Throughout history, medicine has been largely built on statistical grounds, treating individual patients as members of (potentially heterogeneous) groups, which may result in suboptimal treatment outcomes. Ideally, the general focus should be shifted from the general approach towards a more personalised medicine. This research project’s ambition is to take part in this revolution by using computational biomechanics as a tool for personalised medicine in two main research areas, being cancer and minimally invasive procedures. More specifically, the objectives are: (i) Optimisation and personalisation of targeted drug delivery for cancer treatment (i.e. transarterial drug delivery for liver cancer, intraperitoneal chemotherapy for peritoneal carcinomatosis, and lymphatic delivery), (ii) Development of planning tools for minimally invasive interventions (i.e. robot-assisted partial nephrectomies and neuro-interventional procedures), and (iii) Unravelling the role of biomechanics in diverse other applications (e.g. Fontan-related liver pathologies).