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Onderzoeker
Alain Labro
Profiel
Projecten
Publicaties & datasets
Activiteiten
Prijzen & Erkenningen
Octrooien
74
Resultaten
2025
Development of an equine in vitro proarrhythmia assay: towards safe anti-arrhythmic drugs for horses
Lennert Heirman
Rosalie Allewaert
Gunther van Loon
Alain J Labro
Annelies Decloedt
U
Conferentie
2025
Native equine cardiomyocytes as an in vitro model for evaluating anti-arrhythmic drugs and characterizing cardiac electrophysiology
Lennert Heirman
Rosalie Allewaert
Gunther van Loon
Alain J Labro
Annelies Decloedt
U
Conferentie
2025
Oxygen handling practices for in vitro human pluripotent stem cell cardiomyocyte differentiation : a scoping literature review
Lisse Frans
Jeffrey Aalders
Jolanda van Hengel
Alain J Labro
A1
Artikel in een tijdschrift
in
STEM CELL REVIEWS AND REPORTS
2025
2024
Acute and delayed drug effects on voltage-gated potassium channels
Kenny Van Theemsche
Alain J Labro
Dirk J. Snyders
Proefschrift
2024
2023
Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population
Ewa Sieliwonczyk
Maaike Alaerts
Eline Simons
Dirk Snyders
Aleksandra Nijak
Bert Vandendriessche
Dorien Schepers
Dogan Akdeniz
Emeline Van Craenenbroeck
Katleen Knaepen
et al.
A1
Artikel in een tijdschrift
in
ORPHANET JOURNAL OF RARE DISEASES
2023
2022
A possible explanation for the low penetrance of pathogenic KCNE1 variants in Long QT Syndrome type 5
Szilvia Deri
Teodora Hartai
Laszlo Virag
Norbert Jost
Alain J Labro
Andras Varro
Istvan Baczko
Stanley Nattel
Balazs Ordog
A1
Artikel in een tijdschrift
in
PHARMACEUTICALS
2022
Design of new potent and selective thiophene-based K(V)1.3 inhibitors and their potential for anticancer activity
Spela Gubic
Louise Antonia Hendrickx
Xiaoyi Shi
Zan Toplak
Stefan Mozina
Kenny Van Theemsche
Ernesto Lopes Pinheiro-Junior
Steve Peigneur
Alain J Labro
Luis A. Pardo
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2022
Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes
Aleksandra Nijak
Eline Simons
Bert Vandendriessche
Dieter Van de Sande
Erik Fransen
Ewa Sieliwonczyk
Ilse Van Gucht
Emeline Van Craenenbroeck
Johan Saenen
Hein Heidbuchel
et al.
A1
Artikel in een tijdschrift
in
BIOLOGY OPEN
2022
The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels
Laura Coonen
Evelyn Martinez-Morales
Dieter V. Van De Sande
Dirk J. Snyders
D. Marien Cortes
Luis G. Cuello
Alain J Labro
A1
Artikel in een tijdschrift
in
SCIENCE ADVANCES
2022
The recovery from the C-type inactivated state differs between Shaker and Shaker-W434F K+ channels
Laura Coonen
Evelyn Martinez-Morales
Luis G. Cuello
Dirk J. Snyders
Alain J Labro
C3
Conferentie
2022
2021
Constitutive, basal, and beta-alanine-mediated activation of the human mas-related G protein-coupled receptor D induces release of the inflammatory cytokine IL-6 and is dependent on NF-kappa B signaling
Rohit Arora
Kenny Van Theemsche
Samuel Van Remoortel
Dirk J. Snyders
Alain J Labro
Jean-Pierre Timmermans
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
Developmental toxicity and biotransformation of two anti-epileptics in zebrafish embryos and early larvae
Chloe Bars
Jente Hoyberghs
Allan Valenzuela
Laura Buyssens
Miriam Ayuso
Chris Van Ginneken
Alain J Labro
Kenn Foubert
Steven J. Van Cruchten
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
iPSC-cardiomyocyte models of Brugada syndrome : achievements, challenges and future perspectives
Aleksandra Nijak
Johan Saenen
Alain J Labro
Dorien Schepers
Bart L. Loeys
Maaike Alaerts
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells
Dieter V. van de Sande
Ivan Kopljar
Alaerts Maaike
Ard Teisman
David J. Gallacher
Loeys Bart
Dirk J. Snyders
Luc Leybaert
Hua Rong Lu
Alain J Labro
A1
Artikel in een tijdschrift
in
CHANNELS
2021
2020
Choosing the correct stoichiometry from single subunit counting data
Lena Moeller
Alain J Labro
Dirk J. Snyders
Rikard Blunck
C3
Conferentie
2020
Compound heterozygous SCN5A mutations in severe sodium channelopathy with Brugada syndrome : a case report
Aleksandra Nijak
Alain J Labro
Hans De Wilde
Wendy Dewals
Steve Peigneur
Jan Tytgat
Dirk Snyders
Ewa Sieliwonczyk
Eline Simons
Emeline Van Craenenbroeck
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN CARDIOVASCULAR MEDICINE
2020
Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations
Lena Möller
Glenn Regnier
Alain J Labro
Rikard Blunck
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2020
Electrophysiological characterization of a Brugada syndrome SCN5A Belgian founder mutation in induced pluripotent stem cell cardiomyocytes
E. Simons
A. Nijak
B. Vandendriessche
D. Van de Sande
E. Sieliwonczyk
Alain J Labro
D. Snyders
D. Schepers
B. Loeys
M. Alaerts
C3
Conferentie
2020
Hydrophobic drug/toxin binding sites in voltage-dependent K+ and Na+ channels
Kenny Van Theemsche
Dieter Van de Sande
Dirk Snyders
Alain J Labro
A1
Artikel in een tijdschrift
in
FRONTIERS IN PHARMACOLOGY
2020
Reply to Pisupati et al : evaluating single subunit counting data to find the correct stoichiometry
Lena Möller
Glenn Regnier
Alain J Labro
Dirk J. Snyders
Rikard Blunck
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2020
The selectivity filter is involved in the U-type inactivation process of Kv2.1 and Kv3.1 channels
Laura Coonen
Evy Mayeur
Nicolas De Neuter
Dirk J. Snyders
Luis G. Cuello
Alain J Labro
A1
Artikel in een tijdschrift
in
BIOPHYSICAL JOURNAL
2020
2019
Activation of human Mas-related G Protein-coupled Receptor F (MRGPRF) by the cysteine protease Cathepsin S : implication in neuro-immune communication within the gut
Rohit Arora
Samuel Van Remoortel
Geert Van Raemdonck
Geert Baggerman
Roeland Buckinx
Dirk J. Snyders
Alain J Labro
Jean-Pierre Timmermans
C3
Conferentie
2019
Pharmacological profile of the sodium current in human stem cell-derived cardiomyocytes compares to heterologous Nav1.5+β1 model
Dieter V. Van de Sande
Ivan Kopljar
Ard Teisman
David J. Gallacher
Dirk J. Snyders
Hua Rong Lu
Alain J Labro
A1
Artikel in een tijdschrift
in
FRONTIERS IN PHARMACOLOGY
2019
2018
Converting the depolarization-activated shaker KV channel into a hyperpolarization-conducting cation-selective channel by two pore mutations
Evelyn Martinez-Morales
Laura C. Coonen
Dieter V. Van de Sande
Dirk J. Snyders
Alain J Labro
C3
Conferentie
2018
Inverted allosteric coupling between activation and inactivation gates in K+ channels
Alain J Labro
D. Marien Cortes
Cholpon Tilegenova
Luis G. Cuello
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2018
2017
Stoichiometry of Kv2.1/Kv6.4 heterotetramers revealed by fluorescent single channel subunit counting
Lena Moeller
Glenn Regnier
Alain J Labro
Dirk J. Snyders
Rikard Blunck
C3
Conferentie
2017
2016
Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach
Rym Hassiki
Alain J Labro
Zakaria Benlasfar
Cécile Vincke
Mahmoud Somia
Mohamed El Ayeb
Serge Muyldermans
Dirk J. Snyders
Balkiss Bouhaouala-Zahar
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2016
Elucidating interactions between human mas-related G-protein coupled receptors
Samuel Van Remoortel
Rohit Arora
Alain J Labro
Dirk J. Snyders
Roeland Buckinx
Jean-Pierre Timmermans
C3
Conferentie
2016
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore
Evelyn Martínez-Morales
Ivan Kopljar
Jon D. Rainier
Jan Tytgat
Dirk J. Snyders
Alain J Labro
A1
Artikel in een tijdschrift
in
TOXICON
2016
Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels
Ivan Kopljar
Alessandro Grottesi
Tessa de Block
Jon D. Rainier
Jan Tytgat
Alain J Labro
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
NEUROPHARMACOLOGY
2016
2015
Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening
Evelyn Martínez-Morales
Ivan Kopljar
Dirk J. Snyders
Alain J Labro
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2015
Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization
Alain J Labro
Michael F. Priest
Jérôme J. Lacroix
Dirk J. Snyders
Francisco Bezanilla
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2015
Modulation of closed−state inactivation in Kv2.1/Kv6.4 heterotetramers as mechanism for 4−AP induced potentiation
Jeroen I. Stas
Elke Bocksteins
Alain J Labro
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
PLOS ONE
2015
2014
Diversity in the pharmacological profile of heterotetrameric K(V)2/KVS channels for channel blockers
Jeroen I. Stas
Elke Bocksteins
Alain J Labro
Dirk J. Snyders
C3
Conferentie
2014
Exploring the effect of gambierol on the gating machinery of Kv3.1 channels
Ivan Kopljar
Alessandro Grottesi
Jon D. Rainier
Jan Tytgat
Alain J Labro
Dirk J. Snyders
C3
Conferentie
2014
Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker Kv channel
Evelyn Martinez-Morales
Dirk J. Snyders
Alain J Labro
A1
Artikel in een tijdschrift
in
BIOPHYSICAL JOURNAL
2014
Offsetting the electric field sensed by K-V channels through residue substitutions on top of S1
Evelyn Martinez-Morales
Alain J Labro
Dirk J. Snyders
C3
Conferentie
2014
2013
1-Butanol and gambierol : low and high affinity compounds that immobilize charge movement in shaker and K(v)3.1 potassium channels
Evelyn Martinez-Morales
Ivan Kopljar
Alain J Labro
Dirk J. Snyders
C3
Conferentie
2013
Dual effect of PIP2 on shaker K+ channels
Fayal Abderemane-Ali
Zeineb Es-Salah-Lamoureux
Lucie Delemotte
Marina A. Kasimova
Alain J Labro
Dirk J. Snyders
David Fedida
Mounir Tarek
Isabelle Baro
Gildas Loussouarn
C3
Conferentie
2013
Molecular basis for time dependent modulation of Kv3.1 channels that assures action potential repolarization
Alain J Labro
Jerome J. Lacroix
Dirk J. Snyders
Francisco Bezanilla
C3
Conferentie
2013
Structural and functional consequences of replacing glycine 77 with a L-alanine at the KcsA selectivity filter
D. Marien Cortes
Alain J Labro
Luis G. Cuello
C3
Conferentie
2013
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state
Ivan Kopljar
Alain J Labro
Tessa de Block
Jon D. Rainier
Jan Tytgat
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF GENERAL PHYSIOLOGY
2013
2012
Being flexible : the voltage-controllable activation gate of Kv channels
Alain J Labro
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
FRONTIERS IN PHARMACOLOGY
2012
Dual effect of phosphatidyl (4,5)-bisphosphate PIP2 on shaker K+ channels
Fayal Abderemane-Ali
Zeineb Es-Salah-Lamoureux
Lucie Delemotte
Marina A. Kasimova
Alain J Labro
Dirk J. Snyders
David Fedida
Mounir Tarek
Isabelle Baró
Gildas Loussouarn
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2012
Electrophysiological and gene expression profiling at single cell level through an improved whole cell patch clamp quantitative real-time PCR technique
Ken Veys
Alain J Labro
Dirk J. Snyders
C3
Conferentie
2012
Molecular mechanism for depolarization-induced modulation of Kv channel closure
Alain J Labro
Jerome J. Lacroix
Carlos A. Villalba-Galea
Dirk J. Snyders
Francisco Bezanilla
A1
Artikel in een tijdschrift
in
JOURNAL OF GENERAL PHYSIOLOGY
2012
Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp
K. Veys
Alain J Labro
E. De Schutter
D.J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF NEUROSCIENCE METHODS
2012
The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels
Elke Bocksteins
Alain J Labro
Dirk J. Snyders
Durga P. Mohapatra
A1
Artikel in een tijdschrift
in
PLOS ONE
2012
The role of the 2nd threonine within the TTVGYGD sequence of Kv-channels in C-type inactivation gating, ion selectivity and permeation
Alain J Labro
Doris M. Cortes
Dominique G. Gagnon
Dirk J. Snyders
Luis G. Cuello
C3
Conferentie
2012
The silent K+ channel subunit, K(V)6.4. influences the gating charge movement of K(V)2.1 in a heterotetrameric channel complex
Elke Bocksteins
Alain J Labro
Dirk J. Snyders
Durga P. Mohapatra
C3
Conferentie
2012
Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin gambierol
Ivan Kopljar
Alain J Labro
Jon D. Rainier
Jan Tytgat
Dirk J. Snyders
C3
Conferentie
2012
2011
Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1
E. Bocksteins
N. Ottschytsch
J.-P. Timmermans
Alain J Labro
D. J. Snyders
A2
Artikel in een tijdschrift
in
EUROPEAN BIOPHYSICS JOURNAL
2011
Gate closure in Kv1.5 channels is not dependent on the status of the selectivity-filter
Alain J Labro
Alessandro Grottesi
Dirk J. Snyders
C3
Conferentie
2011
Gate closure strictly follows voltage-sensor movements in K-V channels
Alain J Labro
Jerome J. Lacroix
Carlos A. Villalba-Galea
Dirk J. Snyders
Francisco Bezanilla
C3
Conferentie
2011
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain
Frank S. Choveau
Nicolas Rodriguez
Fayal Abderemane Ali
Alain J Labro
Thierry Rose
Shehrazade Dahimene
Helene Boudin
Carole Le Henaff
Denis Escande
Dirk J. Snyders
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2011
Properties of deactivation gating currents in shaker channels
Jerome J. Lacroix
Alain J Labro
Francisco Bezanilla
A1
Artikel in een tijdschrift
in
BIOPHYSICAL JOURNAL
2011
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
Alain J Labro
Inge R. Boulet
Frank S. Choveau
Evy Mayeur
Tine Bruyns
Gildas Loussouarn
Adam L. Raes
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2011
2010
Phosphatidylinositol-4,5-bisphosphate (PIP2) stabilizes the open pore conformation of the Kv11.1 (hERG) channel
Nicolas Rodriguez
Mohamed Yassine Amarouch
Jerome Montnach
Julien Piron
Alain J Labro
Flavien Charpentier
Jean Merot
Isabelle Baro
Gildas Loussouarn
A1
Artikel in een tijdschrift
in
BIOPHYSICAL JOURNAL
2010
Substitution scan of the S4-S5 linker region in KCNQ1 channel : structural scaffold for critical protein interactions
Alain J Labro
Inge R. Boulet
Adam L. Raes
Dirk J. Snyders
C3
Conferentie
2010
The LQT1 phenotype of the KCNQ1 H258R mutant is unmasked by faster stimulation rates
Alain J Labro
Inge R. Boulet
Evy Mayeur
Jean-Pierre Timmermans
Dirk J. Snyders
C3
Conferentie
2010
The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking
Alain J Labro
Inge R. Boulet
Jean-Pierre Timmermans
Natacha Ottschytsch
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
2010
Time and voltage-dependent slowing in the off gating currents from Kv3.1
Ivan Kopljar
Alain J Labro
Tessa De Block
Dirk J. Snyders
C3
Conferentie
2010
2009
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol
Ivan Kopljar
Alain J Labro
Eva Cuypers
Henry W. B. Johnson
Jon D. Rainier
Jan Tytgat
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2009
Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels
Elke Bocksteins
Alain J Labro
Evy Mayeur
Tine Bruyns
Jean-Pierre Timmermans
Dirk Adriaensen
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2009
Negative charges in the loop between the A and B box of the T1 domain are involved in Kv2.1 and Kv2.1/Kv6.3 channel tetramerization
Elke Bocksteins
Alain J Labro
Evy Mayeur
Dirk J. Snyders
C3
Conferentie
2009
2008
A Kv channel with an altered activation gate sequence displays both 'fast' and 'slow' activation kinetics
Alain J Labro
Alessandro Grottesi
Mark S. P. Sansom
Adam L. Raes
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
2008
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
Alain J Labro
Adam L. Raes
Alessandro Grottesi
Diane Van Hoorick
Mark S. P. Sansom
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF GENERAL PHYSIOLOGY
2008
2007
Role of the S6C-terminus in KCNQ1 channel gating
Inge R. Boulet
Alain J Labro
Adam L. Raes
Dirk J. Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF PHYSIOLOGY-LONDON
2007
2006
Modulation of HERG gating by a charge cluster in the N-terminal proximal domain
J. B. Saenen
Alain J Labro
A. Raes
D. J. Snyders
A1
Artikel in een tijdschrift
in
BIOPHYSICAL JOURNAL
2006
N-terminal charges modulate gating properties of hERG
J. B. Saenen
Alain J Labro
A. L. Raes
D. J. Snyders
C3
Conferentie
2006
2005
Coupling of voltage sensing to channel opening reflects intrasubunit interactions in Kv channels
Alain J Labro
AL Raes
DJ Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF GENERAL PHYSIOLOGY
2005
2004
Role of an aromatic residue cluster in the C-terminal S6 part of Kv channels
Alain J Labro
AL Raes
DJ Snyders
C3
Conferentie
2004
2003
Gating of Shaker-type channels requires the flexibility of S6 caused by prolines
Alain J Labro
AL Raes
I Bellens
N Ottschytsch
DJ Snyders
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2003
Intra-subunit link between voltage sensing and gating in Kv channels
Alain J Labro
AL Raes
I Bellens
DJ Snyders
C3
Conferentie
2003