Code
3F010214
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology
Keywords
glucocorticoid receptor
selective GR modulators
glucocorticoids
cancer
Project description
The glucocorticoid receptor (GR), after binding to its ligand, functions as a transcription factor to regulate the expression of multiple target genes. Here we investigate the influence of GR and its ligands: glucocorticoids and selective GR modulators on the cross-talk between cancer cells and their surrounding stromal cells, an interaction known to affect cancer cell invasion via secreted products.