Project

Novel forward genetics screening methodology in human HEK293 cells.

Code

3F007013

Duration

01 October 2013 → 30 September 2017

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Nico Callewaert

Fellow

Andries De Koker

Research disciplines

Natural sciences
- Scientific computing
- Biochemistry and metabolism
- Bioinformatics and computational biology
- Genetics
- Systems biology
Medical and health sciences
- Bioinformatics and computational biology
- Medical biochemistry and metabolism
- Molecular and cell biology
- Morphological sciences
- Oncology
- Bioinformatics and computational biology
- Medical biochemistry and metabolism
- Morphological sciences
- Oncology
- Public health care
- Public health services
- Bioinformatics and computational biology
- Medical biochemistry and metabolism
- Molecular and cell biology
- Morphological sciences
- Oncology
Engineering and technology
- Scientific computing

Keywords

directed cell line evolution HEK293 forward genetics

Project description

Forward genetic approaches are at the basis of much of our understanding of cellular biology. But such approaches are poorly established for mammalian cells. The aim of the project is to optimize and explore the scope of a method for 'directed cell line evolution' that makes use of the property of HEK293-cells to evolve through a more natural mutation-accumulation process.