Project

Intestinal toxicity and oral resorption of conjugated Fusarium mycotoxins, frequently present in feed and food

Duration
01 January 2012 → 31 October 2016
Funding
Ghent University funding
Research disciplines
  • Natural sciences
    • Other chemical sciences
    • Animal biology
  • Medical and health sciences
    • Nutrition and dietetics
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Agricultural and food sciences
    • Agricultural animal production
    • Food sciences and (bio)technology
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
conjugated mycotoxins feed toxicity bioavailability food
 
Project description

The objectives of this study are threefold and are: 1) the synthesis of glucosyalted deoxynivalenol and zearalenone conjugates and acetylated deoxynivalenol derivates, in sufficient quantity to conduct futher in vitro an din vivo experiments; 2) the study of the intestinal cytotoxicity and influence on cytokine response of these derivates; 3) to gain insight in the oral bioavailability and in vivo degree of hydrolysis of these synthetised conjugates using relevant in vitro models with intestinal epithelial cell lines and intestinal wall tissue explants, and in vivo bolus toxicokinetic models.