Project

Characterization of the effects of the US3 protein of alphaherpesviruses on the cytoskeleton and viral spread in order to identify new antiviral strategies

Code

178DI1011

Duration

01 October 2010 → 05 January 2016

Funding

Regional and community funding: IWT/VLAIO

Promotor

Herman Favoreel

Fellow

Thary Jacob

Research disciplines

Natural sciences
- Microbiology
- Systems biology
Medical and health sciences
- Laboratory medicine
- Microbiology
- Laboratory medicine
- Laboratory medicine
- Microbiology

Keywords

herpesvirus Rho GTPase kinase US3 cytoskeleton cofilin

Project description

The US3 protein kinase of alphaherpesviruses induces rearrangements of the actin cytoskeleton that promote viral spread. The aim of the project is to identify cellular proteins that are crucial in initiating or exerting the US3-induced changes in the actin cytoskeleton, thereby representing potential novel targets in the development of antiviral strategies.