Repurposing of cationic amphiphilic drugs as adjuvants to enhance the cellular delivery of RNA therapeutics

01 January 2018 → 31 December 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Medical biochemistry and metabolism
Nanomedicines liposomes siRNA mRNA lysosomes intracellular delivery microfluidics
Project description

Nanomedicine (NM)-mediated delivery of RNA faces many extra-and intracellular barriers. Upon endocytosis by target cells, NMs are trafficked toward lysosomes for degradation and conventional endosomal escape strategies fall short. Here, we propose to exploit cationic amphiphilic drugs (CADs) as adjuvants to trigger lysosomal escape of RNA therapeutics and to formulate CADs into lipid nanoparticles for improved siRNA and mRNA delivery.