Research Explorer

Project

Enlightened Moves: Set-up and application of novel bioluminescence-based systems to monitor the impact of new psychoactive substances on drug transporter dynamics
Code
01D24821
Duration
01 November 2021 → 31 October 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Compound screening
    • In vitro testing
    • Pharmacodynamics
    • Clinical toxicology
    • Proteins
Keywords
New Psychoactive Substances Neurotransmitter transporters Dopamine Transporter (DAT) Norepinephrine Transporter (NET) Serotonin Transporter (SERT) Fluorescence-based assay Bioluminescence-based assay Bio-assay
 
Project description

The emergence of new psychoactive substances is a major threat to public health. This project aims at setting up bio-assays for the dopamine, norepinephrine and serotonin transporters, the target of many stimulants and psychedelics. To investigate their pharmacology and toxicity, new luminescence-based bio-assays will be set up, based on the intra- or intermolecular functional complementation of a split nanoluciferase.