Project

The role of lncRNAs in human cognition

Duration
01 October 2016 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
Rett Syndrome Developmental dissorder
 
Project description

Alterations in MEF2C and FXG1 have both been implicated in Rett Syndrome, a severe neurodevelopmental disorder. However, a number of patients present with abberations that solely affect the noncoding regions neighbouring these genes. This suggest the disruption of crucial regulatory elements in these cases. Our aim is to identify such regulatory elements and functionally validate the impact of such disruptions.