Research Explorer

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Researcher

Bruno De Geest

238 Results

2021

Covalent cell surface conjugation of nanoparticles by a combination of metabolic labeling and click chemistry

Alexander LamootAnnemiek UvynSabah KasmiBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delivery routes matter : safety and efficacy of intratumoral immunotherapy

Emily De LombaerdeOlivier De WeverBruno De Geest

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong ChenSimon Van HerckBart LambrechtNiek SandersStefan LienenklausSunil A. DavidMaría J. VicentStefaan De KokerBruno De Geest

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Lipid-polymer conjugates for innate immune activation

Jana De VriezeBruno De Geest

Multivalent antibody recruiting molecules as a novel type of cancer immunotherapy

Annemiek UvynBruno De Geest

Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables

Edward GeeurickxLien LippensPekka RappuBruno De GeestOlivier De WeverAn Hendrix

A1 Journal Article in NATURE PROTOCOLS

Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators

Anne HuppertsbergLeonard KapsZifu ZhongSascha SchmittJudith StickdornKim DeswarteFrancis CombesChristian CzyschJana De VriezeSabah KasmiNiklas ChoteschovskyAdrian KlefenzCarolina Medina-MontanoPia WinterwerberChaojian ChenMatthias BrosStefan LienenklausNiek SandersKaloian KoynovDetlef SchuppanBart LambrechtSunil A. DavidBruno De GeestLutz Nuhn

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu ZhongNiek SandersStefan LienenklausSunil A. DavidShirin StrohmeierFatima AmanatFlorian KrammerHamida HammadBart LambrechtLynda CoughlanAdolfo García‐SastreBruno De GeestMichael Schotsaert

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020

Control over imidazoquinoline immune stimulation by pH-degradable poly(norbornene) nanogels

Johannes KockelmannJudith StickdornSabah KasmiJana De VriezeMichaela PieszkaDavid Yuen W. NgSunil A. DavidBruno De GeestLutz Nuhn

A1 Journal Article in BIOMACROMOLECULES

Current status of COVID-19 (pre)clinical vaccine development

Tingting YeZifu ZhongAdolfo Garcia-SastreMichael SchotsaertBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent

Jana De VriezeSimon Van HerckLutz NuhnBruno De Geest

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Design of polymeric carriers for cancer chemo- and immunotherapy

Alexandra Van DriesscheBruno De Geest

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch MoodySophie JanssensMichael DrennanDirk Elewaut

A1 Journal Article in EMBO REPORTS

Feasibility of mechanical extrusion to coat nanoparticles with extracellular vesicle membranes

Jan Van DeunQuentin RouxSarah DevilleThibaut Van AckerPekka RappuIlkka MiinalainenJyrki HeinoFrank VanhaeckeBruno De GeestOlivier De WeverAn Hendrix

A1 Journal Article in CELLS

Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy

Hui LiSimon Van HerckYongjun LiuYanyun HaoXiaochu DingLutz NuhnZifu ZhongFrancis CombesNiek SandersStefan LienenklausStefaan De KokerSunil A. DavidYadong WangBruno De GeestZhiyue Zhang

A1 Journal Article in ACS BIOMATERIALS SCIENCE & ENGINEERING

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Joeri TulkensGlenn VergauwenJan Van DeunEdward GeeurickxBert DhondtLien LippensMarie-Angélique De ScheerderIlkka MiinalainenPekka RappuBruno De GeestKatrien VandecasteeleDebby LaukensLinos VandekerckhoveHannelore DenysJo VandesompeleOlivier De WeverAn Hendrix

A1 Journal Article in GUT

Multivalent antibody-recruiting macromolecules : linking increased binding affinity with enhanced innate immune killing

Annemiek UvynBruno De Geest

A1 Journal Article in CHEMBIOCHEM

Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages

Yann BernhardOndrej SedlacekJoachim Van GuyseJohan BenderZifu ZhongBruno De GeestRichard Hoogenboom

A1 Journal Article in BIOMACROMOLECULES

Poly(2-methyl-2-oxazoline) conjugates with doxorubicin : from synthesis of high drug loading water-soluble constructs to in vitro anti-cancer properties

Ondrej SedlacekAlexandra Van DriesscheAnnemiek UvynBruno De GeestRichard Hoogenboom

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Polymer- and lipid-based nanomaterials and conjugates for cancer therapy

Sabah KasmiBruno De Geest

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. ScheerenSunil A. DavidFabian KiesslingTwan LammersBruno De GeestYang Shi

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prilling of API/fatty acid suspensions : screening of additives for drug release modification

Elien De ConinckValérie VanhoorneMatthieu BooneG Van AsscheBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Recombinant DnaK orally administered protects axenic European sea bass against vibriosis

Eamy Nursaliza YaacobParisa NorouzitallabBruno De GeestAline BajekKristof DierckensPeter BossierDaisy Vanrompay

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu ZhongNiek SandersStefan LienenklausSunil DavidShirin StrohmeierFatima AmanatFlorian KrammerHamida HammadBart LambrechtLynda CoughlanAdolfo García-SastreBruno De GeestMichael Schotsaert

Tumor engineered model for low-grade serous ovarian carcinoma (LGSOC) : mimicking the tumor environment on a cellular and biophysical level

Elly De VlieghereEva BlondeelWim CeelenBruno De GeestGeert BerxSandra Van VlierbergheOlivier De Wever

Zebrafish embryos allow prediction of nanoparticle circulation times in mice and facilitate quantification of nanoparticle-cell interactions

Nils-Jorgen Knudsen DalAgnese KocereJens WohlmannSimon Van HerckTobias A. BauerJulien ResseguierShahla BagherifamHilde HyldmoMatthias BarzBruno De GeestFederico Fenaroli

A1 Journal Article in SMALL

2019

A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window

Zhiyue ZhangHui LiSabah KasmiSimon Van HerckKim DeswarteBart LambrechtRichard HoogenboomLutz NuhnBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek UvynRuben De CoenOlivier De WeverKim DeswarteBart LambrechtBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Design and synthesis of cyclic peptide-bile acid conjugates for improving the therapeutic potential of peptide drugs

Dorien Van LysebettenAnnemieke MadderBruno De Geest

Efficient innate immune killing of cancer cells triggered by cell-surface anchoring of multivalent antibody-recruiting polymers

Annemiek UvynRuben De CoenMandy GruijsCees W. TukJana De VriezeMarjolein van EgmondBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interactive polymers for innate immune activation

Simon Van HerckBruno De Geest

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

Jana De VriezeBenoit LouageKim DeswarteZifu ZhongRuben De CoenSimon Van HerckLutz NuhnCamilla Kaas FrichAlexander N ZelikinStefan LienenklausNiek SandersBart LambrechtSunil A DavidBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prilling of API/fatty acid suspensions : processability and characterisation

Elien De ConinckValérie VanhoorneAhmed ElmahdyMatthieu BooneG Van AsscheD MarklBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthetic carbohydrate biomaterials for innate immune-engineering

Ruben De CoenBruno De Geest

The future of layer-by-layer assembly : a tribute to ACS Nano associate editor Helmuth Möhwald

Shuang ZhaoFrank CarusoLars DähneGero DecherBruno De GeestJinchen FanNeus FeliuYury GogotsiPaula T HammondMark C HersamAli KhademhosseiniNicholas KotovStefano LeporattiYan LiFred LisdatLuis M Liz-MarzánSergio MoyaPaul MulvaneyAndrey L RogachSathi RoyDmitry G ShchukinAndre SkirtachMolly M StevensGleb B SukhorukovPaul S WeissZhao YueDingcheng ZhuWolfgang J Parak

A1 Journal Article in ACS NANO

Tumor engineered model for peritoneal metastasis with controllable stiffness

Elly De VlieghereWim CeelenBruno De GeestHeidi DeclercqSandra Van VlierbergheOlivier De Wever

Tumor engineered scaffolds recapitulate a human peritoneal tumor environment at the cellular and biophysical level

Elly De VlieghereWim CeelenBruno De GeestHeidi DeclercqSandra Van VlierbergheOlivier De Wever

Tumor engineering a clinical relevant model that recapitulates the tumor environment of peritoneal metastases in vitro and in vivo

Elly De VlieghereEmiel De JaeghereGlenn WagemansThibaut Van AckerChristian VanhoveSarah NeytsGeert BerxFrank VanhaeckeWim CeelenBruno De GeestHeidi DeclercqSandra Van VlierbergheOlivier De Wever

Unexpected reactivity switch in the statistical copolymerization of 2-oxazolines and 2-oxazines enabling the one-step synthesis of amphiphilic gradient copolymers

Ondrej SedlacekKathleen LavaBart VerbraekenSabah KasmiBruno De GeestRichard Hoogenboom

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach

Simon Van HerckBehrouz HassanniaBenoit LouageRaquel Pita CompostizoRuben De CoenWim Vanden BergheTom Vanden BergheBruno De Geest

A1 Journal Article in EUROPEAN POLYMER JOURNAL

2018

A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry : from chemical characterization to in vivo biodistribution

Francielle Pelegrin GarciaMarlène RippeMychelle VP CompanhoniTalitha Fernandes StefanelloBenoit LouageSimon Van HerckLucie SanceyJean-Luc CollBruno De GeestCelso Vataru NakamuraRachel Auzély-Velty

A2 Journal Article in BIOMATERIALS SCIENCE

Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models

Federico FenaroliUrska RepnikYitian XuKerstin JohannSimon Van HerckPradip DeyFrode Miltzov SkjeldalDominik M FreiShahla BagherifamAgnese KocereRainer HaagBruno De GeestMatthias BarzDavid G RussellGareth Griffiths

A1 Journal Article in ACS NANO

FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles

Lutz NuhnSimon Van HerckAndreas BestKim DeswarteMaria KokkinopoulouIngo LieberwirthKaloian KoynovBart LambrechtBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

Emiel De JaeghereElly De VlieghereJasper Van HoorickSandra Van VlierbergheGlenn WagemansLeen PietersElodie MelsensMarleen PraetJo Van DorpeMatthieu BooneRouba GhobeiraNathalie De GeyterMarc BrackeChristian VanhoveSara NeytGeert BerxBruno De GeestPeter DubruelHeidi DeclercqWim CeelenOlivier De Wever

A1 Journal Article in BIOMATERIALS

High-aspect-ratio nano-materials for biomedical applications

Hui LiBruno De Geest

Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue

Euna YooAlex CD SalyerMichael JH BrushYupeng LiKathryn L TrautmanNikunj M ShuklaAns De BeuckelaerStefan LienenklausKim DeswarteBart LambrechtBruno De GeestSunil A David

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Immunoengineering through cancer vaccines - A personalized and multi-step vaccine approach towards precise cancer immunity

Lien LybaertKarim VermaelenBruno De GeestLutz Nuhn

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart LambrechtSunil A DavidBruno De Geest

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men ChoiEline MeulKaren HeyninckKen DeclerckChandra Sekhar ChirumamillaMaija Lahtela-KakkonenGuy Van CampDmitri KryskoPaul G. EkertSimone FuldaBruno De GeestMarcus ConradValerian KaganWim Vanden BerghePeter VandenabeeleTom Vanden Berghe

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan LienenklausNiek SandersSunil A DavidJan TavernierBruno De Geest

A1 Journal Article in ADVANCED MATERIALS

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties

Bo LouAns De BeuckelaerGeorge DakwarKatrien RemautJohan GrootenKevin BraeckmansBruno De GeestEnrico MastrobattistaStefaan De KokerWim E. Hennink

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against a Vibrio anguillarum infection

Eamy Nursaliza YaacobBruno De GeestJens GoethalsAline BajekKristof DierckensPeter BossierDaisy Vanrompay

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Targeting protumoral tumor-associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation

Lutz NuhnEvangelia BolliSam MassaIsabel VandenbergheKiavash MovahediBart DevreeseJo A Van GinderachterBruno De Geest

A1 Journal Article in BIOCONJUGATE CHEMISTRY

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Joris LammensSéverine MortierLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalSimon Van HerckJos CorverIngmar NopensValérie VanhoorneBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The small GTPase Rab27B stimulates secretion of a subpopulation of ARRDC1-positive small extracellular vesicles (SEV)

Lien LippensRobin BoiyBert DhondtBruno De GeestKatrien VandecasteeleHannelore DenysOlivier De WeverAn Hendrix

Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant

Simon Van HerckLien Van HoeckeBenoit LouageLien LybaertRuben De CoenSabah KasmiAaron P Esser-KahnSunil A DavidLutz NuhnBert SchepensXavier SaelensBruno De Geest

A1 Journal Article in BIOCONJUGATE CHEMISTRY

pH-Sensitive hydrazone-linked doxorubicin nanogels via polymeric-activated ester scaffolds : synthesis, assembly, and in vitro and in vivo evaluation in tumor-bearing zebrafish

Alexandra Van DriesscheAgnese KocereHannelien EveraertLutz NuhnSimon Van HerckGareth GriffithsFederico FenaroliBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

2017

Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization

Sabah KasmiBenoit LouageLutz NuhnGlenn VerstraeteSimon Van HerckMies J van SteenbergenChris VervaetWim E HenninkBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Amphiphilic ferrocene-containing PEG block copolymers as micellar nanocarriers and smart surfactants

Arda AlkanSarah WaldBenoit LouageBruno De GeestKatharina LandfesterFrederik R. Wurm

A1 Journal Article in LANGMUIR

Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide

Vimal Kumar UdhayakumarAns De BeuckelaerJoanne McCaffreyCian M McCruddenJonathan L KirschmanDaryll VanoverLien Van HoeckeKenny RooseKim DeswarteBruno De GeestStefan LienenklausPhilip J SantangeloJohan GrootenHelen O McCarthyStefaan De Koker

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Cancer cell lysate entrapment in CaCO3 engineered with polymeric TLR-agonists : immune-modulating microparticles in view of personalized antitumor vaccination

Lien LybaertKeun Ah RyuLutz NuhnRiet De RyckeOlivier De WeverAlfred C ChonAaron P Esser-KahnBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Design of immune-modulating polymeric microparticles in view of cell-derived cancer vaccination

Lien LybaertBruno De Geest

Design, synthesis and evaluation of advanced polymeric taxane formulations

Benoit LouageBruno De Geest

Developments and future clinical outlook of taxane nanomedicines

Benoit LouageOlivier De WeverWim E HenninkBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Heterocellular 3D scaffolds as biomimetic of peritoneal metastases

Elly De VlieghereEmiel De JaeghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytBruno De GeestPeter DubruelWim CeelenHeidi DeclercqOlivier De Wever

Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo

Elly De VlieghereEmiel De JaeghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytBruno De GeestPeter DubruelWim CeelenHeidi DeclercqOlivier De Wever

Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo

Emiel De JaeghereElly De VlieghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytRouba GhobeiraRino MorentJo Van DorpeMarleen PraetGeert BerxChristian VanhoveBruno De GeestSandra Van VlierbergheWim CeelenHeidi DeclercqOlivier De Wever

Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo

Elly De VlieghereEmiel De JaeghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytBruno De GeestPeter DubruelWim CeelenHeidi DeclercqOlivier De Wever

Immobilization of 2-deoxy-D-ribose-5-phosphate aldolase in polymeric thin films via the Langmuir-Schaefer technique

Stefan ReinickeHuw C ReesPieter EspeelNane VanparijsCarolin BisterfeldMarkus DickRuben R RosencrantzGerald BrezesinskiBruno De GeestFilip Du PrezJoerg PietruszkaAlexander Boeker

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier SaelensBart LambrechtJohan Grooten

A1 Journal Article in SCIENTIFIC REPORTS

Micellar paclitaxel-initiated RAFT polymer conjugates with acid-sensitive behavior

Benoit LouageMies J. van SteenbergenLutz NuhnMartijn RisseeuwIzet KaralicJohan WinneSerge Van CalenberghWim E HenninkBruno De Geest

A1 Journal Article in ACS MACRO LETTERS

Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs

Benoit LouageLiesa TackYadong WangBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Polyelectrolyte-enrobed cancer cells in view of personalized immune-therapy

Lien LybaertKeun Ah RyuRiet De RyckeAlfred C ChonOlivier De WeverKarim VermaelenAaron Esser-KahnBruno De Geest

A1 Journal Article in ADVANCED SCIENCE

Preparation and characterization of alginate microparticles containing a model protein for oral administration in gnotobiotic European sea bass (Dicentrarchus labrax) larvae

Eamy Nursaliza YaacobJens GoethalsAline BajekKristof DierckensPeter BossierBruno De GeestDaisy Vanrompay

A1 Journal Article in MARINE BIOTECHNOLOGY

Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis

Glenn VerstraeteL. VandenbusscheSabah KasmiLutz NuhnD. BrouckaertJeroen Van RenterghemW. GrymonpreValérie VanhoorneTom CoenyeBruno De GeestThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transiently thermoresponsive polymers and their applications in biomedicine

Nane VanparijsLutz NuhnBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Tyrosine-triazolinedione bioconjugation as site-selective protein modification starting from RAFT-derived polymers

Stef VandewalleRuben De CoenBruno De GeestFilip Du Prez

A1 Journal Article in ACS MACRO LETTERS

Uptake of long protein-polyelectrolyte nanotubes by dendritic cells

Diana G Ramírez-WongSaghi SaghazadehSimon Van HerckBruno De GeestAlain M JonasSophie Demoustier-Champagne

A1 Journal Article in BIOMACROMOLECULES

2016

A generic polymer-protein ligation strategy for vaccine delivery

Lien LybaertNane VanparijsKaat FierensMartijn SchuijsLutz NuhnBart LambrechtBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Administration of bacterial heat shock protein 70 to induce a protective innate immune response in European sea bass larvae (Dicentrarchus labrax) against Vibrio anguillarum

Eamy Nursaliza YaacobBruno De GeestJens GoethalsAline BajeckKristof DierckensPeter BossierDaisy Vanrompay

Core/shell protein-reactive nanogels via a combination of RAFT polymerization and vinyl sulfone postmodification

Nane VanparijsLutz NuhnSamantha J PaluckMaria KokkinopoulouIngo LieberwirthHeather D MaynardBruno De Geest

A1 Journal Article in NANOMEDICINE

Design of protein-reactive polymers and core-crosslinked nanoparticles in view of vaccine delivery

Nane VanparijsBruno De Geest

Duality of β-glucan microparticles: antigen carrier and immunostimulants

Kim BaertBruno De GeestHenri De GreveEric CoxBert Devriendt

A1 Journal Article in INTERNATIONAL JOURNAL OF NANOMEDICINE

Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery

Stefaan De KokerJivei CuiNane VanparijsLorenzo AlbertazziJohan GrootenFrank CarusoBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Glenn VerstraeteJeroen Van RenterghemPieter-Jan Van BockstalSabah KasmiBruno De GeestThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Zhiyue ZhangBert SchepensLutz NuhnXavier SaelensMichael SchotsaertNico CallewaertRiet De RyckeQilu ZhangSébastien MoinsSamira BenaliLaetitia MespouilleRichard HoogenboomBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Interactive RAFT polymer-decorated gold nanoparticles for biomedical use

Zhiyue ZhangBruno De Geest

NewTumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells

Elly De VlieghereMarc BrackePieter DemetterWim CeelenChristian VanhoveBruno De GeestOlivier De Wever

Poly(N-isopropylacrylamide) coated gold nanoparticles as colourimetric temperature and salt sensors

Samarendra MajiBelgin CesurZhiyue ZhangBruno De GeestRichard Hoogenboom

A1 Journal Article in POLYMER CHEMISTRY

Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against Vibrio anguillarum

Eamy Nursaliza YaacobBruno De GeestJens GoethalsAline BajekKristof DierckensPeter BossierDaisy Vanrompay

Recombinant ferritin-H induces immunosupression in European sea bass larvae (Dicentrarchus labrax) rather than immunostmulation and protection against Vibrio anguillarum

Eamy Nursaliza YaacobBruno De GeestJens GoethalsAline BajeckKristof DierckensPeter BossierDaisy Vanrompay

Salt-driven deposition of thermoresponsive polymer-coated metal nanoparticles on solid substrates

Zhiyue ZhangSamarendra MajiAndre Bruno da fonseca AntunesRiet De RyckeRichard HoogenboomBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery

Hui LiKaat FierensZhiyue ZhangNane VanparijsMartijn SchuijsKatleen Van SteendamNatalia Feiner GraciaRiet De RyckeThomas De BeerAns De BeuckelaerStefaan De KokerDieter DeforceLorenzo AlbertazziJohan GrootenBart LambrechtBruno De Geest

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers

Zhiyue ZhangNane VanparijsStef VandewalleFilip Du PrezLutz NuhnBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Super resolution imaging of nanoparticles cellular uptake and trafficking

Daan van der ZwaagNane VanparijsSjors WijnandsRiet De RyckeBruno De GeestLorenzo Albertazzi

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains

Sabah KasmiBenoit LouageLutz NuhnAlexandra Van DriesscheJan Van DeunIzet KaralicMartijn RisseeuwSerge Van CalenberghRichard HoogenboomRiet De RyckeOlivier De WeverWim E HenninkBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Well-defined polymer-paclitaxel prodrugs by a grafting-from-drug approach

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz NuhnNane VanparijsAns De BeuckelaerLien LybaertGlenn VerstraeteKim DeswarteStefan LienenklausNikunj M ShuklaAlex CD SalyerBart LambrechtJohan GrootenSunil A DavidStefaan De KokerBruno De Geest

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-independent immediate release polymethacrylate formulations : an observational study

Bart ClaeysReinout VandeputteBruno De GeestJean Paul RemonChris Vervaet

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

2015

Acid-labile thermoresponsive copolymers that combine fast pH-triggered hydrolysis and high stability under neutral conditions

Qilu ZhangZhanyao HouBenoit LouageDingying ZhouNane VanparijsBruno De GeestRichard Hoogenboom

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Capsules changing in brittleness due to leaching of plasticizing agents

Kim Van TittelboomElke GruyaertJ SucaetBruno De GeestJean Paul RemonNele De Belie

Colorimetric logic gates based on poly(2-alkyl-2-oxazoline)coated gold nanoparticles

Victor Retamero De La RosaZhiyue ZhangBruno De GeestRichard Hoogenboom

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Degradable ketal-based block copolymer nanoparticles for anticancer drug delivery : a systematic evaluation

Benoit LouageQilu ZhangNane VanparijsLenny VoorhaarSofie Vande CasteeleYang ShiWim E HenninkJan Van BocxlaerRichard HoogenboomBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Linear polyethylenimine as (multi) functional initiator for organocatalytic L-lactide polymerization

Olivier CoulembierSébastien MoinsSamarendra MajiZhiyue ZhangBruno De GeestPhilippe DuboisRichard Hoogenboom

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Microparticles as antigen delivery systems for oral vaccination

Rebecca De SmetClaude CuvelierBruno De Geest

One-pot preparation of inert well-defined polymers by RAFT polymerization and in situ end group transformation

Qilu ZhangLenny VoorhaarBruno De GeestRichard Hoogenboom

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Polymer-protein conjugation via a 'grafting to' approach: a comparative study of the performance of protein-reactive RAFT chain transfer agents

Nane VanparijsSamarendra MajiBenoit LouageLenny VoorhaarDuchan LaplaceQilu ZhangY ShiWim E HenninkRichard HoogenboomBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

Mathieu BibianJeroen MangelschotsJames GardinerLynne WaddingtonMaria M Diaz AcevedoBruno De GeestBruno Van MeleAnnemieke MadderRichard HoogenboomSam Ballet

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Sequence-selective DNA recognition and enhanced cellular up-take by peptide–steroid conjugates

Yara Ruiz GarciaAbhishek IyerDorien Van LysebettenY Vladimir PabonBenoit LouageMalgorzata HoncharenkoBruno De GeestCI Edvard SmithRoger StrömbergAnnemieke Madder

A1 Journal Article in CHEMICAL COMMUNICATIONS

Solvent-free mechanochemical synthesis of a bicyclononyne tosylate: a fast route towards bioorthogonal clickable poly(2-oxazoline)s

Mathias GlassnerSamarendra MajiVictor Retamero De La RosaNane VanparijsKanykei RyskulovaBruno De GeestRichard Hoogenboom

A1 Journal Article in POLYMER CHEMISTRY

Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake

Abhishek IyerDorien Van LysebettenYara Ruiz GarciaBenoit LouageBruno De GeestAnnemieke Madder

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Tailoring cellular uptake of gold nanoparticles via the hydrophilic-to-hydrophobic ratio of their (co)polymer coating

Zhiyue ZhangKatleen Van SteendamSamarendra MajiLieve BalcaenYulia AnoshkinaQilu ZhangGlenn VanlucheneRiet De RyckeFrank VanhaeckeDieter DeforceRichard HoogenboomBruno De Geest

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

The road to an immune-priming strategy: a case of gnotobiotic European sea bass (Dicentrarchus labrax) larvae

Eamy Nursaliza YaacobBruno De GeestStanislas LaureauJens GoethalsKatelijn SchautteetStefanie LagaeDaisy VanrompayKristof DierckensPeter Bossier

Thermoresponsive polymer coated gold nanoparticles: from MADIX/RAFT copolymerization of N-vinylpyrrolidone and N-vinylcaprolactam to salt and temperature induced nanoparticle aggregation

Samarendra MajiZhiyue ZhangLenny VoorhaarSophie PietersBirgit StubbeSandra Van VlierberghePeter DubruelBruno De GeestRichard Hoogenboom

A1 Journal Article in RSC ADVANCES

Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators

Nane VanparijsRuben De CoenDuchan LaplaceBenoit LouageSamarendra MajiLien LybaertRichard HoogenboomBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells

Elly De VlieghereFélix GremonprezLaurine VersetLore MariënChristopher JonesBram De CraeneGeert BerxBenedicte DescampsChristian VanhoveJean Paul RemonWim CeelenPieter DemetterMarc BrackeBruno De GeestOlivier De Wever

A1 Journal Article in BIOMATERIALS

β-glucan microparticles targeted to APN as mucosal antigen delivery system in oral vaccination of piglets against ETEC infections

Kim BaertBruno De GeestBert DevriendtEric Cox

β-glucan microparticles targeted to epithelial APN as oral antigen delivery system

Kim BaertBruno De GeestRiet De RyckeAndre Bruno da fonseca AntunesHenri De GreveEric CoxBert Devriendt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2014

Bio-hybrid tumor cell-templated capsules: a generic formulation strategy for tumor associated antigens in view of immune therapy

Lien LybaertElly De VlieghereRiet De RyckeNane VanparijsOlivier De WeverStefaan De KokerBruno De Geest

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer-protein conjugates with transient solubility

Qilu ZhangNane VanparijsBenoit LouageBruno De GeestRichard Hoogenboom

A1 Journal Article in POLYMER CHEMISTRY

Fast and accurate partial hydrolysis of poly(2-ethyl-2-oxazoline) into tailored linear polyethylenimine copolymers

Victor Retamero De La RosaEva BauwensBryn MonneryBruno De GeestRichard Hoogenboom

A1 Journal Article in POLYMER CHEMISTRY

Hydrogen bonded multilayer films based on poly(2-oxazoline)s and tannic acid

Anandhakumar SundaramurthyMaarten VergaelenSamarendra MajiRachel Auzély-VeltyZhiyue ZhangBruno De GeestRichard Hoogenboom

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Just spray it: LbL assembly enters a new age

Marijke DierendonckStefaan De KokerRiet De RyckeBruno De Geest

A1 Journal Article in SOFT MATTER

Micro-particle encapsulated carcinoma-associated fibroblast (CAF) deceive and redirect disseminated cancer cells

Elly De VlieghereLaurine VersetChristian VanhoveLore MariënJean Paul RemonPieter DemetterMarc BrackeBruno De GeestOlivier De Wever

Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers

Marijke DierendonckKaat FierensRiet De RyckeLien LybaertSamarendra MajiZhiyue ZhangQilu ZhangRichard HoogenboomBart LambrechtJohan GrootenJean Paul RemonStefaan De KokerBruno De Geest

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Nanoporous microparticles : towards a generic vaccine formulation platform

Marijke DierendonckBruno De GeestStefaan De Koker

Nanoporous polyelectrolyte vaccine microcarriers: a formulation platform for enhancing humoral and cellular immune responses

Stefaan De KokerKaat FierensMarijke DierendonckRiet De RyckeBart LambrechtJohan GrootenJean Paul RemonBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Spray-dried polyelectrolyte microparticles in oral antigen delivery : stability, biocompatibility and cellular uptake

Rebecca De SmetStephanie VERSCHUERELiesbeth AllaisGeorges LeclercqMarijke DierendonckBruno De GeestIsabel Van DriesscheTine DemoorClaude Cuvelier

A1 Journal Article in BIOMACROMOLECULES

Straightforward RAFT procedure for the synthesis of heterotelechelic poly(acrylamide)s

Sofie WallynZhiyue ZhangFrank DriessenJoanna PietrasikBruno De GeestRichard HoogenboomFilip Du Prez

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

2013

Beta-glucan particles as novel antigen delivery systems : towards oral vaccination

Rebecca De SmetStephanie VerschuereTine DemoorLiesbeth AllaisCharles PiletteMarijke DierendonckBruno De GeestClaude Cuvelier

Beta-glucan particles as novel antigen delivery systems: towards oral vaccination

Rebecca De SmetStephanie VERSCHUERELiesbeth AllaisTine DemoorBruno De GeestClaude Cuvelier

CAF-encapsulated mico-particels capture free cancer cells from the peritoneal fluid

Elly De VlieghereLaurine VersetChristian VanhoveLore MariënJean Paul RemonPieter DemetterMarc BrackeBruno De GeestOlivier De Wever

Complexity from simplicity : unique polymer capsules, rods, monoliths, and liquid marbles prepared via HIPE in microfluidics

Muhammed GökmenBusra DereliBruno De GeestFilip Du Prez

A1 Journal Article in PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Dual temperature- and pH-responsive polymers for protein conjugation and vaccine design

Bruno De GeestQilu ZhangNane VanparijsBenoit LouageZhiyue ZhangRichard Hoogenboom

Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel

Wesley De JaeghereBruno De GeestJan Van BocxlaerJean Paul RemonChris VervaetAndre Bruno da fonseca Antunes

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs

Andre Bruno da fonseca AntunesBruno De GeestChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Hydrogen bonded polymeric multilayer films assembled below and above the cloud point temperature

Andre Bruno da fonseca AntunesMarijke DierendonckGertjan VancoillieJean Paul RemonRichard HoogenboomBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Improved anti-inflammatory effects in rabbit eye model using biodegradable poly beta-amino ester nanoparticles of triamcinolone acetonide

Araz SabzevariKhosro AdibkiaHassan HashemiBruno De GeestNavid MohsenzadehFatemeh AtyabiMohammad Hossein GhahremaniMohammad-Reza KhoshayandRassoul Dinarvand

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Magnetically engineered microcapsules as intracellular anchors for remote control over cellular mobility

Anton M PavlovBruno De GeestBenoit LouageLien LybaertStefaan De KokerZdenek KoudelkaAndrei V SapelkinGleb B Sukhorukov

A1 Journal Article in ADVANCED MATERIALS

Mechanical strength and intracellular uptake of CaCO₃- templated LbL capsules composed of biodegradable polyelectrolytes: the influence of the number of layers

Raghavendra PalankarBat-El PinchasikStephan SchmidtBruno De GeestAndreas FeryHelmuth MöhwaldAndre SkirtachMihaela Delcea

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Microparticles delivery system in gnotobiotic European sea bass larvae (Dicentrarchus labrax, L. 1758)

Eamy Nursaliza YaacobBruno De GeestDaisy VanrompayKristof DierckensPeter Bossier

A4 Journal Article in COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES

One-step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells

Bert DevriendtKim BaertMarijke DierendonckHerman FavoreelStefaan De KokerJean Paul RemonBruno De GeestEric Cox

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Polyelectrolyte microparticles as biomimetic mucosal delivery vehicles facilitate antigen presentation by dendritic cells

Bert DevriendtKim BaertMarijke DierendonckHerman FavoreelJean Paul RemonBruno De GeestEric Cox

Polysaccharide-based responsive nanogels for controlled drug delivery

Rachel Auzely-VeltyJing JingEmilie HachetDavid AlaimoElly De VlieghereAnna SzarpakChristine JeromeBruno De Geest

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Anouk VervaeckLien SaerensBruno De GeestThomas De BeerR CarleerP AdriaensensJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Salt plays a pivotal role in the temperature-responsive aggregation and layer-by-layer assembly of polymer-decorated gold nanoparticles

Zhiyue ZhangSamarendra MajiAndre Bruno da fonseca AntunesRiet De RyckeQilu ZhangRichard HoogenboomBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Solvent-free drug crystal engineering for drug nano- and micro suspensions

Andre Bruno da fonseca AntunesBruno De GeestChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions

Bart ClaeysRuben De CoenBruno De GeestVictor Retamero De La RosaRichard HoogenboomRobert CarleerPeter AdriaensensJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Systematic processing of beta-tricalcium phosphate for efficient protein loading and in vitro analysis of antigen uptake

Vinayaraj Ozhukil KollathBruno De GeestSteven MullensStefaan De KokerJan LuytenRosita PersoonsKarl TrainaJean Paul RemonRudi Cloots

A1 Journal Article in ADVANCED ENGINEERING MATERIALS

Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid-polymer conjugates

Jing JingDavid AlaimoElly De VlieghereChristine JérômeOlivier De WeverBruno De GeestRachel Auzély-Velty

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Yeast particles targeted to APN as antigen delivery system to porcine immune cells

Kim BaertBert DevriendtBruno De GeestEric Cox

β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination

Rebecca De SmetTine DemoorStephanie VerschuereMelissa DullaersGary R OstroffGeorges LeclercqLiesbeth AllaisCharles PiletteMarijke DierendonckBruno De GeestClaude Cuvelier

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2012

Biomimetic polyelectrolyte microparticles facilitate antigen presentation by porcine dendritic cells

Bert DevriendtKim BaertMarijke DierendonckHerman FavoreelJean Paul RemonBruno De GeestEric Cox

Crossing the barrier: targeting epithelial receptors for enhanced oral vaccine delivery

Bert DevriendtBruno De GeestBruno GoddeerisEric Cox

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Development and evaluation of solvent-free processing techniques for poorly water soluble drugs

Andre AntunesJean Paul RemonBruno De Geest

Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1

Liesbeth De CockOlivier De WeverSandra Van VlierbergheEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in SOFT MATTER

Engineered 3D microporous gelatin scaffolds to study cell migration

Liesbeth De CockOlivier De WeverHamida HammadBart LambrechtEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Interaction between polymeric multilayer capsules and immune cells

Marijke DierendonckStefaan De KokerChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?

Huub Van KuringenJoke LenoirEls AdriaensJohan BenderBruno De GeestRichard Hoogenboom

A1 Journal Article in MACROMOLECULAR BIOSCIENCE

Patchiness of embedded particles and film stiffness control through concentration of gold nanoparticles

Dorothee KohlerNarayanan MadaboosiMihaela DelceaStephan SchmidtBruno De GeestDmitry VolodkinHelmuth MöhwaldAndre Skirtach

A1 Journal Article in ADVANCED MATERIALS

Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding

Bart ClaeysAnouk VervaeckChris VervaetJean Paul RemonRichard HoogenboomBruno De Geest

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ACS NANO

Polymeric multilayer capsules for drug delivery

Stefaan De KokerRichard HoogenboomBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering

Tuğba DışpınarWim Van CampLiesbeth De CockBruno De GeestFilip Du Prez

A1 Journal Article in MACROMOLECULAR BIOSCIENCE

Redox-responsive degradation of poly(ethylene glycol) (PEG) based cryogels

Filip Du PrezTuğba DışpınarLiesbeth De CockBruno De Geest

Single step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells

Bert DevriendtKim BaertMarijke DierendonckHerman FavoreelJean Paul RemonBruno De GeestEric Cox

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function

Bruno De GeestMonique WillartBart LambrechtCharlotte PollardChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting aminopeptidase N, a newly identified receptor for F4ac fimbriae, enhances the intestinal mucosal immune response

Vesna MelkebeekK RasschaertPhilippe BellotK TillemanHerman FavoreelDieter DeforceBruno De GeestBruno GoddeerisEric Cox

A1 Journal Article in MUCOSAL IMMUNOLOGY

2011

Anisotropic multicompartment micro- and nano-capsules produced via embedding into biocompatible PLL/HA films

Mihaela DelceaNarayanan MadaboosiAlexey M YashchenokPrabal SubediDmitry V VolodkinBruno De GeestHelmuth MöhwaldAndre Skirtach

A1 Journal Article in CHEMICAL COMMUNICATIONS

Design of growth factor-loaded tissue engineering scaffolds

Liesbeth De CockJean Paul RemonBruno De Geest

Designing oral vaccines targeting intestinal dendritic cells

Bert DevriendtBruno De GeestEric Cox

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Designing polymeric particles for antigen delivery

Stefaan De KokerBart LambrechtMonique WillartYvette van KooykJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Evaluation of beta-glucan particles as mucosal delivery systems in the Peyer's patch regions of the murine small intestine

Rebecca De SmetTine DemoorSTEPHANIE VERSCHUEREMarijke DierendonckBruno De GeestClaude Cuvelier

Evaluation of degradable PEG-cryogels as potential cell scaffolds in tissue engineering

Tuğba DışpınarWim Van CampLiesbeth De CockBruno De GeestFilip Du Prez

Evaluation of β-glucan particles as mucosal delivery system in the Peyer's patch regions of the murine small intestine

Rebecca De SmetTine DemoorStephanie VERSCHUEREMarijke DierendonckBruno De GeestClaude Cuvelier

Hydrophobic shell loading of biopolyelectrolyte capsules

Di CuiJing JingThomas BoudouIsabelle Pignot-PaintrandStefaan De KokerBruno De GeestCatherine PicartRachel Auzely-Velty

A1 Journal Article in ADVANCED MATERIALS

Mucosal irritation potential of polyelectrolyte multilayer capsules

Liesbeth De CockJoke LenoirStefaan De KokerVincent VermeerschAndre SkirtachPeter DubruelEls AdriaensChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in BIOMATERIALS

Polymeric multilayer capsules delivering biotherapeutics

Stefaan De KokerLiesbeth De CockPilar Rivera-GilWolfgang J ParakRachel Auzély VeltyChris VervaetJean Paul RemonJohan GrootenBruno De Geest

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Redox-responsive degradable PEG-cryogels as potential cell scaffolds in tissue engineering

Tuğba DışpınarWim Van CampLiesbeth De CockBruno De GeestFilip Du Prez

Release properties of pressurized microgel templated capsules

Stephan SchmidtPaulo AL FernandesBruno De GeestMihaela DelceaAndre SkirtachHelmuth MoehwaldAndreas Fery

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Single-step formation of degradable intracellular biomolecule microreactors

Marijke DierendonckStefaan De KokerRiet De RyckePieter BogaertJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ACS NANO

Use of endospore-forming bacteria as an active oxygen scavenger in plastic packaging materials

Tom AnthierensPeter RagaertSam VerbruggheAssia OuchchenBruno De GeestBert NosedaJohan MertensLynda BeladjalDirk De CuyperWilliam DierickxFilip Du PrezFrank Devlieghere

A1 Journal Article in INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES

2010

A single step process for the synthesis of antigen laden thermosensitive microparticles

Bruno De GeestStefaan De KokerYves GonnissenLiesbeth De CockJohan GrootenJean Paul RemonChris Vervaet

A1 Journal Article in SOFT MATTER

Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery

Stefaan De KokerThomas NaessensBruno De GeestPieter BogaertJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Mathieu VinkenElke DecrockElke De VuystMarijke De BockRoosmarijn VandenbrouckeBruno De GeestJo DemeesterNiek SandersTamara VanhaeckeLuc LeybaertVera Rogiers

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Designing hyaluronic acid-based layer-by-layer capsules as a carrier for intracellular drug delivery

Anna SzarpakDi CuiFrédéric DubreuilBruno De GeestLiesbeth De CockCatherine PicartRachel Auzely-Velty

A1 Journal Article in BIOMACROMOLECULES

Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres

Marijke DierendonckStefaan De KokerClaude CuvelierJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Layer-by-layer incorporation of growth factors in decellularized aortic heart valve leaflets

Liesbeth De CockStefaan De KokerFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Polymeric microcapsules with light responsive properties for encapsulation and release

Matthieu BédardBruno De GeestAndre SkirtachHelmuth MöhwaldGleb B Sukhorukov

A1 Journal Article in ADVANCES IN COLLOID AND INTERFACE SCIENCE

Polymeric multilayer capsules in drug delivery

Liesbeth De CockStefaan De KokerBruno De GeestJohan GrootenChris VervaetJean Paul RemonGleb B SukhorukovMaria N Antipina

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-exploding capsules

Bruno De GeestStefaan De KokerJo DemeesterStefaan De SmedtWim E Hennink

A1 Journal Article in POLYMER CHEMISTRY

Thiol-mediated polymeric materials

Arun Prasath RamaswamyBruno De GeestMuhammed GökmenWim Van CampFilip Du Prez

2009

'Clicked' polymeric microcapsules and beads: Azide-alkyne versus thiol-ene and thiol-yne approach (Abstract of Lecture)

Filip Du PrezArun Prasath RamaswamyMuhammed GökmenWim Van CampBruno De Geest

'Giant' Hollow Multilayer Capsules by Microfluidic Templating

Muhammed GökmenBruno De GeestWE HenninkFilip Du Prez

A1 Journal Article in ACS Applied Materials & Interfaces

Direction specific release from giant microgel-templated polyelectrolyte microcontainers

MF BedardBruno De GeestH MoehwaldGB SukhorukovAndre Skirtach

A1 Journal Article in SOFT MATTER

Exploration of novel functionalization concepts for surfaces, beads and microcapsules (Abstract of lecture)

Filip Du PrezArun Prasath RamaswamyMuhammed GökmenWim Van CampBruno De Geest

Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules

Pilar Rivera-GilStefaan De KokerBruno De GeestWolfgang J Parak

A1 Journal Article in NANO LETTERS

On-demand click functionalization of polyurethane films and foams

David FournierBruno De GeestFilip Du Prez

A1 Journal Article in POLYMER

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Stefaan De KokerBruno De GeestSatwinder SinghRiet De RyckeThomas NaessensYvette Van KooykJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyelectrolyte microcapsules for biomedical applications

Bruno De GeestStefaan De KokerGB SukhorukovO KreftWJ ParakAndre SkirtachJo DemeesterStefaan De SmedtWim E Hennink

A1 Journal Article in Soft Matter

Pulsed in vitro release and in vivo behavior of exploding microcapsules

Bruno De GeestStefaan De KokerJo DemeesterStefaan De SmedtWE Hennink

A1 Journal Article in Journal of Controlled Release

The pros and cons of polyelectrolyte capsules in drug delivery

Bruno De GeestGB SukhorukovH Mohwald

A1 Journal Article in Expert opinion on drug delivery

Thiol-ene and thil-yne 'click' chemistry for preparation of functional beads (Abstract of Lecture)

Arun Prasath RamaswamyMuhammed GökmenBruno De GeestFilip Du Prez

2008

Biodegradable microcapsules designed via "click" chemistry

Bruno De GeestWim Van CampFilip Du PrezStefaan De SmedtJo DemeesterW HENNINK

Biodegradable microcapsules designed via 'click' chemistry

Bruno De GeestWim Van CampFilip Du PrezStefaan De SmedtJo DemeesterWE HENNINK

A1 Journal Article in CHEMICAL COMMUNICATIONS

Biodegradable microgels by click chemistry

Bruno De GeestWim Van CampFilip Du PrezJo DemeesterStefaan De SmedtWim E Hennink

Biodegradable microgels by click chemistry

Bruno De GeestWim Van CampFilip Du PrezJo DemeesterStefaan De SmedtW HENNINK

Degradable microgels and hollow capsules by 'click' chemistry

Bruno De GeestWim Van CampFilip Du PrezJo DemeesterStefaan De SmedtW Hennink

Degradable multilayer films and hollow capsules via a 'Click' strategy

Bruno De GeestWim Van CampFilip Du PrezStefaan De SmedtJo DemeesterWE HENNINK

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Evaluation of encoded layer-by-layer coated microparticles as protease sensors

Barbara StubbeKris GevaertStefaan DerveauxKevin BraeckmansBruno De GeestMarc GoethalsJoël VandekerckhoveJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Layer-by-layer coated digitally encoded microcarriers for quantification of proteins in serum and plasma

Stefaan DerveauxBarbara StubbeC ROELANTM LEBLANSBruno De GeestJo DemeesterStefaan De Smedt

A1 Journal Article in ANALYTICAL CHEMISTRY

Microcapsules Ejecting Nanosized Species into the Environment

Bruno De GeestMJ MCSHANEJo DemeesterStefaan De SmedtWE HENNINK

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanorods as wavelength-selective absorption centers in the visible and near-infrared regions of the electromagnetic spectrum

Andre SkirtachPeter KarageorgievBruno De GeestNicolas Pazos-PerezDieter BraunGleb B. Sukhorukov

A1 Journal Article in ADVANCED MATERIALS

Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process

Yves GonnissenSIV GONCALVESBruno De GeestJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestJo DemeesterStefaan De SmedtNiek Sanders

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestStefan BonnéM VINKENT VAN HAECKEH HEIMBERGE WAGNERV ROGIERSStefaan De SmedtJo DemeesterNiek Sanders

A1 Journal Article in JOURNAL OF GENE MEDICINE

Self exploding microcapsules

Bruno De GeestStefaan De KokerJo DemeesterStefaan De SmedtWim E Hennink

Self-Exploding Beads Releasing Microcarriers

Bruno De GeestStefaan De KokerKristof ImmesoeteJo DemeesterStefaan De SmedtWE HENNINK

A1 Journal Article in ADVANCED MATERIALS

Stimuli-responsive polyelectrolyte microcapsules for biomedical applications

Bruno De GeestA SkirtachG SukhorukovJo DemeesterStefaan De SmedtWE Hennink

2007

In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules

Stefaan De KokerBruno De GeestClaude CuvelierLiesbeth FerdinandeWies DeckersWE HENNINKStefaan De SmedtNico Mertens

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Multifunctional layer-by-layer coating of digitally encoded microparticles

Stefaan DerveauxBruno De GeestC ROELANTKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in LANGMUIR

Nucleic acid delivery: Where material sciences and bio-sciences meet

Katrien RemautNiek SandersBruno De GeestKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in MATERIALS SCIENCE & ENGINEERING R-REPORTS

Release mechanisms for polyelectrolyte capsules

Bruno De GeestNiek SandersGB SUKHORUKOVJo DemeesterStefaan De Smedt

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Self-rupturing and hollow microcapsules prepared from bio-polyelectrolyte-coated microgels

Bruno De GeestC DEJUGNATM PREVOTGB SUKHORUKOVJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Stimuli-responsive multilayered hybrid nanoparticle/polyelectrolyte capsules

Bruno De GeestAndre SkirtachThomas De BeerGB SUKHORUKOVLieven BrackeWilly BaeyensJo DemeesterStefaan De Smedt

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Ultrasound stimulated release and catalysis using polyelectrolyte multilayer capsules

Andre SkirtachBruno De GeestArif MamedovAlexei A. AntipovNicholas A. KotovGleb B. Sukhorukov

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY

Ultrasound-triggered release from multilayered capsules

Bruno De GeestAndre SkirtachAA MAMEDOVAA ANTIPOVNA KOTOVStefaan De SmedtGB SUKHORUKOV

A1 Journal Article in SMALL

2006

Glucose-responsive polyelectrolyte capsules

Bruno De GeestAM JONASJo DemeesterStefaan De Smedt

A1 Journal Article in LANGMUIR

Intracellularly degradable polyelectrolyte microcapsules

Bruno De GeestRoosmarijn VandenbrouckeAM GUENTHERGB SUKHORUKOVWE HENNINKNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

Layer-by-layer coating of degradable microgels for pulsed drug delivery

Bruno De GeestC DEJUGNATEllen VerhoevenGB SUKHORUKOVAM JONASJ PLAINJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Polyelectrolyte microcapsules for pharmaceutical applications

Bruno De GeestS De SmedtJ Demeester

Pulsed drug delivery

Bruno De GeestEls MehuysG LaekemanJo DemeesterStefaan De Smedt

A2 Journal Article in Expert Opinion on Drug Delivery

Self-exploding lipid-coated microgels

Bruno De GeestBarbara StubbeAM JONASTinneke Van ThienenWLJ HINRICHSJo DemeesterStefaan De Smedt

A1 Journal Article in BIOMACROMOLECULES

Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA

Ine LentackerBruno De GeestRoosmarijn VandenbrouckeLiesbeth PeetersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in LANGMUIR

2005

Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching

SR VAN TOMMEBruno De GeestKevin BraeckmansStefaan De SmedtF SIEPMANNJ SIEPMANNCF VAN NOSTRUMWE HENNINK

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Self-rupturing microcapsules

Bruno De GeestC DEJUGNATGB SUKHORUKOVKevin BraeckmansStefaan De SmedtJo Demeester

A1 Journal Article in ADVANCED MATERIALS

Synthesis of monodisperse biodegradable microgels in microfluidic devices

Bruno De GeestJP URBANSKIT THORSENJo DemeesterStefaan De Smedt

A1 Journal Article in LANGMUIR