Research Explorer

Project

Characterization of the effects of the US3 protein of alphaherpesviruses on the cytoskeleton and viral spread in order to identify new antiviral strategies
Code
178DI1011
Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
herpesvirus Rho GTPase kinase US3 cytoskeleton cofilin
 
Project description

The US3 protein kinase of alphaherpesviruses induces rearrangements of the actin cytoskeleton that promote viral spread. The aim of the project is to identify cellular proteins that are crucial in initiating or exerting the US3-induced changes in the actin cytoskeleton, thereby representing potential novel targets in the development of antiviral strategies.