Research Explorer

Project

Exosomes: nanomaps for metastatic niche formation
Acronym
Exosomen-1
Code
3E007612
Duration
01 October 2012 → 30 September 2019
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Physical chemistry
  • Medical and health sciences
    • Public health services
Keywords
Invasion metastatsis exosome
 
Project description
 

Cancer cells secrete soluble factors and chemokines that recruit bone marrow derived cells (BMDC) toward sites of future metastasis formation. Recently, not only soluble factors but also small vesicles (exosomes, 30-100 nm) were described, which contain mRNAs, miRNAs and polypeptides from their cell of origin. These exosomes from the cancer cells are instrumental for BMDCs to prepare the premetastatic niche.