Research Explorer

Project

The role of Ormdl3 in asthma
Code
3F005414
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Respiratory medicine
    • Immunology
    • Respiratory medicine
    • Immunology
    • Respiratory medicine
Keywords
asthma calcium Ormdl3 sphingolipids unfolded portein response
 
Project description
 

Increased transcription of orosomucoid like 3 (Ormdl3) is linked with nonallergic childhood-onset asthma. We developed a full and conditional knockout and a transgenic Ormdl3 overexpressing mouse model, which will allow us to carefully dissect its role in asthma. Mechanistically, we will focus our attention on sphingolipid metabolism, calcium homeostasis and the role of the unfolded protein response.