Research Explorer

Project

Unravelling the neurobiological working mechanism of subanesthetic doses of ketamine by functional imaging in dogs.
Code
01D26115
Duration
01 October 2015 → 09 March 2020
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Social sciences
    • Biological and physiological psychology
    • Clinical and counselling psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
    • Other psychology and cognitive sciences
  • Medical and health sciences
    • Medical imaging and therapy
    • Neurosciences
    • Psychiatry and psychotherapy
    • Medical imaging and therapy
    • Neurosciences
    • Psychiatry and psychotherapy
    • Nursing
    • Other paramedical sciences
    • Medical imaging and therapy
    • Neurosciences
    • Psychiatry and psychotherapy
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural and food sciences
Keywords
dog functional imaging SPECT depression hond biomarkers ketamine
 
Project description
 

Major depressive disorder is a costly brain disorder in Europe. Limitation of existing therapies is the low response rate and lag of onset, which increases suicide risk. Low dose ketamine seems promising in this respect. A dog model will be used to investigate the effect of ketamine on the serotonergic system, brain perfusion and inflammatory biomarkers in dogs.