Research Explorer

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175 Resultaten

2025

Building Sub-Saharan African PBPK populations reveals critical data gaps : a case study on Aflatoxin B1

Orphélie LootensMarthe De BoevreSarah De SaegerJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in TOXINS

Developing evidence-based dosing recommendations for intravenous ciprofloxacin in critically ill children: a population pharmacokinetic study using total and unbound concentrations

Pieter-Jan De SutterEvelyn DhontDaphné VensPeter De PaepeJef WillemsPetra SchelstraeteJan Van BocxlaerAn VermeulenPieter De Cock

Dose-limiting toxicities of paclitaxel in breast cancer patients : studying interactions between pharmacokinetics, physical activity, and body composition : a protocol for an observational cohort study

Len De NysAnita Barzegar-FallahKatrien LanckmansStephane SteurbautDavid BeckwéeAmy de Haar-HollemanSteven ProvynElke GasthuysSofie Vande CasteelePieter-Jan De Sutter et al.

A1 Artikel in een tijdschrift in CANCERS

Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Simon KrolsMuhammad RishfiFien MartensAnouk Van HauwermeirenEllen SandersPieter-Jan De SutterAn VermeulenKaat De WeverSarah-Lee BekaertM. Emmy M. Dolman et al.

A1 Artikel in een tijdschrift in JOURNAL OF MEDICINAL CHEMISTRY

Synergy of body composition, exercise oncology, and pharmacokinetics : a narrative review of personalizing paclitaxel treatment for breast cancer

Nele AdriaenssensStephanie C. M. WuytsStephane SteurbautPieter-Jan De SutterAn VermeulenAmy de Haar-HollemanDavid BeckwéeSteven ProvynSofie Vande CasteeleJinyu Zhou et al.

A1 Artikel in een tijdschrift in CANCERS

Under the magnifying glass : investigating aflatoxin B1 and efavirenz in mycotoxin-drug interactions

Orphélie LootensSarah De SaegerMarthe De BoevreAn Vermeulen

Under the magnifying glass : investigating aflatoxin B1 and efavirenz in mycotoxin-drug interactions

Orphélie LootensAn VermeulenMarthe De BoevreSarah De Saeger

Understanding meropenem disposition in critically ill children : a population PK analysis

Thi Van Anh NguyenEvelyn DhontEmma BeelNick VerougstraeteVeronique StoveSophie VanhaesebrouckDaphne VensPeter De PaepePieter De CockAn Vermeulen

2024

Application of pediatric-adapted modeling and simulation approaches

Pieter-Jan De SutterJonas LangeraertRobin MicheletAn Vermeulen

Hoofdstuk in een boek in Essentials of translational pediatric drug development : from past needs to future oportunities

Comparison of monoclonal antibody disposition predictions using different physiologically based pharmacokinetic modelling platforms

Pieter-Jan De SutterElke GasthuysAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis

Elke GasthuysJudith van OvostSofie Vande CasteeleSarah CosynsWim CeelenJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : results from a randomized trial in ovarian cancer

Jesse DemuytereCharlotte CarlierTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn VermeulenJoseph WeertsJürgen ThomaleHannelore Denys et al.

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF SURGERY

Exploring the impact of efavirenz on aflatoxin B1 metabolism : insights from a physiologically based pharmacokinetic model and a human liver microsome study

Orphélie LootensMarthe De BoevreElke GasthuysSarah De SaegerJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in TOXINS

Optimized packaging and storage strategies to improve immunosensors’ shelf-life

An VermeulenPaula Dias Lopes CamposFrank DevliegherePeter RagaertJan VanfleterenPatricia Khashayar

A1 Artikel in een tijdschrift in IEEE SENSORS JOURNAL

Penetration of antibiotics into subcutaneous and intramuscular interstitial fluid : a meta-analysis of microdialysis studies in adults

Pieter-Jan De SutterEline HermansPieter De CockJan Van BocxlaerElke GasthuysAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Population pharmacokinetics of lisinopril in hypertensive children and adolescents with normal to mildly reduced kidney function

Louis SandraEva DegraeuwePauline De BruyneSiegrid De BaereSiska CroubelsJan Van BocxlaerAnn RaesJohan Vande WalleElke GasthuysAn Vermeulen

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Real world data on the use of lisinopril over 10 years within pediatric nephrology

Eva DegraeuweAnn RaesElke GasthuysEvelien SnauwaertLien DosscheAgnieszka Prytula-EbelsJo DehoorneAn VermeulenJohan Vande Walle

Reliability of physiologically based pharmacokinetic models for the prediction of drug distribution and tissue concentrations

Pieter-Jan De SutterAn VermeulenJan Van Bocxlaer

The use of population pharmacokinetics to extrapolate food effects from human adults and beagle dogs to the pediatric population illustrated with paracetamol as a test case

Elke GasthuysLouis SandraMarina StatelovaMaria VertzoniAn Vermeulen

A1 Artikel in een tijdschrift in PHARMACEUTICALS

Unlocking diversity : towards a comprehensive framework for physiologically based pharmacokinetic population qualification in Sub Saharan Africa

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

2023

Acute balenine supplementation in humans as a natural carnosinase-resistant alternative to carnosine

Sarah de JagerAn VermeulenSiegrid De BaereThibaux Van der StedeEline LievensSiska CroubelsRalf JägerMartin PurpuraJan BourgoisWim Derave

A1 Artikel in een tijdschrift in SCIENTIFIC REPORTS

Building a human physiologically based pharmacokinetic model for aflatoxin B1 to simulate interactions with drugs

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

A1 Artikel in een tijdschrift in PHARMACEUTICS

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreAn VermeulenJia NingElke GasthuysJan Van BocxlaerSarah De Saeger

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

Building a physiologically-based pharmacokinetic model for a carcinogenic food contaminant aflatoxin B1

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis

Helena BraetPeter-Paul FransenRemco MariënGiovanna LolloWim CeelenChris VervaetLieve BalcaenFrank VanhaeckeChristian VanhoveStefan van der Vegte et al.

A1 Artikel in een tijdschrift in ACS APPLIED MATERIALS & INTERFACES

Comparison of monoclonal antibody disposition predictions between different PBPK platforms

Pieter-Jan De SutterElke GasthuysAn Vermeulen

PBPK modelling to predict local lung exposure of meropenem in people with cystic fibrosis

Pieter-Jan De SutterSofia ProostAn Vermeulen

Predicting volume of distribution in neonates : performance of physiologically based pharmacokinetic modelling

Pieter-Jan De SutterPhebe RossignolLien BreënsElke GasthuysAn Vermeulen

A1 Artikel in een tijdschrift in PHARMACEUTICS

Predictive performance of physiologically based pharmacokinetic modelling of beta-lactam antibiotic concentrations in adipose, bone and muscle tissues

Pieter-Jan De SutterPieter De CockTN JohnsonH MustherElke GasthuysAn Vermeulen

A1 Artikel in een tijdschrift in DRUG METABOLISM AND DISPOSITION

Real-world evidence of lisinopril in pediatric hypertension and nephroprotective management : a 10-year cohort study

Eva DegraeuweAnn RaesElke GasthuysEvelien SnauwaertLien DosscheAgnieszka Prytula-EbelsJo DehoorneAn VermeulenJohan Vande Walle

2022

Accuracy of PBPK-predicted tissue concentrations : a case study of beta-lactam antibiotics in fat, bone and muscle

Pieter-Jan De SutterPieter De CockTrevor N JohnsonHelen MustherElke GasthuysAn Vermeulen

Altered intravenous drug disposition in people living with cystic fibrosis : a meta‐analysis integrating top‐down and bottom‐up data

Pieter-Jan De SutterMaxime Van HaeverbekeEva Van BraeckelStephanie Van BiervlietJan Van BocxlaerAn VermeulenElke Gasthuys

A1 Artikel in een tijdschrift in CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

Comment on : 'Penetration of antibacterial agents into pulmonary epithelial lining fluid : an update'

Pieter-Jan De SutterJan De WaeleAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Determination of pharmacokinetic parameters of efavirenz an aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Extensive review of pharmacokinetic and pharmacodynamic properties of ACE-inhibitors and angiotensin receptor blockers in hypertensive children

Eva DegraeuweLouis SandraPaulien De VosAn VermeulenAnn RaesJohan Vande WalleElke Gasthuys

Extensive review of trial methodology investigating therapeutics ACE-inhibitors and angiotensin receptor blockers in hypertensive paediatric patients

Eva DegraeuweLouis SandraPaulien DevosAn VermeulenAnn RaesJohan Vande WalleElke Gasthuys

General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Naim BouazzaAristides DokoumetzidisCatherijne A. J. KnibbeSaskia N. de WildtClaire AmberyPieter De CockElke GasthuysFrantz FoissacSaik UrienAnna-Karin Hamberg et al.

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

High throughput analytical report writing in R : a case study of validating an LC-MS method for the quantification of amoxicillin in human plasma

Pieter-Jan De SutterElke GasthuysAn VermeulenJan Van Bocxlaer

In vitro and in vivo characterization of long-acting aqueous suspensions : towards a predictive semi-mechanistic pharmacokinetic model

Thi Thanh Vy NguyenAn VermeulenJens Ceulemans

Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases

Wim CeelenLouis SandraLeen Van de SandeM GraversenMB MortensenAn VermeulenElke GasthuysDries ReyndersSarah CosynsAnne Hoorens et al.

A1 Artikel in een tijdschrift in EBIOMEDICINE

Physiologically based pharmacokinetic models for the prediction of beta-lactam antibiotic concentrations in perfusion-limited tissues

Pieter-Jan De SutterPieter De CockElke GasthuysAn Vermeulen

Population pharmacokinetics and Bayesian estimations of lisinopril at steady state in hypertensive children with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Possible mechanisms of the interplay between drugs and mycotoxins : is there a possible impact?

Orphélie LootensAn VermeulenSiska CroubelsSarah De SaegerJan Van BocxlaerMarthe De Boevre

A1 Artikel in een tijdschrift in TOXINS

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig Lamberts et al.

A1 Artikel in een tijdschrift in NATURE COMMUNICATIONS

The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer

Jesse DemuytereCharlotte CarlierWouter WillaertPhilippe TummersHannelore DenysTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn Vermeulen et al.

The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer

Jesse DemuytereCharlotte CarlierWouter WillaertPhilippe TummersHannelore DenysTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn Vermeulen et al.

Unravelling the pharmacokinetics of aflatoxin B1 : in vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerAn VermeulenSarah De Saeger

A1 Artikel in een tijdschrift in FRONTIERS IN MICROBIOLOGY

2021

Bayesian population approach to determine lisinopril exposure in hypertensive paediatric patients with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysPaulien De BruyneAn VermeulenAnn RaesJohan Vande Walle

Desmopressin oral lyophilisate in young children : new insights in pharmacokinetics and pharmacodynamics

Lien DosscheRobin MicheletPauline De BruyneCharlotte Van HerzeeleElke GasthuysSøren RittigAn VermeulenJohan Vande Walle

A1 Artikel in een tijdschrift in ARCHIVES OF DISEASE IN CHILDHOOD

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenJan Van BocxlaerSarah De SaegerMarthe De Boevre

Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases : a first in human phase I study

Wim CeelenLouis SandraLeen Van de SandeMartin GraversenAn VermeulenDries ReyndersSarah CosynsAnne HoorensWouter Willaert

Linking in vitro intrinsic dissolution rate and thermodynamic solubility with pharmacokinetic profiles of bedaquiline long-acting aqueous microsuspensions in rats

Thi Thanh Vy NguyenJan BevernageNicolas DarvilleChristophe TistaertJan Van BocxlaerStefaan RossenuAn Vermeulen

A1 Artikel in een tijdschrift in MOLECULAR PHARMACEUTICS

Mycotoxin-drug interactions at the level of CYP450 enzymes

Orphélie LootensSarah De SaegerMarthe De BoevreAn VermeulenJan Van Bocxlaer

Pharmacokinetics and blood pressure effects of ACE-inhibitors in children with hypertension

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Physiologically based pharmacokinetic modelling of lisinopril in children: A case story of angiotensin converting enzyme inhibitors

Feifan XieJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population pharmacokinetic modeling of lisinopril at steady-state in hypertensive paediatric patients with mild to moderate renal impairement

Eva DegraeuweLouis SandraElke GasthuysPaulien De BruyneAnn RaesJohan Vande WalleAn Vermeulen

Population pharmacokinetics of lisinopril in hypertensive children with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPaulien De BruyneAnn RaesJohan Vande Walle

Targeting ferroptosis protects against multiorgan dysfunction and death

Tom Vanden BergheSamya Van CoillieInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusEmily Van SanSze Men ChoiRia RoelandtCatalina Dumitrascu et al.

2020

An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?

Robin MicheletLien DosscheCharlotte Van HerzeelePauline De BruyneElke GasthuysJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Exploration of more personalized treatments in ovarian cancer using a pharmacodynamic protein biomarker and patient-derived xenograft technology

Elien De ThayeJan Van BocxlaerAn VermeulenPieter Colin

Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review

Elke GasthuysLien DosscheRobin MicheletJens Peter NorgaardMathias DevreeseSiska CroubelsAn VermeulenJan Van BocxlaerJohan Vande Walle

A1 Artikel in een tijdschrift in PEDIATRIC DRUGS

Pharmacokinetics in patients with cystic fibrosis : a systematic review of data published between 1999 and 2019

Pieter-Jan De SutterElke GasthuysEva Van BraeckelPetra SchelstraeteStephanie Van BiervlietJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

PKPD modeling and dosing considerations in advanced ovarian cancer patients treated with cisplatin-based intraoperative intraperitoneal chemotherapy

Feifan XieJan Van BocxlaerPieter ColinCharlotte CarlierOlivier Van KerschaverJoseph WeertsHannelore DenysPhilippe TummersWouter WillaertWim Ceelen et al.

A1 Artikel in een tijdschrift in AAPS JOURNAL

2019

A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers

Feifan XieAn VermeulenPieter ColinZeneng Cheng

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer

Feifan XieJan Van BocxlaerAn VermeulenPieter Colin

Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.

Feifan XieKaat De ClercqChris VervaetJan Van BocxlaerPieter ColinAn Vermeulen

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol

Huybrecht T'jollynAn VermeulenJan Van Bocxlaer

A1 Artikel in een tijdschrift in AAPS JOURNAL

SAFEPEDRUG : safer pediatric drugs for children: what have we learned?

Elke GasthuysJohan Vande WalleLien DosscheLieve NuytinckRobin MicheletAn VermeulenSevasti Karamaria

2018

A dried blood spot assay for paclitaxel and its metabolites

Feifan XieElien De ThayeAn VermeulenJan Van BocxlaerPieter Colin

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A model-based analysis of the kinetics of leukocytes in stage III ovarian cancer patients treated with neo-adjuvant chemotherapy, cytoreductive surgery and cisplatin-based intraperitoneal chemoperfusion

Feifan XieCharlotte CarlierWim CeelenJan Van BocxlaerAn VermeulenPieter Colin

A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1

Elke GasthuysJoske MillecamMathias DevreeseAn VermeulenPauline De BruyneJohan Vande WalleJoris DelangheSiska Croubels

A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients

Huybrecht T'jollynAn VermeulenJan Van BocxlaerPieter Colin

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

A systems pharmacology model for inflammatory bowel disease

Violeta Balbas-MartinezLeire Ruiz-CerdaItziar Irurzun-AranaIgnacio Gonzalez-GarciaAn VermeulenJose David Gomez-MantillaInaki F Troconiz

A1 Artikel in een tijdschrift in PLOS ONE

Claiming desmopressin therapeutic equivalence in children requires pediatric data : a population PKPD analysis

Robin MicheletLien DosscheCharlotte Van HerzeeleJan Van BocxlaerAn VermeulenJohan Vande Walle

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine

Julia KorellBruce GreenAllan RaeBart RemmerieAn Vermeulen

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pediatric drug development: towards maturity : desmopressin as a case

Elke GasthuysRobin MicheletLien DosschePauline De BruyneJohan Vande WalleAn VermeulenMathias DevreeseSiska Croubels

PK/PD studies in pigs leading to optimization of treatment dose in MNE?

Elke GasthuysLien DosscheSiska CroubelsPauline De BruyneMathias DevreeseAn VermeulenJohan Vande Walle

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsJoske MillecamStijn SchauvliegeThomas van BergenPauline De BruyneJohan Vande WalleMathias Devreese

A1 Artikel in een tijdschrift in FRONTIERS IN PHARMACOLOGY

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsPauline De BruyneJoske MillecamJohan Vande WalleMathias Devreese

Prediction of pediatric pharmacokinetics to optimize dose regimens using bottom-up, top-down and middle-out approaches

Robin MicheletAn VermeulenJan Van Bocxlaer

Relationship between antipsychotic blood levels and treatment failure during the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study

Rama MelkoteArun SinghAn VermeulenBart RemmerieAdam Savitz

A1 Artikel in een tijdschrift in SCHIZOPHRENIA RESEARCH

Results of a multicenter population pharmacokinetic study of ciprofloxacin in children with complicated urinary tract infection

Kevin MeestersRobin MicheletREINER MAUELAnn RaesJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Artikel in een tijdschrift in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The use of PBPK modeling across the pediatric age range using propofol as a case

Robin MicheletJan Van BocxlaerKarel AllegaertAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

2017

Dosing and switching strategies for paliperidone palmitate 3-month formulation in patients with schizophrenia based on population pharmacokinetic modeling and simulation, and clinical trial data

Mats O MagnussonMahesh N SamtaniElodie L PlanE Niclas JonssonStefaan RossenuAn VermeulenAlberto Russu

A1 Artikel in een tijdschrift in CNS DRUGS

In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics

Nathan BroekaertMathias DevreeseThomas van BergenStijn SchauvliegeMarthe De BoevreSarah De SaegerLynn VanhaeckeFranz BerthillerHerbert MichlmayrAlexandra Malachová et al.

A1 Artikel in een tijdschrift in ARCHIVES OF TOXICOLOGY

Modeling the relationship between exposure to abiraterone and prostate-specific antigen dynamics in patients with metastatic castration-resistant prostate cancer

Xu Steven XuCharles J RyanKim StuyckensMatthew R SmithFred SaadThomas W GriffinYoun C ParkMargaret K YuPeter De PorreAn Vermeulen et al.

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Paediatric PBPK modelling of propofol using the middle out approach

Robin MicheletJan Van BocxlaerAn Vermeulen

PBPK in preterm and term neonates : a review

Robin MicheletJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in CURRENT PHARMACEUTICAL DESIGN

Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison

Elien De ThayeAnouk VervaeckEleonora MarosticaJean Paul RemonJan Van BocxlaerChris VervaetAn Vermeulen

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Population pharmacokinetics of a novel once-every 3 months intramuscular formulation of paliperidone palmitate in patients with schizophrenia

Mats O MagnussonMahesh N SamtaniElodie L PlanE Niclas JonssonStefaan RossenuAn VermeulenAlberto Russu

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound

Huybrecht T'jollynJan SnoeysJan Van BocxlaerLies De BockPieter AnnaertAchiel Van PeerKarel AllegaertGeert MannensAn VermeulenKoen Boussery

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

2016

A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU

Stijn JonckheereNikolaas De NeveHans De BeenhouwerMario BerthAn VermeulenJan Van BocxlaerPieter Colin

A1 Artikel in een tijdschrift in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bioequivalence in adults does not mean bioequivalence in children

Lien DosscheRobin MicheletPauline De BruyneJan Van BocxlaerAn VermeulenJohan Vande Walle

Bioequivalence in adults is not always bioequivalence in children

Lien DosscheAnn RaesPauline De BruyneRobin MicheletAn VermeulenJan Van BocxlaerJohan Vande Walle

Characterizing hepatic clearance in early life : PBPK as modelling tool and tramadol as guide

Huybrecht T'jollynJan Van BocxlaerAn VermeulenKoen Boussery

Deoxynivalenol-3-β-D-glucoside : in vitro cytotoxicity and in vivo oral bioavailability and hydrolysis in broiler chicken and pig

Nathan BroekaertMathias DevreeseThomas van BergenStijn SchauvliegeMarthe De BoevreSarah De SaegerLynn VanhaeckeFranz BerthillerHerbert MichlmayrAlexandra Malachova et al.

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans

Eleonora MarosticaKarel Van AmmelArd TeismanDavid GallacherJan Van BocxlaerFilip De RidderKoen BousseryAn Vermeulen

A1 Artikel in een tijdschrift in AAPS JOURNAL

Population pharmacokinetic modeling of canagliflozin in healthy volunteers and patients with type 2 diabetes mellitus

Eef HoebenWillem De WinterMartine NeyensDamayanthi DevineniAn VermeulenAdrian Dunne

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Population pharmacokinetic modeling of tapentadol extended release (ER) in healthy subjects and patients with moderate or severe chronic pain

Dymphy R HuntjensLia C LiefaardPartha NandyHenk-Jan DrenthAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL DRUG INVESTIGATION

What about confidence intervals? : a word of caution when interpreting PTA simulations

Pieter ColinDouglas J EleveldStijn JonckheereJan Van BocxlaerJan De WaeleAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2015

Building an inflammatory bowel disease network, a systems pharmacology approach

Ignacio Gonzalez-GarciaItziar Irurzun-AranaLeire Ruiz-CerdaChuanpu HuHonghui ZhouAn VermeulenInaki F TroconizJose David Gomez-Mantilla

Correlation between prostate-specific antigen kinetics and overall survival in abiraterone acetate-treated castration-resistant prostate cancer patients

Xu S XuCharles J RyanKim StuyckensMatthew R SmithFred SaadThomas W GriffinYoun C ParkMargaret K YuAn VermeulenItalo Poggesi et al.

A1 Artikel in een tijdschrift in CLINICAL CANCER RESEARCH

Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities

Eleonora MarosticaKarel Van AmmelArd TeismanKoen BousseryJan Van BocxlaerFilip De RidderDavid GallacherAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Irena LoryanVikash SinhaClaire MackieAchiel Van PeerWilhelmus H DrinkenburgAn VermeulenDonald HealdMargareta Hammarlund-UdenaesCarola M Wassvik

A1 Artikel in een tijdschrift in MOLECULAR PHARMACEUTICS

Oral bioavailability, hydrolysis, and comparative toxicokinetics of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol in broiler chickens and pigs

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanGunther AntonissenSiegrid De BaerePatrick De BackerAn VermeulenSiska Croubels

A1 Artikel in een tijdschrift in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation

Huybrecht T'jollynJan SnoeysAn VermeulenRobin MicheletFilip CuykensGeert MannensAchiel Van PeerPieter AnnaertKarel AllegaertJan Van Bocxlaer et al.

A1 Artikel in een tijdschrift in AAPS JOURNAL

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data

Huybrecht T'jollynJan SnoeysPieter ColinJan Van BocxlaerPieter AnnaertFilip CuyckensAn VermeulenAchiel Van PeerKarel AllegaertGeert Mannens et al.

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Population pharmacokinetic model of ibrutinib, a Bruton tyrosine kinase inhibitor, in patients with B cell malignancies

Eleonora MarosticaJuthamas SukbuntherngDavid LouryJan de JongXavier Woot de TrixheAn VermeulenGiuseppe De NicolaoSusan O'BrienJohn C ByrdRanjana Advani et al.

A1 Artikel in een tijdschrift in CANCER CHEMOTHERAPY AND PHARMACOLOGY

Population pharmacokinetic-pharmacodynamic (PKPD) modeling of ibrutinib in patients with B-cell malignancies

Italo PoggesiMaria Luisa SarduEleonora MarosticaJuthamas SukbuntherngBetty Y ChangJan de JongXavier Woot de TrixheAn VermeulenGiuseppe De NicolaoSusan Mary O'Brien et al.

Practical guidance for dosing and switching from paliperidone palmitate 1 monthly to 3 monthly formulation in schizophrenia

Srihari GopalAn VermeulenPartha NandyPaulien RavenstijnIsaac NuamahJosé Antonio Buron VidalJoris BerwaertsAdam SavitzDavid HoughMahesh N Samtani

A1 Artikel in een tijdschrift in CURRENT MEDICAL RESEARCH AND OPINION

Towards patient stratification in systemic lupus erythematosus using a systems pharmacology approach

Jose David Gomez-MantillaItziar Irurzun-AranaLeire Ruiz-CerdaIgnacio Gonzalez-GarciaChuanpu HuHonghui ZhouAn VermeulenInaki F Troconiz

vRNA structured population model for Hepatitis C Virus dynamics

X Woot de TrixheW KrzyzanskiF De RidderAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF THEORETICAL BIOLOGY

2014

A model based analysis of IPEC dosing of paclitaxel in rats

Pieter ColinLieselotte De SmetChris VervaetJean Paul RemonWim CeelenJan Van BocxlaerKoen BousseryAn Vermeulen

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach

Martin JohnsonMagdalena KozielskaVenkatesh Pilla ReddyAn VermeulenHugh A BartonSarah GrimwoodRik de GreefGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery

Irena LoryanVikash SinhaClaire MackieAchiel Van PeerWilhelmus DrinkenburgAn VermeulenDenise MorrisonMario MonshouwerDonald HealdMargareta Hammarlund-Udenaes

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Population pharmacokinetic analysis of abiraterone in chemotherapy-Na < ve and docetaxel-treated patients with metastatic castration-resistant prostate cancer

Kim StuyckensFred SaadXu Steven XuCharles J RyanMatthew R SmithThomas W GriffinMargaret K YuAn VermeulenPartha NandyItalo Poggesi

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Towards model-based dose optimization of antibiotic and anti-cancer treatment regimens in specific patient populations

Pieter ColinJan Van BocxlaerKoen BousseryAn Vermeulen

2013

Mixed-effects beta regression for modeling continuous bounded outcome scores using NONMEM when data are not on the boundaries

Xu Steven XuMahesh N SamtaniAdrian DunnePartha NandyAn VermeulenFilip De Ridder

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Model based dosing rationale for darunavir when co-administered with low-dose ritonavir in pediatric HIV-1 infected patients

Anne BrochotPeter VisTom Van De CasteeleMagda OpsomerFrank TomakaAn VermeulenThomas N Kakuda

Modeling continuous bounded outcome scores using beta regression with NONMEM (R) VII

Mahesh N SamtaniXu Steven XuAdrian DunnePartha NandyAn VermeulenFilip De Ridder

Modelling and simulation of placebo effect: application to drug development in schizophrenia

Venkatesh Pilla ReddyMagdalena KozielskaRik de GreefAn VermeulenJohannes H Proost

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia, part I: the use of PANSS total score and clinical utility

Venkatesh Pilla ReddyMagdalena KozielskaAhmed Abbas SuleimanMartin JohnsonAn VermeulenJing LiuRik de GreefGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in SCHIZOPHRENIA RESEARCH

Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia, part II: the use of subscales of the PANSS score

Venkatesh Pilla ReddyMagdalena KozielskaAhmed Abbas SuleimanMartin JohnsonAn VermeulenJing LiuRik de GreefGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in SCHIZOPHRENIA RESEARCH

Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale

Venkatesh Pilla ReddyMagdalena KozielskaMartin JohnsonNyashadzaishe MafirakurevaAn VermeulenJing LiuRik de GreefDan RujescuGeny MM GroothuisMeindert Danhof et al.

A1 Artikel in een tijdschrift in JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D-2-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D-2-receptor occupancy

Eef HoebenMartine NeyensErik MannaertMark SchmidtAn Vermeulen

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

Predictions of in vivo prolactin levels from in vitro Ki values of D-2 receptor antagonists using an agonist-antagonist interaction model

Klas J PeterssonAn VermeulenLena E Friberg

A1 Artikel in een tijdschrift in AAPS JOURNAL

Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia

Magdalena KozielskaVenkatesh Pilla ReddyMartin JohnsonFilip de RidderAn VermeulenJing LiuGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in SCHIZOPHRENIA RESEARCH

2012

Pharmacokinetic-pharmacodynamic modeling of the D-2 and 5-HT2A receptor occupancy of risperidone and paliperidone in rats

Magdalena KozielskaMartin JohnsonVenkatesh Pilla ReddyAn VermeulenCheryl LiSarah GrimwoodRik de GreefGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with acute coronary syndromes

Xu Steven XuKenneth MoorePaul BurtonKim StuyckensWolfgang MueckStefaan RossenuAlexei PlotnikovMichael GibsonAn Vermeulen

A1 Artikel in een tijdschrift in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Shrinkage in nonlinear mixed-effects population models: quantification, influencing factors, and impact

Xu Steven XuMin YuanMats O KarlssonAdrian DunnePartha NandyAn Vermeulen

A1 Artikel in een tijdschrift in AAPS JOURNAL

2011

A time scaling approach to develop an in vitro-in vivo correlation (IVIVC) model using a convolution-based technique

Cian CostelloStefaan RossenuAn VermeulenAdriaan CletonAdrian Dunne

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Balancing efficacy and safety in the clinical development of an atypical antipsychotic, paliperidone extended-release

Filip De RidderAn Vermeulen

Hoofdstuk in een boek in Clinical trial simulations : applications and trends

Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models

Xu Steven XuAdrian DunneHolly KimkoPartha NandyAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D-2 receptor occupancy of olanzapine in rats

Martin JohnsonMagdalena KozielskaVenkatesh Pilla ReddyAn VermeulenCheryl LiSarah GrimwoodRik de GreefGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in PHARMACEUTICAL RESEARCH

Modeling delayed drug effect using discrete-time nonlinear autoregressive models: a connection with indirect response models

Xu Steven XuHui WangAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients

Sihem Ait-OudhiaAn VermeulenWojciech Krzyzanski

A1 Artikel in een tijdschrift in BIOPHARMACEUTICS & DRUG DISPOSITION

Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders

Venkatesh Pilla ReddyMagdalena KozielskaMartin JohnsonAn VermeulenRik de GreefJing LiuGeny MM GroothuisMeindert DanhofJohannes H Proost

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

2010

Dosing information for paliperidone palmitate - a once-monthly injectable atypical antipsychotic - based on population pharmacokinetic analysis

M SamtaniS GopalC BossieJ SliwaT HaskinsK StuyckensL AlphsAn Vermeulen

Modeling the effectiveness of paliperidone ER and olanzapine in schizophrenia: meta-analysis of 3 randomized, controlled clinical trials

Ignacio OrtegaJuan Jose Perez-RuixoKim StuyckensVladimir PiotrovskyAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF CLINICAL PHARMACOLOGY

Population pharmacokinetics of oral risperidone in children, adolescents and adults with psychiatric disorders

An ThyssenAn VermeulenEliane FuseauMarc-Antoine FabreErik Mannaert

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?

Aaron S KempNina R SchoolerAmir H KalaliLarry AlphsRavi AnandGeorge AwadMichael DavidsonSanjay DubéLarry EreshefskyGeorges Gharabawi et al.

A1 Artikel in een tijdschrift in SCHIZOPHRENIA BULLETIN

2009

An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment

LE FribergAn VermeulenKJF PeterssonMO Karlsson

A1 Artikel in een tijdschrift in CLINICAL PHARMACOLOGY & THERAPEUTICS

D2-receptor occupancies and corresponding plasma concentrations: a comparison of paliperidone extended-release (ER) with risperidone immediate-release (IR)

S RossenuE MannaertL HargarterA MehnertAn Vermeulen

Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic

Mahesh N SamtaniAn VermeulenKim Stuyckens

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

2008

A nonlinear mixed effects IVIVC model for multi-release drug delivery systems

S RossenuC GaynorAn VermeulenAdriaan CletonAdrian Dunne

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells

Wojciech KrzyzanskiJuan Jose Perez-RuixoAn Vermeulen

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

2007

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

An VermeulenVladimir PiotrovskyElizabeth A Ludwig

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Simulation in clinical drug development

Juan Jose Perez-RuixoFilip De RidderHui KimkoMahesh SamtaniEugene CoxSurya MohantyAn Vermeulen

Hoofdstuk in een boek in Biosimulation in drug development

2006

A pharmacokinetic model to document the interconversion between paliperidone's enantiomers

S RossenuAn VermeulenA CletonK TalluriA MertensL JanssensS Boom

A pharmacokinetic model to document the interconversion between the enantiomers of paliperidone

S RossenuAn VermeulenA CletonK TalluriA MertensL JanssensS Boom

2005

Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin

Koen JollingJuan Jose Perez RuixoAlex HemeryckAn VermeulenTony Greway

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetic profile of long-acting injectable risperidone at steady-state: comparison with oral administration

E MannaertAn VermeulenB RemmerieP BouhoursJC Levron

A1 Artikel in een tijdschrift in ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

2004

Risperidone does not affect steady-state pharmacokinetics of divalproex sodium in patients with bipolar disorder

Arun RavindranPeter SilverstoneDenis LacroixErno van SchaickAn VermeulenJennifer Alexander

A1 Artikel in een tijdschrift in CLINICAL PHARMACOKINETICS

2002

The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients

G BondolfiCB EapG BertschyD ZullinoAn VermeulenP Baumann

A1 Artikel in een tijdschrift in PHARMACOPSYCHIATRY

2000

Kinetics and safety of a novel risperidone depot formulation

M EerdekensM RasmussenAn VermeulenR LowenthalA Van Peer

1994

The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes

I VercruysseAn VermeulenFrans BelpaireDL MassartAG Dupont

A1 Artikel in een tijdschrift in FUNDAMENTAL & CLINICAL PHARMACOLOGY

1993

Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat

An VermeulenFrans BelpaireFrits De SmetIsabelle VercruysseMarcus Bogaert

A1 Artikel in een tijdschrift in JOURNALS OF GERONTOLOGY

Influence of human recombinant interleukin-1ß on the enantioselective disposition of propranolol in rats

An VermeulenFrans BelpaireFrits De SmetMarcus Bogaert

A1 Artikel in een tijdschrift in BIOCHEMICAL PHARMACOLOGY

Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure

Frans BelpaireMarie RosseelAn VermeulenFrits de SmetMarcus Bogaert

A1 Artikel in een tijdschrift in MECHANISMS OF AGEING AND DEVELOPMENT

1992

Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat

An VermeulenFrans BelpaireFrits de SmetMarie RosseelMarcus Bogaert

A1 Artikel in een tijdschrift in MECHANISMS OF AGEING AND DEVELOPMENT

Inhibition of the metabolism of propranolol by nicardipine in rats: an in vitro study

I VercruysseAn VermeulenFrans BelpaireDL MassartAG Dupont

The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat

An VermeulenFrans BelpaireEmmanuel MoermanFrits De SmetMarcus Bogaert

A1 Artikel in een tijdschrift in CHIRALITY

1991

Enantioselective pharmacokinetics of propranolol in the rat: marked differences between rat and man

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

High-performance liquid chromatographic method for the simultaneous determination of R-(−)- and S-(+)-hexobarbital in rat plasma

An VermeulenMarie RosseelFrans Belpaire

A1 Artikel in een tijdschrift in JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS

Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate

Marie RosseelAn VermeulenFrans Belpaire

A1 Artikel in een tijdschrift in JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS

The enantiomeric distribution of propranolol is not influenced by its ß-blocking activity

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACY AND PHARMACOLOGY

The influence of aging on the stereoselective pharmacokinetics and the metabolism of metoprolol in the rat

An VermeulenFrans BelpaireFrits de SmetMarcus Bogaert

1990

Effect of aging on the pharmacokinetics of atenolol, metoprolol and propranolol in the rat

Frans BelpaireFrits De SmetLJ VynckierAn VermeulenMarie RosseelMarcus BogaertL Chauvelot-Moachon

A1 Artikel in een tijdschrift in JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stereoselective pharmacokinetics of propranolol in the rat

An VermeulenFrans BelpaireE MoermanMT RosseelFrits De SmetMarcus Bogaert

Stereoselectivity of plasma protein binding and its pharmacokinetic consequences

Frans BelpaireAn VermeulenMarcus Bogaert