This project addresses the predictive value of the temperament-parenting interplay, vitally crucial for all children, to explain the wide range of variability in both maladaptive and adaptive development of youngsters with special needs. Using a three-wave prospective cohort design, transdiagnostic generalizability of processes is tested in and across three neurodevelopmental disabilities (Autism, Down syndrome, Cerebral Palsy) relative to typical controls.