Code
01D26707
Duration
01 October 2007 → 30 September 2013
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology
- Cardiac and vascular medicine
- Physiology
- Urology and nephrology
Keywords
transgenic mice
NO
erection
vasodilation
cyclic GMP
Project description
Erection and vasorelaxation under the influence of NO and NO-releasing substances is based on activation of soluble guanylyl cyclase, existing in different isoforms. Using transgene mices, his project aims to find out the specific isoforms involved in these processes. This is important for the development of selective drugs for the treatment of hypertension and erectile dysfunction.