Project

Detailed study of protein-protein interactions: study of the activation mechanism of TOLL-like receptors

Duration
01 January 2008 → 31 December 2010
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Scientific computing
    • Biochemistry and metabolism
    • Bioinformatics and computational biology
    • Systems biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Medical biochemistry and metabolism
    • Bioinformatics and computational biology
    • Medical biochemistry and metabolism
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
    • Scientific computing
Keywords
homology modelling toll-like receptor innate immunity
 
Project description

Toll-like receptors are activated by interactions between TIR domeins. Homology models are built for the TIR domains. The MAPPIT method and in vitro binding studies with recombinant TIR domains are combined with extensive mutagenesis studies to identify the interaction interfaces. These data are used as input for data-driven in silico docking. This leads to experimentally validated models for TIR-TIR complexes.