Project

The role of soluble guanylate cyclase isoforms in the relaxation effect of vascular smooth muscle cells and in penile corpora cavernosa

Code

01D26707

Duration

01 October 2007 → 30 September 2013

Funding

Regional and community funding: Special Research Fund

Promotor

Johan Van de Voorde

Research disciplines

Medical and health sciences
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology

Keywords

transgenic mice NO erection vasodilation cyclic GMP

Project description

Erection and vasorelaxation under the influence of NO and NO-releasing substances is based on activation of soluble guanylyl cyclase, existing in different isoforms. Using transgene mices, his project aims to find out the specific isoforms involved in these processes. This is important for the development of selective drugs for the treatment of hypertension and erectile dysfunction.