Research Explorer

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Project

Dynamic Interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation

Outputs and Outcomes

Publications

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma

Lien ProvezTom PuttemanMattias LandforsJuliette RoelsLindy ReunesSara T'SasWouter Van LoockeBéatrice LintermansStien De ConinckMorgan ThenozWouter SleeckxNatalia Maćkowska-MaślakTom TaghonMarc R. MansourNadine FarahKoen NorgaPeter VandenbergheRishi S. KotechaSteven GoossensSofie DegermanRenate De SmedtPieter Van Vlierberghe et al.

A1 Journal Article in CANCERS

ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

Hila FishmanShreyas MadiwaleIfat GeronVase BariWouter Van LoockeYael KirschenbaumItamar GanmoreEitan KuglerAvigail Rein-GilGilgi FriedlanderGinette SchibyYehudit BirgerSabine StrehlJean SoulierBirgit KnoechelAdolfo FerrandoSharon Noy-LotanArnon NaglerJames C. MulloyPieter Van VlierbergheShai Izraeli et al.

A1 Journal Article in BLOOD

Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival

Siska Van BelleSara El AshkarKateřina ČermákováFilip MatthijssensSteven GoossensAlessandro CanellaCourtney H. HodgesFrauke ChristJan De RijckPieter Van VlierbergheVáclav VeverkaZeger Debyser et al.

A1 Journal Article in CELLS

Design of a comprehensive fluorescence in situ hybridization assay for genetic classification of T-cell acute lymphoblastic leukemia

Roberta La StarzaValentina PieriniTiziana PieriniValeria NofriniCaterina MatteucciSilvia ArnianiMartina MorettiAnair G. Lema FernandezFabrizia PellaneraDanika Di GiacomoTiziana C. StorlazziAntonella VitalePaolo GorelloGabriella SammarelliGiovanni RotiGiuseppe BassoSabina ChiarettiRobin FoaClaire SchwabChristine J. HarrisonPieter Van VlierbergheCristina Mecucci et al.

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS