Life-science is a data science; it relies on the generation, sharing and integrated analysis of vast quantities of digital data. The knowledge created by connecting life-science data is transforming biological research and drives a new era of integrative biology. ELIXIR is a European Research Infrastructure that brings together international resources in life-sciences to form a single infrastructure enabling scientists to find and share data, exchange expertise and access advanced tools and large scale computational facilities, across borders and across disciplines. This integrative approach offers innovative usage of data leading to an advanced understanding of life and disease. The Belgian ELIXIR Node offers a broad spectrum of services in the domains of human genomics, proteomics and plant science. We will also provide training and tools to facilitate research data management and data-analysis. Our mission is to ensure that researchers in Flanders and Belgium can focus on their research question, rather than on technical details of data, interoperability, compute resources, etc. by providing tailored solutions based on an interoperable infrastructure across Europe.