Project

Skin interaction of the cyclic depsipeptide mycotoxins

Code

01D23812

Duration

01 October 2012 → 30 September 2016

Funding

Regional and community funding: Special Research Fund

Promotor

Bart De Spiegeleer

Fellow

Lien Taevernier

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Dermatology
- Medical biochemistry and metabolism
- Dermatology
- Medical biochemistry and metabolism
- Public health care
- Public health sciences
- Public health services
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Dermatology
- Medical biochemistry and metabolism

Keywords

risk assessment transdermal cyclic depsipeptides skin mycotoxin pharmaceutics

Project description

This research project quantitatively characterises the interaction of cyclic depsipeptides (CDP) with human skin using ex-vivo in-vitro FDC experiments. This knwoledge is required for the global mycotoxin risk assessment due to skin-contact of contaminated cosmeceuticals, food, feed, indoor surfaces and airborne particles, but also for the development of topically applied new CDP-drugs, treating dermatological or systemic diseases after transdermal penetration.