Project

Molecular and structural basis of type-II secretion systems of pathogenic Gram-negative bacteria.

Duration
01 October 2013 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Biochemistry and metabolism
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
Keywords
type II secretion system Gram-negative bacteria general secretion pathway structural biology
 
Project description

The type II secretion system (T2SS) is a multiprotein machinery penetrating the double membrane of Gram-negative bacteria, enabling the secretion of exoproteins and virulence factors. My project is focused on providing structural, kinetic and thermodynamic view of XcpR, motor ATPase of T2SS with its proteinaceous and nucleotide partners. These data are crucial for understanding mechanism of secretion employing T2SS.