Project

Interrelationship of pulmonary inflammation, systemic inflammation and airway remodelling in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD).

Code

3G019509

Duration

01 January 2009 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Guy Brusselle

Research disciplines

Medical and health sciences
- Immunology
- Laboratory medicine
- Physiology
- Respiratory medicine
- Immunology
- Laboratory medicine
- Physiology
- Respiratory medicine
- Immunology
- Laboratory medicine
- Physiology
- Respiratory medicine

Keywords

inflammation remodelling COPD cigarette smoke

Project description

The overall aim of this coordinated, multidisciplinary research proposal is to elucidate the interrelationship between systemic inflammation, pulmonary inflammation and airway remodelling in the pathogenesis of COPD. The central hypothesis is that "COPD ensues from an inappropriate (ie exaggerated, harmful) inflammatory and/or fibrogenic response of the host to cigarette smoke".