Research Explorer

Project

Dynamic Interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation
Acronym
EPITALL
Code
41I03415
Duration
01 July 2015 → 30 June 2020
Funding
European funding: framework programme
Principal investigator
Research disciplines
  • Medical and health sciences
    • Cancer biology
    • Cancer biology
    • Cancer therapy
Keywords
epigenetics T-cell leukemia
Other information
 
Project description
 

Dynamic interplay between histone modifications and DNA methylation defines the chromatin structure of the humane genome and serves as a conceptual framework to understand transcriptional regulation in normal development and human disease. The ultimate goal of this research proposal is to study the chromatin architecture during normal and malignant T cell differentiation in order to define how DNA methylation drives oncogenic gene expression as a novel concept in cancer research.
 
 
 
Disclaimer
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency (ERCEA). Neither the European Union nor the authority can be held responsible for them.