Research Explorer

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Researcher

Arne Martens

Awards & Distinctions

17 Results

2023

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

2021

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen CatrysseBastiaan MaesParul MehrotraArne MartensEsther HosteLiesbet MartensChristian MaueröderAnneleen RemmerieAnna BujkoKarolina Slowicka et al.

A1 Journal Article in CELL REPORTS

Microbes exploit death-induced nutrient release by gut epithelial cells

Christopher AndersonChristopher B. MedinaBrady J. BarronLaura KarvelyteTania Love AaesIrina LambertzJustin S. A. PerryParul MehrotraAmanda GonçalvesKelly Lemeire et al.

A1 Journal Article in NATURE

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van Hove et al.

A1 Journal Article in NATURE COMMUNICATIONS

2020

A20 at the crossroads of cell death, inflammation, and autoimmunity

Arne MartensGeert van Loo

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Mechanistic insights into the regulation of inflammatory pathology by A20

Arne MartensGeert van Loo

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Lien VerboomArne MartensDario PriemEsther HosteMozes SzeHanna-Kaisa VikkulaLisette Van HoveSofie VoetJana RoelsJonathan Maelfait et al.

A1 Journal Article in CELL REPORTS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

2019

A20 phosphorylation controls A20 function

Arne MartensGeert van Loo

Editorial material

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Apostolos PolykratisArne MartensRemzi Onur ErenYoshitaka ShirasakiMai YamagishiYoshifumi YamaguchiSotaro UemuraMasayuki MiuraBernhard HolzmannGeorge Kollias et al.

A1 Journal Article in NATURE CELL BIOLOGY

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosSarah DruwéArne MartensKarolina SlowickaAdrian T TingManolis PasparakisWim DeclercqPeter VandenabeeleGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Identification of immune-responsive gene 1 (IRG1) as a target of A20

Emmy Van QuickelbergheArne MartensLudger GoeminneLieven ClementGeert van LooKris Gevaert

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH