Research Explorer

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Researcher

Bart De Spiegeleer

Publications & Research Data

Awards & Distinctions

431 Results

2026

Navigating in the chemical space of peptides : computational strategies and molecular features to unveil their functional and drug-like properties

Ewerton Cristhian Lima de OliveiraJuliana Auzier Seixas FeioGabriel Pereira CoelhoLidiane Diniz Do NascimentoAnderson Henrique LimaCaio Marcos Flexa RodriguesAnton De SpiegeleerEvelien WynendaeleClaudomiro SalesBart De Spiegeleer et al.

A1 Journal Article in PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Quorum sensing peptides in sarcopenia : insights from iAM373

Liesbeth Crombezsumaira jabeenPetar NaumovskiNele Van Den NoortgateBart De SpiegeleerEvelien WynendaeleAnton De Spiegeleer

The association between statins and gait speed reserve in older adults : effects of concomitant medication

Anton De SpiegeleerAntoon BronselaerIne MahieuDorien VreysAaron HaslbauerJan-Philipp LeibfarthLara Van SchooteAster Wakjira GaredoMirko PetrovicEvelien Wynendaele et al.

A1 Journal Article in GEROSCIENCE

2025

Beyond molecular weight : peptide characteristics influencing the sensitivity of retention to changes in organic solvent in reversed-phase chromatography

Amélie DescampsHannah HirmzEwerton de OliveiraAnton De SpiegeleerJuliana FeioKaue da CostaBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in ACS OMEGA

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Jeroen SpanogheEvelien WynendaeleMarijke VergaelenMaren De ColvenaerTina MarimanKristl VonckEvelien CarretteWytse WadmanErine CraeyLars Emil Larsen et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Role of peptides in skeletal muscle wasting : a scoping review

Petar NaumovskiBart De SpiegeleerAster Wakjira GaredoChristophe Van De WieleVincent MoulyKatarzyna Goljanek‐WhysallKauê Santana da CostaEwerton Cristhian Lima de OliveiraEvelien WynendaeleAnton De Spiegeleer

A1 Journal Article in JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

Sample preparation in analytical peptidomics : it's all about timing

Amélie DescampsBart De SpiegeleerEvelien WynendaelePetar NaumovskiAnton De Spiegeleer

A2 Journal Article in TALANTA OPEN

Sustainability of drug discovery, development and use as embedded in European pharmaceutical policies

Bart De SpiegeleerEvelien Wynendaele

A1 Journal Article in CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY

2024

BrainPepPass : a framework based on supervised dimensionality reduction for predicting blood-brain barrier-penetrating peptides

Ewerton Cristhian Limade OliveiraHannah HirmzEvelien WynendaeleJuliana Auzier Seixas FeioIgor Matheus MoreiraKauê Santana da CostaAnderson H. LimaBart De SpiegeleerClaudomiro de Souza de Sales Júnior

A1 Journal Article in JOURNAL OF CHEMICAL INFORMATION AND MODELING

Geneesmiddelenontwikkeling en AI : rollen de moleculen nu gewoon uit de computer?

Evelien WynendaeleHannah HirmzBart De Spiegeleer

Bookchapter in Geneeskunde in tijden van AI : handvatten voor vandaag en morgen

Geriatricians-on-the-Move for sustainable ageing

Anton De SpiegeleerBart De Spiegeleer

Editorial material

Machine learning insights into CaCO3 phase transitions : synthesis and phase prediction

Yanqi HuangBart De SpiegeleerBogdan ParakhonskiyAndre Skirtach

A1 Journal Article in CERAMICS INTERNATIONAL

On the pivotal role of drug discovery in sustainable EU pharma reform

Bart De SpiegeleerBenoit DeprezEelko HakMichal MarkuszewskiEvelien Wynendaele

Editorial material

Quality control of L-ascorbic acid 2-phosphate magnesium using reversed-phase liquid chromatography

Evelien WynendaeleJonas UrlaubXiaolong XuUlrike HolzgrabeBart De Spiegeleer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHIC SCIENCE

Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting

Anton De SpiegeleerAmélie DescampsEvelien WynendaelePetar NaumovskiLiesbeth CrombezMarta PlanasLidia FeliuDaniel KnappeVincent MoulyAnne Bigot et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The continuing challenge of drug recalls: insights from a ten-year FDA data analysis

Seppe GhijsEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Saliva and Muscle Study (SaMu) : rationale and protocol for associations between salivary microbiome and accelerated muscle ageing

Liesbeth CrombezAmélie DescampsHannah HirmzMartijn LambertJonas CalewaertD. SilukM. MarkuszewskiM. BiesemansG. PetrellaD. Cicero et al.

A2 Journal Article in JOURNAL OF FRAILTY & AGING

2023

Characterizing non-covalent protein complexes using asymmetrical flow field-flow fractionation on-line coupled to native mass spectrometry

Iro Konstantina VentouriWayne ChangFlorian MeierRoland DrexelGovert W. SomsenPeter J. SchoenmakersBart De SpiegeleerRob HaselbergAlina Astefanei

A1 Journal Article in ANALYTICAL CHEMISTRY

Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives

Kris CooremanBart De SpiegeleerChristof Van PouckeDavid VanavermaeteDaan DelbareEvelien WynendaeleBavo De Witte

A1 Journal Article in ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Environment-functionality-cost balance of an analytical reagent

Hannah HirmzFrederick VerbekeBartosz WielgomasChristophe FurmanEmmanuelle LipkaBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in SUSTAINABLE CHEMISTRY AND PHARMACY

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam-based P2RX7-antagonists

Lorenzo AvigoChristophe FurmanAlina GhinetTeodora SanduEvelien WynendaeleBartosz WielgomasBart De SpiegeleerEmmanuelle Lipka

A1 Journal Article in ELECTROPHORESIS

Peptidomics : LC-MS operational parameters do matter

Amélie DescampsKevin Van der borghtAnton De SpiegeleerEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Potential role of statins in treatment of acute sarcopenia

Anton De SpiegeleerHasan KahyaLiesbeth CrombezAmélie DescampsRoland RösslerReto W. KressigBruno LapauwEvelien WynendaeleDirk ElewautBart De Spiegeleer et al.

A1 Journal Article in MEDICAL HYPOTHESES

2022

A bioanalytical screening method for Enterococcus faecalis RNPP-type quorum sensing peptides in murine feces

Frederick VerbekeNathan DebunneYorick JanssensBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOANALYSIS

A fit-for-purpose LC-MS/MS method for the analysis of selected Streptococcal quorum sensing peptides in human saliva

Frederick VerbekeKevin Van der borghtAnton De SpiegeleerNathan DebunneYorick JanssensEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection

Fanta Gashe FufaEvelien WynendaeleBart De SpiegeleerSultan Suleman

A1 Journal Article in MALARIA JOURNAL

Exploring the in-vivo role of quorum sensing peptides : preclinical and bioanalytical contributions

Frederick VerbekeBart De SpiegeleerEvelien Wynendaele

Liquid chromatography-mass spectrometry (LC-MS) analysis of bioactive peptides

Evelien WynendaeleKevin Van der borghtNathan DebunneBart De Spiegeleer

Bookchapter in Bioactive peptides from food : aources, analysis, and functions

Quality-by-design principles applied to the establishment of a pharmaceutical quality control laboratory in a resource-limited setting : the lab water

Sultan SulemanSileshi Belew YohannesDereje KebebeMarkos DugumaHenok TeshomeGemmechu HasenEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY

Statin intake and all-cause mortality among older nursing home residents

Anton De SpiegeleerJordi Van MigerodeAntoon BronselaerEvelien WynendaeleMilan PeelmanFilip VandaeleGeert ByttebierGuy De TréLuc BelmansChristophe Van De Wiele et al.

A1 Journal Article in GERONTOLOGY

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Anton De SpiegeleerEvelien WynendaeleAmélie DescampsNathan DebunneBart BraeckmanMarjan De MeyJulie CoudenysLiesbeth CrombezFrederick VerbekeYorick Janssens et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice : a new factor in the host-microbiome interaction

Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf Hoffmann et al.

A1 Journal Article in BMC BIOLOGY

2021

Adjunctive use of statins for COVID-19

Mike SathekgeGeert ByttebierBart De SpiegeleerBo SaxbergVeronica UeckermannLuc BelmansMyriam AlexanderDavid Fedson

Editorial material

Apoptosis imaging in oncology by means of positron emission tomography : a review

Christophe Van De WieleSezgin UstmertBart De SpiegeleerPieter-Jan De JongheMike SathekgeMaes Alex

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Applications in medicine : mental health

Yorick JanssensEvelien WynendaeleKurt AudenaertBart De Spiegeleer

Bookchapter in Biologically active peptides : from basic science to applications for human health

BBPpred : sequence-based prediction of blood-brain barrier peptides with feature representation learning and logistic regression

Ruyu DaiWei ZhangWending TangEvelien WynendaeleQizhi ZhuYannan BinBart De SpiegeleerJunfeng Xia

A1 Journal Article in JOURNAL OF CHEMICAL INFORMATION AND MODELING

Conformational stability as a quality attribute for the cell therapy raw material human serum albumin

Evelien WynendaeleGamaliel Junren MaXiaolong XuNam-Joon ChoBart De Spiegeleer

A1 Journal Article in RSC ADVANCES

Cov-MS : a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients

Bart Van PuyveldeKatleen Van UytfangheOlivier TytgatLaurence Van OudenhoveRalf GabrielsRobbin BouwmeesterSimon DaledTim Van Den BosschePathmanaban RamasamySigrid Verhelst et al.

A2 Journal Article in JACS AU

Dietary muramidase degrades bacterial peptidoglycan to NOD-activating muramyl dipeptides and reduces duodenal inflammation in broiler chickens

Ya WangEvy GoossensVenessa EeckhautEstefania Pérez CalvoRual Lopez-UlibarriIrene EisingMikkel KlausenNathan DebunneBart De SpiegeleerRichard Ducatelle et al.

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

Aaron G. PothFrancis C.K. ChiuSofie StalmansBrett R. HamiltonYen-Hua HuangDavid M. ShacklefordRahul PatilThao T. LeMeng-Wei KanThomas Durek et al.

A2 Journal Article in MEDICINE IN DRUG DISCOVERY

Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review

Sileshi BelewSultan SulemanEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in ENVIRONMENTAL POLLUTION

Faecal microbiota transplants : why do we not consider them as Advanced Therapy Medicinal Products?

Frederick VerbekeBart De Spiegeleer

A1 Journal Article in UNITED EUROPEAN GASTROENTEROLOGY JOURNAL

Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBs

Geert ByttebierLuc BelmansMyriam AlexanderBo E. H. SaxbergBart De SpiegeleerAnton De SpiegeleerNick DevrekerJens Van PraetKarolien VanhoveReinhilde Reybrouck et al.

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

PapRIV : a BV-2 microglial cell activating quorum sensing peptide

Yorick JanssensNathan DebunneAnton De SpiegeleerEvelien WynendaeleMarta PlanasLidia FeliuAlessandra QuartaChristel ClaesDebby Van DamPeter Paul De Deyn et al.

A1 Journal Article in SCIENTIFIC REPORTS

Quorum sensing peptides as a novel microbiomal causative factor in promoting colorectal cancer metastasis : the EntF metabolite case

Nathan DebunneBart De SpiegeleerEvelien Wynendaele

Sustainability in drug discovery

Evelien WynendaeleChristophe FurmanBartosz WielgomasPer LarssonEelko HakThomas BlockSerge Van CalenberghNicolas WillandMichal MarkuszewskiLuke R. Odell et al.

A2 Journal Article in MEDICINE IN DRUG DISCOVERY

2020

A simplified checklist for the visual inspection of finished pharmaceutical products : a way to empower frontline health workers in the fight against poor-quality medicines

B. SchiavettiEvelien WynendaeleV MelotteJ. Van der ElstBart De SpiegeleerR. Ravinetto

A2 Journal Article in JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case

Nathalie BrackeYorick JanssensEvelien WynendaeleLiesa TackAlex MaesChristophe Van De WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development of a dissolution method for lumefantrine and artemether in immediate release fixed dose artemether/lumefantrine tablets

Sileshi Belew YohannesSultan SulemanMarkos DugumaHenok TeshomeEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Functional quality of selected antimalarial and antihelminthic medicines

Sileshi Belew YohannesBart De SpiegeleerLuc DuchateauSultan Suleman

Influence of blood collection methods and long-term plasma storage on quorum-sensing peptide stability

Nathan DebunneAnton De SpiegeleerDorian DepuydtYorick JanssensAmélie DescampsEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in ACS OMEGA

LC-MS compatible antiadsorption diluent for peptide analysis

Frederick VerbekeNathalie BrackeNathan DebunneEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in ANALYTICAL CHEMISTRY

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Quality characterization of raw materials used in advanced therapy medicinal products : HEPES, APMg and albumin

Xiaolong XuBart De Spiegeleer

Quorum sensing molecules as a novel microbial factor impacting muscle cells

Anton De SpiegeleerDirk ElewautNele Van Den NoortgateYorick JanssensNathan DebunneSelien Van LangenhoveSrinath GovindarajanBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quorum sensing peptides and their interactions with the host

Evelien WynendaeleNathan DebunneFrederick VerbekeYorick JanssensAnton De SpiegeleerBart De Spiegeleer

Bookchapter in Quorum sensing : microbial rules of life

Quorum sensing peptides as possible brain-influencing microbiome mediators

Yorick JanssensBart De SpiegeleerEvelien Wynendaele

Structural study of L-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy

Xiaolong XuMagdalena WozniczkaKristof Van HeckeDieter BuystDimitrije MaraChris VervaetKaren HermanEvelien WynendaeleEric DeconinckBart De Spiegeleer

A1 Journal Article in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The effects of ARBs, ACEis, and statins on clinical outcomes of COVID-19 infection among nursing home residents

Anton De SpiegeleerAntoon BronselaerJames T. TeoGeert ByttebierGuy De TréLuc BelmansRichard DobsonEvelien WynendaeleChristophe Van de WieleFilip Vandaele et al.

A1 Journal Article in JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION

Thermal sensitivity as a quality control attribute for biotherapeutics : the L‐asparaginase case

Han YaoEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in DRUG TESTING AND ANALYSIS

2019

A Surface Acoustic Wave (SAW) biosensor method for functional quantification of E. coli l-asparaginase

Han YaoCristina Soto FernándezXiaolong XuEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in TALANTA

Bacterial quorum sensing peptides as mediators of the gut-brain axis

Yorick JanssensEvelien WynendaeleNathan DebunneKurt AudenaertDebby Van DamAlessandra QuartaPeter PonsaertsBart De Spiegeleer

Biological characterisation of somatropin-derived cryptic peptides

Liesa TackNathalie BrackeFrederick VerbekeEvelien WynendaeleEwald PauwelsAlex MaesChristophe Van de WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

Disbiome : a database describing microbiome alterations in different disease states

Yorick JanssensAntoon BronselaerEvelien WynendaeleGuy De TréBart De Spiegeleer

Bookchapter in Reference module in biomedical sciences

Distinct neutrophil C5a receptor inflammatory events in cows initiated by chemoattractant C5a and lipopolysaccharide around parturition and in mid lactation

Xanthippe BoulougourisCarolien RogiersMario Van PouckeBart De SpiegeleerLuc PeelmanLuc DuchateauChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Hazard analysis of falsified peptide 'medicines'

Steven JanvierBart De SpiegeleerEric DeconinckCeline Vanhee

Hot-melt preparation of a non-biodegradable peptide implant : a proof of principle

Matthias D'HondtFrederick VerbekePieter WuytensAndre SkirtachBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Methylation of selected CpG islands involved in the transcription of myeloperoxidase and superoxide dismutase 2 in neutrophils of periparturient and mid-lactation cows

Xanthippe BoulougourisCarolien RogiersMario Van PouckeBart De SpiegeleerLuc PeelmanLuc DuchateauChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Peptides as epigenetic modulators : therapeutic implications

Yorick JanssensEvelien WynendaeleWim Vanden BergheBart De Spiegeleer

A1 Journal Article in CLINICAL EPIGENETICS

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases

Valérie VanhoorneE PeetersInge Van TongelenKoen BousseryEvelien WynendaeleBart De SpiegeleerJean Paul RemonChris Vervaet

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

PSMA-targeting positron emission agents for imaging solid tumors other than non-prostate carcinoma : a systematic review

Christophe Van De WieleMike SathekgeBart De SpiegeleerPieter-Jan De JongheLaurence BeelsAlex Maes

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quality exploration of L-asparaginase : analytical characterization

Han YaoBart De Spiegeleer

Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia

Sileshi Belew YohannesSultan SulemanTesfaye MohammedYimer MekonnenMarkos DugumaHenok TeshomeBikila BayisaEvelien WynendaeleMathias D'HondtLuc Duchateau et al.

A1 Journal Article in MALARIA JOURNAL

Residual active pharmaceutical ingredient on the primary packaging of medicines : a valuable GMP-marker

Evelien WynendaeleMiguel ColpaertNathan DebunneAnne KosgeiBart De Spiegeleer

A1 Journal Article in TALANTA

Zwitterionic-hydrophilic interaction liquid chromatography for L-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy

Xiaolong XuJonas UrlaubMagdalena WoźniczkaEvelien WynendaeleKaren HermanCurd SchollmayerBernd DiehlSerge Van CalenberghUlrike HolzgrabeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2018

99mTc-HMPAO SPECT after single and repeated subanaesthetic ketamine in healthy dogs

Lise VlerickKathelijne PeremansRobrecht DockxKurt AudenaertChris BaekenBart De SpiegeleerJimmy SaundersTim BosmansIngeborgh Polis

Analysis of iodinated quorum sensing peptides by LC-UV/ESI ion trap mass spectrometry

Yorick JanssensFrederick VerbekeNathan DebunneEvelien WynendaeleKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Are injectable illegal polypeptide drugs safe? : case report demonstrating the presence of haemolytic Bacillus cereus in two illegal peptide drugs

Steven JanvierElke WattijnNadine BotteldoornBart De SpiegeleerEric DeconinckCeline Vanhee

A1 Journal Article in DRUG TESTING AND ANALYSIS

Characterisation of magnesium ascorbyl phosphate, a raw material in cell therapy

Xiaolong XuMagdalena WoźniczkaToon VerstraelenKristof Van HeckePatrick BultinckCarl MenschDieter BuystEric DeconinckEvelien WynendaeleKaren Herman et al.

Chromatography of quorum sensing peptides : an important functional class of the bacterial peptidome

Nathan DebunneFrederick VerbekeYorick JanssensEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in CHROMATOGRAPHIA

Circular dichroism in functional quality evaluation of medicines

Han YaoEvelien WynendaeleXiaolong XuAnne KosgeiBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Detection and quantification of Enterococcus faecalis RNPP-type quorum sensing peptides in bacterial culture media by UHPLC-MS

Frederick VerbekeNathan DebunneYorick JanssensLiesa TackEvelien WynendaelePetra RigoleTom CoenyeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Han YaoJana VandenbosscheCari E Sänger-van de GriendYorick JanssensCristina Soto FernándezXiaolong XuEvelien WynendaeleGovert Willem SomsenRob HaselbergBart De Spiegeleer

A1 Journal Article in TALANTA

Disbiome database : linking the microbiome to disease

Yorick JanssensJoachim NielandtAntoon BronselaerNathan DebunneFrederick VerbekeEvelien WynendaeleFilip Van ImmerseelYves-Paul VandewynckelGuy De TréBart De Spiegeleer

A1 Journal Article in BMC MICROBIOLOGY

Do quorum sensing peptides play a role in psychiatric disorders?

Evelien WynendaeleYorick JanssensNathan DebunneKurt AudenaertBart De Spiegeleer

Falsification of biotechnology drugs : current dangers and/or future disasters?

Steven JanvierBart De SpiegeleerCeline VanheeEric Deconinck

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Impurity profiling of the most frequently encountered falsified polypeptide drugs on the Belgian market

Steven JanvierKarlien CheynsMichaël CanfynSéverine GoscinnyBart De SpiegeleerCeline VanheeEric Deconinck

A1 Journal Article in TALANTA

Is there a role for quorum sensing peptides in cancer?

Evelien WynendaeleYorick JanssensNathan DebunneOlivier De WeverBart De Spiegeleer

Quality of anthelminthic medicines available in Jimma Ethiopia

Sileshi Belew YohannesSultan SulemanEvelien WynendaeleMatthias D'HondtAnne KosgeiLuc DuchateauBart De Spiegeleer

A1 Journal Article in ACTA TROPICA

Quality of isotopically labelled internal standards for peptide quantification

Nathan DebunneFrederick VerbekeYorick JanssensLiesa TackEvelien WynendaeleBart De Spiegeleer

Regulatory status of N-alkylamide containing health products

Evelien WynendaeleBart De SpiegeleerBert GevaertYorick JanssensSultan SulemanSteven CattoorJimmy SaundersLieselotte Veryser

A1 Journal Article in REGULATORY TOXICOLOGY AND PHARMACOLOGY

Residual API on the packaging : a GMP-marker?

Evelien WynendaeleMiguel ColpaertAnne KosgeiNathan DebunneBart De Spiegeleer

Screening of quorum sensing peptides for biological effects in neuronal cells

Yorick JanssensEvelien WynendaeleFrederick VerbekeNathan DebunneBert GevaertKurt AudenaertChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in PEPTIDES

The influence of subanaesthetic ketamine on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT

Lise VlerickKathelijne PeremansRobrecht DockxKurt AudenaertChris BaekenBart De SpiegeleerJimmy SaundersIngeborgh Polis

A1 Journal Article in PLOS ONE

The quality of medicines used in children and supplied by private pharmaceutical wholesalers in Kinshasa, Democratic Republic of Congo : a prospective survey

Benedetta SchiavettiEvelien WynendaeleBart De SpiegeleerGeremie J MbinzeNicodème KalendaRoland MariniVera MelotteEpco HaskerBruno MeessenRaffaella Ravinetto et al.

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

Joshua A JackmanVivian V CostaSoohyun ParkAna Luiza CV RealJae Hyeon ParkPablo L CardozoAbdul Rahim FerhanIsabella G OlmoThaiane P MoreiraJordana L Bambirra et al.

A1 Journal Article in NATURE MATERIALS

Treatment of malaria and related symptoms using traditional herbal medicine in Ethiopia

Sultan SulemanTakele Beyene TufaDereje KebebeSileshi BelewYimer MekonnenFanta GasheSeid MussaEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Zingiber officinale Roscoe and Echinops kebericho Mesfin showed antiplasmodial activities against Plasmodium berghei in a dose-dependent manner in Ethiopia

Abdissa BiruksewAhmed ZeynudinYonas AlemuLemu GolassaMoti YohannesAsfaw DebellaGeme UrgeBart De SpiegeleerSultan Suleman

A2 Journal Article in ETHIOPIAN JOURNAL OF HEALTH SCIENCES

2017

Analysis of illegal peptide drugs via HILIC-DAD-MS

Steven JanvierEvelien De SutterEvelien WynendaeleBart De SpiegeleerCeline VanheeEric Deconinck

A1 Journal Article in TALANTA

Analytics in microbiome : investigating quorum sensing peptides

Nathan DebunneFrederick VerbekeEvelien WynendaeleYorick JanssensBart De Spiegeleer

Are injectable SFFC polypeptide drugs safe? : case report demonstrating the presence of haemolytic Bacillus cereus in two illegal polypeptide drugs

Steven JanvierE WattijnN BotteldoornBart De SpiegeleerE DeconinckC Vanhee

Chemical classification of cyclic depsipeptides

Lien TaevernierEvelien WynendaeleBert GevaertBart De Spiegeleer

A1 Journal Article in CURRENT PROTEIN AND PEPTIDE SCIENCE

Exploration of cryptic peptides : analytical, pharmacological and regulatory contributions

Bert GevaertBart De Spiegeleer

Faecal microbiota transplantation : a regulatory hurdle?

Frederick VerbekeYorick JanssensEvelien WynendaeleBart De Spiegeleer

Editorial material

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification and quantification of falsified peptide drugs via HILIC-DAD-MS

Steven JanvierEvelien De SutterEvelien WynendaeleBart De SpiegeleerCeline VanheeEric Deconinck

In vitro functional quality characterization of NOTA-modified somatropins

Nathalie BrackeHan YaoEvelien WynendaeleFrederick VerbekeXiaolong XuBert GevaertAlex MaesChristophe Van De WieleMike SathekgeSarah De Saeger et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography-mass spectrometry

Lieselotte VeryserLien TaevernierEvelien WynendaeleYannick VerheustAnn DumoulinBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo

Frederick VerbekeSeverine De CraemerNathan DebunneYorick JanssensEvelien WynendaeleChristophe Van de WieleBart De Spiegeleer

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Poor dissolution of anthelminthic medicines : a risk for reduced efficacy

B SileshiS SultanEvelien WynendaeleKaat AnnéLuc DuchateauBart De SpiegeleerBruno Levecke

2016

An analytical quality by design (aQbD) approach for a L-asparaginaseactivity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Analytical, pharmacokinetic and regulatory characterisation of selected plant N-alkylamides

Lieselotte VeryserBart De Spiegeleer

Bacterial quorum sensing peptides and the inter-kingdom communication with human cancer cells

Frederick VerbekeEvelien WynendaeleYorick JanssensBart De Spiegeleer

Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBert GevaertKathelijne PeremansBart De Spiegeleer

A1 Journal Article in TOXICOLOGY LETTERS

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT

Bert GevaertEvelien WynendaeleSofie StalmansNathalie BrackeMatthias D'HondtIlse SmoldersAnn Van EeckhautBart De Spiegeleer

A1 Journal Article in NEUROPHARMACOLOGY

Characterization data on the topical carrier DDC642

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc CA StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A2 Journal Article in DATA IN BRIEF

Do cyclic depsipeptide mycotoxins beauvericin and enniatins cross the blood-brain barrier?

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBart De Spiegeleer

Exploration of the medicinal peptide space

Bert GevaertSofie StalmansEvelien WynendaeleLien TaevernierNathalie BrackeMatthias D'HondtBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Fish hydrolysates : a regulatory perspective of bioactive peptides

Bert GevaertLieselotte VeryserFrederick VerbekeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Functional quality of somatropin derivatives : NOTA-modifications and peptides

Nathalie BrackeBart De Spiegeleer

Human skin permeation of emerging mycotoxins (beauvericin and enniatins)

Lien TaevernierLieselotte VeryserNathalie RocheKathelijne PeremansChristian Paul G. BurvenichCatherine DelesalleBart De Spiegeleer

A1 Journal Article in JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

Implementation of a single quad MS detector in routine QC analysis of peptide drugs

Matthias D'HondtBert GevaertEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Implementation of UHPLC-single quad MS platform : the next level transforming pharmaceutical quality control laboratories

Evelien WynendaeleBert GevaertLieselotte VeryserXiaolong XuFrederick VerbekeBart De Spiegeleer

Impurity profiling of L-asparaginase preparation

Han YaoNathalie BrackeBert GevaertXiaolong XuEvelien WynendaeleRob HaselbergGovert SomsenBart De Spiegeleer

Laser capture microdissection of intestinal tissue from sea bass larvae using an optimized RNA integrity assay and validated reference genes

Marlien SchaeckWard De SpiegelaereJurgen De CraeneWim Van Den BroeckBart De SpiegeleerChristian Paul G. BurvenichFreddy HaesebrouckAnnemie Decostere

A1 Journal Article in SCIENTIFIC REPORTS

Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models

Lieselotte VeryserLien TaevernierTanmayee JoshiPratima TatkeEvelien WynendaeleNathalie BrackeSofie StalmansKathelijne PeremansChristian Paul G. BurvenichMartijn Risseeuw et al.

A1 Journal Article in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE

Pharmaceutical regulatory framework in Ethiopia : a critical evaluation of its legal basis and implementation

Sultan Suleman WegaAbdulkadir WoliyiKifle WoldemichaelKora TushuneLuc DuchateauAgnes DegrooteRoy VancauwenbergheNathalie BrackeBart De Spiegeleer

A2 Journal Article in ETHIOPIAN JOURNAL OF HEALTH SCIENCES

Pre-clinical pharmacokinetics of selected quorum sensing peptides

Yorick JanssensEvelien WynendaeleFrederick VerbekeBart De Spiegeleer

Quality control of cationic cell-penetrating peptides

Sofie StalmansBert GevaertFrederick VerbekeMatthias D'HondtNathalie BrackeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quality of selected medicines in Ethiopia : analytical and regulatory contributions

Sultan Suleman WegaBart De Spiegeleer

Quantitative in vitro and in vivo evaluation of intestinal and blood-brain barrier transport kinetics of the plant N-alkylamide pellitorine

Lieselotte VeryserNathalie BrackeEvelien WynendaeleTanmayee JoshiPratima TatkeLien TaevernierBart De Spiegeleer

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

Quorum sensing peptides: the missing link between microbiome and disease?

Evelien WynendaeleFrederick VerbekeYorick JanssensNathan DebunneBart De Spiegeleer

Regulatory development of geriatric medicines : to GIP or not to GIP?

Bart De SpiegeleerEvelien WynendaeleNathalie BrackeLieselotte VeryserLien TaevernierAgnes DegrooteSofie Stalmans

A1 Journal Article in AGEING RESEARCH REVIEWS

Skin, mucosal and blood-brain barrier kinetics of model cyclic depsipeptides : the mycotoxins beauvericin and enniatins

Lien TaevernierBart De Spiegeleer

The effects of quorum sensing peptides on colon cancer cells: implications for the role of the gut microbiome

Yorick JanssensEvelien WynendaeleFrederick VerbekeAn HendrixOlivier De WeverMarc BrackeBart De Spiegeleer

The human microbiota in health and disease: the role of quorum sensing peptides

Evelien WynendaeleFrederick VerbekeYorick JanssensBart De Spiegeleer

The mycotoxin definition reconsidered towards fungal cyclic depsipeptides

Lien TaevernierEvelien WynendaeleLeen De VreeseChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Topical acyclovir treatment of occult equine sarcoids: an in vitro and in vivo study

Maarten HaspeslaghLien TaevernierAn MaesLieven VlaminckBart De SpiegeleerSiska CroubelsAnn Martens

Topical distribution of acyclovir in normal equine skin and equine sarcoids : an in vitro study

Maarten HaspeslaghLien TaevernierAn MaesLieven VlaminckBart De SpiegeleerSiska CroubelsAnn Martens

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

Using Tc-99m-HMPAO SPECT as tool to compare two transcranial magnetic stimulation protocols and their long-term effects in dogs

Robrecht DockxChris BaekenLise VlerickRomain DupratFilip De VosBart De SpiegeleerAndré DobbeleirJimmy SaundersIngeborgh PolisEric Achten et al.

2015

An analytical quality-by-design (aQbD) approach for a L-asparaginase activity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Analytical quality-by-design approach for sample treatment of BSA-containing solutions

Lien TaevernierEvelien WynendaeleMatthias D'HondtBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Assessment of efficacy and quality of two albendazole brands commonly used against soil-transmitted helminth infections in school children in Jimma Town, Ethiopia

Sileshi Belew YohannesMestawet GetachewSultan Suleman WegaTesfaye MohammedHabetewold DetiMatthias D'HondtEvelien WynendaeleZeleke Mekonnen KurmaneJozef VercruysseLuc Duchateau et al.

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Biomarkers to predict severity of bovine E. coli mastitis in the periparturient period: bridging the gap between genotype and phenotype

Christian Paul G. BurvenichXanthippe BoulougourisCarolien RogiersCatherine DelesalleLuc DuchateauLuc PeelmanMario Van PouckeGianfranco GabaiBart De Spiegeleer

Blood–brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

Mathieu VerbekenEvelien WynendaeleElodie MauchaufféeNathalie BrackeSofie StalmansEngin BojnikSandor BenyheKathelijne PeremansIngeborgh PolisChristian Paul G. Burvenich et al.

A1 Journal Article in PEPTIDES

Cell-penetrating peptides selectively cross the blood-brain barrier in vivo

Sofie StalmansNathalie BrackeEvelien WynendaeleBert GevaertKathelijne PeremansChristian Paul G. BurvenichIngeborgh PolisBart De Spiegeleer

A1 Journal Article in PLOS ONE

Classification of peptides according to their blood-brain barrier influx

Sofie StalmansBert GevaertEvelien WynendaeleJoachim NielandtGuy De TréKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Communication of quorum sensing peptides with breast cancer cells

Frederick VerbekeEvelien WynendaeleMarianne LauwersAn HendrixChristian Paul G. BurvenichOlivier De Wevermarc brackeBart De Spiegeleer

Crosstalk between the microbiome and cancer cells by quorum sensing peptides

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

A1 Journal Article in PEPTIDES

Effect of ketamine on the regional cerebral blood flow and binding index of the 5-HT2A receptor radioligand 123I-R91150 in the canine brain

Tim WaelbersIngeborgh PolisSimon VermeireAndre DobbeleirJos EerselsBart De SpiegeleerKurt AudenaertKathelijne Peremans

A1 Journal Article in JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH

Enniatin-containing solutions for oromucosal use: quality-by-design ex-vivo transmucosal risk assessment of composition variability

Lien TaevernierSven DetroyerLieselotte VeryserBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of local tolerance of a plant extract by the slug mucosal irritation (SMI) assay

Lieselotte VeryserJoke LenoirJente BoonenNathalie BrackeEvelien WynendaeleEls AdriaensHans NelisBram De WeverJean Paul RemonBart De Spiegeleer

A2 Journal Article in JOURNAL OF TOXICOLOGICAL EDUCATION

Exploring the chemical space of quorum sensing peptides

Evelien WynendaeleBert GevaertSofie StalmansFrederick VerbekeBart De Spiegeleer

A1 Journal Article in BIOPOLYMERS

Gas chromatographic method for the determination of lumefantrine in antimalarial finished pharmaceutical products

Sultan Suleman WegaYannick VerheustAnn DumoulinEvelien WynendaeleMatthias D'HondtKirsten VandercruyssenLieselotte VeryserLuc DuchateauBart De Spiegeleer

A1 Journal Article in JOURNAL OF FOOD AND DRUG ANALYSIS

Implementation of a single quad MS detector in high-throughput transdermal research of plant extracts

Lieselotte VeryserLien TaevernierNathalie RochePhillip BlondeelBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Onbeschikbaarheid van geneesmiddelen in het ziekenhuis: beheer, oorzaken en budgetimpact

Barbara ClausKim PauwelsMariëlle BaertJan DepoorterElfi De WeerdtKoen BousseryBart De SpiegeleerSABRINA COMMEYNE

A4 Journal Article in FARMACEUTISCH TIJDSCHRIFT VOOR BELGIE [1971]

Peptide profiling of internet obtained Cerebrolysin using HPLC-ESI-IT & UHPLC-Q-IM-TOF mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

Peptide profiling of internet-obtained cerebrolysin using high performance liquid chromatography–electrospray ionization ion trap and ultra high performance liquid chromatography–ion mobility–quadrupole time of flight mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

A1 Journal Article in DRUG TESTING AND ANALYSIS

Phase I dose-escalation study evaluating the safety and pharmacokinetics of oral artesunate in patients with advanced hepatocullular carcinoma (DESPARTH trial)

Yves-Paul VandewynckelK RombautsXavier VerhelstLucas Van BortelBart De SpiegeleerAnja GeertsHans Van Vlierberghe

Quality evaluation of synthetic quorum sensing peptides used in R&D

Frederick VerbekeEvelien WynendaeleSarah BraetMatthias D'HondtBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Quality-by-design risk assessment of topical formulation variability

Lien TaevernierSven DetroyerLieselotte VeryserBart De Spiegeleer

Quorum sensing peptides selectively penetrate the blood-brain barrier

Evelien WynendaeleFrederick VerbekeSofie StalmansBert GevaertYorick JanssensChristophe Van De WieleKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PLOS ONE

Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 (IL8RA) genotype following Interleukin-8 incubation

Joren VerbekeXanthippe BoulougourisCarolien RogiersChristian Paul G. BurvenichLuc PeelmanBart De SpiegeleerSarne De Vliegher

A1 Journal Article in BMC VETERINARY RESEARCH

Regional cerebral blood flow changes after accelerated repetitive transcranial magnetic stimulation of the canine frontal cortex

Robrecht DockxChris BaekenRomain DupratFilip De VosBart De SpiegeleerAndré DobbeleirJimmy SaundersIngeborgh PolisKurt AudenaertKathelijne Peremans

Surface acoustic wave biosensor as a functional quality method in pharmaceutics

Nathalie BrackeSophia BarhdadiEvelien WynendaeleBert GevaertMatthias D'HondtBart De Spiegeleer

A1 Journal Article in SENSORS AND ACTUATORS B-CHEMICAL

The blood-brain barrier (BBB) permeability properties of plant N-alkylamides

Lieselotte VeryserEvelien WynendaeleNathalie BrackeBart De Spiegeleer

The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides

Lieselotte VeryserJente BoonenLien TaevernierJoren GuillaumeMartijn RisseeuwSyed Nisar Hussain ShahNathalie RocheSerge Van CalenberghBart De Spiegeleer

A1 Journal Article in SKIN PHARMACOLOGY AND PHYSIOLOGY

The quality of paediatric medicines supplied by private wholesalers in Kinshasa, DRC

Raffaella RavinettoDaniel Ngeleka MutoloBart De SpiegeleerRoland MariniEpco HaskerBenedetta Schiavetti

The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

Bart De SpiegeleerFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeEvelien Wynendaele

A1 Journal Article in PLOS ONE

The use of UHPLC coupled to single quad MS detection in Franz diffusion cell methodologies

Lieselotte VeryserLien TaevernierEvelien WynendaeleNathalie RocheBart De Spiegeleer

To what extent do cell-penetrating peptides selectively cross the blood-brain barrier?

Sofie StalmansBart De Spiegeleer

Towards a peptide implant: analytics, dry heat behavior and functional characterization

Matthias D'HondtBart De Spiegeleer

Two phenotypes of bovine neutrophils during lactation: fiction or fact?

Xanthippe BoulougourisCarolien RogiersCatherine DelesalleLuc DuchateauLuc PeelmanMario Van PouckeBart De SpiegeleerChristian Paul G. Burvenich

2014

A preliminary analysis of the quality of pediatric medicines supplied by private wholesalers in Kinshasa, DRC

Benedetta SchiavettiDaniel Ngeleka MutoloRoland Marini Djang'Eing'ABart De SpiegeleerEpco HaskerJosiane Van Der Elst

Adsorption of cyclic depsipeptide mycotoxins to glass

Lien TaevernierStijn VansteelandtBart De Spiegeleer

Analytical characterisation of NOTA-modified somatropins

Nathalie BrackeEvelien WynendaeleMatthias D'HondtRob HaselbergGovert W SomsenEwald PauwelsChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Are plant N-alkylamide cosmenutriceuticals also active in the central nervous system?

Lieselotte VeryserEvelien WynendaeleLien TaevernierFrederick VerbekeTanmayee JoshiPratima TatkeBart De Spiegeleer

Blood-brain barrier transport of short proline-rich antimicrobial peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeDaniel KnappeRalf HoffmannKathelijne PeremansIngeborgh PolisChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Brain SPECT in the impulsive-agressive dog

Kathelijne PeremansSimon VermeireTim WaelbersEva VandermeulenAndré DobbeleirBart De SpiegeleerKurt Audenaert

Bookchapter in PET and SPECT in psychiatry

Crosstalk between mammalian cells and the microbiome through quorum sensing peptides, influencing cancer metastasis

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

Matthias D'HondtFrederick VerbekeSofie StalmansBert GevaertEvelien WynendaeleBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Development of geriatric medicines: to GIP or not to GIP?

Sofie StalmansNathalie BrackeBart De Spiegeleer

Development of peptide and protein based radiopharmaceuticals

Evelien WynendaeleNathalie BrackeSofie StalmansBart De Spiegeleer

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Do cell-penetrating peptides cross the blood-brain barrier

Sofie StalmansEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling

Matthias D'HondtMaria FedorovaChien-Yu PengBert GevaertLien TaevernierRalf HoffmannBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exploration of quorum sensing peptides: the missing link between microbiome and cancer outcome?

Evelien WynendaeleBart De Spiegeleer

Exploration of the peptide drug space

Bert GevaertEvelien WynendaeleMathieu VerbekenMatthias D'HondtSofie StalmansKathelijne PeremansChristian Paul G. BurvenichCatherine DelesalleBart De Spiegeleer

Flatworm models in pharmacological research: the importance of compound stability testing

Sofie StalmansMaxime WillemsEls AdriaensJean Paul RemonMatthias D'HondtBart De Spiegeleer

A1 Journal Article in REGULATORY TOXICOLOGY AND PHARMACOLOGY

How does the human microbiome affect cancer outcome?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

How the exploration of the chemical space of cell-penetrating peptides helps to understand their functionality

Sofie StalmansEvelien WynendaeleBart De Spiegeleer

Human skin kinetics of cyclic depsipeptide mycotoxins

Lien TaevernierLieselotte VeryserNathalie RocheBart De Spiegeleer

Identification of a microscopically selected microorganism in milk samples

Nathalie BrackeMario Van PouckeBram BaertEvelien WynendaeleLobke De BelsWim Van Den BroeckLuc PeelmanChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules

Matthias D'HondtEvelien WynendaeleKirsten VandercruyssenTieneke BautersJohan VandenbrouckeSteven MullensChris VervaetJean Paul RemonBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

LC-UV/MS quality analytics of paediatric artemether formulations

Kirsten VandercruyssenMatthias D'HondtValentijn VergoteHerwig JansenChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

N-alkylamides : from plant to brain

Lieselotte VeryserEvelien WynendaeleLien TaevernierFrederick VerbekeTanmayee JoshiPratima TatkeBart De Spiegeleer

A2 Journal Article in FUNCTIONAL FOODS IN HEALTH AND DISEASE

Pharmacopeial characterization of asparaginase

Han YaoMatthias D'HondtYves BenoitTieneke BautersBart De Spiegeleer

Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey

Sultan Suleman WegaGemechu ZelekeHabtewold DetiZeleke Mekonnen KurmaneLuc DuchateauBruno LeveckeJozef VercruysseMatthias D'HondtEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum

Lieselotte VeryserLien TaevernierNathalie RocheKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PHYTOMEDICINE

Quorum sensing peptides: missing link between microbiome and health?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Raman model development for the protein conformational state classification in different freeze-dried formulations

Sigrid PietersJean-Michel RogerThomas De BeerMatthias D'HondtBart De SpiegeleerYvan Vander Heyden

A1 Journal Article in ANALYTICA CHIMICA ACTA

Related impurities in peptide medicines

Matthias D'HondtNathalie BrackeLien TaevernierBert GevaertFrederick VerbekeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Risk evaluation of impurities in topical excipients: the acetol case

Jente BoonenLieselotte VeryserLien TaevernierNathalie RocheKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Similars for biologics and ATMPs: quo vadis?

Nathalie BrackeBart De Spiegeleer

Solid-state heat stability of peptides : kinetics and mechanisms

Matthias D'HondtChien-Yu PengRalf HoffmannBart De Spiegeleer

Surface acoustic wave biosensor as a functional-quality method in pharmaceutics

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

Surface acoustic wave biosensor as an analytical tool in pharmaceutics : a quality by design approach

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

Synthesis and degradation impurities in peptide drugs

Matthias D'HondtBart De Spiegeleer

The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs

Antita AdriaensKathelijne PeremansTim WaelbersEva VandermeulenSiska CroubelsLuc DuchateauAndré DobbeleirKurt AudenaertJos EerselsSimon Vermeire et al.

A1 Journal Article in PLOS ONE

The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with 123I-R91150 SPECT

Antita AdriaensIngeborgh PolisSimon VermeireTim WaelbersSiska CroubelsLuc DuchateauSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne Peremans

A1 Journal Article in EUROPEAN NEUROPSYCHOPHARMACOLOGY

The moving boundaries in starting materials: from small molecules to biopharma and ATMPs

Matthias D'HondtNathalie BrackeBart De Spiegeleer

The possible role of somatropin derivatives as a theranostic in oncology

Nathalie BrackeEvelien WynendaeleSophia BarhdadiChristophe Van De WieleBart De Spiegeleer

UHPLC-MS/MS method for the determination of the cyclic depsipeptide mycotoxins beauvericin and enniatins in in vitro transdermal experiments

Lien TaevernierLieselotte VeryserKirsten VandercruyssenMatthias D'HondtStijn VansteelandtSarah De SaegerBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2013

5-HT2A Receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT

Tim WaelbersIngeborgh PolisSimon VermeireAndré DobbeleirJos EerselsBart De SpiegeleerKurt AudenaertGuido SlegersKathelijne Peremans

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

A critical quality parameter in quantitative fused-core chromatography : the injection volume

Jente BoonenMatthias D'HondtLieselotte VeryserKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

Sultan Suleman WegaKirsten VandercruyssenEvelien WynendaeleMatthias D'HondtNathalie BrackeLuc DuchateauChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Analytical QbD development of a pharmacopeial monograph for the anticancer drug asparaginase

Han YaoMatthias D'HondtPieter-Jan Van BockstalYves BenoitTieneke BautersBart De Spiegeleer

Androgenic and spermatogenic activity of alkylamide-rich ethanol solution extract of Anacyclus pyrethrum DC

Vikas SharmaJente BoonenBart De SpiegeleerVinot Dixit

A1 Journal Article in PHYTOTHERAPY RESEARCH

Buserelin: a solid state peptide degradation kinetic and mechanistic study

Matthias D'HondtChien-Yu PengRalf HoffmannBart De Spiegeleer

Chemical-functional diversity in cell-penetrating peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertMatthias D'HondtKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PLOS ONE

Interaction between the serotonergic and opioid system : effect of 10 days oral morphine on the canine cerebral 5-HT2A receptor density measured with SPECT

Kathelijne PeremansAntita AdriaensEva VandermeulenSimon VermeireTim WaelbersJos EerselsLuc DuchateauAndré DobbeleirBart De SpiegeleerKurt Audenaert et al.

Morphine and the canine brain : the influence of morphine on cerebral perfusion and 5-HT2A receptors

Antita AdriaensIngeborgh PolisKathelijne PeremansBart De Spiegeleer

Normal regional distribution of cerebral blood flow in dogs: comparison between 99mTc-ethylcysteinate dimer and 99mTc-hexamethylpropylene amine oxime single photon emission computed tomography

Antita AdriaensIngeborgh PolisTim WaelbersEva VandermeulenAndré DobbeleirBart De SpiegeleerKathelijne Peremans

A1 Journal Article in VETERINARY RADIOLOGY & ULTRASOUND

Quantitative pretreatment VOI analysis of liver metastases 99mTc-MAA SPECT/CT and FDG PET/CT in relation with treatment response to SIRT

Christophe Van De WieleK StellamansE BrugmanGilles MeesBart De SpiegeleerYves D'AsselerL BeelsA Maes

A1 Journal Article in NUKLEARMEDIZIN-NUCLEAR MEDICINE

Quorumpeps database : chemical space, microbial origin and functionality of quorum sensing peptides

Evelien WynendaeleAntoon BronselaerJoachim NielandtMatthias D'HondtSofie StalmansNathalie BrackeFrederick VerbekeChristophe Van De WieleGuy De TréBart De Spiegeleer

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations

Sigrid PietersYvan Vander HeydenJean-Michel RogerMatthias D'HondtLaurent HansenBernard PalagosBart De SpiegeleerJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Reversed-phase fused-core HPLC modeling of peptides

Matthias D'HondtBert GevaertSofie StalmansSylvia Van DorpeEvelien WynendaeleKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Skin penetration enhancing properties of the plant N-alkylamide spilanthol

Bart De SpiegeleerJente BoonenSvetlana MalyshevaJosé Diana Di MavunguSarah De SaegerNathalie RochePhillip BlondeelLien TaevernierLieselotte Veryser

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Somatropin (rhGH) functional quality characterization by LC/CE-MS and SAW (Surface Acoustic Wave) biosensor techniques

Nathalie BrackeEvelien WynendaeleRob HaselbergGovert SomsenSophia BarhdadiBart De Spiegeleer

Surface acoustic wave technology as a tool for functional quality characterization of new compounds and biosimilars

Nathalie BrackeEvelien WynendaeleChristophe Van De WieleBart De Spiegeleer

The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology

Kathelijne PeremansLuc DuchateauSimon VermeireEva VandermeulenAndré DobbeleirIngrid GielenIngeborgh PolisBernadette Van RyssenEvelien de BakkerJimmy Saunders et al.

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

Time dependent effects of a single bolus morphine on canine regional brain perfusion

Ingeborgh PolisAntita AdriaensEva VandermeulenSimon VermeireTim WaelbersBart De SpiegeleerAndré DobbeleirJos EerselsKurt AudenaertKathelijne Peremans

Transdermal evaluation of caffeine in different formulations and excipients

Lieselotte VeryserJente BoonenEls MehuysNathalie RocheJean Paul RemonKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF CAFFEINE RESEARCH

Transsplenic portal scintigraphy using 99mTc-pertechnetate for the diagnosis of portosystemic shunts in cats: a retrospective review of 12 patients

Eva VandermeulenAnaïs CombesHilde De RoosterIngeborgh PolisBart De SpiegeleerJimmy SaundersKathelijne Peremans

A1 Journal Article in JOURNAL OF FELINE MEDICINE AND SURGERY

2012

Alkamid database: chemistry, occurrence and functionality of plant N-alkylamides

Jente BoonenAntoon BronselaerJoachim NielandtLieselotte VeryserGuy De TréBart De Spiegeleer

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Analytical characterization of the blood-brain barrier transport of peptides

Sylvia Van DorpeBart De Spiegeleer

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens

Patricia CzihalDaniel KnappeStefanie FritscheMichael ZahnNicole BertholdStefania PiantavignaUwe MüllerSylvia Van DorpeNicole HerthAnnegret Binas et al.

A1 Journal Article in ACS CHEMICAL BIOLOGY

Blood-brain barrier modelling of bioactive peptides

Bart De SpiegeleerMatthias D'HondtSofie StalmansSylvia Van Dorpe

Brainpeps: the blood-brain barrier peptide database

Sylvia Van DorpeAntoon BronselaerJoachim NielandtSofie StalmansEvelien WynendaeleKurt AudenaertChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansHung Hsuchou et al.

A1 Journal Article in BRAIN STRUCTURE & FUNCTION

Chiral nickel(II) complexes in the preparation of C-11- and F-18-labelled enantiomerically pure alpha-amino acids

Alexander PopkovBart De Spiegeleer

A1 Journal Article in DALTON TRANSACTIONS

Compromised neutrophil function and bovine E. coli mastitis: is C5a the missing link?

Mieke StevensBart De SpiegeleerLuc PeelmanXanthippe BoulougourisAnthony CapucoChristian Paul G. Burvenich

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Differential microRNA expression analysis in blastocysts by whole mount in situ hybridization and reverse transcription quantitative polymerase chain reaction on laser capture microdissection samples

Karen GoossensWard De SpiegelaereMieke StevensChristian Paul G. BurvenichBart De SpiegeleerPieter CornillieAlex Van ZeverenAnn Van SoomLuc Peelman

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Dry heat stress stability of model peptide: buserelin

Matthias D'HondtBart De Spiegeleer

Exploring the Brainpeps database

Sofie StalmansMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Exploring the chemical-functional space of cell-penetrating peptides

Sofie StalmansEvelien WynendaeleBart De Spiegeleer

Functional quality of peptide drugs

Mathieu VerbekenNathalie BrackeBart De Spiegeleer

Functional quality of spilanthol, a plant N-alkylamide for dermal applications

Jente BoonenBart De Spiegeleer

Gene expression analysis in specific cell populations of bovine blastocysts using laser capture microdissection

Ward De SpiegelaereKaren GoossensMieke StevensAnn Van SoomLuc PeelmanChristian Paul G. BurvenichBart De SpiegeleerPieter Cornillie

Human skin penetration of selected model mycotoxins

Jente BoonenSvetlana MalyshevaLien TaevernierJosé Diana Di MavunguSarah De SaegerBart De Spiegeleer

A1 Journal Article in TOXICOLOGY

Improved positive electrospray ionization of patulin by adduct formation: usefulness in liquid chromatography-tandem mass spectrometry multi-mycotoxin analysis

Svetlana MalyshevaJosé Diana Di MavunguJente BoonenBart De SpiegeleerIrina Y GoryachevaLynn VanhaeckeSarah De Saeger

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

In vitro metabolic stability of iodinated obestatin peptides

Bart De SpiegeleerSylvia Van DorpeValentijn VergoteEvelien WynendaeleEwald PauwelsChristophe Van De WielePablo Garcia-SolisJuan Carlos Solis-Sainz

A1 Journal Article in PEPTIDES

Increase of the transdermal penetration of testosterone by miconazole nitrate

Bram BaertNathalie RocheChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in ARCHIVES OF PHARMACAL RESEARCH

Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response

Matthias D'HondtEvelien WynendaeleTieneke BautersJohan VandenbrouckeHugo RobaysBart De Spiegeleer

Ketamine decreases the cerebral binding index of the selective 5-HT2A receptor radioligand 123I-R91150 measured with µSPECT in cats

Tim WaelbersIngeborgh PolisSimon VermeireAndré DobbeleirJ EersselsBart De SpiegeleerKurt AudenaertGuido SlegersKathelijne Peremans

LC-MS N-alkylamide profiling of an ethanolic Anacyclus pyrethrum root extract

Jente BoonenVikas SharmaVinod DixitChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PLANTA MEDICA

LC-MS N-alkylamide profiling of an ethanolic Anacyclus pyrethrum root extract

Vikas SharmaJente BoonenBart De SpiegeleerVinod K Dixit

Molecular weights under discussion?

Bart De SpiegeleerMatthias D'Hondt

A2 Journal Article in PHARMEUROPA

Penetration enhancing effect of phytoceramides

Lieselotte VeryserJente BoonenJoren GuillaumeMartijn RisseeuwSerge Van CalenberghBart De Spiegeleer

Receptor and blood-brain barrier characterisation of opioid peptides in drug research and early development

Bart De SpiegeleerSofie StalmansEvelien WynendaeleNathalie BrackeMathieu VerbekenKathelijne PeremansIngeborgh PolisChristian Paul G. Burvenich

Receptor and blood-brain barrier characterization of opioid peptides in drug research and early development

Mathieu VerbekenSofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertKathelijne PeremansIngeborgh PolisChristian Paul G. BurvenichBart De Spiegeleer

Relative response factor determination of β-artemether degradants by a dry heat stress approach

Bart De SpiegeleerMatthias D'HondtElien VangheluweKirsten VandercruyssenHerwig JansenIlse KoijenJacques Van Gompel

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder

Simon VermeireKurt AudenaertRudy De MeesterEva VandermeulenTim WaelbersBart De SpiegeleerJos EerselsAndré DobbeleirKathelijne Peremans

A1 Journal Article in PSYCHIATRY RESEARCH-NEUROIMAGING

SIRT of liver metastases: physiological and pathophysiological considerations

Christophe Van De WieleAlex MaesEddy BrugmanYves D'AsselerBart De SpiegeleerGilles MeesKarin Stellamans

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Skin penetration enhancing effect of the plant N-alkylamide spilanthol

Bart De SpiegeleerJente BoonenLieselotte VeryserLien TaevernierSvetlana MalyshevaJosé Diana Di MavunguSarah De Saeger

Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate

Matthias D'HondtElien VangheluweSylvia Van DorpeJente BoonenTieneke BautersBRIGITTE PELFRENEJohan VandenbrouckeHugo RobaysBart De Spiegeleer

A1 Journal Article in AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Surface acoustic wave technology as a tool for functional characterization of new compounds

Nathalie BrackeLaurens DeneveBart De Spiegeleer

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

Rasmus KarstadGeir IsaksenEvelien WynendaeleYngve GuttormsenBart De SpiegeleerBjorn-Olav BrandsdalJohn Sigurd SvendsenJohan Svenson

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

The influence of chronic morphine on the canine cerebral 5-HT2A receptor availability measured with SPECT

Antita AdriaensIngeborgh PolisSimon VermeireEva VandermeulenTim WaelbersJos EerselsAndré DobbeleirLuc DuchateauSylvia Van DorpeBart De Spiegeleer et al.

The influence of ketamine on the regional cerebral perfusion and on the binding index of the selective 5-HT2A receptor radioligand 123I-R91150 measured with SPECT in the canine brain

Tim WaelbersIngeborgh PolisSimon VermeireAndré DobbeleirJ EersselsBart De SpiegeleerKurt AudenaertGuido SlegersKathelijne Peremans

The influence of morphine on cerebral 5-HT2A receptor availability in dogs: a SPECT study

Antita AdriaensIngeborgh PolisSimon VermeireTim WaelbersLuc DuchateauStanislas SysSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne Peremans

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

The influence of peptide impurity profiles on functional tissue-organ bath response: the 11-mer peptide INSL6[151-161] case

Mathieu VerbekenEvelien WynendaeleRomain LefebvreEls GoossensBart De Spiegeleer

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

The potential role of quorum-sensing peptides in oncology

Evelien WynendaeleEwald PauwelsChristophe Van De WieleChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in MEDICAL HYPOTHESES

Transdermal penetration enhancing effect of the N-alkylamide spilanthol

Jente BoonenLieselotte VeryserLien TaevernierNathalie RocheBart De Spiegeleer

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt¹-DALDA: effect on opioid activity and biodistribution

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleMariana SpeteaNathalie BrackeSofie StalmansCecilia BettiNga N ChungCarole LemieuxJohannes Zuegg et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2011

ADME behaviour of some Dmt-DALDA-peptide derivatives

Sylvia Van DorpeIris VandenbroeckEvelien WynendaeleMathieu VerbekenAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils

Mieke StevensMario Van PouckeLuc PeelmanP RainardBart De SpiegeleerCarolien RogiersGerlinde Van de WalleLuc DuchateauChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Blood-brain barrier and ADME properties of selected DALDA-peptide derivatives

Sylvia Van DorpeEvelien WynendaeleChristian Paul G. BurvenichAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Blood-brain barrier characteristics of opioid peptides

Sylvia Van DorpeChristophe Van De WieleAntita AdriaensIngeborgh PolisKathelijne PeremansBart De Spiegeleer

Chemical-functional space exploration of plant N-alkylamides

Jente BoonenVikas SharmaVinot DixitBart De Spiegeleer

Chemical-functional space exploration of plant N-alkylamides

Jente BoonenVikas SharmaVinot DixitBart De Spiegeleer

Classification of quorum-sensing peptides

Evelien WynendaeleEwald PauwelsChristophe Van De WieleAntoon BronselaerGuy De TréBart De Spiegeleer

Desirability function combining metabolic stability and functionality of peptides

Sylvia Van DorpeAntita AdriaensSimon VermeireIngeborgh PolisKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF PEPTIDE SCIENCE

Development of a quorum-sensing peptide database: quorumpeps

Evelien WynendaeleAntoon BronselaerGuy De TréEwald PauwelsMaxime BoucartChristophe Van De WieleBart De Spiegeleer

Differential gene expression of the toll-like receptor-4 cascade and neutrophil function in early- and mid-lactating dairy cows

Mieke StevensLuc PeelmanBart De SpiegeleerAdel PezeshkiGerlinde Van de WalleLuc DuchateauChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Dry heat stress stability evaluation of casein peptide mixture

Matthias D'HondtWim DemaréSylvia Van DorpeEvelien WynendaeleChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in FOOD CHEMISTRY

Functional quality of topical drugs: analytical exploration of the Franz diffusion test

Bram BaertBart De Spiegeleer

Fused-core HPLC method development implemented in a short-term stability study of Triple IT solution

Matthias D'HondtElien VangheluweNadia LemeireTieneke BautersBRIGITTE PELFRENEJohan VandenbrouckeHugo RobaysBart De Spiegeleer

In vivo imaging of apoptosis in oncology : an update

CHRISTEL VANGESTELMarc PeetersGilles MeesRuth OltenfreiterHendrikus H BoersmaPhilip H ElsingaChris ReutelingspergerNancy Van DammeBart De SpiegeleerChristophe Van De Wiele

A1 Journal Article in MOLECULAR IMAGING

Ion mobility spectrometry as a high-throughput technique for in vitro transdermal Franz diffusion cell experiments of ibuprofen

Bram BaertStijn VansteelandtBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control

Bram BaertJente BoonenCéline ThierensBart De Spiegeleer

A2 Journal Article in INTERNATIONAL JOURNAL OF ION MOBILITY SPECTROMETRY

Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism blocking agent

Bram BaertBart De Spiegeleer

A1 Journal Article in SKIN PHARMACOLOGY AND PHYSIOLOGY

Neuro-imaging the serotonin 2A receptor as a valid biomarker for canine behavioural disorders

Simon VermeireKurt AudenaertRudy De MeesterEva VandermeulenTim WaelbersBart De SpiegeleerJos EerselsAndré DobbeleirKathelijne Peremans

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

New insights into electrospray ionization of patulin

Svetlana MalyshevaJosé Diana Di MavunguJente BoonenBart De SpiegeleerIrina Yu GoryachevaCarlos Van PeteghemSarah De Saeger

New N-alkylamides from Anacyclus pyrethrum

Jente BoonenVikas SharmaVinot DixitBart De Spiegeleer

Purity profiling and the associated functional effects of a new peptide

Mathieu VerbekenRomain LefebvreGoossens ElsLuyten WalterSchoofs LilianeBart De Spiegeleer

Purity profiling of peptide drugs

Sylvia Van DorpeMathieu VerbekenEvelien WynendaeleBart De Spiegeleer

A2 Journal Article in JOURNAL OF BIOANALYSIS AND BIOMEDICINE

Recognition of anatomical predilection sites in canine elbow pathology on bone scans using micro-single photon emission tomography

Kathelijne PeremansSimon VermeireAndré DobbeleirIngrid GielenYves SamoyKoen PironEva VandermeulenGuido SlegersHenri van BreeBart De Spiegeleer et al.

A1 Journal Article in VETERINARY JOURNAL

Short-term storage stability of Triple IT solution

Matthias D'HondtElien VangheluweNadia LemeireTieneke BautersBRIGITTE PELFRENEJohan VandenbrouckeHugo RobaysBart De Spiegeleer

Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs

Simon VermeireKurt AudenaertEva VandermeulenTim WaelbersBart De SpiegeleerHenri van BreeKathelijne Peremans

A1 Journal Article in VETERINARY JOURNAL

Skin penetration of silica microparticles

Jente BoonenBram BaertJo LambertBart De Spiegeleer

A1 Journal Article in PHARMAZIE

Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats

Vikas SharmaJente BoonenNagendra ChauhanMayank ThakurBart De SpiegeleerVinot Dixit

A1 Journal Article in PHYTOMEDICINE

Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats

Vikas SharmaJente BoonenNagendra ChauhanMayank ThakurBart De SpiegeleerVinot Dixit

Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

Mathieu VerbekenSultan Suleman WegaBram BaertElien VangheluweSylvia Van DorpeChristian Paul G. BurvenichLuc DuchateauFrans H JansenBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Structural modification and biological evaluation of Dmt1-DALDA analogues

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleNga ChungCarole LemieuxPeter W SchillerDirk TourwéBart De SpiegeleerSteven Ballet

Variation of inflammatory dynamics and mediators in primiparous cows after intramammary challenge with Escherichia coli

Adel PezeshkiPhilippe StordeurHugues WallemacqFrederic SchyntsMieke StevensPhilippe BoutetLuc PeelmanBart De SpiegeleerLuc DuchateauFabrice Bureau et al.

A1 Journal Article in VETERINARY RESEARCH

2010

A new discriminative criterion for the development of Franz diffusion tests for transdermal pharmaceuticals

Bram BaertJente BoonenChristian Paul G. BurvenichNathalie RocheFilip StillaertPhillip BlondeelJan Van BocxlaerBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Amide fused-core chromatography of spilanthol as applied on a patch development

Jente BoonenBart De Spiegeleer

An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defense

Adel PezeshkiAnthony CapucoBart De SpiegeleerLuc PeelmanMieke StevensRobert CollierChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides

Sylvia Van DorpeAntita AdriaensIngeborgh PolisKathelijne PeremansJan Van BocxlaerBart De Spiegeleer

A1 Journal Article in PEPTIDES

Bioactive peptides as potential new drugs: from analytics to tissue bath functionality

Mathieu VerbekenSylvia Van DorpeRomain LefebvreBart De Spiegeleer

Characterisation of modified pharmaceutical proteins: the somatropin case

Evelien WynendaeleDaphne WiskerkeBart De Spiegeleer

Chemical quality control of peptide functionality testing in tissue baths

Mathieu VerbekenSylvia Van DorpeRomain LefebvreBart De Spiegeleer

Comparative drugability evaluation of MOR opioid peptides in functional brain research

Bart De SpiegeleerSylvia Van DorpeOlga JedlickovaAntita AdriaensSimon VermeireIngeborgh PolisKathelijne Peremans

Dry heat stress stability of casein hydrolysate peptide mixture

Matthias D'HondtWim DemaréBart De Spiegeleer

Functional differences of iodinated obestatin peptides: in vitro metabolic stability profile

Sylvia Van DorpeIngeborg WallezBart De Spiegeleer

Functional drugability of MOR-opioid peptides through desirability

Sylvia Van DorpeOlga JedlickovaAntita AdriaensTim WaelbersSimon VermeireIngeborgh PolisKathelijne PeremansBart De Spiegeleer

Functional quality analytics of peptide drugs: the obestatin case

Valentijn VergoteBart De SpiegeleerHenri van Bree

HPLC-MS characterisation of chelate modified somatropin

Evelien WynendaeleEwald PauwelsSylvia Van DorpeValentijn VergoteChristophe Van De WieleBart De Spiegeleer

Hydrophilic interaction LC of peptides: columns comparison and clustering

Sylvia Van DorpeValentijn VergoteAdel PezeshkiChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops

S BozdagW WeyenbergEls AdriaensMMM DhondtV VergoteChris VervaetKristof De PrijckHans NelisBart De SpiegeleerA Ludwig et al.

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Influence of injection volume and solvent strength on spilantholchromatography using RP fused-core amide stationary phase

Jente BoonenBart De Spiegeleer

LC-MS characterization and cell-binding properties of chelate modified somatropin

Evelien WynendaeleKoen MertensEwald PauwelsChristophe Van De WieleBart De Spiegeleer

LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol

Jente BoonenBram BaertChristian Paul G. BurvenichPhillip BlondeelSarah De SaegerBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

LC-MS quality control of modified pharmaceutical proteins : the somatropin case

Evelien WynendaeleEwald PauwelsChristophe Van De WieleSylvia Van DorpeBart De Spiegeleer

Metabolic fate of lactoferricin based antimicrobial peptides: effect of truncation and incorporation of amino acid analogs on the in vitro metabolic stability

Johan SvensonValentijn VergoteRasmus KarstedChristian Paul G. BurvenichJohn SvendsenBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Morphine decreases 5-HT2A receptor binding measured with SPECT in the canine frontal cortex

Antita AdriaensSimon VermeireTim WaelbersLuc DuchateauStanislas SysAndré DobbeleirSylvia Van DorpeJ EerselsBart De SpiegeleerKurt Audenaert et al.

Nanoparticles : between food handling and skin penetration

Jente BoonenBram BaertBart De Spiegeleer

Physiology and pathophysiology of the mammary gland in primiparous cows with special emphasis to dry period length and experimental E.coli mastitis

Adel PezeshkiChristian Paul G. BurvenichBart De SpiegeleerJalil Mehrzad

Quality analysis of salmon calcitonin in a polymeric bioadhesive pharmaceutical formulation: sample preparation optimization by DOE

Matthias D'HondtSylvia Van DorpeEls MehuysDieter DeforceBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quality analytics of internet pharmaceuticals

Bram BaertBart De Spiegeleer

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Serotonin 2A receptor imaging in canine behavioural disorders : an animal model for human psychiatric disorders

Simon VermeireKurt AudenaertRudy De MeesterEva VandermeulenTim WaelbersBart De SpiegeleerJos EerselsAndré DobbeleirKathelijne Peremans

Severity variation of clinical E.coli mastitis in cows: where do we stand?

Christian Paul G. BurvenichLuc PeelmanBart De SpiegeleerMieke StevensAdel PezeshkiJohan DetilleuxAnthony Capuco

The influence of morphine on 5-HT2A receptor availability using SPECT: a preliminary study in dogs

Antita AdriaensSimon VermeireTim WaelbersLuc DuchateauStanislas SysSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne PeremansIngeborgh Polis

The metabolisation of different iodinated peptide species

Bart De SpiegeleerSylvia Van DorpeEwald Pauwels

The metabolisation of different iodinated peptide species

Bart De SpiegeleerSylvia Van DorpeEwald Pauwels

Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts

Jente BoonenBart De SpiegeleerBram BaertNathalie RocheChristian Paul G. Burvenich

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers

Matthieu RavelingienSteven MullensJan LuytenMatthias D'HondtJente BoonenBart De SpiegeleerTom CoenyeChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2009

Adsorption of peptides at the sample drying step: influence of solvent evaporation technique, vial material and solution additive

Adel PezeshkiValentijn VergoteSylvia Van DorpeBram BaertChristian Paul G. BurvenichAlexander PopkovBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Analytical characterization of the BBB functionality of the opioid-peptides EM-1, EM-2 and CTAP.

Sylvia Van DorpeNathalie PintelonAntita AdriaensIngeborgh PolisKathelijne PeremansWeihong PanChristian Paul G. BurvenichBart De Spiegeleer

Analytical profiling, modeling and transdermal/transmucosal characteristics of bioactive N-alkylamides

Bart De SpiegeleerJente BoonenChristian Paul G. BurvenichPhillip BlondeelBram Baert

Analytical, biopharmaceutical and regulatory evaluation of topical testosterone preparations

Bram BaertSudakar AnnavarapuChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in European Journal of Pharmaceutics and Biopharmaceutics

Central administration of obestatin fails to show inhibitory effects on food and water intake in mice

Annemie Van DijckDebby Van DamValentijn VergoteBart De SpiegeleerWalter LuytenLiliane SchoofsPeter Paul De Deyn

A1 Journal Article in Regulatory Peptides

Chemical and metabolic stability of lactoferricin-based cationic antimicrobial tripeptides

Valentijn VergoteJohan SvensonChristian Paul G. BurvenichRasmus KarstadBart De Spiegeleer

Chemical and metabolic stability of lactoferricin-derived cationic antimicrobial tripeptides

Bart De SpiegeleerValentijn VergoteJohan SvensonRasmus KarstadChristian Paul G. Burvenich

Concentration-dependent peptide losses during the drying step in the sample preparation: influence of additives

Adel PezeshkiValentijn VergoteChristian Paul G. BurvenichBart De Spiegeleer

Development of peptide receptor binding assays: methods to avoid false negatives

Valentijn VergoteSylvia Van DorpeMathieu VerbekenChristian Paul G. BurvenichChristophe Van De WieleWilliam BanksBart De Spiegeleer

A1 Journal Article in REGULATORY PEPTIDES

Functional genomics of bovine neutrophil during lactation

Mieke StevensAdel PezeshkiBart De SpiegeleerLuc PeelmanChristian Paul G. Burvenich

Functional quality of new peptide drugs: receptor-binding and tissue-interactions

Mathieu VerbekenValentijn VergoteChristian Paul G. BurvenichChristophe Van De WieleAndras RonaiKlara GyiresWalter LuytenBart De Spiegeleer

Gene expression of TLR4 and associated genes in bovine neutrophils during early and mid lactation

Mieke StevensMario Van PouckeLuc DuchateauLuc PeelmanAdel PezeshkiBart De SpiegeleerChristian Paul G. Burvenich

Innate defense of bovine teat canal in nonlactating Holstein cows

Adel PezeshkiMieke StevensAnthony CapucoAnnarita BrunoLuc PeelmanBart De SpiegeleerChristian Paul G. Burvenich

Peptidomics of bovine mammary gland: Concentration-dependent peptide losses during sample preparation can be minimized applying n-nonyl-β-D-glucopyranoside

Adel PezeshkiValentijn VergoteChristian Paul G. BurvenichBart De Spiegeleer

Prepartum immune status and mammary gland involution in cows with modified dry period lengths

Adel PezeshkiAnthony V. CapucoRobert J. CollierBart De SpiegeleerChristian Paul G. Burvenich

Qbd analytical development of calcitonin bioadhesive formulation

Kevin GeenensNELE CLOTTENSValentijn VergoteDelphine CouckeEls MehuysBart De Spiegeleer

Quality specifications for peptide drugs: a regulatory-pharmaceutical approach

Valentijn VergoteChristian Paul G. BurvenichChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in Journal of Peptide Science

The paradox of scored tablets: a cost-saving risk

Bart De SpiegeleerLindsay Van HoorebekeAnton De SpiegeleerPieter CasteleinLucas Van Bortel

A1 Journal Article in Pharmazie

Transdermal behaviour of the N-alkylamide spilanthol

Jente BoonenEline HaletChristian Paul G. BurvenichPhillip BlondeelBart De Spiegeleer

2008

Bovine mammary gland peptibolomics: Adsorption of peptides at the sample drying step

Adel PezeshkiValentijn VergoteChristian Paul G. BurvenichBart De Spiegeleer

Development of quality specifications for peptide drugs

Bart De SpiegeleerValentijn VergoteChristian Paul G. Burvenich

Development of system suitability tests for in vitro skin integrity control: impedance and capacitance.

Bart De SpiegeleerBram BaertValentijn VergoteSylvia Van Dorpe

Growth factor/peptide receptor imaging for the development of targeted therapy in oncology

Christophe Van De WieleH BoersmaRudi DierckxPhilippus ElsingaBart De SpiegeleerA Van Waarde

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

HPLC analysis and stress stability of peptide drugs

Valentijn VergoteBram BaertBart De Spiegeleer

Impurity profiling quality control testing of synthetic peptides using liquid chromatography-photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: the obestatin case

Bart De SpiegeleerValentijn VergoteAdel PezeshkiKathelijne PeremansChristian Paul G. Burvenich

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products

Valentijn VergoteSylvia Van DorpeKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PEPTIDES

Inhibiting protease-activity in peptidomics: strategies during sampling and receptor studies

Valentijn VergoteAdel PezeshkiSylvia Van DorpeChristian Paul G. BurvenichBart De Spiegeleer

LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin

Valentijn VergoteBram BaertEva VandermeulenKathelijne PeremansHenri van BreeGuido SlegersChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Nuclear medicine and large animal studies in the pharmacological development of psychotropics

Kathelijne PeremansBart De SpiegeleerKurt Audenaert

Editorial material

Pharmaceutical drugability of peptides

Bart De SpiegeleerValentijn VergoteSylvia Van DorpeBram BaertKurt AudenaertChristophe Van De WieleKathelijne PeremansChristian Paul G. Burvenich

Quality assessment of pharmacy and internet obtained topical testosterone formulations.

Bram BaertValentijn VergoteBart De Spiegeleer

Screening methodology for chemical and metabolic stability of potential peptide drugs

Bart De SpiegeleerValentijn VergoteAdel PezeshkiSylvia Van DorpeBram BaertChristian Paul G. Burvenich

Solvent effects on the transdermal penetration of the OECD model compound caffeine.

Bram BaertJente BoonenJo LambertChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

The effect of dry period length reduction to 28 days on the performance of multiparous dairy cows in the subsequent lactation

Adel PezeshkiJalil MehrzadGholam Reza GhorbaniBart De SpiegeleerRobert CollierChristian Paul G. Burvenich

A1 Journal Article in Canadian Journal of Animal Science

The use of [I-123]-2-iodo-L-phenylalanine as an early radiotherapy evaluation tool: In vitro R1M rabdomyosarcoma cell and in vivo mouse experiments

Veerle KersemansValentijn VergoteVirginie de GelderIndira MadaniHubert ThierensWilfried De NeveJ MERTENSGuido SlegersChristian Paul G. BurvenichKathelijne Peremans et al.

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

2007

Adsorption of the model drug testosterone on laboratory tips

Samuel BodéBram BaertBart De Spiegeleer

Analysis of iodinated peptides by LC-DAD/ESI ion trap mass spectrometry

Valentijn VergoteSamuel BodéKathelijne PeremansHenri van BreeBram BaertGuido SlegersChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Assessment of the solid-state composition of an active salicylanilide compound by FT-Raman spectroscopy

Bart De SpiegeleerBram BaertN DIERICXD SEGHERSFrancis VerpoortLieven Van VoorenChristian Paul G. BurvenichGuido Slegers

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis

J MEHRZADH DOSOGNEBart De SpiegeleerLuc DuchateauChristian Paul G. Burvenich

A1 Journal Article in VETERINARY RESEARCH

Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs

Bart De SpiegeleerBram BaertElien VangheluweIlse BecueJan De SmetPieter SpanogheChristophe WillePaul Van der MeerenGuido Slegers

A1 Journal Article in JOURNAL OF SOLUTION CHEMISTRY

Imaging of the serotonin-2A receptor before and after pipamperone administration in the canine brain

Kurt AudenaertBart De SpiegeleerE BUNTINXValentijn VergoteEva VandermeulenSimon VermeireAndré DobbeleirFilip De VosKathelijne Peremans

Peptibolomics of the cows' udder: peptide profiling of the teat canal

Lukas SenepartValentijn VergoteAdel PezeshkiSamuel BodéSteve LefeverBram BaertKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

Stability of the OECD model compound benzoic acid in receptor fluids of Franz diffusion cells

Samuel BodéBram BaertM VANGELEJo LambertChristian Paul G. BurvenichGuido SlegersBart De Spiegeleer

A1 Journal Article in PHARMAZIE

The effect of pipamperone on the binding index of 123I-5I-R91150, a selective 5-HT2A receptor radioligand, in the canine brain

Kathelijne PeremansBart De SpiegeleerValentijn VergoteEva VandermeulenSimon VermeireAndré DobbeleirE BUNTINXFilip De VosKurt Audenaert

The effect of pipamperone on the binding index of 123I-5I-R91150, a selective 5-HT2A receptor radioligand,in the canine brain

Kathelijne PeremansBart De SpiegeleerValentijn VergoteEva VandermeulenSimon VermeireAndré DobbeleirE BUNTINXFilip De VosKurt Audenaert

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds

Bram BaertE DECONINCKMireille Van GeleMarian SlodickaP STOPPIESamuel BodéGuido SlegersY VANDER HEYDENJo LambertJ BEETENS et al.

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma

Kathelijne PeremansVeerle KersemansTiziana LiutiEva VandermeulenBart CornelissenIngrid GielenBart De SpiegeleerJ MERTENSChristian Paul G. BurvenichGuido Slegers

A1 Journal Article in VETERINARY RADIOLOGY & ULTRASOUND

Variation in gene expression of the TLR4 pathway in unstimulated circulating bovine neutrophils during early and mid lactation

Steve LefeverA DE KETELAERELuc DuchateauG VERMEULENLukas SenepartBart De SpiegeleerLuc PeelmanChristian Paul G. Burvenich

2006

Analytical characterisation of arsenic anticoccidials and their determination in poultry feed

Bram BaertBart De SpiegeleerSamuel BodéGuido SlegersSofie LangendriesLiesbet Poppe

Characterisation of a preservative system in an oily preparation

Bart De SpiegeleerE WATTYNGuido SlegersP VEYSG DERRIEULieven Van Vooren

A1 Journal Article in PHARMAZIE

Comparative biodistribution study of the new tumor tracer [I-123]-2-iodo-L-phenylalanine with [I-123]-2-iodo-L-tyrosine

Veerle KersemansBart CornelissenK KERSEMANSRudi DierckxBart De SpiegeleerJ MERTENSGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Development of a dissolution method for a meloxicam oral suspension using solubility and IVIVC data

D SEGHERSLieven Van VoorenBart De Spiegeleer

I-123/125-labelled 2-iodo-L-phenylalanine and 2-iodo-D-phenylalanine: comparative uptake in various tumour types and biodistribution in mice

Veerle KersemansBart CornelissenK KERSEMANSM BAUWENSRudi DierckxBart De SpiegeleerJ MERTENSGuido Slegers

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Influence of sedation and data acquisition method on tracer uptake in animal models: [I-123]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice

Veerle KersemansBart De SpiegeleerJ MERTENSGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging.

Veerle KersemansK KERSEMANSBart CornelissenLudovicus StaelensBart De SpiegeleerJ MERTENSGuido Slegers

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

RADIOSTABILITY OF VANCOMYCIN

Samuel BodéElien VangheluweBram BaertN VAN HOOFLuc Van HoorebekeHubert ThierensJean Paul RemonHubert De BrabanderBart De Spiegeleer

Stoichiometry of complexes by quantifying qualitative UV-VIS spectroscopic shifts

Bram BaertBart De SpiegeleerGuido SlegersCeline Lagae

Synthesis and HPLC-purification of [Br-77]TMC125-R165335 (etravirine), a new anti-HIV drug of the DAPY-NNRTI class

Bart De SpiegeleerFilip DumontKathelijne PeremansChristian Paul G. BurvenichLieven Van VoorenJ ROSIERL BAERTP WIGERINCKGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing

Bart De SpiegeleerE WATTYNGuido SlegersPaul Van der MeerenK VLAMINCKLieven Van Vooren

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

2005

Determination of the relative amounts of three crystal forms of a benzimidazole drug in complex finished formulations by FT-Raman spectroscopy

Bart De SpiegeleerD SEGHERSR WIEMEJ SCHAUBROECKFrancis VerpoortGuido SlegersLieven Van Vooren

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products

J DIANAL VANDENBOSCHBart De SpiegeleerJ HOOGMARTENSE ADAMS

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In vivo evaluation and dosimetry of I-123-2-iodo-D-phenylalanine, a new potential tumor-specific tracer for SPECT in an R1M rhabdomyrosarcoma athymic mouse model

Veerle KersemansBart CornelissenKlaus BacherK KERSEMANSHubert ThierensRudi DierckxBart De SpiegeleerGuido SlegersJ MERTENS

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Mass uniformity: Influence of operational compression conditions on breakability of scored tablets as part of manufacturing robustness evaluation

Bart De SpiegeleerLieven Van VoorenT THONISSENPhilippe JoyeBart CornelissenG LAMMENSGuido Slegers

A1 Journal Article in JOURNAL OF FOOD AND DRUG ANALYSIS

2003

Anti-microbial preservatives in oily preparations

Bart De SpiegeleerP Van NimmenG LammensGuido SlegersI Huyghe

A2 Journal Article in PHARMEUROPA

Distribution study of three-phase emulsions using confocal laser scanning microscopy (CLSM)

Bart De SpiegeleerJan CocquytPatric Van OostveldtPaul Van der MeerenLieven Van Vooren

Investigation of preservative systems by experimental design: drug product optimisation and robustness characterisation

Bart De SpiegeleerLieven Van VoorenElke WattijnGuido SlegersW VAN DEN BOSSCHEPaul Van der MeerenP VEYSK VLAMINCKH NUYTTENP MUSSCHE

Physical stability of diluted suspo-emulsions

Bart De SpiegeleerLieven Van VoorenZ. PoladiJan CocquytPaul Van der Meeren

Physico-chemical screening tests using IV2SOL technology in the development of liquid pharmaceutical formulations

Bart De SpiegeleerE WATTYNGuido SlegersW VAN DEN BOSSCHEH DOSOGNE

Raman spectroscopy in the polymorphic characterisation of drugs

Bart De SpiegeleerN DIERICXFrancis VerpoortP VEYSK VLAMINCKLieven Van Vooren

2002

Statistical analysis of tablet breakability methods

Lieven Van VoorenBart De SpiegeleerT ThonissenPhilippe JoyeJ Van DurmeGuido Slegers

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

2001

A novel bending point criterion for dissolution profile interpretation

L Van VoorenG KrikilionJ RosierBart De Spiegeleer

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Dissolution stability and IVIVC investigation of a buccal tablet

Bart De SpiegeleerL Van VoorenJ VoorspoelsD ThoneJ Rosier

A1 Journal Article in ANALYTICA CHIMICA ACTA

Evaluation of dissolution profiles using principal component analysis

E AdamsR De MaesschalckBart De SpiegeleerY Vander HeydenJ Smeyers-VerbekeDL Massart

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

1996

Half-fraction and full factorial designs versus central composite design for retention modelling in reversed-phase ion-pair liquid chromatography

Jacques O De BeerCatherine V VandenbrouckeDésiré L MassartBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

1992

Relationship between content limits and assay methods : an interlaboratory statistical evaluation

Jacques O De BeerBart De SpiegeleerJos HoogmartensIsabelle SamsonDesiré L MassartMartine Moors

A1 Journal Article in ANALYST

1991

High-performance thin-layer chromatographic analysis of thiazine dyes on silica, cyano, and reversed-phase C18 layers

BM Van LiedekerkeAndreas De LeenheerBart De Spiegeleer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHIC SCIENCE

1990

Planar chromatography : most flexible analytic technique in the pharmaceutical industry

A ParadisBart De Spiegeleer

A1 Journal Article in ANALUSIS

The tissue distribution in rats of [PT-195M]carboplatin following intravenous, intraperitoneal and oral administration

N TinkerBart De SpiegeleerH SharmaH JacksonC McAuliffeJP Reman

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

1989

A rapid high-performance thin-layer chromatographic screening method for sulfonamides residues in animal muscle tissues

L Van PouckeD RousseauBart De SpiegeleerCarlos Van Peteghem

High performance liquid chromatography stability study of malonyl-coenzyme A, using statistical experimental designs

Bart De SpiegeleerKarel SintobiinJan Desmet

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

Planar chromatography of Echinacea species extracts with automated multiple development

Marc FM TrypsteenRobert GE Van SeverenBart De Spiegeleer

A1 Journal Article in ANALYST

Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA)

J ClaereboudtBart De SpiegeleerEA De BruijnR GijbelsM Claeys

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Synthese en analyse van N-13-cisplatin, (ethyleendiamine)(1-C-11-malonaat)platinum(II) en Pt-195m-carboplatin

Bart De Spiegeleer

1988

High-performance liquid chromatography of α-substituted acetic acid derivatives

Bart De SpiegeleerGuido SlegersW Van Den BosscheA ClaeysP De Moerloose

A1 Journal Article in JOURNAL OF LIQUID CHROMATOGRAPHY

Synthesis and radiopharmaceutical preparation of (ethylenediamine) (1-carbon-11-malonate) platinum(II) for PET studies

Bart De SpiegeleerPatrick GoethalsGuido SlegersEric GillisWalter Van den BosscheProsper De Moerloose

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

1987

A strategy for two-dimensional, high-performance thin-layer chromatography, applied to local anesthetics

Bart De SpiegeleerW Van Den BosscheP De MoerlooseD Massart

A1 Journal Article in CHROMATOGRAPHIA

Criterion for evaluation and optimization in thin-layer chromatography

Bart De SpiegeleerProsper De MoerlooseGuido Slegers

A1 Journal Article in ANALYTICAL CHEMISTRY

Intellectual flexibility

Bart De Spiegeleer

A1 Journal Article in CHEMICAL & ENGINEERING NEWS

1986

Direct assay for phosphotransacetylase and acetyl-coenzyme a carboxylase by high-performance liquid chromatography

Bart De SpiegeleerGeert MannensGuido SlegersWalter Van den BosscheAlbert Claeys

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Microscale synthesis of nitrogen-13-labeled cisplatin

Bart De SpiegeleerGuido SlegersCarlos VandecasteeleWalter Van den BosscheKarel SchelstraeteAlbert ClaeysProsper De Moerloose

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography

Bart De SpiegeleerGuido SlegersW Van Den Bossche

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

1985

Determination of methyl nicotinate in pharmaceutical creams by high-performance thin-layer chromatography

Bart De SpiegeleerW Van Den BosscheP De MoerlooseH Stevens

A1 Journal Article in CHROMATOGRAPHIA

1984

Quantitative analysis of cis-dichlorodiammineplatinum(II) by high-performance thin-layer chromatography

Bart De SpiegeleerGuido SlegersW Van Den BosscheP De Moerloose

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY