Code
01N03618
Duration
01 January 2018 → 31 December 2021
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Biochemistry and metabolism not elsewhere classified
- Systems biology not elsewhere classified
-
Medical and health sciences
- Medical biochemistry and metabolism not elsewhere classified
- Medical biochemistry and metabolism not elsewhere classified
- Biomarker discovery and evaluation not elsewhere classified
- Drug discovery and development not elsewhere classified
- Medicinal products not elsewhere classified
- Pharmaceutics not elsewhere classified
- Pharmacognosy and phytochemistry not elsewhere classified
- Pharmacology not elsewhere classified
- Pharmacotherapy not elsewhere classified
- Toxicology and toxinology not elsewhere classified
- Other pharmaceutical sciences not elsewhere classified
- Medical biochemistry and metabolism not elsewhere classified
Keywords
Nanomedicines
liposomes
siRNA
mRNA
lysosomes
intracellular delivery
microfluidics
Project description
Nanomedicine (NM)-mediated delivery of RNA faces many extra-and intracellular barriers. Upon endocytosis by target cells, NMs are trafficked toward lysosomes for degradation and conventional endosomal escape strategies fall short. Here, we propose to exploit cationic amphiphilic drugs (CADs) as adjuvants to trigger lysosomal escape of RNA therapeutics and to formulate CADs into lipid nanoparticles for improved siRNA and mRNA delivery.