Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Project

In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan

Outputs and Outcomes

Code

01CD6323

Duration

01 November 2023 → 31 July 2024

Funding

Regional and community funding: Special Research Fund

Promotor

Frank Peelman

Fellow

Nick Deploey

Research disciplines

Medical and health sciences
- Cell signalling
- Structural biology

Keywords

structure-activity relationship deep mutational scan Glucocorticoid receptor mutagenesis

Project description

We generate thousands of GR mutants and test them in different relevant gene activation and repression assays. We model the effect of the mutants on the GR structure to reveal in detail how GR ligands obtain their specific gene activation and repression profile which can lead to the development of better GR ligands with fewer side effects.

English

Dutch

English

Cookie settings

In addition to functional cookies which are necessary for the website to function, Ghent University uses non-functional cookies such as statistical cookies and social media cookies. These non-functional cookies can also be placed by third parties, for example to measure the use of the site or to share content on social media. Certain media are only available if you accept the cookies. You can set and modify your cookie preferences yourself. Find out what cookies we use and why in the Cookie Statement.

Analytics

AnalyticsWe'll collect information about your visit to our site. It helps us understand how the site is used – what's working, what might be broken and what we should improve.

Powered by