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Researcher
Alan Van Goethem
Profile
Projects
Publications
Activities
Awards & Distinctions
33
Results
2023
Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation
Alan Van Goethem
Jill Deleu
Nurten Yigit
Celine Everaert
Myrthala Moreno-Smith
Sanjeev A Vasudevan
Fjoralba Zeka
Fleur Demuynck
Eveline Barbieri
Franki Speleman
et al.
A2
Journal Article
in
NAR CANCER
2023
2018
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Fjoralba Zeka
Anneleen Decock
Alan Van Goethem
Katrien Vanderheyden
Fleur Demuynck
Tim Lammens
Hetty Helsmoortel
Joëlle Vermeulen
Rosa Noguera
Ana P. Berbegall
et al.
A1
Journal Article
in
JCI INSIGHT
2018
Circulating microRNA biomarkers for metastatic neuroblastoma
Fjoralba Zeka
Alan Van Goethem
Tim Lammens
Anneleen Decock
Hetty Helsmoortel
Genevieve Laureys
Michael Hogarty
Eveline Barbieri
Jason Shohet
Frank Berthold
et al.
C3
Conference
2018
Longitudinal evaluation of murine serum microRNAs as biomarkers for neuroblastoma burden and therapeutic TP53 reactivation
Alan Van Goethem
Nurten Yigit
Celine Everaert
Myrthala Moreno-Smith
Sanjeev A Vasudevan
Fjoralba Zeka
Fleur Demunck
Eveline Barbieri
Franki Speleman
Pieter Mestdagh
et al.
C3
Conference
2018
Pharmacological restoration of tumour suppressor protein p53 in neuroblastoma : seeking synergy and non-invasive biomarkers
Alan Van Goethem
Jo Vandesompele
Tom Van Maerken
A2
Journal Article
in
BELGIAN JOURNAL OF MEDICAL ONCOLOGY
2018
2017
Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma
Alan Van Goethem
Nurten Yigit
Myrthala Moreno-Smith
Sanjeev A Vasudevan
Eveline Barbieri
Franki Speleman
Jason Shohet
Jo Vandesompele
Tom Van Maerken
A1
Journal Article
in
ONCOTARGET
2017
EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research
Jan Van Deun
Pieter Mestdagh
Patrizia Agostinis
Özden Akay
Sushma Anand
Jasper Anckaert
Zoraida Andreu Martinez
Tine Baetens
Els Beghein
Laurence Bertier
et al.
A1
Journal Article
in
NATURE METHODS
2017
MicroRNA expression analysis using small RNA sequencing discovery and RT-qPCR-based validation
Alan Van Goethem
Pieter Mestdagh
Tom Van Maerken
Jo Vandesompele
Bookchapter
in
Functional genomics : methods and protocols
2017
Restoration of p53 in neuroblastoma : seeking synergy and non-invasive biomakers
Alan Van Goethem
Tom Van Maerken
Jo Vandesompele
Dissertation
2017
2016
Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples
Alan Van Goethem
Nurten Yigit
Celine Everaert
Myrthala Moreno-Smith
Liselot Mus
Eveline Barbieri
Franki Speleman
Pieter Mestdagh
Jason Shohet
Tom Van Maerken
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2016
Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma
Liselot Mus
Shana Claeys
Bram De Wilde
Genevieve Laureys
Alan Van Goethem
Johannes Schulte
Katleen De Preter
Irina Lambertz
Franki Speleman
C3
Conference
2016
Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma
Liselot Mus
Shana Claeys
Bram De Wilde
Genevieve Laureys
Alan Van Goethem
Johannes Schulte
Katleen De Preter
Irina Lambertz
Franki Speleman
C3
Conference
2016
Identification of non-invasive biomarkers for treatment response in neuroblastoma by circulating miRNA profiling
Alan Van Goethem
Nurten Yigit
Mythala Moreno-Smith
Celine Everaert
Olivier Delattre
Pieter Mestdagh
Saurabh Agarwal
Eveline Barbieri
Isabelle Janoueix-Lerosey
Jason Shohet
et al.
C3
Conference
2016
The HBP1 tumor suppressor is an epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys
Irina Lambertz
Alan Van Goethem
Candy Kumps
Sara De Brouwer
Annelies Fieuw
Tom Van Maerken
Kristina Althoff
Johannes Schulte
Jean-Baptiste Demoulin
et al.
C3
Conference
2016
2015
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma
Ali Rihani
Alan Van Goethem
Maté Ongenaert
Sara De Brouwer
Pieter-Jan Volders
Saurabh Agarwal
Katleen De Preter
Pieter Mestdagh
Jason Shohet
Franki Speleman
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2015
HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Candy Kumps
Sara De Brouwer
Annelies Fieuw
Tom Van Maerken
Kristina Althoff
Johannes Schulte
Jean-Baptiste Demoulin
et al.
C3
Conference
2015
Synergistic combined molecular treatment targeting the HBP1 tumor suppressor gene in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Anneleen Beckers
Candy Kumps
Tom Van Maerken
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conference
2015
The HBP1 tumour suppressor at multiple regulatory cross roads in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Anneleen Beckers
Candy Kumps
Tom Van Maerken
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conference
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel R Carter
Alex Cazes
Belamy B Cheung
Marilena De Mariano
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conference
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conference
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conference
2015
lncRNAs as upstream regulators and downstream effectors of TP53 in neuroblastoma
Dries Rombaut
Steve Lefever
Pieter-Jan Volders
Jan Koster
Sven Lindner
Johannes Schulte
Alan Van Goethem
Rogier Versteeg
Peter van Sluis
Jo Vandesompele
et al.
C3
Conference
2015
2014
Characterization of ALK driven molecular networks identifies perturbed RET and cholinergic signaling in neuroblastoma
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindler
Anneleen Beckers
Els Janssens
Marilena De Mariano
Sara De Brouwer
Jay Gibbons
Genevieve Laureys
et al.
C3
Conference
2014
Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma
Alan Van Goethem
Gwen Nichols
Franki Speleman
Jo Vandesompele
Tom Van Maerken
C3
Conference
2014
Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma
Alan Van Goethem
Gwen Nichols
Franki Speleman
Jo Vandesompele
Tom Van Maerken
C3
Conference
2014
Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma
Alan Van Goethem
Gwen Nichols
Franki Speleman
Jo Vandesompele
Tom Van Maerken
C3
Conference
2014
Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma
Alan Van Goethem
Gwen Nichols
Franki Speleman
Jo Vandesompele
Tom Van Maerken
C3
Conference
2014
Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer
Tom Van Maerken
Ali Rihani
Alan Van Goethem
Anne De Paepe
Franki Speleman
Jo Vandesompele
A1
Journal Article
in
CANCER LETTERS
2014
The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity
Shana Claeys
Candy Kumps
Irina Lambertz
Sara De Brouwer
Sven Lindner
Alan Van Goethem
Tom Van Maerken
Jorge Vialard
Jan Cools
Johannes Schulte
et al.
C3
Conference
2014
The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity
Shana Claeys
Candy Kumps
Irina Lambertz
Sara De Brouwer
Sven Lindner
Alan Van Goethem
Tom Van Maerken
Jorge Vialard
Jan Cools
Johannes Schulte
et al.
C3
Conference
2014
miRBase Tracker : keeping track of microRNA annotation changes
Gert Van Peer
Steve Lefever
Jasper Anckaert
Anneleen Beckers
Ali Rihani
Alan Van Goethem
Pieter-Jan Volders
Fjoralba Zeka
Maté Ongenaert
Pieter Mestdagh
et al.
A1
Journal Article
in
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
2014
2013
Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma
Tom Van Maerken
Ali Rihani
Alan Van Goethem
Anne De Paepe
Franki Speleman
Jo Vandesompele
A2
Journal Article
in
PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE
2013