Project

The role of soluble guanylate cyclase isoforms in the relaxation effect of vascular smooth muscle cells and in penile corpora cavernosa

Duration
01 October 2007 → 30 September 2013
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Physiology
    • Urology and nephrology
    • Cardiac and vascular medicine
    • Physiology
    • Urology and nephrology
    • Cardiac and vascular medicine
    • Physiology
    • Urology and nephrology
Keywords
transgenic mice NO erection vasodilation cyclic GMP
 
Project description

Erection and vasorelaxation under the influence of NO and NO-releasing substances is based on activation of soluble guanylyl cyclase, existing in different isoforms. Using transgene mices, his project aims to find out the specific isoforms involved in these processes. This is important for the development of selective drugs for the treatment of hypertension and erectile dysfunction.