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Researcher
An Vermeulen
Profile
Projects
Publications
Activities
Awards & Distinctions
149
Results
2023
Building A Physiologically Based Pharmacokinetic Model For A Carcinogenic Food Contaminant
Orphélie Lootens
Marthe De Boevre
Jia Ning
Elke Gasthuys
Jan Van Bocxlaer
Sarah De Saeger
An Vermeulen
U
Conference
2023
Building a human physiologically based pharmacokinetic model for aflatoxin B1 to simulate interactions with drugs
Orphélie Lootens
Marthe De Boevre
Jia Ning
Elke Gasthuys
Jan Van Bocxlaer
Sarah De Saeger
An Vermeulen
A1
Journal Article
in
PHARMACEUTICS
2023
CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis
Helena Braet
Peter-Paul Fransen
Remco Mariën
Giovanna Lollo
Wim Ceelen
Chris Vervaet
Lieve Balcaen
Frank Vanhaecke
Christian Vanhove
Stefan van der Vegte
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2023
Comparison of monoclonal antibody disposition predictions between different PBPK platforms
Pieter-Jan De Sutter
Elke Gasthuys
An Vermeulen
U
Conference
2023
PBPK modelling to predict local lung exposure of meropenem in people with cystic fibrosis
Pieter-Jan De Sutter
Sofia Proost
An Vermeulen
U
Conference
2023
Predictive performance of physiologically based pharmacokinetic modelling of beta-lactam antibiotic concentrations in adipose, bone and muscle tissues
Pieter-Jan De Sutter
Pieter De Cock
TN Johnson
H Musther
Elke Gasthuys
An Vermeulen
A1
Journal Article
in
DRUG METABOLISM AND DISPOSITION
2023
Real-world evidence of lisinopril in pediatric hypertension and nephroprotective management : a 10-year cohort study
Eva Degraeuwe
Ann Raes
Elke Gasthuys
Evelien Snauwaert
Lien Dossche
Agnieszka Prytula-Ebels
Jo Dehoorne
An Vermeulen
Johan Vande Walle
C3
Conference
2023
2022
Accuracy of PBPK-predicted tissue concentrations : a case study of beta-lactam antibiotics in fat, bone and muscle
Pieter-Jan De Sutter
Pieter De Cock
Trevor N Johnson
Helen Musther
Elke Gasthuys
An Vermeulen
C3
Conference
2022
Altered intravenous drug disposition in people living with cystic fibrosis : a meta‐analysis integrating top‐down and bottom‐up data
Pieter-Jan De Sutter
Maxime Van Haeverbeke
Eva Van Braeckel
Stephanie Van Biervliet
Jan Van Bocxlaer
An Vermeulen
Elke Gasthuys
A1
Journal Article
in
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
2022
Comment on : 'Penetration of antibacterial agents into pulmonary epithelial lining fluid : an update'
Pieter-Jan De Sutter
Jan De Waele
An Vermeulen
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2022
Determination of pharmacokinetic parameters of efavirenz an aflatoxin B1 : an approach to unravel possible interactions
Orphélie Lootens
An Vermeulen
Elke Gasthuys
Jan Van Bocxlaer
Sarah De Saeger
Marthe De Boevre
C3
Conference
2022
Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions
Orphélie Lootens
An Vermeulen
Elke Gasthuys
Jan Van Bocxlaer
Sarah De Saeger
Marthe De Boevre
C3
Conference
2022
Extensive review of pharmacokinetic and pharmacodynamic properties of ACE-inhibitors and angiotensin receptor blockers in hypertensive children
Eva Degraeuwe
Louis Sandra
Paulien De Vos
An Vermeulen
Ann Raes
Johan Vande Walle
Elke Gasthuys
C3
Conference
2022
Extensive review of trial methodology investigating therapeutics ACE-inhibitors and angiotensin receptor blockers in hypertensive paediatric patients
Eva Degraeuwe
Louis Sandra
Paulien Devos
An Vermeulen
Ann Raes
Johan Vande Walle
Elke Gasthuys
C3
Conference
2022
General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children
Naim Bouazza
Aristides Dokoumetzidis
Catherijne A. J. Knibbe
Saskia N. de Wildt
Claire Ambery
Pieter De Cock
Elke Gasthuys
Frantz Foissac
Saik Urien
Anna-Karin Hamberg
et al.
A1
Journal Article
in
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
2022
High throughput analytical report writing in R : a case study of validating an LC-MS method for the quantification of amoxicillin in human plasma
Pieter-Jan De Sutter
Elke Gasthuys
An Vermeulen
Jan Van Bocxlaer
C3
Conference
2022
In vitro and in vivo characterization of long-acting aqueous suspensions : towards a predictive semi-mechanistic pharmacokinetic model
Thi Thanh Vy Nguyen
An Vermeulen
Jens Ceulemans
Dissertation
2022
Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases
Wim Ceelen
Louis Sandra
Leen Van de Sande
M Graversen
MB Mortensen
An Vermeulen
Elke Gasthuys
Dries Reynders
Sarah Cosyns
Anne Hoorens
et al.
A1
Journal Article
in
EBIOMEDICINE
2022
Physiologically based pharmacokinetic models for the prediction of beta-lactam antibiotic concentrations in perfusion-limited tissues
Pieter-Jan De Sutter
Pieter De Cock
Elke Gasthuys
An Vermeulen
C3
Conference
2022
Population pharmacokinetics and Bayesian estimations of lisinopril at steady state in hypertensive children with mild to moderate renal impairment
Louis Sandra
Eva Degraeuwe
Elke Gasthuys
An Vermeulen
Pauline De Bruyne
Ann Raes
Johan Vande Walle
C3
Conference
2022
Possible mechanisms of the interplay between drugs and mycotoxins : is there a possible impact?
Orphélie Lootens
An Vermeulen
Siska Croubels
Sarah De Saeger
Jan Van Bocxlaer
Marthe De Boevre
A1
Journal Article
in
TOXINS
2022
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Samya Van Coillie
Emily Van San
Ines Goetschalckx
Bartosz Wiernicki
Banibrata Mukhopadhyay
Wulf Tonnus
Sze Men Choi
Ria Roelandt
Catalina Dumitrascu
Ludwig Lamberts
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2022
Unravelling the pharmacokinetics of aflatoxin B1 : in vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes
Orphélie Lootens
Marthe De Boevre
Elke Gasthuys
Jan Van Bocxlaer
An Vermeulen
Sarah De Saeger
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2022
2021
Bayesian population approach to determine lisinopril exposure in hypertensive paediatric patients with mild to moderate renal impairment
Louis Sandra
Eva Degraeuwe
Elke Gasthuys
Paulien De Bruyne
An Vermeulen
Ann Raes
Johan Vande Walle
C3
Conference
2021
Desmopressin oral lyophilisate in young children : new insights in pharmacokinetics and pharmacodynamics
Lien Dossche
Robin Michelet
Pauline De Bruyne
Charlotte Van Herzeele
Elke Gasthuys
Søren Rittig
An Vermeulen
Johan Vande Walle
A1
Journal Article
in
ARCHIVES OF DISEASE IN CHILDHOOD
2021
Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions
Orphélie Lootens
An Vermeulen
Jan Van Bocxlaer
Sarah De Saeger
Marthe De Boevre
C3
Conference
2021
Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases : a first in human phase I study
Wim Ceelen
Louis Sandra
Leen Van de Sande
Martin Graversen
An Vermeulen
Dries Reynders
Sarah Cosyns
Anne Hoorens
Wouter Willaert
C3
Conference
2021
Linking in vitro intrinsic dissolution rate and thermodynamic solubility with pharmacokinetic profiles of bedaquiline long-acting aqueous microsuspensions in rats
Thi Thanh Vy Nguyen
Jan Bevernage
Nicolas Darville
Christophe Tistaert
Jan Van Bocxlaer
Stefaan Rossenu
An Vermeulen
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2021
Mycotoxin-drug interactions at the level of CYP450 enzymes
Orphélie Lootens
Sarah De Saeger
Marthe De Boevre
An Vermeulen
Jan Van Bocxlaer
C3
Conference
2021
Pharmacokinetics and blood pressure effects of ACE-inhibitors in children with hypertension
Louis Sandra
Eva Degraeuwe
Elke Gasthuys
An Vermeulen
Pauline De Bruyne
Ann Raes
Johan Vande Walle
C3
Conference
2021
Physiologically based pharmacokinetic modelling of lisinopril in children: A case story of angiotensin converting enzyme inhibitors
Feifan Xie
Jan Van Bocxlaer
An Vermeulen
A1
Journal Article
in
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
2021
Population pharmacokinetic modeling of lisinopril at steady-state in hypertensive paediatric patients with mild to moderate renal impairement
Eva Degraeuwe
Louis Sandra
Elke Gasthuys
Paulien De Bruyne
Ann Raes
Johan Vande Walle
An Vermeulen
C3
Conference
2021
Population pharmacokinetics of lisinopril in hypertensive children with mild to moderate renal impairment
Louis Sandra
Eva Degraeuwe
Elke Gasthuys
An Vermeulen
Paulien De Bruyne
Ann Raes
Johan Vande Walle
C3
Conference
2021
Targeting ferroptosis protects against multiorgan dysfunction and death
Tom Vanden Berghe
Samya Van Coillie
Ines Goetschalckx
Bartosz Wiernicki
Banibrata Mukhopadhyay
Wulf Tonnus
Emily Van San
Sze Men Choi
Ria Roelandt
Catalina Dumitrascu
et al.
Preprint
2021
2020
An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?
Robin Michelet
Lien Dossche
Charlotte Van Herzeele
Pauline De Bruyne
Elke Gasthuys
Jan Van Bocxlaer
Johan Vande Walle
An Vermeulen
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2020
Exploration of more personalized treatments in ovarian cancer using a pharmacodynamic protein biomarker and patient-derived xenograft technology
Elien De Thaye
Jan Van Bocxlaer
An Vermeulen
Pieter Colin
Dissertation
2020
PKPD modeling and dosing considerations in advanced ovarian cancer patients treated with cisplatin-based intraoperative intraperitoneal chemotherapy
Feifan Xie
Jan Van Bocxlaer
Pieter Colin
Charlotte Carlier
Olivier Van Kerschaver
Joseph Weerts
Hannelore Denys
Philippe Tummers
Wouter Willaert
Wim Ceelen
et al.
A1
Journal Article
in
AAPS JOURNAL
2020
Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review
Elke Gasthuys
Lien Dossche
Robin Michelet
Jens Peter Norgaard
Mathias Devreese
Siska Croubels
An Vermeulen
Jan Van Bocxlaer
Johan Vande Walle
A1
Journal Article
in
PEDIATRIC DRUGS
2020
Pharmacokinetics in patients with cystic fibrosis : a systematic review of data published between 1999 and 2019
Pieter-Jan De Sutter
Elke Gasthuys
Eva Van Braeckel
Petra Schelstraete
Stephanie Van Biervliet
Jan Van Bocxlaer
An Vermeulen
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2020
2019
A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
Feifan Xie
An Vermeulen
Pieter Colin
Zeneng Cheng
A1
Journal Article
in
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
2019
Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer
Feifan Xie
Jan Van Bocxlaer
An Vermeulen
Pieter Colin
Dissertation
2019
Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.
Feifan Xie
Kaat De Clercq
Chris Vervaet
Jan Van Bocxlaer
Pieter Colin
An Vermeulen
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2019
PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol
Huybrecht T'jollyn
An Vermeulen
Jan Van Bocxlaer
A1
Journal Article
in
AAPS JOURNAL
2019
SAFEPEDRUG : safer pediatric drugs for children: what have we learned?
Elke Gasthuys
Johan Vande Walle
Lien Dossche
Lieve Nuytinck
Robin Michelet
An Vermeulen
Sevasti Karamaria
C3
Conference
2019
2018
A dried blood spot assay for paclitaxel and its metabolites
Feifan Xie
Elien De Thaye
An Vermeulen
Jan Van Bocxlaer
Pieter Colin
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2018
A model-based analysis of the kinetics of leukocytes in stage III ovarian cancer patients treated with neo-adjuvant chemotherapy, cytoreductive surgery and cisplatin-based intraperitoneal chemoperfusion
Feifan Xie
Charlotte Carlier
Wim Ceelen
Jan Van Bocxlaer
An Vermeulen
Pieter Colin
C3
Conference
2018
A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1
Elke Gasthuys
Joske Millecam
Mathias Devreese
An Vermeulen
Pauline De Bruyne
Johan Vande Walle
Joris Delanghe
Siska Croubels
C3
Conference
2018
A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients
Huybrecht T'jollyn
An Vermeulen
Jan Van Bocxlaer
Pieter Colin
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2018
A systems pharmacology model for inflammatory bowel disease
Violeta Balbas-Martinez
Leire Ruiz-Cerda
Itziar Irurzun-Arana
Ignacio Gonzalez-Garcia
An Vermeulen
Jose David Gomez-Mantilla
Inaki F Troconiz
A1
Journal Article
in
PLOS ONE
2018
Claiming desmopressin therapeutic equivalence in children requires pediatric data : a population PKPD analysis
Robin Michelet
Lien Dossche
Charlotte Van Herzeele
Jan Van Bocxlaer
An Vermeulen
Johan Vande Walle
A1
Journal Article
in
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
2018
Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine
Julia Korell
Bruce Green
Allan Rae
Bart Remmerie
An Vermeulen
A1
Journal Article
in
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
2018
PK/PD studies in pigs leading to optimization of treatment dose in MNE?
Elke Gasthuys
Lien Dossche
Siska Croubels
Pauline De Bruyne
Mathias Devreese
An Vermeulen
Johan Vande Walle
C3
Conference
2018
Pediatric drug development: towards maturity : desmopressin as a case
Elke Gasthuys
Robin Michelet
Lien Dossche
Pauline De Bruyne
Johan Vande Walle
An Vermeulen
Mathias Devreese
Siska Croubels
C3
Conference
2018
Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population
Elke Gasthuys
An Vermeulen
Siska Croubels
Pauline De Bruyne
Joske Millecam
Johan Vande Walle
Mathias Devreese
C3
Conference
2018
Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population
Elke Gasthuys
An Vermeulen
Siska Croubels
Joske Millecam
Stijn Schauvliege
Thomas van Bergen
Pauline De Bruyne
Johan Vande Walle
Mathias Devreese
A1
Journal Article
in
FRONTIERS IN PHARMACOLOGY
2018
Prediction of pediatric pharmacokinetics to optimize dose regimens using bottom-up, top-down and middle-out approaches
Robin Michelet
An Vermeulen
Jan Van Bocxlaer
Dissertation
2018
Relationship between antipsychotic blood levels and treatment failure during the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study
Rama Melkote
Arun Singh
An Vermeulen
Bart Remmerie
Adam Savitz
A1
Journal Article
in
SCHIZOPHRENIA RESEARCH
2018
Results of a multicenter population pharmacokinetic study of ciprofloxacin in children with complicated urinary tract infection
Kevin Meesters
Robin Michelet
REINER MAUEL
Ann Raes
Jan Van Bocxlaer
Johan Vande Walle
An Vermeulen
A1
Journal Article
in
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2018
The use of PBPK modeling across the pediatric age range using propofol as a case
Robin Michelet
Jan Van Bocxlaer
Karel Allegaert
An Vermeulen
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2018
2017
Dosing and switching strategies for paliperidone palmitate 3-month formulation in patients with schizophrenia based on population pharmacokinetic modeling and simulation, and clinical trial data
Mats O Magnusson
Mahesh N Samtani
Elodie L Plan
E Niclas Jonsson
Stefaan Rossenu
An Vermeulen
Alberto Russu
A1
Journal Article
in
CNS DRUGS
2017
In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics
Nathan Broekaert
Mathias Devreese
Thomas van Bergen
Stijn Schauvliege
Marthe De Boevre
Sarah De Saeger
Lynn Vanhaecke
Franz Berthiller
Herbert Michlmayr
Alexandra Malachová
et al.
A1
Journal Article
in
ARCHIVES OF TOXICOLOGY
2017
Modeling the relationship between exposure to abiraterone and prostate-specific antigen dynamics in patients with metastatic castration-resistant prostate cancer
Xu Steven Xu
Charles J Ryan
Kim Stuyckens
Matthew R Smith
Fred Saad
Thomas W Griffin
Youn C Park
Margaret K Yu
Peter De Porre
An Vermeulen
et al.
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2017
PBPK in preterm and term neonates : a review
Robin Michelet
Jan Van Bocxlaer
An Vermeulen
A1
Journal Article
in
CURRENT PHARMACEUTICAL DESIGN
2017
Paediatric PBPK modelling of propofol using the middle out approach
Robin Michelet
Jan Van Bocxlaer
An Vermeulen
C3
Conference
2017
Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison
Elien De Thaye
Anouk Vervaeck
Eleonora Marostica
Jean Paul Remon
Jan Van Bocxlaer
Chris Vervaet
An Vermeulen
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2017
Population pharmacokinetics of a novel once-every 3 months intramuscular formulation of paliperidone palmitate in patients with schizophrenia
Mats O Magnusson
Mahesh N Samtani
Elodie L Plan
E Niclas Jonsson
Stefaan Rossenu
An Vermeulen
Alberto Russu
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2017
Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound
Huybrecht T'jollyn
Jan Snoeys
Jan Van Bocxlaer
Lies De Bock
Pieter Annaert
Achiel Van Peer
Karel Allegaert
Geert Mannens
An Vermeulen
Koen Boussery
A1
Journal Article
in
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
2017
2016
A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU
Stijn Jonckheere
Nikolaas De Neve
Hans De Beenhouwer
Mario Berth
An Vermeulen
Jan Van Bocxlaer
Pieter Colin
A1
Journal Article
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2016
Bioequivalence in adults does not mean bioequivalence in children
Lien Dossche
Robin Michelet
Pauline De Bruyne
Jan Van Bocxlaer
An Vermeulen
Johan Vande Walle
C3
Conference
2016
Bioequivalence in adults is not always bioequivalence in children
Lien Dossche
Ann Raes
Pauline De Bruyne
Robin Michelet
An Vermeulen
Jan Van Bocxlaer
Johan Vande Walle
C3
Conference
2016
Characterizing hepatic clearance in early life : PBPK as modelling tool and tramadol as guide
Huybrecht T'jollyn
Jan Van Bocxlaer
An Vermeulen
Koen Boussery
Dissertation
2016
Deoxynivalenol-3-β-D-glucoside : in vitro cytotoxicity and in vivo oral bioavailability and hydrolysis in broiler chicken and pig
Nathan Broekaert
Mathias Devreese
Thomas van Bergen
Stijn Schauvliege
Marthe De Boevre
Sarah De Saeger
Lynn Vanhaecke
Franz Berthiller
Herbert Michlmayr
Alexandra Malachova
et al.
C3
Conference
2016
Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
Robin Michelet
Lien Dossche
Pauline De Bruyne
Pieter Colin
Koen Boussery
Johan Vande Walle
Jan Van Bocxlaer
An Vermeulen
C3
Conference
2016
Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
Robin Michelet
Lien Dossche
Pauline De Bruyne
Pieter Colin
Koen Boussery
Johan Vande Walle
Jan Van Bocxlaer
An Vermeulen
C3
Conference
2016
Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
Robin Michelet
Lien Dossche
Pauline De Bruyne
Pieter Colin
Koen Boussery
Johan Vande Walle
Jan Van Bocxlaer
An Vermeulen
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2016
PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans
Eleonora Marostica
Karel Van Ammel
Ard Teisman
David Gallacher
Jan Van Bocxlaer
Filip De Ridder
Koen Boussery
An Vermeulen
A1
Journal Article
in
AAPS JOURNAL
2016
Population pharmacokinetic modeling of canagliflozin in healthy volunteers and patients with type 2 diabetes mellitus
Eef Hoeben
Willem De Winter
Martine Neyens
Damayanthi Devineni
An Vermeulen
Adrian Dunne
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2016
Population pharmacokinetic modeling of tapentadol extended release (ER) in healthy subjects and patients with moderate or severe chronic pain
Dymphy R Huntjens
Lia C Liefaard
Partha Nandy
Henk-Jan Drenth
An Vermeulen
A1
Journal Article
in
CLINICAL DRUG INVESTIGATION
2016
What about confidence intervals? : a word of caution when interpreting PTA simulations
Pieter Colin
Douglas J Eleveld
Stijn Jonckheere
Jan Van Bocxlaer
Jan De Waele
An Vermeulen
A1
Journal Article
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2016
2015
Building an inflammatory bowel disease network, a systems pharmacology approach
Ignacio Gonzalez-Garcia
Itziar Irurzun-Arana
Leire Ruiz-Cerda
Chuanpu Hu
Honghui Zhou
An Vermeulen
Inaki F Troconiz
Jose David Gomez-Mantilla
C3
Conference
2015
Correlation between prostate-specific antigen kinetics and overall survival in abiraterone acetate-treated castration-resistant prostate cancer patients
Xu S Xu
Charles J Ryan
Kim Stuyckens
Matthew R Smith
Fred Saad
Thomas W Griffin
Youn C Park
Margaret K Yu
An Vermeulen
Italo Poggesi
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2015
Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities
Eleonora Marostica
Karel Van Ammel
Ard Teisman
Koen Boussery
Jan Van Bocxlaer
Filip De Ridder
David Gallacher
An Vermeulen
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2015
Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates
Irena Loryan
Vikash Sinha
Claire Mackie
Achiel Van Peer
Wilhelmus H Drinkenburg
An Vermeulen
Donald Heald
Margareta Hammarlund-Udenaes
Carola M Wassvik
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2015
Oral bioavailability, hydrolysis, and comparative toxicokinetics of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol in broiler chickens and pigs
Nathan Broekaert
Mathias Devreese
Thomas De Mil
Sophie Fraeyman
Gunther Antonissen
Siegrid De Baere
Patrick De Backer
An Vermeulen
Siska Croubels
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2015
Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
Huybrecht T'jollyn
Jan Snoeys
An Vermeulen
Robin Michelet
Filip Cuykens
Geert Mannens
Achiel Van Peer
Pieter Annaert
Karel Allegaert
Jan Van Bocxlaer
et al.
A1
Journal Article
in
AAPS JOURNAL
2015
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data
Huybrecht T'jollyn
Jan Snoeys
Pieter Colin
Jan Van Bocxlaer
Pieter Annaert
Filip Cuyckens
An Vermeulen
Achiel Van Peer
Karel Allegaert
Geert Mannens
et al.
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2015
Population pharmacokinetic model of ibrutinib, a Bruton tyrosine kinase inhibitor, in patients with B cell malignancies
Eleonora Marostica
Juthamas Sukbuntherng
David Loury
Jan de Jong
Xavier Woot de Trixhe
An Vermeulen
Giuseppe De Nicolao
Susan O'Brien
John C Byrd
Ranjana Advani
et al.
A1
Journal Article
in
CANCER CHEMOTHERAPY AND PHARMACOLOGY
2015
Population pharmacokinetic-pharmacodynamic (PKPD) modeling of ibrutinib in patients with B-cell malignancies
Italo Poggesi
Maria Luisa Sardu
Eleonora Marostica
Juthamas Sukbuntherng
Betty Y Chang
Jan de Jong
Xavier Woot de Trixhe
An Vermeulen
Giuseppe De Nicolao
Susan Mary O'Brien
et al.
C3
Conference
2015
Practical guidance for dosing and switching from paliperidone palmitate 1 monthly to 3 monthly formulation in schizophrenia
Srihari Gopal
An Vermeulen
Partha Nandy
Paulien Ravenstijn
Isaac Nuamah
José Antonio Buron Vidal
Joris Berwaerts
Adam Savitz
David Hough
Mahesh N Samtani
A1
Journal Article
in
CURRENT MEDICAL RESEARCH AND OPINION
2015
Towards patient stratification in systemic lupus erythematosus using a systems pharmacology approach
Jose David Gomez-Mantilla
Itziar Irurzun-Arana
Leire Ruiz-Cerda
Ignacio Gonzalez-Garcia
Chuanpu Hu
Honghui Zhou
An Vermeulen
Inaki F Troconiz
C3
Conference
2015
vRNA structured population model for Hepatitis C Virus dynamics
X Woot de Trixhe
W Krzyzanski
F De Ridder
An Vermeulen
A1
Journal Article
in
JOURNAL OF THEORETICAL BIOLOGY
2015
2014
A model based analysis of IPEC dosing of paclitaxel in rats
Pieter Colin
Lieselotte De Smet
Chris Vervaet
Jean Paul Remon
Wim Ceelen
Jan Van Bocxlaer
Koen Boussery
An Vermeulen
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2014
Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach
Martin Johnson
Magdalena Kozielska
Venkatesh Pilla Reddy
An Vermeulen
Hugh A Barton
Sarah Grimwood
Rik de Greef
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2014
Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery
Irena Loryan
Vikash Sinha
Claire Mackie
Achiel Van Peer
Wilhelmus Drinkenburg
An Vermeulen
Denise Morrison
Mario Monshouwer
Donald Heald
Margareta Hammarlund-Udenaes
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2014
Population pharmacokinetic analysis of abiraterone in chemotherapy-Na < ve and docetaxel-treated patients with metastatic castration-resistant prostate cancer
Kim Stuyckens
Fred Saad
Xu Steven Xu
Charles J Ryan
Matthew R Smith
Thomas W Griffin
Margaret K Yu
An Vermeulen
Partha Nandy
Italo Poggesi
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2014
Towards model-based dose optimization of antibiotic and anti-cancer treatment regimens in specific patient populations
Pieter Colin
Jan Van Bocxlaer
Koen Boussery
An Vermeulen
Dissertation
2014
2013
Mixed-effects beta regression for modeling continuous bounded outcome scores using NONMEM when data are not on the boundaries
Xu Steven Xu
Mahesh N Samtani
Adrian Dunne
Partha Nandy
An Vermeulen
Filip De Ridder
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2013
Model based dosing rationale for darunavir when co-administered with low-dose ritonavir in pediatric HIV-1 infected patients
Anne Brochot
Peter Vis
Tom Van De Casteele
Magda Opsomer
Frank Tomaka
An Vermeulen
Thomas N Kakuda
C3
Conference
2013
Modeling continuous bounded outcome scores using beta regression with NONMEM (R) VII
Mahesh N Samtani
Xu Steven Xu
Adrian Dunne
Partha Nandy
An Vermeulen
Filip De Ridder
C3
Conference
2013
Modelling and simulation of placebo effect: application to drug development in schizophrenia
Venkatesh Pilla Reddy
Magdalena Kozielska
Rik de Greef
An Vermeulen
Johannes H Proost
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2013
Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia, part I: the use of PANSS total score and clinical utility
Venkatesh Pilla Reddy
Magdalena Kozielska
Ahmed Abbas Suleiman
Martin Johnson
An Vermeulen
Jing Liu
Rik de Greef
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
SCHIZOPHRENIA RESEARCH
2013
Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia, part II: the use of subscales of the PANSS score
Venkatesh Pilla Reddy
Magdalena Kozielska
Ahmed Abbas Suleiman
Martin Johnson
An Vermeulen
Jing Liu
Rik de Greef
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
SCHIZOPHRENIA RESEARCH
2013
Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale
Venkatesh Pilla Reddy
Magdalena Kozielska
Martin Johnson
Nyashadzaishe Mafirakureva
An Vermeulen
Jing Liu
Rik de Greef
Dan Rujescu
Geny MM Groothuis
Meindert Danhof
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2013
Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D-2-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D-2-receptor occupancy
Eef Hoeben
Martine Neyens
Erik Mannaert
Mark Schmidt
An Vermeulen
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2013
Predictions of in vivo prolactin levels from in vitro Ki values of D-2 receptor antagonists using an agonist-antagonist interaction model
Klas J Petersson
An Vermeulen
Lena E Friberg
A1
Journal Article
in
AAPS JOURNAL
2013
Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia
Magdalena Kozielska
Venkatesh Pilla Reddy
Martin Johnson
Filip de Ridder
An Vermeulen
Jing Liu
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
SCHIZOPHRENIA RESEARCH
2013
2012
Pharmacokinetic-pharmacodynamic modeling of the D-2 and 5-HT2A receptor occupancy of risperidone and paliperidone in rats
Magdalena Kozielska
Martin Johnson
Venkatesh Pilla Reddy
An Vermeulen
Cheryl Li
Sarah Grimwood
Rik de Greef
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2012
Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with acute coronary syndromes
Xu Steven Xu
Kenneth Moore
Paul Burton
Kim Stuyckens
Wolfgang Mueck
Stefaan Rossenu
Alexei Plotnikov
Michael Gibson
An Vermeulen
A1
Journal Article
in
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
2012
Shrinkage in nonlinear mixed-effects population models: quantification, influencing factors, and impact
Xu Steven Xu
Min Yuan
Mats O Karlsson
Adrian Dunne
Partha Nandy
An Vermeulen
A1
Journal Article
in
AAPS JOURNAL
2012
2011
A time scaling approach to develop an in vitro-in vivo correlation (IVIVC) model using a convolution-based technique
Cian Costello
Stefaan Rossenu
An Vermeulen
Adriaan Cleton
Adrian Dunne
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2011
Balancing efficacy and safety in the clinical development of an atypical antipsychotic, paliperidone extended-release
Filip De Ridder
An Vermeulen
Bookchapter
in
Clinical trial simulations : applications and trends
2011
Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models
Xu Steven Xu
Adrian Dunne
Holly Kimko
Partha Nandy
An Vermeulen
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2011
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D-2 receptor occupancy of olanzapine in rats
Martin Johnson
Magdalena Kozielska
Venkatesh Pilla Reddy
An Vermeulen
Cheryl Li
Sarah Grimwood
Rik de Greef
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2011
Modeling delayed drug effect using discrete-time nonlinear autoregressive models: a connection with indirect response models
Xu Steven Xu
Hui Wang
An Vermeulen
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2011
Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients
Sihem Ait-Oudhia
An Vermeulen
Wojciech Krzyzanski
A1
Journal Article
in
BIOPHARMACEUTICS & DRUG DISPOSITION
2011
Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders
Venkatesh Pilla Reddy
Magdalena Kozielska
Martin Johnson
An Vermeulen
Rik de Greef
Jing Liu
Geny MM Groothuis
Meindert Danhof
Johannes H Proost
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2011
2010
Dosing information for paliperidone palmitate - a once-monthly injectable atypical antipsychotic - based on population pharmacokinetic analysis
M Samtani
S Gopal
C Bossie
J Sliwa
T Haskins
K Stuyckens
L Alphs
An Vermeulen
C3
Conference
2010
Modeling the effectiveness of paliperidone ER and olanzapine in schizophrenia: meta-analysis of 3 randomized, controlled clinical trials
Ignacio Ortega
Juan Jose Perez-Ruixo
Kim Stuyckens
Vladimir Piotrovsky
An Vermeulen
A1
Journal Article
in
JOURNAL OF CLINICAL PHARMACOLOGY
2010
Population pharmacokinetics of oral risperidone in children, adolescents and adults with psychiatric disorders
An Thyssen
An Vermeulen
Eliane Fuseau
Marc-Antoine Fabre
Erik Mannaert
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2010
What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?
Aaron S Kemp
Nina R Schooler
Amir H Kalali
Larry Alphs
Ravi Anand
George Awad
Michael Davidson
Sanjay Dubé
Larry Ereshefsky
Georges Gharabawi
et al.
A1
Journal Article
in
SCHIZOPHRENIA BULLETIN
2010
2009
An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment
LE Friberg
An Vermeulen
KJF Petersson
MO Karlsson
A1
Journal Article
in
CLINICAL PHARMACOLOGY & THERAPEUTICS
2009
D2-receptor occupancies and corresponding plasma concentrations: a comparison of paliperidone extended-release (ER) with risperidone immediate-release (IR)
S Rossenu
E Mannaert
L Hargarter
A Mehnert
An Vermeulen
C3
Conference
2009
Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic
Mahesh N Samtani
An Vermeulen
Kim Stuyckens
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2009
2008
A nonlinear mixed effects IVIVC model for multi-release drug delivery systems
S Rossenu
C Gaynor
An Vermeulen
Adriaan Cleton
Adrian Dunne
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2008
Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells
Wojciech Krzyzanski
Juan Jose Perez-Ruixo
An Vermeulen
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2008
2007
Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder
An Vermeulen
Vladimir Piotrovsky
Elizabeth A Ludwig
A1
Journal Article
in
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
2007
Simulation in clinical drug development
Juan Jose Perez-Ruixo
Filip De Ridder
Hui Kimko
Mahesh Samtani
Eugene Cox
Surya Mohanty
An Vermeulen
Bookchapter
in
Biosimulation in drug development
2007
2006
A pharmacokinetic model to document the interconversion between paliperidone's enantiomers
S Rossenu
An Vermeulen
A Cleton
K Talluri
A Mertens
L Janssens
S Boom
C3
Conference
2006
A pharmacokinetic model to document the interconversion between the enantiomers of paliperidone
S Rossenu
An Vermeulen
A Cleton
K Talluri
A Mertens
L Janssens
S Boom
C3
Conference
2006
2005
Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin
Koen Jolling
Juan Jose Perez Ruixo
Alex Hemeryck
An Vermeulen
Tony Greway
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2005
Pharmacokinetic profile of long-acting injectable risperidone at steady-state: comparison with oral administration
E Mannaert
An Vermeulen
B Remmerie
P Bouhours
JC Levron
A1
Journal Article
in
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
2005
2004
Risperidone does not affect steady-state pharmacokinetics of divalproex sodium in patients with bipolar disorder
Arun Ravindran
Peter Silverstone
Denis Lacroix
Erno van Schaick
An Vermeulen
Jennifer Alexander
A1
Journal Article
in
CLINICAL PHARMACOKINETICS
2004
2002
The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients
G Bondolfi
CB Eap
G Bertschy
D Zullino
An Vermeulen
P Baumann
A1
Journal Article
in
PHARMACOPSYCHIATRY
2002
2000
Kinetics and safety of a novel risperidone depot formulation
M Eerdekens
M Rasmussen
An Vermeulen
R Lowenthal
A Van Peer
C3
Conference
2000
1994
The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes
I Vercruysse
An Vermeulen
Frans Belpaire
DL Massart
AG Dupont
A1
Journal Article
in
FUNDAMENTAL & CLINICAL PHARMACOLOGY
1994
1993
Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat
An Vermeulen
Frans Belpaire
Frits De Smet
Isabelle Vercruysse
Marcus Bogaert
A1
Journal Article
in
JOURNALS OF GERONTOLOGY
1993
Influence of human recombinant interleukin-1ß on the enantioselective disposition of propranolol in rats
An Vermeulen
Frans Belpaire
Frits De Smet
Marcus Bogaert
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
1993
Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure
Frans Belpaire
Marie Rosseel
An Vermeulen
Frits de Smet
Marcus Bogaert
A1
Journal Article
in
MECHANISMS OF AGEING AND DEVELOPMENT
1993
1992
Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat
An Vermeulen
Frans Belpaire
Frits de Smet
Marie Rosseel
Marcus Bogaert
A1
Journal Article
in
MECHANISMS OF AGEING AND DEVELOPMENT
1992
Inhibition of the metabolism of propranolol by nicardipine in rats: an in vitro study
I Vercruysse
An Vermeulen
Frans Belpaire
DL Massart
AG Dupont
C3
Conference
1992
The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat
An Vermeulen
Frans Belpaire
Emmanuel Moerman
Frits De Smet
Marcus Bogaert
A1
Journal Article
in
CHIRALITY
1992
1991
Enantioselective pharmacokinetics of propranolol in the rat: marked differences between rat and man
An Vermeulen
Frans Belpaire
Frits de Smet
Marcus Bogaert
C3
Conference
1991
High-performance liquid chromatographic method for the simultaneous determination of R-(−)- and S-(+)-hexobarbital in rat plasma
An Vermeulen
Marie Rosseel
Frans Belpaire
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS
1991
Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate
Marie Rosseel
An Vermeulen
Frans Belpaire
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS
1991
The enantiomeric distribution of propranolol is not influenced by its ß-blocking activity
An Vermeulen
Frans Belpaire
Frits de Smet
Marcus Bogaert
A1
Journal Article
in
JOURNAL OF PHARMACY AND PHARMACOLOGY
1991
The influence of aging on the stereoselective pharmacokinetics and the metabolism of metoprolol in the rat
An Vermeulen
Frans Belpaire
Frits de Smet
Marcus Bogaert
P1
Conference
1991
1990
Effect of aging on the pharmacokinetics of atenolol, metoprolol and propranolol in the rat
Frans Belpaire
Frits De Smet
LJ Vynckier
An Vermeulen
Marie Rosseel
Marcus Bogaert
L Chauvelot-Moachon
A1
Journal Article
in
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
1990
Stereoselective pharmacokinetics of propranolol in the rat
An Vermeulen
Frans Belpaire
E Moerman
MT Rosseel
Frits De Smet
Marcus Bogaert
C3
Conference
1990
Stereoselectivity of plasma protein binding and its pharmacokinetic consequences
Frans Belpaire
An Vermeulen
Marcus Bogaert
P1
Conference
1990