Acroniem
FWO13-FKM-002
Code
3L000213
Looptijd
01-10-2013 → 30-09-2028
Financiering
Research Foundation - Flanders (FWO)
Promotor
Onderzoeksdisciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Physiology
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Physiology
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Physiology
Trefwoorden
klinische studie
modifier gen identificatie
ectopische mineralisatie
genodermatose
pseudoxanthoma elasticum
cellulaire pathways
Projectomschrijving
Pseudoxanthoma elasticum (PXE) is characterized by skin, ocular and cardiovascular manifestations, based on mineralization of elastic fibres. This project aims i) to gain insight in the cellular mechanisms leading to ectopic mineralization, ii) a comprehensive study of the cardiovascular phenotype of patients and their family and iii) to identify of modifier genes to optimize the follow-up of patients.