Project

Glucocorticoid and selective glucocorticoid receptor modulator effects on tumour eco-system

Code
3F010214
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
glucocorticoid receptor selective GR modulators glucocorticoids cancer
 
Project description

The glucocorticoid receptor (GR), after binding to its ligand, functions as a transcription factor to regulate the expression of multiple target genes. Here we investigate the influence of GR and its ligands: glucocorticoids and selective GR modulators on the cross-talk between cancer cells and their surrounding stromal cells, an interaction known to affect cancer cell invasion via secreted products.