Code
01T02608
Duration
01 May 2009 → 31 August 2010
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Dermatology
- Molecular and cell biology
- Orthopaedics
- Dermatology
- Orthopaedics
- Dermatology
- Molecular and cell biology
- Orthopaedics
Keywords
TGF-beta signaling
Cutis Laxa
fibulin
elastin
Project description
The molecular basis of autosomal dominant and recessive forms of Cutis Laxa will be studied and genotype-phenotype correlations will be formulated. The functional consequences of mutations in elastin and fibulin will be investigated for their effect on TGF-beta signaling and by studying cardiovascular and other phenotypic consequences in a zebrafish model.