Research Explorer

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Project

The barrier role of the vitreoretinal interface toward intravitreal injected proteins, viruses and siRNA nanoparticles: ex vivo bovine screening models and siRNA nanoparticle design.

Outputs and Outcomes

Publications

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery

Karen PeynshaertHelena VanlucheneKaat De ClerckAn-Katrien MinnaertMorgane VerhoevenNoémie GouspillouNezahat BostanToshio HisatomiGeraldine AccouFélix SauvageKevin BraeckmansStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Yeast-produced fructosamine-3-kinase retains mobility after ex vivo intravitreal injection in human and bovine eyes as determined by Fluorescence Correlation Spectroscopy

An-Katrien MinnaertLoes van SchieHendrik GrootaertJonas HimpeSimon DevosWannes WeytsHerlinde De KeersmaeckerKevin BraeckmansElisabeth Van AkenJoris DelangheStefaan De SmedtNico CallewaertKatrien Remaut et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Together is better : mRNA co‐encapsulation in lipoplexes is required to obtain ratiometric co‐delivery and protein expression on the single cell level

Heyang ZhangJeroen BussmannFlorian H. HuhnkeJoke DevoldereAn-Katrien MinnaertWim JiskootFriedhelm SerwaneJoachim SpatzMagnus RödingStefaan De SmedtKevin BraeckmansKatrien Remaut et al.

A1 Journal Article in ADVANCED SCIENCE

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Vaccinia virus protein B18R : influence on mRNA immunogenicity and translation upon non-viral delivery in different ocular cell types

An-Katrien MinnaertJoke DevoldereKaren PeynshaertLaure VercruysseStefaan De SmedtKatrien Remaut

A1 Journal Article in PHARMACEUTICS