Cox
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2012
2011
Anisotropic multicompartment micro- and nano-capsules produced via embedding into biocompatible PLL/HA films
Mihaela Delcea
Narayanan Madaboosi
Alexey M Yashchenok
Prabal Subedi
Dmitry V Volodkin
Bruno De Geest
Helmuth Möhwald
Andre Skirtach
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2011
Design of growth factor-loaded tissue engineering scaffolds
Liesbeth De Cock
Jean Paul Remon
Bruno De Geest
Dissertation
2011
Designing oral vaccines targeting intestinal dendritic cells
Bert Devriendt
Bruno De Geest
Eric Cox
A1
Journal Article
in
EXPERT OPINION ON DRUG DELIVERY
2011
Designing polymeric particles for antigen delivery
Stefaan De Koker
Bart Lambrecht
Monique Willart
Yvette van Kooyk
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2011
Evaluation of beta-glucan particles as mucosal delivery systems in the Peyer's patch regions of the murine small intestine
Rebecca De Smet
Tine Demoor
Stephanie VERSCHUERE
Marijke Dierendonck
Bruno De Geest
Claude Cuvelier
C3
Conference
2011
Evaluation of degradable PEG-cryogels as potential cell scaffolds in tissue engineering
Tuğba Dışpınar
Wim Van Camp
Liesbeth De Cock
Bruno De Geest
Filip Du Prez
C3
Conference
2011
Evaluation of β-glucan particles as mucosal delivery system in the Peyer's patch regions of the murine small intestine
Rebecca De Smet
Tine Demoor
Stephanie VERSCHUERE
Marijke Dierendonck
Bruno De Geest
Claude Cuvelier
C3
Conference
2011
Hydrophobic shell loading of biopolyelectrolyte capsules
Di Cui
Jing Jing
Thomas Boudou
Isabelle Pignot-Paintrand
Stefaan De Koker
Bruno De Geest
Catherine Picart
Rachel Auzely-Velty
A1
Journal Article
in
ADVANCED MATERIALS
2011
Mucosal irritation potential of polyelectrolyte multilayer capsules
Liesbeth De Cock
Joke Lenoir
Stefaan De Koker
Vincent Vermeersch
Andre Skirtach
Peter Dubruel
Els Adriaens
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS
2011
Polymeric multilayer capsules delivering biotherapeutics
Stefaan De Koker
Liesbeth De Cock
Pilar Rivera-Gil
Wolfgang J Parak
Rachel Auzély Velty
Chris Vervaet
Jean Paul Remon
Johan Grooten
Bruno De Geest
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2011
Redox-responsive degradable PEG-cryogels as potential cell scaffolds in tissue engineering
Tuğba Dışpınar
Wim Van Camp
Liesbeth De Cock
Bruno De Geest
Filip Du Prez
C3
Conference
2011
Release properties of pressurized microgel templated capsules
Stephan Schmidt
Paulo AL Fernandes
Bruno De Geest
Mihaela Delcea
Andre Skirtach
Helmuth Moehwald
Andreas Fery
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2011
Single-step formation of degradable intracellular biomolecule microreactors
Marijke Dierendonck
Stefaan De Koker
Riet De Rycke
Pieter Bogaert
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
ACS NANO
2011
Use of endospore-forming bacteria as an active oxygen scavenger in plastic packaging materials
Tom Anthierens
Peter Ragaert
Sam Verbrugghe
Assia Ouchchen
Bruno De Geest
Bert Noseda
Johan Mertens
Lynda Beladjal
Dirk De Cuyper
William Dierickx
et al.
A1
Journal Article
in
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
2011
2010
A single step process for the synthesis of antigen laden thermosensitive microparticles
Bruno De Geest
Stefaan De Koker
Yves Gonnissen
Liesbeth De Cock
Johan Grooten
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
SOFT MATTER
2010
Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery
Stefaan De Koker
Thomas Naessens
Bruno De Geest
Pieter Bogaert
Jo Demeester
Stefaan De Smedt
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2010
Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death
Mathieu Vinken
Elke Decrock
Elke De Vuyst
Marijke De Bock
Roosmarijn Vandenbroucke
Bruno De Geest
Jo Demeester
Niek Sanders
Tamara Vanhaecke
Luc Leybaert
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2010
Designing hyaluronic acid-based layer-by-layer capsules as a carrier for intracellular drug delivery
Anna Szarpak
Di Cui
Frédéric Dubreuil
Bruno De Geest
Liesbeth De Cock
Catherine Picart
Rachel Auzely-Velty
A1
Journal Article
in
BIOMACROMOLECULES
2010
Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres
Marijke Dierendonck
Stefaan De Koker
Claude Cuvelier
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2010
Layer-by-layer incorporation of growth factors in decellularized aortic heart valve leaflets
Liesbeth De Cock
Stefaan De Koker
Filip De Vos
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
BIOMACROMOLECULES
2010
Polymeric microcapsules with light responsive properties for encapsulation and release
Matthieu Bédard
Bruno De Geest
Andre Skirtach
Helmuth Möhwald
Gleb B Sukhorukov
A1
Journal Article
in
ADVANCES IN COLLOID AND INTERFACE SCIENCE
2010
Polymeric multilayer capsules in drug delivery
Liesbeth De Cock
Stefaan De Koker
Bruno De Geest
Johan Grooten
Chris Vervaet
Jean Paul Remon
Gleb B Sukhorukov
Maria N Antipina
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2010
Self-exploding capsules
Bruno De Geest
Stefaan De Koker
Jo Demeester
Stefaan De Smedt
Wim E Hennink
A1
Journal Article
in
POLYMER CHEMISTRY
2010
Thiol-mediated polymeric materials
Arun Prasath Ramaswamy
Bruno De Geest
Muhammed Gökmen
Wim Van Camp
Filip Du Prez
C3
Conference
2010
2009
'Clicked' polymeric microcapsules and beads: Azide-alkyne versus thiol-ene and thiol-yne approach (Abstract of Lecture)
Filip Du Prez
Arun Prasath Ramaswamy
Muhammed Gökmen
Wim Van Camp
Bruno De Geest
C3
Conference
2009
'Giant' Hollow Multilayer Capsules by Microfluidic Templating
Muhammed Gökmen
Bruno De Geest
WE Hennink
Filip Du Prez
A1
Journal Article
in
ACS Applied Materials & Interfaces
2009
Direction specific release from giant microgel-templated polyelectrolyte microcontainers
MF Bedard
Bruno De Geest
H Moehwald
GB Sukhorukov
Andre Skirtach
A1
Journal Article
in
SOFT MATTER
2009
Exploration of novel functionalization concepts for surfaces, beads and microcapsules
Filip Du Prez
Arun Prasath Ramaswamy
Muhammed Gökmen
Wim Van Camp
Bruno De Geest
C3
Conference
2009
Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules
Pilar Rivera-Gil
Stefaan De Koker
Bruno De Geest
Wolfgang J Parak
A1
Journal Article
in
NANO LETTERS
2009
On-demand click functionalization of polyurethane films and foams
David Fournier
Bruno De Geest
Filip Du Prez
A1
Journal Article
in
POLYMER
2009
Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens
Stefaan De Koker
Bruno De Geest
Satwinder Singh
Riet De Rycke
Thomas Naessens
Yvette Van Kooyk
Jo Demeester
Stefaan De Smedt
Johan Grooten
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2009
Polyelectrolyte microcapsules for biomedical applications
Bruno De Geest
Stefaan De Koker
GB Sukhorukov
O Kreft
WJ Parak
Andre Skirtach
Jo Demeester
Stefaan De Smedt
Wim E Hennink
A1
Journal Article
in
Soft Matter
2009
Pulsed in vitro release and in vivo behavior of exploding microcapsules
Bruno De Geest
Stefaan De Koker
Jo Demeester
Stefaan De Smedt
WE Hennink
A1
Journal Article
in
Journal of Controlled Release
2009
The pros and cons of polyelectrolyte capsules in drug delivery
Bruno De Geest
GB Sukhorukov
H Mohwald
A1
Journal Article
in
Expert opinion on drug delivery
2009
Thiol-ene and thil-yne 'click' chemistry for preparation of functional beads (Abstract of Lecture)
Arun Prasath Ramaswamy
Muhammed Gökmen
Bruno De Geest
Filip Du Prez
C3
Conference
2009
2008
Biodegradable microcapsules designed via "click" chemistry
Bruno De Geest
Wim Van Camp
Filip Du Prez
Stefaan De Smedt
Jo Demeester
W HENNINK
C3
Conference
2008
Biodegradable microcapsules designed via 'click' chemistry
Bruno De Geest
Wim Van Camp
Filip Du Prez
Stefaan De Smedt
Jo Demeester
WE HENNINK
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2008
Biodegradable microgels by click chemistry
Bruno De Geest
Wim Van Camp
Filip Du Prez
Jo Demeester
Stefaan De Smedt
Wim E Hennink
C3
Conference
2008
Biodegradable microgels by click chemistry
Bruno De Geest
Wim Van Camp
Filip Du Prez
Jo Demeester
Stefaan De Smedt
W HENNINK
C3
Conference
2008
Degradable microgels and hollow capsules by 'click' chemistry
Bruno De Geest
Wim Van Camp
Filip Du Prez
Jo Demeester
Stefaan De Smedt
W Hennink
C3
Conference
2008
Degradable multilayer films and hollow capsules via a 'Click' strategy
Bruno De Geest
Wim Van Camp
Filip Du Prez
Stefaan De Smedt
Jo Demeester
WE HENNINK
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2008
Evaluation of encoded layer-by-layer coated microparticles as protease sensors
Barbara Stubbe
Kris Gevaert
Stefaan Derveaux
Kevin Braeckmans
Bruno De Geest
Marc Goethals
Joël Vandekerckhove
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2008
Layer-by-layer coated digitally encoded microcarriers for quantification of proteins in serum and plasma
Stefaan Derveaux
Barbara Stubbe
C ROELANT
M LEBLANS
Bruno De Geest
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2008
Microcapsules Ejecting Nanosized Species into the Environment
Bruno De Geest
MJ MCSHANE
Jo Demeester
Stefaan De Smedt
WE HENNINK
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2008
Nanorods as wavelength-selective absorption centers in the visible and near-infrared regions of the electromagnetic spectrum
Andre Skirtach
Peter Karageorgiev
Bruno De Geest
Nicolas Pazos-Perez
Dieter Braun
Gleb B. Sukhorukov
A1
Journal Article
in
ADVANCED MATERIALS
2008
Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process
Yves Gonnissen
SIV GONCALVES
Bruno De Geest
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2008
Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)
Roosmarijn Vandenbroucke
Bruno De Geest
Jo Demeester
Stefaan De Smedt
Niek Sanders
C1
Conference
2008
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)
Roosmarijn Vandenbroucke
Bruno De Geest
Stefan Bonné
M VINKEN
T VAN HAECKE
H HEIMBERG
E WAGNER
V ROGIERS
Stefaan De Smedt
Jo Demeester
et al.
A1
Journal Article
in
JOURNAL OF GENE MEDICINE
2008
Self exploding microcapsules
Bruno De Geest
Stefaan De Koker
Jo Demeester
Stefaan De Smedt
Wim E Hennink
C3
Conference
2008
Self-Exploding Beads Releasing Microcarriers
Bruno De Geest
Stefaan De Koker
Kristof Immesoete
Jo Demeester
Stefaan De Smedt
WE HENNINK
A1
Journal Article
in
ADVANCED MATERIALS
2008
Stimuli-responsive polyelectrolyte microcapsules for biomedical applications
Bruno De Geest
A Skirtach
G Sukhorukov
Jo Demeester
Stefaan De Smedt
WE Hennink
C3
Conference
2008
2007
In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules
Stefaan De Koker
Bruno De Geest
Claude Cuvelier
Liesbeth Ferdinande
Wies Deckers
WE HENNINK
Stefaan De Smedt
Nico Mertens
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2007
Multifunctional layer-by-layer coating of digitally encoded microparticles
Stefaan Derveaux
Bruno De Geest
C ROELANT
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
LANGMUIR
2007
Nucleic acid delivery: Where material sciences and bio-sciences meet
Katrien Remaut
Niek Sanders
Bruno De Geest
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
MATERIALS SCIENCE & ENGINEERING R-REPORTS
2007
Release mechanisms for polyelectrolyte capsules
Bruno De Geest
Niek Sanders
GB SUKHORUKOV
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2007
Self-rupturing and hollow microcapsules prepared from bio-polyelectrolyte-coated microgels
Bruno De Geest
C DEJUGNAT
M PREVOT
GB SUKHORUKOV
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2007
Stimuli-responsive multilayered hybrid nanoparticle/polyelectrolyte capsules
Bruno De Geest
Andre Skirtach
Thomas De Beer
GB SUKHORUKOV
Lieven Bracke
Willy Baeyens
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2007
Ultrasound stimulated release and catalysis using polyelectrolyte multilayer capsules
Andre Skirtach
Bruno De Geest
Arif Mamedov
Alexei A. Antipov
Nicholas A. Kotov
Gleb B. Sukhorukov
A1
Journal Article
in
JOURNAL OF MATERIALS CHEMISTRY
2007
Ultrasound-triggered release from multilayered capsules
Bruno De Geest
Andre Skirtach
AA MAMEDOV
AA ANTIPOV
NA KOTOV
Stefaan De Smedt
GB SUKHORUKOV
A1
Journal Article
in
SMALL
2007
2006
Glucose-responsive polyelectrolyte capsules
Bruno De Geest
AM JONAS
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
LANGMUIR
2006
Intracellularly degradable polyelectrolyte microcapsules
Bruno De Geest
Roosmarijn Vandenbroucke
AM GUENTHER
GB SUKHORUKOV
WE HENNINK
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED MATERIALS
2006
Layer-by-layer coating of degradable microgels for pulsed drug delivery
Bruno De Geest
C DEJUGNAT
Ellen Verhoeven
GB SUKHORUKOV
AM JONAS
J PLAIN
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2006
Polyelectrolyte microcapsules for pharmaceutical applications
Bruno De Geest
S De Smedt
J Demeester
Dissertation
2006
Pulsed drug delivery
Bruno De Geest
Els Mehuys
G Laekeman
Jo Demeester
Stefaan De Smedt
A2
Journal Article
in
Expert Opinion on Drug Delivery
2006
Self-exploding lipid-coated microgels
Bruno De Geest
Barbara Stubbe
AM JONAS
Tinneke Van Thienen
WLJ HINRICHS
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOMACROMOLECULES
2006
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA
Ine Lentacker
Bruno De Geest
Roosmarijn Vandenbroucke
Liesbeth Peeters
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
LANGMUIR
2006
2005
Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching
SR VAN TOMME
Bruno De Geest
Kevin Braeckmans
Stefaan De Smedt
F SIEPMANN
J SIEPMANN
CF VAN NOSTRUM
WE HENNINK
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2005
Self-rupturing microcapsules
Bruno De Geest
C DEJUGNAT
GB SUKHORUKOV
Kevin Braeckmans
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
ADVANCED MATERIALS
2005
Synthesis of monodisperse biodegradable microgels in microfluidic devices
Bruno De Geest
JP URBANSKI
T THORSEN
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
LANGMUIR
2005