Research Explorer

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Researcher

Alain Labro

Awards & Distinctions

71 Results

2024

Acute and delayed drug effects on voltage-gated potassium channels

Kenny Van TheemscheAlain J LabroDirk J. Snyders

2023

Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population

Ewa SieliwonczykMaaike AlaertsEline SimonsDirk SnydersAleksandra NijakBert VandendriesscheDorien SchepersDogan AkdenizEmeline Van CraenenbroeckKatleen Knaepen et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

2022

A possible explanation for the low penetrance of pathogenic KCNE1 variants in Long QT Syndrome type 5

Szilvia DeriTeodora HartaiLaszlo ViragNorbert JostAlain J LabroAndras VarroIstvan BaczkoStanley NattelBalazs Ordog

A1 Journal Article in PHARMACEUTICALS

Design of new potent and selective thiophene-based K(V)1.3 inhibitors and their potential for anticancer activity

Spela GubicLouise Antonia HendrickxXiaoyi ShiZan ToplakStefan MozinaKenny Van TheemscheErnesto Lopes Pinheiro-JuniorSteve PeigneurAlain J LabroLuis A. Pardo et al.

A1 Journal Article in CANCERS

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes

Aleksandra NijakEline SimonsBert VandendriesscheDieter Van de SandeErik FransenEwa SieliwonczykIlse Van GuchtEmeline Van CraenenbroeckJohan SaenenHein Heidbuchel et al.

A1 Journal Article in BIOLOGY OPEN

The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels

Laura CoonenEvelyn Martinez-MoralesDieter V. Van De SandeDirk J. SnydersD. Marien CortesLuis G. CuelloAlain J Labro

A1 Journal Article in SCIENCE ADVANCES

The recovery from the C-type inactivated state differs between Shaker and Shaker-W434F K+ channels

Laura CoonenEvelyn Martinez-MoralesLuis G. CuelloDirk J. SnydersAlain J Labro

2021

Constitutive, basal, and beta-alanine-mediated activation of the human mas-related G protein-coupled receptor D induces release of the inflammatory cytokine IL-6 and is dependent on NF-kappa B signaling

Rohit AroraKenny Van TheemscheSamuel Van RemoortelDirk J. SnydersAlain J LabroJean-Pierre Timmermans

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Developmental toxicity and biotransformation of two anti-epileptics in zebrafish embryos and early larvae

Chloe BarsJente HoyberghsAllan ValenzuelaLaura BuyssensMiriam AyusoChris Van GinnekenAlain J LabroKenn FoubertSteven J. Van Cruchten

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells

Dieter V. van de SandeIvan KopljarAlaerts MaaikeArd TeismanDavid J. GallacherLoeys BartDirk J. SnydersLuc LeybaertHua Rong LuAlain J Labro

A1 Journal Article in CHANNELS

iPSC-cardiomyocyte models of Brugada syndrome : achievements, challenges and future perspectives

Aleksandra NijakJohan SaenenAlain J LabroDorien SchepersBart L. LoeysMaaike Alaerts

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020

Choosing the correct stoichiometry from single subunit counting data

Lena MoellerAlain J LabroDirk J. SnydersRikard Blunck

Compound heterozygous SCN5A mutations in severe sodium channelopathy with Brugada syndrome : a case report

Aleksandra NijakAlain J LabroHans De WildeWendy DewalsSteve PeigneurJan TytgatDirk SnydersEwa SieliwonczykEline SimonsEmeline Van Craenenbroeck et al.

A1 Journal Article in FRONTIERS IN CARDIOVASCULAR MEDICINE

Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations

Lena MöllerGlenn RegnierAlain J LabroRikard BlunckDirk J. Snyders

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrophysiological characterization of a Brugada syndrome SCN5A Belgian founder mutation in induced pluripotent stem cell cardiomyocytes

E. SimonsA. NijakB. VandendriesscheD. Van de SandeE. SieliwonczykAlain J LabroD. SnydersD. SchepersB. LoeysM. Alaerts

Hydrophobic drug/toxin binding sites in voltage-dependent K+ and Na+ channels

Kenny Van TheemscheDieter Van de SandeDirk SnydersAlain J Labro

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Reply to Pisupati et al : evaluating single subunit counting data to find the correct stoichiometry

Lena MöllerGlenn RegnierAlain J LabroDirk J. SnydersRikard Blunck

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The selectivity filter is involved in the U-type inactivation process of Kv2.1 and Kv3.1 channels

Laura CoonenEvy MayeurNicolas De NeuterDirk J. SnydersLuis G. CuelloAlain J Labro

A1 Journal Article in BIOPHYSICAL JOURNAL

2019

Activation of human Mas-related G Protein-coupled Receptor F (MRGPRF) by the cysteine protease Cathepsin S : implication in neuro-immune communication within the gut

Rohit AroraSamuel Van RemoortelGeert Van RaemdonckGeert BaggermanRoeland BuckinxDirk J. SnydersAlain J LabroJean-Pierre Timmermans

Pharmacological profile of the sodium current in human stem cell-derived cardiomyocytes compares to heterologous Nav1.5+β1 model

Dieter V. Van de SandeIvan KopljarArd TeismanDavid J. GallacherDirk J. SnydersHua Rong LuAlain J Labro

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2018

Converting the depolarization-activated shaker KV channel into a hyperpolarization-conducting cation-selective channel by two pore mutations

Evelyn Martinez-MoralesLaura C. CoonenDieter V. Van de SandeDirk J. SnydersAlain J Labro

Inverted allosteric coupling between activation and inactivation gates in K+ channels

Alain J LabroD. Marien CortesCholpon TilegenovaLuis G. Cuello

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Stoichiometry of Kv2.1/Kv6.4 heterotetramers revealed by fluorescent single channel subunit counting

Lena MoellerGlenn RegnierAlain J LabroDirk J. SnydersRikard Blunck

2016

Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach

Rym HassikiAlain J LabroZakaria BenlasfarCécile VinckeMahmoud SomiaMohamed El AyebSerge MuyldermansDirk J. SnydersBalkiss Bouhaouala-Zahar

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Elucidating interactions between human mas-related G-protein coupled receptors

Samuel Van RemoortelRohit AroraAlain J LabroDirk J. SnydersRoeland BuckinxJean-Pierre Timmermans

Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore

Evelyn Martínez-MoralesIvan KopljarJon D. RainierJan TytgatDirk J. SnydersAlain J Labro

A1 Journal Article in TOXICON

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels

Ivan KopljarAlessandro GrottesiTessa de BlockJon D. RainierJan TytgatAlain J LabroDirk J. Snyders

A1 Journal Article in NEUROPHARMACOLOGY

2015

Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening

Evelyn Martínez-MoralesIvan KopljarDirk J. SnydersAlain J Labro

A1 Journal Article in SCIENTIFIC REPORTS

Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization

Alain J LabroMichael F. PriestJérôme J. LacroixDirk J. SnydersFrancisco Bezanilla

A1 Journal Article in NATURE COMMUNICATIONS

Modulation of closed−state inactivation in Kv2.1/Kv6.4 heterotetramers as mechanism for 4−AP induced potentiation

Jeroen I. StasElke BocksteinsAlain J LabroDirk J. Snyders

A1 Journal Article in PLOS ONE

2014

Diversity in the pharmacological profile of heterotetrameric K(V)2/KVS channels for channel blockers

Jeroen I. StasElke BocksteinsAlain J LabroDirk J. Snyders

Exploring the effect of gambierol on the gating machinery of Kv3.1 channels

Ivan KopljarAlessandro GrottesiJon D. RainierJan TytgatAlain J LabroDirk J. Snyders

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker Kv channel

Evelyn Martinez-MoralesDirk J. SnydersAlain J Labro

A1 Journal Article in BIOPHYSICAL JOURNAL

Offsetting the electric field sensed by K-V channels through residue substitutions on top of S1

Evelyn Martinez-MoralesAlain J LabroDirk J. Snyders

2013

1-Butanol and gambierol : low and high affinity compounds that immobilize charge movement in shaker and K(v)3.1 potassium channels

Evelyn Martinez-MoralesIvan KopljarAlain J LabroDirk J. Snyders

Dual effect of PIP2 on shaker K+ channels

Fayal Abderemane-AliZeineb Es-Salah-LamoureuxLucie DelemotteMarina A. KasimovaAlain J LabroDirk J. SnydersDavid FedidaMounir TarekIsabelle BaroGildas Loussouarn

Molecular basis for time dependent modulation of Kv3.1 channels that assures action potential repolarization

Alain J LabroJerome J. LacroixDirk J. SnydersFrancisco Bezanilla

Structural and functional consequences of replacing glycine 77 with a L-alanine at the KcsA selectivity filter

D. Marien CortesAlain J LabroLuis G. Cuello

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

Ivan KopljarAlain J LabroTessa de BlockJon D. RainierJan TytgatDirk J. Snyders

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

2012

Being flexible : the voltage-controllable activation gate of Kv channels

Alain J LabroDirk J. Snyders

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Dual effect of phosphatidyl (4,5)-bisphosphate PIP2 on shaker K+ channels

Fayal Abderemane-AliZeineb Es-Salah-LamoureuxLucie DelemotteMarina A. KasimovaAlain J LabroDirk J. SnydersDavid FedidaMounir TarekIsabelle BaróGildas Loussouarn

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophysiological and gene expression profiling at single cell level through an improved whole cell patch clamp quantitative real-time PCR technique

Ken VeysAlain J LabroDirk J. Snyders

Molecular mechanism for depolarization-induced modulation of Kv channel closure

Alain J LabroJerome J. LacroixCarlos A. Villalba-GaleaDirk J. SnydersFrancisco Bezanilla

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp

K. VeysAlain J LabroE. De SchutterD.J. Snyders

A1 Journal Article in JOURNAL OF NEUROSCIENCE METHODS

The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels

Elke BocksteinsAlain J LabroDirk J. SnydersDurga P. Mohapatra

A1 Journal Article in PLOS ONE

The role of the 2nd threonine within the TTVGYGD sequence of Kv-channels in C-type inactivation gating, ion selectivity and permeation

Alain J LabroDoris M. CortesDominique G. GagnonDirk J. SnydersLuis G. Cuello

The silent K+ channel subunit, K(V)6.4. influences the gating charge movement of K(V)2.1 in a heterotetrameric channel complex

Elke BocksteinsAlain J LabroDirk J. SnydersDurga P. Mohapatra

Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin gambierol

Ivan KopljarAlain J LabroJon D. RainierJan TytgatDirk J. Snyders

2011

Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1

E. BocksteinsN. OttschytschJ.-P. TimmermansAlain J LabroD. J. Snyders

A2 Journal Article in EUROPEAN BIOPHYSICS JOURNAL

Gate closure in Kv1.5 channels is not dependent on the status of the selectivity-filter

Alain J LabroAlessandro GrottesiDirk J. Snyders

Gate closure strictly follows voltage-sensor movements in K-V channels

Alain J LabroJerome J. LacroixCarlos A. Villalba-GaleaDirk J. SnydersFrancisco Bezanilla

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain

Frank S. ChoveauNicolas RodriguezFayal Abderemane AliAlain J LabroThierry RoseShehrazade DahimeneHelene BoudinCarole Le HenaffDenis EscandeDirk J. Snyders et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Properties of deactivation gating currents in shaker channels

Jerome J. LacroixAlain J LabroFrancisco Bezanilla

A1 Journal Article in BIOPHYSICAL JOURNAL

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure

Alain J LabroInge R. BouletFrank S. ChoveauEvy MayeurTine BruynsGildas LoussouarnAdam L. RaesDirk J. Snyders

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2010

Phosphatidylinositol-4,5-bisphosphate (PIP2) stabilizes the open pore conformation of the Kv11.1 (hERG) channel

Nicolas RodriguezMohamed Yassine AmarouchJerome MontnachJulien PironAlain J LabroFlavien CharpentierJean MerotIsabelle BaroGildas Loussouarn

A1 Journal Article in BIOPHYSICAL JOURNAL

Substitution scan of the S4-S5 linker region in KCNQ1 channel : structural scaffold for critical protein interactions

Alain J LabroInge R. BouletAdam L. RaesDirk J. Snyders

The LQT1 phenotype of the KCNQ1 H258R mutant is unmasked by faster stimulation rates

Alain J LabroInge R. BouletEvy MayeurJean-Pierre TimmermansDirk J. Snyders

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking

Alain J LabroInge R. BouletJean-Pierre TimmermansNatacha OttschytschDirk J. Snyders

A1 Journal Article in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Time and voltage-dependent slowing in the off gating currents from Kv3.1

Ivan KopljarAlain J LabroTessa De BlockDirk J. Snyders

2009

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

Ivan KopljarAlain J LabroEva CuypersHenry W. B. JohnsonJon D. RainierJan TytgatDirk J. Snyders

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels

Elke BocksteinsAlain J LabroEvy MayeurTine BruynsJean-Pierre TimmermansDirk AdriaensenDirk J. Snyders

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Negative charges in the loop between the A and B box of the T1 domain are involved in Kv2.1 and Kv2.1/Kv6.3 channel tetramerization

Elke BocksteinsAlain J LabroEvy MayeurDirk J. Snyders

2008

A Kv channel with an altered activation gate sequence displays both 'fast' and 'slow' activation kinetics

Alain J LabroAlessandro GrottesiMark S. P. SansomAdam L. RaesDirk J. Snyders

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

Alain J LabroAdam L. RaesAlessandro GrottesiDiane Van HoorickMark S. P. SansomDirk J. Snyders

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

2007

Role of the S6C-terminus in KCNQ1 channel gating

Inge R. BouletAlain J LabroAdam L. RaesDirk J. Snyders

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

2006

Modulation of HERG gating by a charge cluster in the N-terminal proximal domain

J. B. SaenenAlain J LabroA. RaesD. J. Snyders

A1 Journal Article in BIOPHYSICAL JOURNAL

N-terminal charges modulate gating properties of hERG

J. B. SaenenAlain J LabroA. L. RaesD. J. Snyders

2005

Coupling of voltage sensing to channel opening reflects intrasubunit interactions in Kv channels

Alain J LabroAL RaesDJ Snyders

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

2004

Role of an aromatic residue cluster in the C-terminal S6 part of Kv channels

Alain J LabroAL RaesDJ Snyders

2003

Gating of Shaker-type channels requires the flexibility of S6 caused by prolines

Alain J LabroAL RaesI BellensN OttschytschDJ Snyders

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Intra-subunit link between voltage sensing and gating in Kv channels

Alain J LabroAL RaesI BellensDJ Snyders